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PresentationI would like to now turn the call over to Niels Riedemann, CEO and Founder of InflaRx. Niels, please go ahead.Good morning and good afternoon, everyone. Thank you for standing by, and thank you for joining our conference call to discuss our top line data for INF904 in HS and CSU. [Operator Instructions] And please note that today's call is being recorded. [Operator Instructions]Niels RiedemannCo-Founder, CEO & Executive Director Good morning, everyone. It's my pleasure to welcome you as well to ...

INF904 Topline Phase 2a Data Hidradenitis suppurativa (HS) & chronic spontaneous urticaria (CSU) NOVEMBER 10, 2025 NIELS RIEDEMANN, M.D., PH.D. 1 Speakers PROF. JOHN INGRAM Clinical Professor & Consultant Dermatologist, Cardiff University & Specialty Lead for Dermatology, Health and Care Research Wales CAMILLA CHONG, M.D. Chief Medical Officer, InflaRx Chief Executive Officer, Founder, InflaRx This presentation contains forward-looking statements. All statements other than statements of historical fact are ...

Core Insights - InflaRx N.V. announced positive topline data from a Phase 2a basket study of INF904 for hidradenitis suppurativa (HS) and chronic spontaneous urticaria (CSU), indicating strong efficacy and safety profiles [1][2][19] - The company plans to advance INF904 into Phase 2b trials in HS and expand its clinical program in CSU, highlighting the drug's potential as a "pipeline-in-a-product" [2][11][20] Phase 2a Data in HS - The Phase 2a trial involved 31 HS patients, with efficacy data reported from 29 patients across three dosing cohorts: 60 mg BID, 90 mg BID, and 120 mg BID [3][12] - Key clinical endpoints included reductions in abscesses and nodules (AN), draining tunnels (dT), and improvements in pain and quality of life measures [4][5][10] - INF904 demonstrated rapid and consistent reductions in ANs and dTs, with the highest dosing cohort showing the strongest clinical activity [5][6][10] - Safety data indicated no serious adverse events, with only mild adverse events reported [9][10] Phase 2a Data in CSU - The Phase 2a trial for CSU included 31 patients, with efficacy data reported from 30 patients across 60 mg BID and 120 mg BID dosing cohorts [15][22] - Clinical endpoints included changes in the Urticaria Activity Score (UAS7) and Urticaria Control Test (UCT7), with significant reductions observed, particularly in patients with severe CSU [17][19][22] - Safety data showed no serious adverse events, reinforcing the drug's safety profile [19][22] Market Potential - InflaRx estimates the addressable market for INF904 could exceed $1 billion, emphasizing the need for novel therapies in HS and CSU [11][20] - The company is actively engaging with potential collaborators to expedite development goals for INF904 [6][20] Future Plans - InflaRx aims to complete the 4-week post-treatment observation period and present final results at major scientific meetings [1][22] - A Capital Markets Event is planned to showcase the potential of INF904 [1][2]

Core Insights - InflaRx N.V. is set to report topline data from its Phase 2a clinical trial of oral C5aR inhibitor INF904 for hidradenitis suppurativa (HS) and chronic spontaneous urticaria (CSU) on November 10, 2025 [1] - The company will host a webcast/conference call on the same day to discuss the clinical data and feature insights from key opinion leaders [2] - InflaRx will also publish its third quarter 2025 financial and operating results via Form 6-K on the same day [3] Company Overview - InflaRx is a biopharmaceutical company focused on anti-inflammatory therapeutics, utilizing proprietary anti-C5a and anti-C5aR technologies to develop specific inhibitors targeting the complement activation factor C5a and its receptor C5aR [4] - The company has developed vilobelimab, a first-in-class anti-C5a monoclonal antibody, and is also working on INF904, an orally administered small molecule inhibitor [4] - Founded in 2007, InflaRx has offices in Jena and Munich, Germany, and Ann Arbor, MI, USA [5]

