Core Insights - Conduit Pharmaceuticals has filed a new composition of matter patent for AZD5904, a myeloperoxidase (MPO) inhibitor, which could provide up to 20 years of new intellectual property protection and enable enhanced formulation strategies for various diseases [1][2][4] Group 1: Patent and Development - The new solid form of AZD5904 shows significantly improved solubility compared to previous forms, allowing for new formulations that align better with disease biology and patient needs [2] - The patent filing marks a significant advancement for AZD5904, which previously had limited intellectual property coverage focused on idiopathic male infertility [2][4] - The improved solid form is expected to play a central role in Conduit's clinical development strategy, not only for male infertility but also for other conditions related to oxidative stress and MPO-driven inflammation [5] Group 2: Clinical Background and Market Opportunity - AZD5904 was originally developed by AstraZeneca for multiple sclerosis and chronic obstructive pulmonary disease (COPD), demonstrating robust target engagement in five Phase 1 clinical studies without major safety concerns [3] - In preclinical models, AZD5904 showed significant positive effects on sperm function, addressing a medical unmet need as male infertility contributes to 50% of infertility cases globally [3] Group 3: Company Overview - Conduit Pharmaceuticals operates as a multi-asset clinical stage life science company, focusing on efficient compound development and leveraging artificial intelligence and cybernetics [6] - The company aims to build an integrated platform-driven approach and seeks exits through third-party licensing deals following successful clinical trials [6]

Core Insights - Conduit Pharmaceuticals has expanded its partnership with Sarborg to utilize advanced machine learning for analyzing clinical data from AstraZeneca-acquired assets, aiming to optimize development pathways and uncover new insights [1][2] Group 1: Partnership Details - The new agreement allows Sarborg to apply its proprietary machine learning algorithms to analyze Conduit's clinical and safety data, focusing on identifying missed insights and potential drug repurposing opportunities [2] - The collaboration includes a non-exclusive, non-transferable license for Conduit to access Sarborg's advanced algorithmic platform for six months, building on an existing Services Agreement [3] Group 2: Strategic Goals - The partnership aims to re-evaluate historical clinical trial data to identify specific patient subgroups that may have shown therapeutic benefits, which could refine Conduit's future clinical development strategy [2] - Dr. David Tapolczay, CEO of Conduit Pharmaceuticals, emphasized the commitment to leveraging data science to maximize the potential of their pipeline, particularly for key assets like AZD1656 [4] Group 3: Company Overview - Conduit Pharmaceuticals is a clinical-stage life science company focused on an efficient model for compound development, acquiring and funding Phase 2-ready assets while utilizing AI and cybernetics [4] - The company aims for exits through third-party license deals following successful clinical trials, representing a departure from traditional pharma/biotech business models [4]

As filed with the Securities and Exchange Commission on September 4, 2024 Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-1 REGISTRATION STATEMENT Under The Securities Act of 1933 (I.R.S. Employer Identification Number) 4995 Murphy Canyon Road, Suite 300 San Diego, CA 92134 (760) 471-8536 (Address, including zip code, and telephone number, including area code, of Registrant's principal executive offices) David Tapolczay Chief Executive Officer Conduit Pha ...

As filed with the Securities and Exchange Commission on September 4, 2024 Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-1 REGISTRATION STATEMENT Under The Securities Act of 1933 CONDUIT PHARMACEUTICALS INC. (Exact name of Registrant as specified in its charter) (State or other jurisdiction of incorporation or organization) Delaware 2834 87-3272543 (Primary Standard Industrial Classification Code Number) (I.R.S. Employer Identification Number) 4995 Murph ...

As filed with the Securities and Exchange Commission on December 1, 2023 Registration No. 333-275056 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Amendment No. 1 to FORM S-1 REGISTRATION STATEMENT Under The Securities Act of 1933 CONDUIT PHARMACEUTICALS INC. (Exact name of Registrant as specified in its charter) | | | (State or other jurisdiction of incorporation or organization) (Primary Standard Industrial Classification Code Number) (I.R.S. Employer Identification Number) 4995 ...

As filed with the Securities and Exchange Commission on December 1, 2023 Registration No. 333-275056 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Amendment No. 1 to FORM S-1 REGISTRATION STATEMENT Under The Securities Act of 1933 CONDUIT PHARMACEUTICALS INC. (Exact name of Registrant as specified in its charter) | | | (State or other jurisdiction of incorporation or organization) (Primary Standard Industrial Classification Code Number) (I.R.S. Employer Identification Number) If an ...

As filed with the Securities and Exchange Commission on October 17, 2023 Registration No. 333-__________ UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-1 REGISTRATION STATEMENT Under The Securities Act of 1933 CONDUIT PHARMACEUTICALS INC. (Exact name of Registrant as specified in its charter) (State or other jurisdiction of incorporation or organization) Delaware 2834 87-3272543 (Primary Standard Industrial Classification Code Number) (I.R.S. Employer Identification Number) 4 ...