Tevogen to Align Long-Term Stock-Based Incentive Program With Company Milestones, Including Revenue Tevogen to Align Long-Term Stock-Based Incentive Program With Company Milestones, Including Revenue WARREN, N.J., Jan. 29, 2026 (GLOBE NEWSWIRE) -- Tevogen (“Tevogen Bio Holdings Inc.” or “Company”) (Nasdaq: TVGN), today announced that the current time- and individual performance-based long-term stock incentive program will be modified to align awards with defined company milestones including revenue. The ...

Core Insights - Tevogen Bio Holdings Inc. reported significant scientific and operational milestones in 2025, focusing on scalable cell therapy development [1][5] Group 1: Platform Development - Tevogen advanced its proprietary ExacTcell™ platform, enhancing laboratory yields of target-specific cytotoxic T lymphocytes (CTLs) to improve consistency and throughput [2][3] - The improvements in the ExacTcell™ platform are aimed at enabling efficient clinical supply and supporting future clinical and commercial manufacturing across multiple programs [3] Group 2: Pipeline Expansion - Tevogen completed T cell target identification for five additional HLA restrictions, significantly expanding potential patient coverage for its SARS-CoV-2-specific CTL product [4] - The company advanced target discovery and preclinical activities for CTL therapies, supported by its advanced analytics division, Tevogen.AI, which aids in peptide target identification and prioritization [4][9] Group 3: Strategic Positioning - The CEO of Tevogen emphasized that 2025 was a defining year, highlighting the establishment of a scalable CTL platform and the foundation for manufacturing necessary for clinical and commercial outcomes [5] - Tevogen is exploring future strategic initiatives, including domestic generics, biosimilars, medical devices, and innovative insurance solutions, to broaden patient access and advance sustainable innovation [10]

Core Viewpoint - Tevogen Bio Holdings Inc. has made a significant charitable contribution of 230,000 shares to support underserved communities through a recognized nonprofit organization [2][3] Company Overview - Tevogen is a next-generation healthcare enterprise focused on affordability, efficiency, and scientific rigor, utilizing AI and precision T cell therapy platforms [4] - The company aims to develop advanced therapies across various therapeutic areas and enhance the healthcare system's scalability [4] Clinical Development - Tevogen Bio has completed a proof-of-concept clinical trial for its genetically unmodified allogeneic T cells, indicating potential in treating various diseases [5] - The pipeline includes programs in virology, oncology, and neurology, leveraging the proprietary ExacTcell™ platform [5] Technological Innovation - Tevogen.AI is designed to enhance drug development by improving target detection and clinical trial design through predictive technologies [6] - The platform collaborates with major technology providers like Microsoft and Databricks to facilitate rapid therapeutic discovery [6] Strategic Initiatives - The company is exploring future initiatives in domestic generics, biosimilars, medical devices, and innovative insurance solutions to broaden patient access [7] - These initiatives align with Tevogen's mission to promote sustainable innovation and create a more equitable healthcare model [7]

Core Viewpoint - Tevogen Bio Holdings Inc. demonstrates its commitment to community support through a significant donation of 50,000 shares by its Founder and CEO, Dr. Ryan Saadi, to the Mt. Bethel Fire Company, reflecting the company's dedication to local first responders and the Warren Township community [2][3][4]. Company Overview - Tevogen is a next-generation healthcare enterprise focused on affordability, efficiency, and scientific rigor, utilizing advanced artificial intelligence and precision T cell therapy platforms to develop life-saving therapies [5]. - The company has an estimated asset valuation of $10 billion and a secured cash runway for commercialization, indicating strong financial health and growth potential [4]. Clinical and Technological Advancements - Tevogen Bio has completed a proof-of-concept clinical trial for its single-HLA–restricted, genetically unmodified allogeneic T cells, with a pipeline that includes programs in virology, oncology, and neurology [6]. - The Tevogen.AI platform aims to transform drug development by enhancing target detection and optimizing clinical trial design, utilizing cloud and data services from major technology providers [7][8]. Strategic Initiatives - Tevogen is exploring future initiatives that may include domestic generics, biosimilars, medical devices, and innovative insurance solutions, reflecting its mission to advance sustainable innovation and broaden patient access [9].

