机构简介： 弘尚资产由来自公募基金的优秀团队和全球风险投资巨擘红杉资本联合创建，公司成立于2013年10月，是红杉资本在中国唯一的权益证券资产管 理平台。公司成立以来，凭借优秀业绩和稳健运作，屡获金阳光、金长江及金牛奖等行业大奖，跻身国内知名阳光私募基金公司。弘尚资产专注 于绝对收益目标的权益类投资策略，以基本面研究驱动的权益类资产管理能力为核心竞争力，公司投研团队包括大型基金公司高管、外资投研主 管、金牛基金经理、新财富最佳分析师等资深投研大将。非投研板块的业务带头人全部来自公募基金，具有深厚的管理经验和行业影响力，确保 公司持续稳健发展。公司是中国基金业协会会员，具备投顾资格。 以上内容为证券之星据公开信息整理，由AI算法生成（网信算备310104345710301240019号），不构成投资建议。 根据市场公开信息及8月25日披露的机构调研信息，知名私募弘尚资产近期对2家上市公司进行了调研，相关名单如下： 1）特宝生物 （弘尚资产参与公司电话接待） 调研纪要：特宝生物在乙肝功能性治愈方面，认为未来将趋于不同机制药物与干扰素、核苷（酸）类似物的联合优化。慢乙肝临床治愈门诊旨在 广覆盖乙肝诊疗网络，提供全病 ...

调研纪要：公司与北美运营商的主要业务集中在宽带接入和无线网络领域，2027年业务规划尚未明确。 与多个北美大客户的合作进展不同，有的产品验证接近完成，有的仍在进行中。上海和嘉善工厂将 800G系列产品产能提升至年化200万只，明年上半年继续扩产。今年扩产计划顺利推进，明年产能配套 目标较之前有所提升。今年扩产依靠自有资金，明年可能使用香港发行融资，物料储备足够支撑今年需 求。 调研纪要：特宝生物在乙肝功能性治愈方面，认为未来将趋于不同机制药物与干扰素、核苷(酸)类似物 的联合优化。慢乙肝临床治愈门诊旨在广覆盖乙肝诊疗网络，提供全病程科学管理。公司与ligos合作探 索清除感染细胞后的再感染控制，收购九天生物以利用其基因治疗平台提供更精准解决方案。新技术如 siRN已进入临床联合应用阶段，未来关键在于联合用药策略优化。干扰素渗透率提升依赖于疾病认知 深化与不良反应管理优化。 2)剑桥科技（603083）(蜂巢基金管理有限公司参与公司业绩说明会&现场参观) 证券之星消息，根据市场公开信息及8月25日披露的机构调研信息，蜂巢基金近期对2家上市公司进行了 调研，相关名单如下： 1)特宝生物(蜂巢基金管理有限公司参与公 ...

证券之星消息，根据市场公开信息及8月25日披露的机构调研信息，金鹰基金近期对6家上市公司进行了 调研，相关名单如下： 1)稳健医疗（300888）(金鹰基金参与公司业绩说明会&线上调研) 调研纪要：全棉时代第二季度实现13%同比增长，7-8月销售增速回升，坚持四大战略推动业务发展。 医疗板块成长空间大，将围绕三大战略展开，重点提升产品结构和生产效率，推进海外供应链建设。棉 柔巾业务增长持续好于大盘，下半年将推出多款新品，加强渠道建设。GRI上半年受中美关税战影响， 但供应链已全面恢复，预计下半年趋势向好。高端敷料、手术室耗材、健康个护业务增速较高，传统敷 料业务保持稳定。全棉时代上半年毛利率提升，下半年将继续优化商品组合和渠道结构，提升利润率。 线下门店将聚焦高质量开店，提升同店同比，优化会员服务。所得税率上升主要因业务结构变化和全棉 时代子公司迁址导致。 调研纪要：联赢激光2025年上半年实现营收15.33亿元，同比增长5.3%，归母净利润5,792万元，同比增 长13.16%。上半年新签订单25亿元，锂电业务17亿，非锂电业务8亿，全年订单目标45亿。公司涉及半 固态和全固态电池设备，已交付7台装配段设备 ...

