以下文章来源于新周刊 ，作者钱雨朦 新周刊 . 中国最新锐的生活方式周刊。 从医30年，研究不孕症20年，唐荣欣写下了《种下一粒光：一起面对辅助生殖治疗中的那些难题》一书，科普不孕症和试管婴儿相关的知识。在记录"这群非要生孩子 的女人的故事"时，她也会迟疑，放在当下的环境里，这些内容会不会有些过时或者说教感，无法被相当一部分年轻人理解。 但作为一名生殖科医生，唐荣欣更想要帮助更多女性认清一个事实："无论是在什么年纪、是否选择生育，你需要知道，生育是一种能力，但这种能力并不会伴随你一 生，所以应该尽早对其有所了解和计划，对生育或助孕拥有自由选择的权利。" 文 ｜ 钱雨朦 编辑 ｜ 陆一鸣 来源｜ 新周刊（ID:new-weekly） 封面来源 ｜ IC Photo 早晨8点，上海市第十人民医院门诊14楼生殖医学中心，副主任医师唐荣欣快步走过写着"生命之窗"四个字的标示牌，走向诊室。 推开绿色的诊室大门，室内的光线是暖色调的，窗台上还有一盆长势很好的绿植。一个女性子宫及卵巢的模型摆在桌上，角落里堆着十几卷锦旗，它们来自 做试管婴儿成功的患者。 唐荣欣在这里工作了8年，每年完成近400个取卵周期。一个"取卵周期"是 ...

Core Viewpoint - The research conducted by George Church's team at Harvard University presents a breakthrough method for initiating meiosis from human induced pluripotent stem cells (iPSCs), which could significantly advance the study of infertility and reproductive medicine [3][4][5]. Group 1: Importance of Meiosis - Meiosis is essential for the formation of eggs and sperm, reducing the chromosome number by half to ensure normal fertilization [7]. - Approximately 15% of couples face infertility issues, with meiotic failure being a major cause [7]. Group 2: Research Methodology - The study established a method to directly initiate meiosis from male or female iPSCs by using a combination of DNMT1 inhibition, retinoic acid signaling activation, and overexpression of regulatory factors [4][9]. - The process can activate meiosis within 15 days, bypassing the primordial germ cell (PGC) stage, which traditionally takes about 120 days [12][14]. Group 3: Findings and Observations - The research identified three key components for effective meiosis initiation: 1. DNMT1 inhibitor to erase DNA methylation and enhance gene expression [9]. 2. Retinoic acid to simulate in vivo signals for germ cell development [10]. 3. Overexpression of genes like BCL2, BOLL, MEIOC, and HOXB5 to prevent cell death and promote meiosis [10]. - The study achieved a 22% expression rate of core meiotic genes in the induced cells, with significant milestones observed under a microscope [10][14]. Group 4: Unexpected Discoveries - The research team discovered that culturing at 34°C significantly improved the efficiency of meiosis initiation, suggesting temperature as a conserved regulatory factor across genders [12]. Group 5: Future Applications - The ability to induce meiosis in human cells could revolutionize reproductive medicine, enabling the screening of male contraceptives and studying genetic mutations linked to infertility [17]. - Future applications may include generating human reproductive cells in vitro, potentially aiding many infertility patients [17].