Core Viewpoint - Tevogen Bio Holdings Inc. has made a significant contribution to the Warren Township Honorary Policemen's Benevolent Association, with its Founder and CEO, Dr. Ryan Saadi, donating 230,000 shares of common stock to support local community initiatives [2][3][4]. Group 1: Donation Impact - The donation will be utilized to acquire critical equipment that enhances the safety of police officers and residents, thereby strengthening community services [6][7]. - The contribution reflects a commitment to community welfare and acknowledges the importance of law enforcement in maintaining safety [5][8]. Group 2: Company Overview - Tevogen is recognized for its disciplined execution and has a significant multi-billion-dollar potential in its long-term vision, emphasizing responsibility towards the communities it serves [9]. - The company operates as a next-generation healthcare enterprise, focusing on affordability, efficiency, and scientific rigor, leveraging advanced technologies for developing life-saving therapies [11]. Group 3: Research and Development - Tevogen Bio has completed a proof-of-concept clinical trial for its T cell therapy, with a pipeline that spans virology, oncology, and neurology [12]. - The company is also developing Tevogen.AI, a platform aimed at transforming drug development through advanced predictive technologies [13]. Group 4: Future Initiatives - Tevogen is exploring strategic initiatives that may include domestic generics, biosimilars, medical devices, and innovative insurance solutions, reflecting its mission to advance sustainable innovation in healthcare [14].

Core Insights - Tevogen Bio Holdings Inc. has been recognized in the 2025 New Jersey Power List by NJBIZ for its influence on the state's economic and innovation landscape [1][2] Company Overview - Tevogen is a next-generation healthcare enterprise focused on affordability, efficiency, and scientific rigor, utilizing AI and precision T cell therapy platforms [4] - The company is committed to advancing life-saving therapies across various therapeutic areas and aims to broaden patient access through innovative healthcare solutions [7] Technological Advancements - The ExacTcell™ platform is a key innovation, with a pipeline addressing infectious diseases, oncology, and neurology [2][5] - Tevogen.AI technology is designed to enhance drug development by improving target detection and clinical trial design, leveraging cloud services from major tech providers [6] Financial Projections - Tevogen anticipates approximately $1 billion in first-year specialty-care revenue and a cumulative five-year revenue forecast of $18–22 billion [2] Expansion and Commitment - The company is expanding its operations with a new 17,428-square-foot manufacturing facility and headquarters, which will centralize R&D and regulatory functions [3]

Core Insights - Tevogen Bio Holdings Inc. has achieved a clinical milestone by completing T cell target identification for five additional human leukocyte antigen (HLA) restrictions, expanding the accessibility of its ExacTcell™ platform [1][4] - The identification of these additional HLA targets allows for the treatment of approximately 65% of the U.S. population, significantly increasing coverage for minority populations [2][3] - The investigational T cell therapy, TVGN 489, has demonstrated 100% viral clearance in high-risk patients with COVID-19, with no reinfections or cases of Long COVID reported [7] Company Developments - The ExacTcell™ platform employs advanced immunological screening to identify immune system targets across various HLA types, aiming to provide treatments for a broader range of infectious diseases and cancers [4] - The selection of additional HLA targets is aimed at ensuring equitable access to treatments for patients of diverse racial and ethnic backgrounds [3] Market Context - Long COVID has affected approximately 35 million U.S. adults, leading to an estimated economic burden of $2.6 trillion to $3.7 trillion, highlighting the urgent need for effective treatments like Tevogen's T cell therapies [3] - The expansion of patient eligibility through multi-HLA targeting is a significant step towards universal T cell therapeutics, enhancing the potential market for Tevogen's products [7]

