YKYY013 注射液是悦康科创和公司全资子公司杭州天龙药业有限公司自主研发的一款偶联 N-乙酰半乳 糖胺（N-acetylgalactosamine，GalNAc）配体的化学合成双链 siRNA 药物，通过 RNA 干扰作用有效沉 默乙型肝炎病毒（HBV）基因组转录的信使 RNA（Messenger RNA，mRNA），进而抑制乙肝病原蛋 白的产生，抑制 HBV 的复制，并为宿主免疫重建创造条件，最终实现乙肝的功能性治愈。临床拟用于 慢性乙型肝炎病毒感染的治疗。 格隆汇9月22日丨悦康药业(688658.SH)公布，公司子公司北京悦康科创医药科技股份有限公司（称"悦 康科创"）于近日获得美国食品药品监督管理局（简称"FDA"）关于同意 YKYY013 注射液用于治疗慢 性乙型肝炎病毒感染进行临床试验的函告（Study May Proceed Letter，IND 编号：177486）。 ...

YKYY013注射液是悦康科创和公司全资子公司杭州天龙药业有限公司自主研发的一款偶联N-乙酰半乳 糖胺(N-acetylgalactosamine，GalNAc)配体的化学合成双链siRNA药物，通过RNA干扰作用有效沉默乙 型肝炎病毒(HBV)基因组转录的信使RNA(Messenger RNA，mRNA)，进而抑制乙肝病原蛋白的产生， 抑制HBV的复制，并为宿主免疫重建创造条件，最终实现乙肝的功能性治愈。临床拟用于慢性乙型肝 炎病毒感染的治疗。 悦康药业(688658.SH)发布公告，公司子公司北京悦康科创医药科技股份有限公司(简称"悦康科创")于近 日获得美国食品药品监督管理局(以下简称"FDA")关于同意YKYY013注射液用于治疗慢性乙型肝炎病毒 感染进行临床试验的函告(Study May Proceed Letter，IND编号：177486)。 ...

Group 1: TeBao Bio - TeBao Bio is focusing on functional cure for hepatitis B, aiming for a combination of different mechanism drugs with interferon and nucleos(t)ide analogs for optimization [1] - The company is expanding its hepatitis B treatment network and aims to provide comprehensive management throughout the disease course [1] - Collaboration with Ligos is underway to explore reinfection control after clearing infected cells, and acquisition of JiuTian Bio is intended to leverage its gene therapy platform for more precise solutions [1] - New technologies like siRNA have entered clinical application stages, with future strategies focusing on optimizing combination therapies [1] - Increased penetration of interferon relies on enhanced disease awareness and improved management of adverse reactions [1] Group 2: JingSheng Machinery - JingSheng Machinery achieved revenue of 5.799 billion and net profit of 639 million in the first half of 2025 [2] - The photovoltaic business has declined due to industry cyclical adjustments, while the semiconductor business has grown due to accelerated domestic production [2] - The company has successfully delivered 12-inch silicon epitaxy equipment to leading domestic clients and is promoting carbon silicon equipment effectively [2] - The sapphire materials business has seen year-on-year growth, and semiconductor consumables have achieved domestic substitution for quartz crucibles, leading in market share [2] - Clients include well-known companies such as TCL Zhonghuan and Changdian Technology, with strict credit management to reduce order fulfillment risks [2]

Group 1: Company Insights - Teabo Bio is focusing on functional cure for hepatitis B, aiming for a combination of different mechanism drugs with interferons and nucleos(t)ide analogs for optimized treatment [1] - Teabo Bio is collaborating with Ligos to explore reinfection control after clearing infected cells and has acquired Jiutian Bio to leverage its gene therapy platform for more precise solutions [1] - Bai Li Tianheng is developing iza-bren in collaboration with BMS, with three new II/III phase overseas key registration clinical trials initiated for triple-negative breast cancer, EGFR mutation non-small cell lung cancer, and urothelial carcinoma [2] - Bai Li Tianheng has submitted the first nuclear medicine candidate drug BL-RC001 for domestic IND application and has nine DC drugs in clinical trials [2] - Cambridge Technology is focusing on broadband access and wireless networks in North America, with plans to increase production capacity for 800G series products to an annualized 2 million units [3] - Cambridge Technology's expansion plans are progressing smoothly, with potential financing from Hong Kong issuance next year to support increased production capacity [3] Group 2: Industry Trends - The trend in hepatitis B treatment is shifting towards a combination of therapies, indicating a growing recognition of the need for comprehensive disease management [1] - The oncology sector is seeing increased investment in clinical trials, with companies like Bai Li Tianheng aiming to become leaders in cancer treatment within five years [2] - The telecommunications industry is experiencing growth in demand for high-capacity products, as evidenced by Cambridge Technology's expansion plans and partnerships with major North American clients [3]

