Core Viewpoint - The article emphasizes the importance of adhering to the recommended administration guidelines for oral semaglutide to achieve optimal therapeutic effects in weight loss and blood sugar control [12][14]. Administration Guidelines - The FDA recommends taking oral semaglutide before breakfast with no more than 4 ounces (approximately 120 milliliters) of water, followed by a minimum 30-minute wait before consuming breakfast or other medications [2]. - Taking the medication before any meal or after any meal is less effective due to shorter fasting periods compared to taking it before breakfast [3][5]. - If a person only eats lunch and dinner, taking the medication before lunch is acceptable; similarly, if only breakfast and dinner are consumed, taking it before dinner is also permissible [6]. Fasting and Water Intake - Longer fasting times before taking the medication result in higher plasma concentrations of semaglutide, leading to better clinical outcomes [5]. - Drinking excessive water to mask the bitterness of the pill is not advisable, as it may hinder the absorption of the active ingredient [9][10]. - It is crucial to wait at least 30 minutes after taking the medication before eating to avoid food interference with absorption [11]. Occasional Non-compliance - Missing a dose or occasionally not following the guidelines does not significantly impact overall efficacy, but consistent non-compliance can affect results [12][13]. Efficacy Comparison - Oral semaglutide (Rybelsus) and injectable semaglutide (Ozempic) are equally effective, with studies showing similar results in A1C reduction and weight loss among similar patient populations [15][17].