Core Insights - Tevogen Bio Holdings Inc. has made significant advancements in its PredicTcell™ platform, which aims to enhance precision immunotherapy through advanced machine learning and transformer-based models, supported by Microsoft and Databricks [1][3] Development Progress - The alpha version of PredicTcell was trained on over 124,000 records with transformer-based architecture and 91,000 records using traditional machine learning, achieving recall levels of approximately 92–97% and precision between 38–43% [2] - The beta version has expanded its training dataset to around 1.4 million records, with a total dataset exceeding 6.7 billion records, significantly increasing the number of features for training from 22 to 27 [5][6] Clinical Implications - The advancements in the PredicTcell platform could lead to T-cell therapies that reliably bind to their target, potentially transforming clinical success rates and reducing drug development costs [3][6] - Insights from Tevogen's ExacTcell™ platform and positive Phase 1 trial results inform the beta version's focus on higher precision in identifying virology targets [3] Market Potential - The company aims to raise efficacy standards in T-cell therapies, unlock new markets in immunotherapy, and improve patient access to life-saving therapies across various diseases, including infectious diseases and oncology [3][6]

Core Insights - Tevogen Bio Holdings Inc. emphasizes the potential of its investigational precision T cell therapy, TVGN 489, for treating Long COVID, which affects an estimated 20 million Americans [2][5] - Recent peer-reviewed studies indicate the presence of residual SARS-CoV-2 proteins and RNA long after acute infection, suggesting a viral reservoir that contributes to Long COVID symptoms [3] - TVGN 489 is designed to target multiple SARS-CoV-2 proteins across the entire viral genome, showing efficacy in reducing viral load and persisting in patients for at least 6 months without interfering with their immune responses [4] Scientific Evidence - Peer-reviewed studies published in notable journals report the detection of residual SARS-CoV-2 proteins and RNA for months to years post-infection, indicating chronic immune inflammation linked to Long COVID [3] - These findings support the development of therapeutic approaches aimed at eliminating residual virus and restoring immune homeostasis [3] Product Development - TVGN 489, derived from Tevogen's ExacTcell™ platform, is an off-the-shelf cytotoxic CD8+ T lymphocyte therapy targeting multiple viral proteins, not limited to the Spike protein [4] - In proof-of-concept trials, TVGN 489 demonstrated efficacy in reducing viral load across all patients, with CTLs persisting for at least 6 months [4] Company Outlook - The CEO of Tevogen expresses optimism regarding TVGN 489's potential to restore homeostasis in Long COVID patients, highlighting the company's preparations for clinical manufacturing [5]

Core Insights - Tevogen Bio Holdings Inc. has significant internally developed assets that are not reflected on its balance sheet but represent substantial long-term value [1][3] - The company plans to provide detailed information and valuation of these assets in the near future [1] Asset Overview - Key assets include PredicTcell™, which utilizes AI algorithms to predict peptide–T cell receptor interactions, thereby accelerating development and expanding the pipeline [1] - AdapTcell™ employs AI models to decode HLA–T cell interactions, enhancing immune system insights and revealing new therapeutic paths [2] Intellectual Property and Technology - Tevogen holds three granted U.S. patents and has twelve pending U.S. patents, including two related to artificial intelligence [6] - The company has strategic collaborations with Microsoft and Databricks to support its AI technology [6] Drug Development and Clinical Pipeline - The ExacTcell™ platform focuses on highly purified, target-specific CD8+ cytotoxic T lymphocytes (CTL) [6] - The clinical pipeline includes therapeutics designed to treat cancers while allowing patients to continue oncology care, with potential expansion into non-oncology indications [6] Financial Position - Tevogen has access to a line of credit and is well-capitalized for current operations [6] - The company is establishing internal GMP manufacturing capabilities [6] Facilities - Tevogen operates a drug discovery lab in Philadelphia and has its headquarters in New Jersey [6]