Core Insights - The company reported a 49.08% year-on-year increase in R&D expenses for the first three quarters of 2025, focusing on new PEG integrated interferon mutant injection for hepatitis B treatment and γδT cell tumor immunotherapy clinical research [1][2] Group 1: R&D Investments - The primary investment is in the development of new PEG integrated interferon, which is expected to significantly improve the clinical cure rate for chronic hepatitis B through genetic testing [1] - The company has completed a large sample (940 cases) whole genome scan, establishing a seamless clinical research plan for II-III phase trials with clinical cure as the endpoint [1] Group 2: Tumor Immunotherapy - The company has conducted clinical observations on 36 cases of liver cancer, melanoma, and acute myeloid leukemia, demonstrating good safety for allogeneic γδT cells [2] - Acute myeloid leukemia has been identified as the core clinical development direction based on systematic analysis of preliminary clinical data [2] Group 3: Strategic Expansion - The company has strategically extended its recombinant protein technology platform into the field of recombinant human collagen, achieving breakthroughs in molecular structure and expression systems [2] - This new business segment is expected to complement existing serious medical operations while entering the consumer healthcare market [2] Group 4: Long-term Development - Through high-intensity R&D investments, the company is transforming its technological advantages into future market competitiveness, building a solid moat for sustainable long-term development [2] - The company is poised for continuous breakthroughs based on steady progress in its pipeline products and the gradual establishment of new business segments [2]

Core Viewpoint - San Yuan Gene reported a slight increase in revenue for the first half of the year, while facing increased costs due to depreciation, operational maintenance, and interest expenses related to new facility construction and R&D investments [2] Group 1: Financial Performance - The company achieved operating revenue of 118 million yuan, representing a year-on-year increase [2] - The net profit attributable to shareholders decreased year-on-year, but the second quarter net profit reached 5.7851 million yuan, indicating a significant recovery from the first quarter [2] - R&D expenses for the first half amounted to 12.9358 million yuan, accounting for 10.93% of operating revenue, with a year-on-year growth of 103.31% [2] Group 2: R&D Focus - The company is focusing on the development of a new PEG-integrated interferon mutant for the treatment of chronic hepatitis B, which is expected to significantly improve clinical cure rates [3] - San Yuan Gene is utilizing advanced genome-wide detection technology to identify suitable patient populations for the new interferon treatment, positioning itself as a leader in precision medicine for hepatitis B [3] - The company has completed the enrollment of 940 subjects for genome-wide detection clinical studies, with 149 new enrollments during the reporting period [3] Group 3: Collagen Protein Development - San Yuan Gene has made significant progress in the development of recombinant human collagen products, achieving the world's first efficient production of recombinant human type II and III collagen based on mammalian cell expression [4] - The company plans to increase R&D investment in collagen-related cosmetic and medical device products, aiming for regulatory approval and market launch in phases [4] - The focus on accelerating technology transfer and deepening industry collaboration is intended to enhance the company's core competitiveness in the collagen field [4]