研究团队在浙江大学、复旦大学、上海交通大学等4家生殖医学中心开展了为期数年的多中心随机对照 试验。共纳入450对严重男性不育夫妇，其中225对接受常规第二代试管婴儿技术治疗，225对接受第二 代叠加第三代技术治疗。结果显示，两组患者在首次移植活产率，以及一年累计活产率上均无显著差 异。 新华社杭州12月24日电（记者黄筱）12月23日晚，一项由中国科学院院士、浙江大学医学院附属妇产科 医院名誉院长黄荷凤领衔的研究成果，在国际医学期刊《英国医学杂志》发表。该研究通过临床试验证 实，针对严重男性不育患者，价格更昂贵的第三代试管婴儿技术并未显示出比第二代技术更高的活产 率。这一结论为国际诊疗指南提供了关键循证依据，有望显著降低不孕治疗成本，惠及更多家庭。 专家介绍，我国每年有约5000万不孕人群，其中男性因素占40%。以往很多患者倾向于选择"更高级"的 第三代技术，单次检测费用就需要约2到3万元。此项研究将帮助患者避免不必要的医疗支出，减轻经济 负担，纠正了当前辅助生殖技术使用中的误区。 "这个结果出乎很多人意料。"黄荷凤表示，研究结果明确显示，对于严重男性不育患者，常规第二代技 术仍是首选策略，不必盲目追求更复杂 ...

Core Viewpoint - The article discusses the challenges and realities of assisted reproductive technology (ART) in China, emphasizing the importance of understanding fertility as a capability that may not last a lifetime, and the need for women to plan and make informed choices regarding reproduction [3][19][38]. Group 1: Assisted Reproductive Technology Overview - Assisted reproductive technology has rapidly developed over the past 40 years, with the first test-tube baby born in 1978 and the first in mainland China in 1988 [13]. - The success rate of assisted reproduction varies significantly with age, with women over 35 facing increased challenges in conceiving [15][17]. - The complete assisted reproductive cycle, including ovulation induction, egg retrieval, embryo transfer, and pregnancy maintenance, typically takes two to three months [8]. Group 2: Patient Demographics and Trends - There is a growing trend of older couples seeking ART services due to late marriage and childbearing, with many individuals unaware of the biological limitations of fertility [15][19]. - The incidence of infertility in China has increased from 12% in 2007 to 18% in 2020, highlighting a rising public health concern [28]. Group 3: Patient Experiences and Challenges - Many patients experience emotional and psychological stress during the ART process, often leading to anxiety about their fertility metrics [17][36]. - The article illustrates various patient stories, including those who have successfully conceived and those who have faced challenges, emphasizing the emotional journey involved in ART [19][38]. Group 4: Male Involvement in Fertility - Male fertility issues account for at least 30% of infertility cases, yet men often play a minimal role in the ART process [26][28]. - The article stresses the importance of male partners being actively involved in the fertility journey, as their support can significantly impact the emotional well-being of their partners [28]. Group 5: Medical and Social Perspectives on Infertility - The definition of infertility is complex, as many individuals diagnosed with infertility may not have other health issues, raising questions about the medicalization of fertility challenges [31][35]. - Cultural perceptions of fertility and motherhood can add pressure to women, influencing their emotional responses to infertility [36].