Group 1 - The article discusses the health risks associated with staying up late, particularly its detrimental effects on liver health, as emphasized by Shen Tu Yinhong, a representative inheritor of traditional Chinese medicine [4][5] - It highlights the importance of the liver's self-repair during the hours of 11 PM to 3 AM, suggesting that late-night habits can lead to liver blood deficiency and related issues such as insomnia and anxiety [4] - The company, Tongjun Valley, has developed a product called "Zhenyangmian," which aims to address sleep problems by nourishing liver blood and calming the mind, combining traditional wisdom with modern technology [4][5] Group 2 - The "Zhenyangmian" product features a blend of various precious medicinal ingredients, including Ganoderma and sour jujube seed, with a focus on the synergistic effects of "double mushrooms" [5] - The company employs a fermentation process that enhances nutrient absorption, incorporating natural calming ingredients like gamma-aminobutyric acid to help users relax and sleep better [5] - Tongjun Valley is committed to the modernization of traditional Chinese medicine through technological innovation, aiming to provide more health solutions and ensure the longevity of traditional practices in contemporary society [5]

【SynBioCon】 获 悉， 近日， 东北林业大学、中国中医科学院中药研究所、浙江寿仙谷医药股份有限公司 等多 家单位联合在中国工程院院刊《 Engineering 》 在线发表了题为 "Unveiling the Spatiotemporal Landscape of Ganoderma lingzhi : Insights into Ganoderic Acid Distribution and Biosynthesis" 的研究论文，通过时 空多组学技术系统解析了灵芝酸的生物合成机制。通过空间质谱成像技术精准绘制了灵芝酸在原基和子实体中的时空 动态分布图谱；完成灵芝 T2T 完整基因组测序并构建了高分辨率单细胞转录组图谱，成功解析了子实体皮壳层的发 育轨迹；发现一个新颖的 CYP450 酶特异性催化生成灵芝酸关键中间体 —— 丹芝酸 E 和 F 。该研究为阐明灵芝 酸复杂的生物合成网络提供了时空多组学研究范式，为开发灵芝酸小分子创新药物和实现资源可持续利用奠定理。 灵芝作为药食两用的 " 仙草 " ，在中医药中已有 2000 多年应用历史。由于其基因组小、生长周期短、遗传体系完 善等特点，灵芝已成为 ...