Reducing inflammation helps create a regenerative environment in the Central Nervous SystemTORONTO and HAIFA, Israel, Dec. 19, 2025 (GLOBE NEWSWIRE) -- NurExone Biologic Inc. (TSXV: NRX) (OTCQB: NRXBF) (FSE: J90) (“NurExone” or the “Company”) today announced new laboratory data demonstrating that its proprietary exosomes can significantly reduce inflammatory activity compared to untreated cells and cells treated with a commercially available exosome product. “Inflammation and regeneration are conflicting bi ...

Supported by Scientific Evidence Showing Tissue Repair Quality of Company’s ExosomesTORONTO and HAIFA, Israel, Dec. 12, 2025 (GLOBE NEWSWIRE) -- NurExone Biologic Inc. (TSXV: NRX) (OTCQB: NRXBF) (FSE: J90) (“NurExone” or the “Company”), a preclinical-biotechnology company developing exosome-based therapies for central nervous system injuries, today announced meaningful progress in its long-term clinical-readiness strategy. The Company has begun the process of evaluating potential Israeli production partners ...

Core Insights - NurExone Biologic Inc. reported its financial results for Q3 2025, highlighting significant advancements in its exosome-based therapies for central nervous system injuries [1][24] Financial Performance - Net R&D expenses for Q3 2025 were US$0.70 million, an increase from US$0.50 million in Q3 2024, attributed to higher headcount and service provider costs [19] - G&A expenses decreased slightly to US$0.76 million in Q3 2025 from US$0.78 million in Q3 2024, mainly due to lower service provider costs [20] - The net loss for Q3 2025 was US$1.47 million, compared to US$1.25 million in Q3 2024 [21] Corporate Developments - The company accelerated the expiry of 8.2 million warrants, raising approximately C$3.2 million to support corporate needs [3] - NurExone announced reproducible dose-dependent vision recovery in a glaucoma model, reinforcing the potential of its lead candidate, ExoPTEN [4] - The company secured patent grants in the U.S. and Israel for its exosome production process, enhancing its intellectual property position [11][12] Scientific Recognition - NurExone was named a finalist in two prestigious international award programs, highlighting its innovative approach in regenerative medicine [6] - The company enhanced its scientific visibility through presentations at leading conferences, including the Precision EV Forum 2025 [5] Upcoming Events - An investor webinar titled "Investing in the Future of Exosome Therapeutics" is scheduled for December 10, 2025, to discuss recent achievements and strategic priorities [7] Capital Raising Activities - The company raised C$1.4 million through private placements in August and September 2025, which will be used for working capital and clinical development [8][9][10] Manufacturing Expansion - Plans for a U.S. commercial exosome production facility in Indianapolis were announced, supported by an incentive offer of up to US$0.26 million [13] - NurExone joined the ARMI/BioFabUSA BioFab Startup Lab to strengthen its U.S. biomanufacturing presence [15]

Core Insights - NurExone Biologic Inc. has successfully raised over C$3.18 million through accelerated warrant exercises, enhancing its financial position for ongoing development of its exosome-based therapeutic platform [1][4][5] Financial Summary - The proceeds from the warrant exercises include C$1,207,418.88 from the exercise of 2,515,456 September 2023 Warrants at C$0.48 each and C$1,978,575.55 from 5,653,073 January 2024 Warrants at C$0.35 each [2][3] - The total gross proceeds from the exercises amounted to C$3,185,994.43, which will be utilized for general corporate purposes and working capital [3][4] Management Commentary - The CEO expressed satisfaction with the full participation from warrantholders, indicating that the additional capital will strengthen the company's financial position and support the advancement of its therapeutic pipeline [5] - The CFO noted that the participation reflects investor confidence in the company's strategy and exosome-based platform, allowing for efficient resource allocation towards clinical development [5] Scientific Recognition - NurExone has been nominated as a finalist for the Galien Foundation's inaugural Prix Galien Bridges Awards, recognizing its contributions to life sciences innovation [6][7] - The company was also recognized as a finalist in the Falling Walls Science Breakthroughs of the Year Summit in Berlin, highlighting its leadership in exosome-based medicine [6][7] Company Overview - NurExone is a biotechnology company focused on developing regenerative exosome-based therapies for central nervous system injuries, with its lead candidate, ExoPTEN, showing promising preclinical data [9] - The company has received Orphan Drug Designation from the FDA and EMA, facilitating its path towards clinical trials in the U.S. and Europe [9]

