Core Viewpoint - The research reveals a new mechanism by which psychological stress promotes pancreatic cancer through ALKBH5 deficiency and RNA transfer via extracellular vesicles, suggesting potential therapeutic strategies [3][9]. Group 1: Mechanism of Psychological Stress in Pancreatic Cancer - Psychological stress induces ALKBH5 deficiency, which leads to abnormal m6A modifications in RNA, promoting tumor innervation and progression of pancreatic ductal adenocarcinoma (PDAC) [3][6]. - The study demonstrates that pain perception and other stressors activate sympathetic nerves to release norepinephrine, downregulating ALKBH5 in tumor cells [6][9]. Group 2: Clinical Correlation and Potential Treatment - In PDAC patients, ALKBH5 levels are negatively correlated with tumor innervation and patient survival time [7]. - A natural flavonoid compound, fisetin, has been identified to inhibit neuronal uptake of extracellular vesicles carrying m6A-modified RNA, thereby suppressing excessive tumor innervation and cancer progression [7][9].