Core Insights - Mirxes Holding Limited, a leading cancer early screening company based in Singapore, was listed on the Hong Kong Stock Exchange on May 23, 2025, and quickly gained recognition by being included in the Hang Seng Composite Index and the Hong Kong Stock Connect program within four months [1][2] Company Performance - Since its listing, Mirxes has shown impressive market performance, becoming the first unicorn in Southeast Asia's biotechnology sector with a market capitalization exceeding $1 billion on its listing day [2] - For the first half of 2025, the company reported revenues of $10.5 million, a 9.4% increase compared to the same period in 2024, with gross profit rising to $7.1 million, reflecting a 51.1% year-on-year growth and an increase in gross margin from 49.0% to 67.6% [2] - The company's losses decreased by 36.3% year-on-year to $28.23 million, and cash and cash equivalents rose to $108 million, providing a solid financial foundation for future R&D and commercialization efforts [2] Product and Technology - Mirxes continues to lead the industry with its core competencies, including the world's first approved molecular diagnostic product for gastric cancer screening, GASTROClear™, which has received regulatory approval in Singapore and Thailand, as well as "Breakthrough Medical Device" designation from the FDA in the U.S. [3] - The lung cancer detection product, LUNGClear™, has also performed well, contributing significantly to revenue growth in Southeast Asia and Japan due to its non-invasive and cost-effective nature [3] - The company's miRNA technology has been recognized in China, being included in expert consensus guidelines for early screening and diagnosis of common malignant tumors [3] Market Impact - The inclusion of Mirxes in the Hong Kong Stock Connect program not only broadens its investor base but also serves as a new model for the international development of Asian biotechnology companies [3] - This development highlights Hong Kong's role as a crucial bridge connecting China and the global market, allowing mainland investors to easily participate in the growth of high-quality biotechnology firms [3]

Core Viewpoint - MIRXES-B (02629) has seen a significant increase in stock price, reaching a new high of 40.66 HKD, which is over 70% higher than its IPO price of 23.3 HKD [1] Company Overview - Mirxes is a Singapore-based RNA biotechnology company focused on developing and commercializing precise, non-invasive, and affordable blood miRNA tests for early cancer and disease screening [1] - The flagship product, GASTROClear™/觅小卫™, is a blood miRNA-based molecular diagnostic kit for gastric cancer screening, approved in multiple countries including Singapore and the EU, and has received breakthrough medical device certification from the US FDA [1] - GASTROClear™ has completed a prospective clinical trial with a sample size of 9,472 in China and is currently in the registration application process [1] Market Position - The company is recognized as a global leader in the field of early cancer detection based on miRNA, possessing significant technological, product, and market advantages [1] - The global cancer screening market is noted to have vast potential with high entry barriers [1] - GASTROClear™ is the only approved molecular diagnostic IVD product for gastric cancer screening in the global market, holding the largest market share of 66.3% in the Southeast Asian miRNA-based liquid biopsy gastric cancer screening market as of 2023 [1]

Core Viewpoint - MIRXES-B (02629) has seen a significant increase in stock price, reaching a new high of 40.66 HKD, which is over 70% higher than its IPO price of 23.3 HKD [1] Company Overview - Mirxes is a Singapore-based RNA biotechnology company focused on developing and commercializing precise, non-invasive, and affordable blood miRNA tests for early cancer and other disease screening [1] - The flagship product, GASTROClear™/觅小卫™, is a blood miRNA-based molecular diagnostic kit for gastric cancer screening, approved in multiple countries including Singapore and the EU, and has received breakthrough medical device certification from the US FDA [1] - GASTROClear™ has completed a prospective clinical trial with a sample size of 9,472 in China and is currently in the registration application process [1] Market Position - According to Guoyuan International, the company holds significant technological, product, and market advantages in the field of miRNA-based early cancer detection, positioning it as a global leader [1] - Everbright Securities International noted the vast market potential for global cancer screening, highlighting high industry entry barriers [1] - GASTROClear™ is the only approved molecular diagnostic IVD product for gastric cancer screening globally, holding the largest market share of 66.3% in the Southeast Asian miRNA liquid biopsy gastric cancer screening market as of 2023 [1]