Core Insights - NurExone Biologic Inc. has been accepted into the BioFab Startup Lab, which is part of the Advanced Regenerative Manufacturing Institute (ARMI) and its BioFabUSA program, aimed at accelerating the commercialization of regenerative innovations [1][2][3] Company Overview - NurExone is a biotechnology company focused on developing regenerative exosome-based therapies for central nervous system injuries, with its lead product, ExoPTEN, showing strong preclinical data for treating acute spinal cord and optic nerve injuries, both of which are multi-billion-dollar markets [6] - The company has established a U.S. subsidiary, Exo-Top Inc., to support its North American growth strategy and plans to create a GMP-compliant facility for naive exosome production [3][6] Industry Context - The BioFab Startup Lab program is federally supported and aims to help early-stage biotechnology companies transition regenerative innovations into scalable manufacturing, reflecting a strategic national capability for the U.S. in biomanufacturing [2][5] - Biofabrication, which involves using living cells and biological materials to manufacture tissues and therapeutic products, is seen as the foundation for next-generation regenerative medicine technologies [4]

Core Insights - NurExone Biologic Inc. is gaining global recognition for its leadership in developing exosome-based regenerative therapies, particularly through the participation of Dr. Ina Sarel at the Precision EV Forum 2025 [1][2][5] Company Overview - NurExone is a biopharmaceutical company focused on exosome-based therapies for central nervous system injuries, with its lead product, ExoPTEN, showing strong preclinical data for treating acute spinal cord and optic nerve injuries [6] - The company has established Exo-Top Inc., a U.S. subsidiary, to support its North American growth strategy [6] Product Development - ExoPTEN has received Orphan Drug Designation for acute spinal cord injury, facilitating early discussions with the FDA and focusing on innovation and patient safety [3][4] - The product aims to address significant unmet needs in central nervous system repair, demonstrating the ability to restore nerve function and reduce inflammation in preclinical models [4] Regulatory Engagement - Dr. Sarel's presentation at the forum will address regulatory challenges in the clinical development of ExoPTEN, highlighting the company's proactive approach to regulatory approval [2][5] - The invitation to speak at the forum reflects strong international interest in NurExone's lead program and its regulatory strategy [2][5]

Core Insights - NurExone Biologic Inc. announced promising preclinical results for its lead candidate ExoPTEN, demonstrating a reproducible, dose-dependent therapeutic effect in an eye model of glaucoma [1][2] Company Developments - The study was conducted in collaboration with the Goldschleger Eye Institute at Sheba Medical Center, showing that ExoPTEN's biological activity increases with higher dosing levels, leading to measurable recovery of visual function in animals with optic nerve injury [2][4] - Prof. Michael Belkin confirmed the potential of ExoPTEN to repair damaged optic nerves, which is crucial for addressing vision loss in patients with conditions like glaucoma [3] - Dr. Tali Kizhner highlighted the significance of the dose-response data as a step towards future clinical trials, emphasizing the dual action of exosomes and siRNA in promoting regeneration [3][4] Research Findings - The optic nerve crush model used in the experiments mimics glaucoma-related nerve damage, with both low and high doses of ExoPTEN showing improved visual signal strength in treated animals [4][5] - High-dose ExoPTEN treatment resulted in response amplitudes comparable to uninjured eyes, indicating substantial functional recovery [5][7] - The study's results align with previous findings from June and December 2024, which demonstrated structural preservation and survival of retinal ganglion cells [2][6] Financial and Corporate Actions - The company is accelerating the expiration date of certain warrants, which could yield approximately C$3.2 million if exercised, to be used for general corporate and working capital purposes [11][12] - The acceleration was triggered by the company's common shares trading above specified thresholds for 20 consecutive days [13] - The agreement with POSITIVE Communications has been extended to July 10, 2026, with additional financial terms [16][17] Market Position - NurExone focuses on developing exosome-based regenerative therapies for central nervous system injuries, with ExoPTEN showing strong preclinical data for treating acute spinal cord and optic nerve injuries, both representing multi-billion-dollar markets [18]

