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突破性进展!"智能控糖贴片"登顶《自然》子刊:一贴见效,35天血糖无忧
GLP1减重宝典· 2025-08-26 09:15
Core Viewpoint - A revolutionary diabetes treatment has emerged from the repurposing of a century-old drug, nitroglycerin, into a smart skin patch that utilizes gene-switch technology to control blood sugar levels effectively [4][9]. Group 1: Research Breakthroughs - The research team from ETH Zurich has transformed the traditional nitroglycerin patch into a "gene switch controller" that enables the body to produce GLP-1 (glucagon-like peptide-1) on demand by simply applying the patch to the skin [5][11]. - This innovative approach allows for precise control of protein drug production, eliminating the risks associated with drug overdosing [7][11]. Group 2: Experimental Results - In animal studies, the patch demonstrated a "three-in-one" effect: stable blood sugar levels for 35 days, restoration of normal insulin secretion, and significant weight loss [6][12]. - The technology showed no cardiovascular side effects typically associated with traditional nitroglycerin use, such as blood pressure fluctuations [6][12]. Group 3: Future Applications - The hNORM system has potential applications beyond diabetes, including obesity and Alzheimer's disease, indicating a broader scope for this technology [12]. - The research team anticipates that this non-invasive cell therapy could revolutionize chronic disease treatment, paving the way for a "patch era" in medical therapies [12].