Group 1: Teabo Bio - Teabo Bio is focusing on functional cure for hepatitis B, aiming for a combination of different mechanism drugs with interferons and nucleos(t)ide analogs for optimization [1] - The company is collaborating with Ligos to explore reinfection control after clearing infected cells and has acquired Jiutian Bio to leverage its gene therapy platform for more precise solutions [1] - New technologies like siRNA have entered clinical application stages, with future strategies focusing on optimizing combination therapies [1] Group 2: Ruijie Networks - Ruijie Networks reported that over 90% of its data center product revenue in the first half of the year came from internet clients, with 400G products accounting for over 60% [2] - The demand for cloud computing infrastructure remains strong, with expected continued capital expenditure increases in the internet sector [2] - The company’s overseas revenue reached 1.145 billion yuan, a 48% year-on-year increase, primarily targeting the SMB market [2] Group 3: Baillie Tianheng - Baillie Tianheng is collaborating with BMS to develop iza-bren and has initiated three key overseas clinical trials for treating triple-negative breast cancer, EGFR-mutant non-small cell lung cancer, and urothelial carcinoma [3] - The company has made breakthroughs in its RC nuclear drug platform, with its first candidate drug BL-RC001 submitted for domestic IND application [3] - As of June 30, the company’s R&D expenses amounted to 1.038 billion yuan, with expectations for future clinical research costs to increase [3]

Group 1: TeBao Bio - TeBao Bio is focusing on functional cure for hepatitis B, aiming for a combination of different mechanism drugs with interferons and nucleos(t)ide analogs for optimization [1] - The company is collaborating with Ligos to explore reinfection control after clearing infected cells and has acquired JiuTian Bio to leverage its gene therapy platform for more precise solutions [1] - New technologies like siRNA have entered the clinical combination application stage, with future strategies focusing on optimizing combination therapies [1] Group 2: Cambridge Technology - Cambridge Technology's main business with North American operators is concentrated in broadband access and wireless networks, with unclear business planning for 2027 [1] - The company is making progress with several major North American clients, with some product verifications nearing completion while others are still ongoing [1] - The production capacity for the 800G series products at Shanghai and JiaShan factories is being increased to an annualized 2 million units, with plans for further expansion in the first half of next year [1] Group 3: Hive Fund - Hive Fund was established in 2018, with a total asset management scale of 48.884 billion yuan, ranking 86th out of 210 [2] - The fund's scale for non-monetary public funds is 48.879 billion yuan, ranking 76th out of 210 [2] - The best-performing public fund product in the past year is the Hive Advanced Manufacturing Mixed Initiation A, with a latest net value of 1.27 and a growth of 63.35% over the past year [2]

Group 1: Company Insights - Jin Ying Fund recently conducted research on six listed companies, including Wenjian Medical, which reported a 13% year-on-year growth in Q2 and plans to enhance product structure and production efficiency [1] - Te Bao Bio is focusing on functional cure for hepatitis B, exploring combination therapies and expanding its clinical management network [1] - Rui Jie Network's data center product revenue growth is driven by internet clients, with over 90% of revenue coming from this sector, and expects continued strong demand for cloud computing infrastructure [2] - Bai Li Tian Heng is collaborating with BMS on key clinical trials for cancer treatments and has made progress in its nuclear medicine platform [3] - Lian Ying Laser achieved a revenue of 1.533 billion yuan in H1 2025, with a 5.3% year-on-year increase, and has set an annual order target of 4.5 billion yuan [4][5] - Lepu Medical's subsidiary focuses on elderly care services, and the company has received approval for its self-developed facial filler product [6] Group 2: Industry Trends - The medical sector is seeing significant growth potential, particularly in high-end dressings and health personal care, with a focus on optimizing product mix and channel structure [1] - The internet industry is expected to continue increasing capital expenditure on intelligent computing, indicating a robust demand for data center products [2] - The oncology treatment market is evolving with new drug candidates entering clinical trials, reflecting a growing focus on innovative cancer therapies [3] - The lithium battery equipment market is experiencing steady growth, with significant orders from both lithium and non-lithium sectors [4][5] - The healthcare technology sector is advancing with AI-integrated monitoring devices, indicating a trend towards more personalized and efficient healthcare solutions [6]