Core Insights - NurExone Biologic Inc. announced promising preclinical results for its lead candidate ExoPTEN, demonstrating a reproducible, dose-dependent therapeutic effect in an eye model of glaucoma [1][2] - The study, conducted in collaboration with the Goldschleger Eye Institute, showed that higher doses of ExoPTEN lead to measurable recovery of visual function in animals with optic nerve injury [2][3] - The company is accelerating the expiration of certain warrants, which could yield approximately C$3.2 million if exercised, to support corporate and working capital needs [11][12] Company Developments - ExoPTEN has shown a clear, dose-dependent effect in improving visual signal strength, with high-dose groups achieving response amplitudes comparable to uninjured eyes [5][7] - The optic nerve crush model used in the study mimics damage seen in glaucoma, a leading cause of irreversible blindness [4] - The collaboration with Prof. Ygal Rotenstreich's team is expected to open new treatment avenues for blinding glaucoma and other ophthalmological conditions [6] Financial and Strategic Moves - The company is accelerating the expiration of 2,515,456 September 2023 Warrants and 5,653,073 January 2024 Warrants due to meeting specific trading price thresholds [11][13] - The warrants will now expire on November 7, 2025, and approximately 89% are held by U.S.-based investors [15][14] - The agreement with POSITIVE Communications has been extended to July 10, 2026, with additional financial terms [16][17] Research and Development - The dose-response study is the third independent investigation of ExoPTEN's activity, complementing previous results that showed structural preservation of retinal ganglion cells [3][4] - The findings support the potential of ExoPTEN as a therapeutic option for patients with optic nerve damage, advancing towards future clinical trials [3][18] - NurExone is focused on developing regenerative therapies for central nervous system injuries, with ExoPTEN targeting multi-billion-dollar markets [18]

Core Insights - NurExone Biologic Inc. is establishing its first U.S. commercial exosome production facility in Indianapolis, Indiana, with an incentive offer of up to US$255,000 [1][2][3] - The Indianapolis facility will serve as Exo-Top's U.S. manufacturing base, producing exosomes for both NurExone's therapeutic pipeline and business-to-business opportunities in regenerative aesthetics [2][4] - Indiana's life sciences sector generates over US$99 billion annually and has attracted more than US$1.5 billion in venture investments since 2019, making it an attractive location for Exo-Top [3][6] Company Overview - NurExone is focused on developing exosome-based regenerative therapies for central nervous system injuries, with its lead product, ExoPTEN, showing strong preclinical data [6] - The company aims to progress towards first-in-human clinical trials and plans to uplist to a major U.S. stock exchange [4][6] - Exo-Top Inc. has been established as a U.S. subsidiary to anchor NurExone's North American growth strategy [6]

Core Insights - NurExone Biologic Inc. has received a patent grant from the Israel Patent Office for the production of extracellular vesicles from stem cells, complementing a recent U.S. Notice of Allowance for the same application [2][3] - The company is actively participating in key U.S. conferences to showcase its exosome manufacturing platform and engage with potential partners and investors [4][5] - NurExone has completed a non-brokered private placement, raising approximately C$632,655.68 to support its preclinical pipeline and U.S. manufacturing initiatives [6][7] Patent and Intellectual Property - The granted patent enhances NurExone's international intellectual property portfolio, which is crucial for its exosome-based regenerative therapies [2][3] Conference Participation - Dr. Ina Sarel will present at the 7th Annual Exosome-Based Therapeutic Development Summit, focusing on regulatory practices in exosome research [4] - Dr. Lior Shaltiel will speak at the Bioprocess International Conference, discussing advancements in spinal cord injury treatments [5] Financing and Capital Structure - The private placement involved 930,376 units at C$0.68 per unit, with each unit consisting of one common share and one-half of a warrant [6][7] - The warrants allow holders to purchase common shares at C$0.88 for 36 months, with potential acceleration if the share price exceeds C$1.70 [7] Related Party Transactions - Jay Richardson, a director of the company, participated in the private placement, which is classified as a related party transaction [9][10] Company Overview - NurExone focuses on developing regenerative exosome-based therapies for central nervous system injuries, with its lead product, ExoPTEN, showing strong preclinical data [13] - The company aims to provide solutions for quality exosomes and targeted delivery systems, establishing a U.S. subsidiary, Exo-Top Inc., to support its growth strategy [13]