Core Insights - InflaRx N.V. is participating in the Guggenheim Securities 2nd Annual Healthcare Innovation Conference scheduled for November 10 - 12, 2025, in Boston, MA, with a fireside chat on November 11 at 2:30 PM ET and one-on-one investor meetings on the same day [1] Company Overview - InflaRx is a biopharmaceutical company focused on anti-inflammatory therapeutics, utilizing proprietary anti-C5a and anti-C5a receptor technologies to develop specific inhibitors targeting the complement activation factor C5a [2] - The company has developed vilobelimab, a first-in-class anti-C5a monoclonal antibody, which has shown disease-modifying clinical activity and tolerability in multiple studies [2] - InflaRx is also working on INF904, an orally administered small molecule inhibitor that targets C5a-induced signaling via the C5a receptor [2] - Founded in 2007, InflaRx has offices in Jena and Munich, Germany, and Ann Arbor, MI, USA [3]

Core Points - InflaRx N.V. has regained compliance with Nasdaq's minimum bid price requirement as of September 11, 2025, after its ordinary shares closed at $1.00 or greater for 10 consecutive business days from August 27, 2025, to September 10, 2025 [1][2] Company Overview - InflaRx N.V. is a biopharmaceutical company focused on developing anti-inflammatory therapeutics by targeting the complement system, specifically through its proprietary anti-C5a and anti-C5a receptor technologies [3] - The company has developed vilobelimab, a first-in-class anti-C5a monoclonal antibody that has shown disease-modifying clinical activity and tolerability in multiple studies [3] - InflaRx is also working on INF904, an orally administered small molecule inhibitor targeting C5a-induced signaling via the C5a receptor [3] - Founded in 2007, InflaRx has offices in Jena and Munich, Germany, and Ann Arbor, MI, USA [4]

Company Overview - InflaRx N.V. is a biopharmaceutical company focused on developing anti-inflammatory therapeutics by targeting the complement system [3] - The company has developed vilobelimab, a first-in-class anti-C5a monoclonal antibody, which has shown disease-modifying clinical activity and tolerability in multiple studies [3] - InflaRx is also working on INF904, an orally administered small molecule inhibitor of C5a-induced signaling [3] Upcoming Events - InflaRx will participate in the Cantor Global Healthcare Conference from September 3 to 5, 2025, with a fireside chat scheduled for September 4 at 9:10 AM ET [1] - The company will also conduct one-on-one investor meetings on September 4 during the Cantor conference [1] - Additionally, InflaRx will present at the H.C. Wainwright 27th Annual Global Investment Conference from September 8 to 10, 2025, with a presentation on September 9 at 3:30 PM ET [2] - One-on-one investor meetings will also take place on September 9 at the H.C. Wainwright conference [2]

Company Overview - InflaRx N.V. is a biopharmaceutical company focused on developing anti-inflammatory therapeutics by targeting the complement system [2] - The company utilizes proprietary anti-C5a and anti-C5a receptor technologies to create specific inhibitors of the complement activation factor C5a [2] - InflaRx has developed vilobelimab, a first-in-class anti-C5a monoclonal antibody, which has shown disease-modifying clinical activity in multiple studies [2] Upcoming Financial Results - InflaRx will report its second quarter 2025 financial and operating results on August 7, 2025, before the market opens [1] - No conference call is planned for this earnings report [1] Product Development - InflaRx is also developing INF904, an orally administered small molecule inhibitor targeting C5a-induced signaling [2] - The company was founded in 2007 and has offices in Jena and Munich, Germany, as well as Ann Arbor, MI, USA [2][3]

Core Points - InflaRx N.V. has received a notice from Nasdaq indicating that its common shares have closed below the minimum bid price of $1.00 for the last 30 consecutive business days [1] - The company has until January 7, 2026, to regain compliance with the Minimum Bid Price Rule, with the possibility of transferring to the Nasdaq Capital Market for an additional compliance period [2] - The notice does not have an immediate effect on the listing or trading of the company's shares, and InflaRx plans to monitor its share price and explore options for compliance [3] Company Overview - InflaRx is a biopharmaceutical company focused on developing anti-inflammatory therapeutics by targeting the complement system, specifically through its proprietary anti-C5a and anti-C5a receptor technologies [4] - The company has developed vilobelimab, a first-in-class anti-C5a monoclonal antibody, and is also working on INF904, an orally administered small molecule inhibitor [4] - Founded in 2007, InflaRx has offices in Jena and Munich, Germany, and Ann Arbor, MI, USA [5]