Group 1: Galaxy Fund Research Insights - Galaxy Fund recently conducted research on six listed companies, focusing on their strategies to cope with market challenges and growth opportunities [1][2][3][4][5][6]. Group 2: Company-Specific Highlights - **Weixing New Materials (002372)**: The company is addressing industry demand pressure by enhancing product quality, accelerating business transformation, and implementing cost-saving measures. It has achieved channel penetration in Jiangsu, Zhejiang, and Shanghai, with plans for gradual expansion in other regions. The company anticipates a decline in product prices year-on-year in the first half of 2025, but a recovery in prices quarter-on-quarter is expected. The overall market demand remains weak, and the company aims for steady growth through new product combinations and a water ecosystem strategy [1]. - **Zhaoyi Innovation (603986)**: The company reported strong growth across its business lines in Q2 2024, with NOR Flash experiencing high single-digit growth and niche DRAM growing over 50%. The company expects significant revenue growth in niche DRAM in the second half of the year, driven by tight supply and rising contract prices. Overall gross margins are expected to remain stable, with a focus on customized storage technology and expanding into the automotive MCU market [2]. - **Tebao Bio**: The company is exploring combination therapies for hepatitis B treatment, focusing on optimizing drug strategies. It aims to enhance disease management through a comprehensive treatment network and is collaborating with Ligos for advanced solutions. New technologies like siRNA are entering clinical application stages, with a focus on optimizing combination therapy strategies [3]. - **Baili Tianheng**: The company is advancing its clinical trials for multiple cancer treatments in collaboration with BMS. It has submitted an IND application for its first nuclear medicine candidate and is progressing with several drug candidates in clinical trials. The company aims to become a leading player in oncology treatment within five years [4]. - **Stanley (002588)**: The company achieved steady growth in the first half of the year, with revenue reaching 6.391 billion yuan, a year-on-year increase of 12.66%. The compound fertilizer sales increased by 200,410 tons, up 9.68% year-on-year. Profit growth in Q2 was attributed to improved performance in new materials and better pricing strategies [5]. - **Reliable Co. (301009)**: The company experienced a decline in profits in Q2 due to promotional activities. It plans to expand its institutional and specialty channel business while launching its own brand. The company aims to increase its market share in baby care products despite facing intense competition [6].

8月22日，三元基因（837344.BJ）发布半年度业绩报告，期内公司实现营业收入1.18亿元，同比小幅增 长，市场份额持续扩大。报告期内，新厂区智能化建设和研发基地项目的折旧摊销费用、运营维护费用 以及利息费用的费用化核算显著增加，并且公司持续加大研发投入，本期归母净利润同比下降，但二季 度实现净利润578.51万元，相较一季度扭亏为盈，净利润实现了较大幅度增长。 公告显示，三元基因上半年费用化研发投入为1293.58万元，占营业收入比例为10.93%，同比增长达 103.31%。公司整体研发投入共计1719.04万元，占营业收入比例为14.52％。研发费用重点用于新型PEG 集成干扰素突变体注射液伴随基因检测治疗乙肝项目和肿瘤免疫细胞治疗项目。 乙肝功能性治愈，国际领先的全能干扰素 据介绍，三元基因研发的新型PEG集成干扰素突变体采用先进的精准定点修饰技术，可大幅提高药品质 量，并降低生产成本。该药物结合干扰素适用人群的基因检测，预期可大幅度提高慢性乙型肝炎临床治 愈率。公司采用新一代基因检测技术，通过全基因组检测，筛选适合全能干扰素应用的肝病人群，该方 案在乙肝精准医疗领域处于国际领先水平。该产品是迄今 ...

证券研究报告 凯因科技 (688687 CH) 利润持续增长，期待派益生顺利获批 2025 年 8 月 17 日│中国内地 生物医药 公司公布上半年业绩：收入 5.7 亿元，同比-5%；归母净利润 0.5 亿元，同 比+12%。其中二季度公司实现收入 3.3 亿元，同比-13%；归母净利润 0.2 亿元，同比+7%。公司利润持续释放，siRNA 已于 7M25 获批开展乙肝临床 实验，派益生（长效干扰素）有望 25 年内获批。我们看好公司作为国内肝 病领域领先力量，派益生顺利获批、持续扩充产品、进军乙肝大市场，维持 "买入"评级。 存量品种表现稳健，费用率持续优化 1）根据 PDB 样本医院数据，1Q25 金舒喜、凯因益生市场份额持续保持领 先，凯力唯在肝病专家学术合作+下沉县域市场的有效策略下展现较强韧性； 2）公司控费同时加码研发，2Q25 销售、管理、研发费用率分别为 48%、 11%、13%（环比-1 pct、-1 pct、+3 pct）。我们看好公司持续优化费率、 重视研发，在提高利润率水平的同时布局长远。 聚焦乙肝功能性治愈，长效干扰素蓄势待发 1）公司聚焦乙肝功能性治愈，KW040 已于 7M2 ...

