Core Points - The article discusses the deteriorating health condition of Cai Lei, a former vice president of JD.com, who has lost his ability to speak and move due to amyotrophic lateral sclerosis (ALS) [1][3] - Cai Lei was diagnosed with ALS in 2019, a rare and currently incurable disease that leads to muscle atrophy and eventual death [3][4] - His wife, Duan Rui, highlights the emotional and physical struggles they face, indicating that Cai Lei may soon require a gastrostomy for nutrition [3] Summary by Sections Health Condition - Cai Lei has completely lost his ability to speak and has significant loss of strength in his arms and legs, requiring assistance to stand [3] - He can currently consume only soft food, and there are concerns about future nutritional needs potentially requiring surgical intervention [3] Background Information - Cai Lei was born in May 1978 and served as the vice president of JD.com [3] - He established the "Gradual Recovery Mutual Aid Home" to create a medical big data research platform for ALS patients, connecting thousands of patients [3][4] - Under his initiative, the first pathological research gene sample bank for ALS in China was established, contributing to genetic research on the disease [4]

Core Viewpoint - The article highlights the inspiring journey of Cai Lei, who, despite being diagnosed with ALS (Amyotrophic Lateral Sclerosis), has made significant contributions to the awareness and research of the disease, becoming a symbol of resilience for many patients [2][3]. Group 1: Recognition and Achievements - Cai Lei was awarded the title of "National Self-Reliance Model" during the 7th National Self-Reliance Model and Disability Assistance Commendation Conference [1] - He expressed immense gratitude for the recognition, stating it serves as encouragement not only for him but also for the countless individuals suffering from rare diseases like ALS [2] - Cai Lei has established the "Gradual Recovery Mutual Aid Home" and a pathological research gene sample bank for ALS patients, linking over ten thousand patients [2][3] Group 2: Financial Contributions and Research Impact - In 2024, Cai Lei invested over 40 million yuan in research, with more than 30 million yuan allocated to external research donations [3] - Significant breakthroughs have been made in treating the two most common gene types among ALS patients, with ten drug pipelines entering clinical trial phases [3] Group 3: Personal Struggles and Family Support - Cai Lei's condition has deteriorated, making independent movement and clear speech difficult; however, he continues to engage with his family and the public through AI technology [3][4] - His son visited him, showcasing a touching moment of interaction, highlighting the importance of family support during challenging times [7]