Core Viewpoint - BeiGene (06160) reported strong financial performance in Q1 2025, achieving revenue of 8.048 billion RMB, a year-on-year increase of 50.2%, driven by robust sales of its core products, Brukinsa® (Zebutinib) and Tislelizumab [1][2]. Financial Performance - The company transitioned from a loss to profit in both operating profit and total profit for Q1 2025, with significant improvement in operating cash flow [1]. - The full-year revenue guidance for 2025 remains unchanged, projected between 35.2 billion RMB and 38.1 billion RMB, supported by the anticipated strong growth of Brukinsa® in the U.S. and other key markets [1]. Product Performance - Brukinsa® achieved global sales of 5.692 billion RMB, a 63.7% increase year-on-year, with U.S. sales reaching 4.041 billion RMB, up 61.9% [2][3]. - In Europe, Brukinsa® sales were 836 million RMB, a 75.4% increase, while in China, sales reached 590 million RMB, a 43.1% increase [3]. Research and Development - The company is advancing its pipeline in hematologic malignancies, with the BCL2 inhibitor Sonrotoclax entering registration clinical trials and ongoing trials for various indications [3][4]. - BGB-16673, a BTK degrader, is in Phase 3 trials, expected to address BTK resistance issues [5]. PD-1 Product Development - Tislelizumab (替雷利珠单抗) generated sales of 1.245 billion RMB, a 19.3% increase, benefiting from new indications and increased hospital access [6]. - The product is approved in 46 markets globally, with over 1.5 million patients treated, and has recently gained reimbursement in 11 new markets [6]. Future Outlook - The company plans to host an investor R&D day on June 26, focusing on its breast cancer pipeline and broader oncology product portfolio [8]. - BeiGene will adopt a new English name, BeOne Medicines Ltd., and relocate its registration to Switzerland, expected to be completed later this year [8].

5月7日，百济神州发布2025年一季报。披露公司Q1营收增长50.2%至80.48亿元，净亏损9450.3万元。 2025年第一季度，百泽安®的销售额总计12.45亿元，同比增长19.3%。百泽安®销售额的增长，主要得益于在中国获批 新适应症纳入医保所带来的新增患者需求以及药品进院数量的增加。百泽安®已在中国PD-1市场取得领先的市场份 额。目前，百泽安®在中国获批14项适应症，其中符合纳入条件的13项适应症已纳入国家医保目录。 公司自主研发的BTK抑制剂百悦泽®是全球获批适应症最广泛的BTK抑制剂。它同时也是唯一一款给药灵活，可每日 一次或每日两次的BTK抑制剂。 百悦泽®临床开发项目迄今已在全球超过30个国家和地区开展超过35项试验，入组约7,100例患者。百悦泽®目前已在 全球75个市场获批，本季度在11个市场新增纳入或扩大报销范围，包括日本、欧洲和巴西。 百悦泽®"头对头"对比亿珂®（伊布替尼）用于治疗复发或难治性（R/R）CLL/小淋巴细胞淋巴瘤（SLL）成人患者的 全球临床三期ALPINE试验展示出持续的无进展生存期（PFS）获益，且心血管事件发生率较低。 百悦泽®说明书更新已在美国、欧盟和英国获 ...