Core Viewpoint - The company, Kaiyin Technology, is actively advancing its drug development projects and has reported positive financial performance in Q1 2025, indicating growth potential in the biopharmaceutical sector focused on viral and immune diseases [6][8]. Group 1: Drug Development Progress - The company has received acceptance for its new drug application for chronic hepatitis B treatment by the National Medical Products Administration in September 2024, with further updates to be provided by regulatory announcements [2]. - In 2025, the company plans to accelerate the clinical progress of several projects, including KW-051 for shingles, KW-045 for herpetic pharyngitis, and KW-053 for genital warts, while also focusing on the Phase I clinical study of a new drug KW-040 [3]. - The company is concentrating on innovative drug development for functional cure of hepatitis B, with ongoing clinical trials for KW-001 and KW-027, and has submitted a clinical trial application for KW-040 [6]. Group 2: Market Position and Competition - The domestic hepatitis C market presents significant growth opportunities, with the company’s product, Kailiwei, expected to leverage its competitive advantages in product strength and promotional strategies to achieve breakthroughs [4]. - The company is enhancing the brand influence of its product Jinshuxi, which has been included in the Jiangxi centralized procurement, aiming for increased market share through strategic channel optimization and cancer screening initiatives [5]. Group 3: Financial Performance - In Q1 2025, the company reported a main revenue of 232 million yuan, an increase of 8.9% year-on-year, and a net profit of approximately 25.67 million yuan, reflecting a 15.92% year-on-year growth [6]. - The company’s gross profit margin stands at 82.95%, with a debt ratio of 24.29%, indicating a strong financial position [6]. - Recent institutional ratings show 5 buy ratings and 2 hold ratings, with an average target price of 44.97 yuan over the past 90 days [6][8].

Core Viewpoint - In 2024, Beijing Kain Technology Co., Ltd. experienced a decline in revenue but an increase in net profit, indicating a shift in operational dynamics and potential risks [1]. Revenue Decline and Market Challenges - The company's revenue for 2024 was 1,230,296,984.43 yuan, a decrease of 12.87% from 2023's 1,412,006,182.85 yuan [2]. - The decline was primarily due to the implementation of centralized procurement policies for key products, leading to price reductions and transitional impacts on revenue [3]. Net Profit Growth and Cost Efficiency - The net profit attributable to shareholders was 142,369,228.09 yuan, up 22.18% from 116,524,994.34 yuan in 2023 [4]. - This growth was driven by the execution of centralized procurement policies and a reduction in overall sales costs, with operating costs decreasing by 4.01% [5]. Non-Recurring Profit Growth and Core Profitability - The non-recurring net profit was 136,983,136.25 yuan, reflecting an 11.75% increase from 122,577,218.12 yuan in 2023 [6]. - The growth was lower than the overall net profit increase due to higher non-recurring gains, but it still indicated enhanced core profitability [7]. Earnings Per Share and Shareholder Returns - Basic earnings per share rose to 0.85 yuan, a 21.43% increase from 0.70 yuan in 2023 [8]. - This increase was attributed to the growth in net profit, indicating improved returns for shareholders [9]. Non-Recurring Earnings Per Share Growth - The non-recurring earnings per share was 0.82 yuan, up 12.33% from 0.73 yuan in 2023 [11]. - This growth suggests an improvement in the quality of earnings after excluding non-recurring items [12]. Expense Changes and Structural Adjustments - Sales expenses decreased by 24.70% to 597,482,346.66 yuan from 793,421,431.11 yuan in 2023, attributed to cost reduction strategies [13]. - Management expenses increased by 11.64% to 114,875,541.78 yuan, possibly due to business adjustments [13]. - Financial expenses were negative, indicating that income from interest exceeded expenses, although the absolute value decreased [13]. Research and Development Investment - R&D expenses totaled 138,157,828.57 yuan, a 2.94% increase from 134,215,207.89 yuan in 2023, representing 12.79% of revenue [14][15]. - The number of R&D personnel decreased to 126, but the commitment to R&D investment remained strong, reflecting a focus on innovation [16][17]. Cash Flow Variability - Net cash flow from operating activities was 104,285,937.46 yuan, down 17.63% from 126,603,431.56 yuan in 2023, influenced by changes in payment collection [18]. - Cash flow from investing activities was -176,916,706.00 yuan, indicating increased outflows for capital projects [18]. - Cash flow from financing activities surged by 848.19% to 84,544,154.88 yuan, primarily due to increased bank borrowings for project funding [19]. Executive Compensation - The chairman received a pre-tax compensation of 4.232 million yuan, while the general manager received 2.015 million yuan [23][24]. - High executive compensation reflects the company's commitment to attracting and retaining talent while holding leadership accountable for performance [27].