Group 1: Galaxy Fund Research Insights - Galaxy Fund recently conducted research on six listed companies, focusing on their strategies to cope with market challenges and growth opportunities [1][2][3][4][5][6]. Group 2: Company-Specific Highlights - **Weixing New Materials (002372)**: The company is addressing industry demand pressure by enhancing product quality, accelerating business transformation, and implementing cost-saving measures. It has achieved channel penetration in Jiangsu, Zhejiang, and Shanghai, with plans for gradual expansion in other regions. The company anticipates a decline in product prices year-on-year in the first half of 2025, but a recovery in prices quarter-on-quarter is expected. The overall market demand remains weak, and the company aims for steady growth through new product combinations and a water ecosystem strategy [1]. - **Zhaoyi Innovation (603986)**: The company reported strong growth across its business lines in Q2 2024, with NOR Flash experiencing high single-digit growth and niche DRAM growing over 50%. The company expects significant revenue growth in niche DRAM in the second half of the year, driven by tight supply and rising contract prices. Overall gross margins are expected to remain stable, with a focus on customized storage technology and expanding into the automotive MCU market [2]. - **Tebao Bio**: The company is exploring combination therapies for hepatitis B treatment, focusing on optimizing drug strategies. It aims to enhance disease management through a comprehensive treatment network and is collaborating with Ligos for advanced solutions. New technologies like siRNA are entering clinical application stages, with a focus on optimizing combination therapy strategies [3]. - **Baili Tianheng**: The company is advancing its clinical trials for multiple cancer treatments in collaboration with BMS. It has submitted an IND application for its first nuclear medicine candidate and is progressing with several drug candidates in clinical trials. The company aims to become a leading player in oncology treatment within five years [4]. - **Stanley (002588)**: The company achieved steady growth in the first half of the year, with revenue reaching 6.391 billion yuan, a year-on-year increase of 12.66%. The compound fertilizer sales increased by 200,410 tons, up 9.68% year-on-year. Profit growth in Q2 was attributed to improved performance in new materials and better pricing strategies [5]. - **Reliable Co. (301009)**: The company experienced a decline in profits in Q2 due to promotional activities. It plans to expand its institutional and specialty channel business while launching its own brand. The company aims to increase its market share in baby care products despite facing intense competition [6].

Core Viewpoint - San Yuan Gene reported a slight increase in revenue for the first half of the year, while facing increased costs due to depreciation, operational maintenance, and interest expenses related to new facility construction and R&D investments [2] Group 1: Financial Performance - The company achieved operating revenue of 118 million yuan, representing a year-on-year increase [2] - The net profit attributable to shareholders decreased year-on-year, but the second quarter net profit reached 5.7851 million yuan, indicating a significant recovery from the first quarter [2] - R&D expenses for the first half amounted to 12.9358 million yuan, accounting for 10.93% of operating revenue, with a year-on-year growth of 103.31% [2] Group 2: R&D Focus - The company is focusing on the development of a new PEG-integrated interferon mutant for the treatment of chronic hepatitis B, which is expected to significantly improve clinical cure rates [3] - San Yuan Gene is utilizing advanced genome-wide detection technology to identify suitable patient populations for the new interferon treatment, positioning itself as a leader in precision medicine for hepatitis B [3] - The company has completed the enrollment of 940 subjects for genome-wide detection clinical studies, with 149 new enrollments during the reporting period [3] Group 3: Collagen Protein Development - San Yuan Gene has made significant progress in the development of recombinant human collagen products, achieving the world's first efficient production of recombinant human type II and III collagen based on mammalian cell expression [4] - The company plans to increase R&D investment in collagen-related cosmetic and medical device products, aiming for regulatory approval and market launch in phases [4] - The focus on accelerating technology transfer and deepening industry collaboration is intended to enhance the company's core competitiveness in the collagen field [4]

Investment Rating - The report maintains a "Buy" rating for the company with a target price of 47.33 RMB [7][5]. Core Views - The company reported a revenue of 570 million RMB for the first half of 2025, a decrease of 5% year-on-year, while the net profit attributable to the parent company was 50 million RMB, an increase of 12% year-on-year. The second quarter revenue was 330 million RMB, down 13% year-on-year, with a net profit of 20 million RMB, up 7% year-on-year. The company is expected to receive approval for its long-acting interferon product, Paiyisheng, within 2025, which is anticipated to strengthen its position in the domestic hepatitis market [1][5]. Summary by Sections Financial Performance - The company achieved a revenue of 570 million RMB in H1 2025, down 5% year-on-year, and a net profit of 50 million RMB, up 12% year-on-year. In Q2 2025, revenue was 330 million RMB, down 13% year-on-year, with a net profit of 20 million RMB, up 7% year-on-year [1]. Product Development - The company is focusing on functional cures for hepatitis B, with KW-040 approved for clinical trials in July 2025. The long-acting interferon has a new indication for adult chronic hepatitis B, which is expected to be approved within 2025 and enter the medical insurance negotiation in 2026 [3][4]. Research and Development - The company increased its R&D investment to 71.41 million RMB in H1 2025, accounting for 12.6% of revenue, up 0.8 percentage points year-on-year. The company is also expanding its product pipeline in the field of immune diseases [4]. Profit Forecast Adjustments - The profit forecast for 2025-2027 has been adjusted, with expected revenues of 1.28 billion RMB, 1.50 billion RMB, and 1.69 billion RMB, representing a decrease of 7%, 7%, and 8% from previous estimates. The net profits are expected to be 170 million RMB, 210 million RMB, and 240 million RMB, with adjustments of -1%, -1%, and -9% respectively [12][5]. Valuation - Using the SOTP valuation method, the company's reasonable valuation is estimated at 8.09 billion RMB, with a target price of 47.33 RMB per share [13][5].