撰文丨王聪 编辑丨王多鱼 排版丨水成文 本周 （7 月 7 日-7 月 14 日） ，国际顶尖学术期刊 Cell 共上线了 11 篇研究论文，其中 8 篇来自华人学者，这些研究分别在 结构生物学、AI 蛋 白质进化和设计、AI 基因组模型、脑科学、光遗传学 和 合成生物学 领域取得了新突破。 麻疹病毒聚合酶复合物与非核苷抑制剂的结构及抑制机制 2025 年 7 月 7 日，上海科技大学 张贺桥 / Roger Kornberg 团队在 Cell 期刊发表了题为： Structures of the measles virus polymerase complex with non-nucleoside inhibitors and mechanism of inhibition 的研究论文 【1】 。 该研究解析了 麻疹病毒 （MeV） 聚合酶 复合物及其与非核苷抑制剂结合后的结构，并揭示了抑制机制，为抗病毒药物的理性设计奠定了基础。 AI 蛋白质工程计算模拟方法，实现蛋白质高效进化模拟和功能设计 2025 年 7 月 7 日，中国科学院遗传与发育生物学研究所 高彩霞 团队在国际顶尖学术期刊 Cell 期刊 ...

编辑丨王多鱼 排版丨水成文 蛋白质工程 ，是基于蛋白质具有的灵活性，通过人工手段改变氨基酸序列，实现对蛋白质结构和功能的修 饰和改造。与基因组工程相比，它可直接对蛋白质分子进行操纵，借助突变的迭代积累，快速完成蛋白功 能的优化和创新，速度较自然演变实现了指数级提升。鉴于蛋白质工程在基础研究和产业应用的广泛潜 力，预计相关的市场规模超过数百亿美元。 目前，蛋白质工程改造的策略主要包括结构引导的蛋白质理性设计和定向进化，但这些方法往往依赖经 验，且存在实验周期长、成本高的问题，限制了其规模化应用。理想的蛋白质工程策略，应能以最小的投 入实现最优的工程性能。 近年来， 人工智能 （ Artificial Intelligence，AI ） 迅猛发展，在生命科学领域的应用也不断涌现。通过 训练特定蛋白专有的人工智能模型实现突变模拟和功能改造是蛋白质工程新方向。但这些模型在拓展应用 到多种蛋白时存在困难，面临通用性欠佳的问题；此外，模型训练和下游验证需要大量的计算和实验成 本，进一步限制了其广泛应用 （图 1A） 。因此，有必要开发一种高效、普适且无需复杂模型训练的蛋白 质工程计算模拟策略，以最大限度地减少计算负荷、实 ...

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Financing Overview - A total of 11 financing events occurred in Shanghai this week, with 9 disclosing amounts totaling approximately 1.98 billion yuan [5][8] - The majority of financing events were concentrated in the Pudong New Area and Songjiang District, each with 2 events, while other areas had 1 event each [5] - Angel round financing was the most common, with 5 events, followed by 2 events each in Series B and strategic financing [8] Company Financing Dynamics - Xiangdao Travel announced the completion of over 1.3 billion yuan in Series C financing, aimed at expanding its market presence and enhancing its service offerings [14][15] - Jingyin Pharmaceutical completed nearly 50 million USD in B+ round financing, which will be used to advance its clinical pipeline and product development [16][18] - Pait Fresh Life secured 25 million USD in angel round financing to enhance its supply chain and product innovation in the pet food sector [19][20] - Kaan Chuang Neng completed several million yuan in Pre-A+ round financing, focusing on the development of hydrogen liquefaction systems [21][22] - Qianjue Robotics raised several million yuan in angel round financing to accelerate technology development and product iteration [23][24] - Aokun Technology completed several million yuan in angel round financing, which will be used for aviation measurement and control product development [25][26] - Baiyi Yuan Biotechnology received several million yuan in strategic financing from Kangzhe Pharmaceutical to support product development and market expansion [27][28] Industry Focus - The advanced manufacturing sector saw 3 financing events this week, focusing on aerospace, sensors, and communication technologies [29] - The Shanghai Institute of Microsystem and Information Technology made significant progress in developing high-performance MEMS fast-response mirrors for satellite laser communication [29][30] - Shanghai is committed to enhancing its manufacturing capabilities through policies aimed at supporting enterprise development and achieving high-quality growth in the manufacturing sector [30]