Core Insights - IBD represents a significant unmet clinical need with a complex pathogenesis and no current cure, affecting over 10 million people globally, with projections of 1.5 million patients in China by 2025 and a market size of $100 billion by 2032 [1][2] Group 1: IBD Overview - Inflammatory Bowel Disease (IBD) includes Ulcerative Colitis (UC) and Crohn's Disease (CD), characterized by a complex autoimmune nature and unclear mechanisms [1] - The clinical remission rates for most IBD drugs remain low, typically between 10%-20%, with high-dose approved drugs achieving over 15% [3] Group 2: Treatment Landscape - The treatment landscape for IBD is evolving with the introduction of new therapies, including IL-23 p19 monoclonal antibodies and JAK inhibitors, following the initial success of TNF-α targeting drugs [2] - New generation therapies, such as TL1A monoclonal antibodies, show promising clinical data, with duvakitug achieving a 47.8% clinical remission rate in UC and 48% endoscopic remission in CD [3] Group 3: Market Dynamics - Major multinational corporations (MNCs) are rapidly expanding their presence in the IBD market, with expectations of high transaction values for quality clinical-stage assets exceeding $2 billion [4] - Chinese innovative pharmaceutical companies are emerging with differentiated products, such as the oral S1P modulator and various promising candidates in clinical trials [4]