Group 1 - A recent incident in Fujian highlights the dangers of improperly taking medication, where a man experienced a severe drop in blood pressure after splitting a controlled-release antihypertensive tablet, leading to a medical emergency [1] - Medications labeled with "controlled-release," "sustained-release," or "enteric-coated" should be swallowed whole, as breaking or crushing them can lead to rapid drug release, potentially causing shock or death [1][2] - Controlled-release tablets are designed to release medication at a constant rate, allowing for once-daily dosing, while regular tablets require multiple doses throughout the day [2] Group 2 - Sustained-release tablets, while having a different manufacturing process than controlled-release tablets, also aim for slow drug release and should not be split, as this can lead to adverse reactions [4] - Enteric-coated tablets are designed to dissolve in the intestines rather than the stomach; splitting them can cause premature dissolution in the stomach, affecting efficacy and potentially irritating the gastric lining [4] - Capsules should not be opened, as this can expose the medication to stomach acid, affecting its release and increasing gastrointestinal side effects [4] Group 3 - Patients should be aware of the proper sequence and timing for taking medications, as this can impact their effectiveness and reduce the risk of adverse reactions [5] - It is advised to space the intake of traditional Chinese medicine and Western medicine by about half an hour, and to take certain medications after meals to minimize gastrointestinal irritation [5] - Storage conditions for medications, including temperature and humidity, are crucial for maintaining their efficacy; for example, insulin must be stored between 2°C and 8°C to remain effective [6][8]

近日，有媒体报道，福建一名男子为减少用药剂量，自行将降压药片掰开服用，结果短短30分钟内血压 急剧下降至无法测出，随即瘫倒昏迷，经紧急送医抢救才脱离生命危险。据悉，该男子吃的是降压药的 一种类型：控释片。南京江北人民医院药学部主任石戈平提醒，控释片作为特殊剂型药品之一，掰开即 会破坏特有的骨架结构，让药效瞬间爆发，即便药片表面有刻痕，也严禁掰开。 大多数普通片剂通常可以掰开或碾碎，若药片有预切刻痕，可沿刻痕掰开，不影响剂量准确性。但对于 一些对光线、温湿度敏感的药物，掰开可能导致有效成分降解，也建议在专业医生的指导下科学服用。 另外，患者在吃药前需注意观察药物是否有开裂现象，有些时候因为药品保存不当，或者质量问题破损 开裂，这也相当于被"掰开"，同样存在风险。 许倩倩 "控释片这类药品是通过特殊的制剂工艺，使药物可以在体内均匀释放，从而在较长时间内平稳发挥药 效。"石戈平主任解释说，控释片内部有特殊的骨架结构，一旦掰开，骨架被破坏，原本应该在十几个 小时内缓慢释放的药量，可能在短时间内全部释放，导致血药浓度聚升，引发血压急剧下降等严重不良 反应。"这类药品即便表面有刻痕，也不能掰开服用。" 有些患者在服用一些 ...