Workflow
间充质干细胞
icon
Search documents
非人灵长类动物体内提取出成体干细胞
Ke Ji Ri Bao· 2025-07-14 01:03
Core Insights - The collaboration between UCLA's Broad Stem Cell Research Center and Aarhus University has successfully isolated adult stem cells from the gray mouse lemur, paving the way for stem cell therapies that are more aligned with human clinical needs [1][2] Group 1: Research Findings - The research team isolated muscle stem cells and mesenchymal stem cells from the gray mouse lemur, revealing that their behavior patterns are more similar to human stem cells than to those of mice [1] - The muscle tissue of the gray mouse lemur shows a high degree of microstructural similarity to human muscle, with faster division rates of muscle stem cells compared to those in mice [2] - The presence of fat cells in the gray mouse lemur's muscle tissue, which are absent in mice, is attributed to the unique adipogenic capabilities of mesenchymal stem cells, regulated by complement factor D protein [2] Group 2: Clinical Implications - The findings suggest that the gray mouse lemur is a more ideal model for human muscle research, providing new therapeutic targets for conditions such as muscle atrophy and age-related muscle loss [2] - The research team is exploring optimal delivery methods, dosage control, and timing for stem cell therapies to transition from laboratory settings to clinical applications [2]