Core Viewpoint - Hepatitis B remains a significant global health challenge, with approximately 254 million chronic hepatitis B virus (HBV) infections worldwide and an annual death toll of 555,000 due to related diseases. The need for improved screening, diagnosis, treatment, and management is emphasized to meet the World Health Organization's goal of eliminating viral hepatitis as a public health threat by 2030 [1][4]. Group 1: Current Situation and Challenges - The prevalence of chronic hepatitis B in China exceeds 75 million, accounting for about 30% of global infections. The 2022 guidelines emphasize the need to reduce new infections by 90% and mortality by 65% by 2030, with a target diagnosis rate of 90% and treatment rate of 80% [4][5]. - Despite advancements in antiviral therapies since the introduction of lamivudine in 1997, treatment options remain limited, and achieving functional cure remains a challenge. Current therapies can control the disease but do not effectively eliminate the virus [3][9]. Group 2: Treatment Innovations - Several innovative drugs are under development, including receptor blockers, core protein inhibitors, long-acting interferons, and small nucleic acid drugs. Notably, small interfering RNA (siRNA) and antisense oligonucleotides (ASO) are gaining attention for their potential to be launched between 2026 and 2027 [3][9]. - The ideal treatment endpoint for hepatitis B is achieving functional cure, which involves sustained suppression of HBV replication and improvement in liver health. Achieving this requires the clearance of HBV DNA and surface antigens [5][6]. Group 3: Clinical Perspectives and Future Directions - The concept of functional cure is critical, as it significantly reduces the risk of disease progression, including liver cancer. Studies indicate that achieving surface antigen clearance can lower the incidence of liver cancer from 7.8% to 0.6% [5][6]. - The pharmaceutical industry is focusing on developing new drugs that target multiple stages of the HBV lifecycle, with a growing demand for such therapies in clinical settings. The collaboration between pharmaceutical companies and clinical experts is essential for advancing treatment options [10][11].

Core Viewpoint - The company reported a net loss of 508 million yuan with no operating revenue, marking a year-on-year increase of 190.66% after the cessation of its COVID-19 neutralizing antibody drug production. The market capitalization has plummeted from over 36 billion HKD to less than 1.8 billion HKD [1]. Financial Performance - The company did not achieve operating revenue in 2024, only generating other income of 141 million yuan. This was impacted by a decrease in bank interest income by 20.8 million yuan due to lower deposit rates and a 13.6% reduction in government subsidy income [2]. - As of the end of 2024, the company's cash and cash equivalents decreased by 9.3% to 2.413 billion yuan due to operational and R&D expenditures [2]. - Administrative expenses were reduced by 22% to 153 million yuan, primarily due to pipeline focus and organizational optimization, resulting in a decrease in employee costs by 39.7 million yuan. The number of employees dropped from 146 in 2022 to 98 in 2024, marking the first time the workforce fell below 100 [2]. R&D Pipeline - R&D expenditures decreased by 38% to 250 million yuan, mainly due to prioritizing the hepatitis B virus (HBV) functional cure project and strategic organizational optimization, which led to a reduction in third-party contract costs by 80 million yuan and employee costs by 68 million yuan [3]. - The company initially established a pipeline of 10 innovative candidate products in 2022 but only reported progress on 7 major candidates in the 2024 annual report. Key products include BRII-179, Elebsiran, and Tobevibart, all currently in Phase II clinical trials [3]. Strategic Focus - The primary focus remains on infectious diseases, particularly the three core candidates in the hepatitis B pipeline. The company aims to enhance the functional cure rate for hepatitis B through combination therapies [4][5]. - The company has strategically acquired rights to BRII-179 to ensure a stable supply for future clinical development after the bankruptcy of VBI Vaccines, which previously held rights to the product [5]. - The company is seeking partners to advance other promising projects, such as long-acting HIV therapies and treatments for multi-drug resistant infections, while emphasizing that commercialization discussions are premature [6].