HCB101注射液
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复星医药子公司与FBD签许可协议 丰富肿瘤领域产品管线
Zheng Quan Shi Bao Wang· 2025-06-30 12:08
Core Viewpoint - Fosun Pharma's subsidiary, Fuhong Hanlin, has signed a licensing agreement with FBD to collaborate on the development, production, and commercialization of the investigational drug HCB101, a SIRPα-Fc fusion protein for cancer treatment [1][2]. Group 1: Licensing Agreement Details - Fuhong Hanlin will pay up to $59 million to FBD and up to $143 million in milestone payments based on annual net sales of the licensed product in specific regions [1]. - The agreement includes royalty payments based on a one to two-digit percentage of annual net sales of the licensed product, with potential reductions under certain conditions [1]. - The agreement allows Fuhong Hanlin to terminate the contract if FBD reaches major financial terms with third parties regarding the licensed product [1]. Group 2: Product Information - HCB101 is a SIRPα-Fc fusion protein that enhances macrophage phagocytosis of tumor cells by binding with high affinity to CD47 [2]. - The HCB101 injection has shown preliminary efficacy in early clinical trials for tumor patients, including those with solid tumors, and is currently in the Ib/IIa clinical trial phase in China [2]. Group 3: Company Background - FBD, established in 2021 and based in Hong Kong, is a subsidiary of Hanchor Bio Inc., which focuses on new drug development in the field of cancer immunotherapy [3]. - As of December 31, 2024, Hanchor Bio Inc. reported total assets of approximately NT$5.42 billion, equity of about NT$2.31 billion, and total liabilities of around NT$3.11 billion, with a net loss of approximately NT$1.354 billion and no operating revenue for 2024 [3]. - The collaboration aims to leverage both companies' strengths in drug development and commercialization to enhance Fosun Pharma's product pipeline in oncology and provide more treatment options for patients [3].