Nugevia™ supports metabolic, mitochondrial, and neuroinflammatory biology impacted by GLP-1-driven weight loss Jupiter, Florida, Jan. 28, 2026 (GLOBE NEWSWIRE) -- Jupiter Neurosciences, Inc. (NASDAQ: JUNS) (“Jupiter” or the “Company”), a clinical-stage pharmaceutical company developing JOTROL™, a patented resveratrol-based platform, today announced a strategic initiative to support individuals using GLP-1-based weight loss therapies through its Nugevia™ consumer longevity product line. This initiative reinf ...

Core Insights - Jupiter Neurosciences, Inc. is focused on treatments for neuroinflammation and rare diseases using its patented resveratrol delivery platform, JOTROL [1] - The company has a clinical pipeline with over $50 billion in combined market opportunities [1] Company Overview - Christer Rosen is the Co-Founder, CEO, and Chairman of Jupiter Neurosciences since January 1, 2016, with a background in founding and leading multiple businesses [2] - Rosen previously founded EffRx Pharmaceuticals, where he developed the osteoporosis drug Binosto, which received FDA and EU approvals [2] - Alison Silva serves as the President and Chief Business Officer of Jupiter Neurosciences, with extensive experience in drug development and regulatory strategy [4] - Silva has held leadership roles in various biotech companies, including Cotinga Pharmaceuticals and Synlogic, and has a strong background in orphan drug strategy [4][5]

Core Insights - Jupiter Neurosciences is advancing its JOTROL platform into a Phase 2a clinical trial for Parkinson's disease, marking a significant regulatory milestone with FDA clearance [4][5] - The company launched its Nugevia consumer brand, targeting the $8 trillion longevity market, with initial products designed to enhance brand visibility and generate revenue [6][7] - Jupiter has secured strategic financing of up to $20 million to support its clinical and commercial initiatives, providing flexibility and control over capital access [10][11][12] Company Achievements - Jupiter Neurosciences completed its first full year as a public company, establishing a foundation for long-term value creation and executing major initiatives [2][3] - The JOTROL platform has demonstrated a nine-fold improvement in bioavailability and effective blood-brain barrier penetration, supporting its therapeutic potential [5][20] - The Nugevia product line includes three initial offerings—GLO, PWR, and MND—integrating JOTROL with other bioavailable ingredients to support various aspects of health [7][21] Market Positioning - The Nugevia brand is supported by high-profile ambassadors, enhancing its market presence and performance-driven identity [8] - A dedicated website for Nugevia was launched, facilitating pre-orders and establishing a subscription-based model for recurring revenue [9] - Jupiter's dual-path strategy focuses on both therapeutic applications for CNS disorders and consumer longevity products, positioning the company for growth in both sectors [17][22] Financial Strategy - The strategic financing agreement with Yorkville Advisors allows Jupiter to access capital as needed, ensuring stability during its growth phase [10][11] - The financing structure is designed to be non-toxic and fully controlled by the company, allowing for advantageous capital access [11][12] - The company aims to strengthen its financial position while supporting ongoing operations and clinical trials without compromising shareholder interests [12]

Core Insights - Jupiter Neurosciences, Inc. has received FDA clearance for its Investigational New Drug application to initiate a Phase 2a clinical trial of JOTROL for Parkinson's disease [1][2][3] - The Phase 2a trial aims to evaluate the safety and tolerability of JOTROL, with additional endpoints to assess pharmacokinetics and pharmacodynamics [2][3] - JOTROL has shown strong safety and bioavailability in Phase I studies, with preclinical evidence suggesting potential neuroprotective benefits [3][4] Company Overview - Jupiter Neurosciences is a clinical-stage pharmaceutical company focused on neuroinflammation and healthy aging, with a therapeutic pipeline targeting CNS disorders and rare diseases [6] - The company is advancing JOTROL, a proprietary resveratrol formulation, which has demonstrated over nine-fold higher bioavailability compared to traditional resveratrol [4][8] - Jupiter is also expanding into the consumer longevity market with its Nugevia product line, which leverages the same delivery technology as JOTROL [6][9] Market Context - Parkinson's disease affects over 10 million people globally, with no current disease-modifying treatments available, highlighting a significant unmet medical need [5] - The global market for Parkinson's therapeutics is projected to exceed $14 billion by 2030, indicating a strong demand for innovative treatments [5]

Core Insights - Jupiter Neurosciences, Inc. has entered into two strategic financing agreements with Yorkville Advisors Global, LP, allowing access to up to $20 million in capital to support its Phase 2 trial for Parkinson's disease and to accelerate the growth of its Nugevia product line [1][2][6] Financing Details - The financing includes a $4 million pre-paid advance available upon execution of the agreements, with an additional $2 million expected shortly after the effectiveness of a registration statement [3] - The pre-paid advances will be issued at a 7% original issue discount and will bear interest, with a maturity date of 12 months after signing [3] - The company has the option to sell up to $14 million of common stock over a 24-month period under a standby equity purchase agreement (SEPA), with shares issued at a 3.0% discount to market price [4][7] Product and Market Focus - The proceeds from the financing will primarily support the Phase 2 trial of JOTROL, a resveratrol delivery platform for treating Parkinson's disease, and will also be used for marketing and sales growth of the Nugevia nutritional product line [2][6] - Jupiter Neurosciences is advancing a therapeutic pipeline targeting CNS disorders and rare diseases, while also expanding into the consumer longevity market with Nugevia [6][10] JOTROL and Nugevia - JOTROL has demonstrated over nine times higher bioavailability compared to earlier resveratrol products, addressing the issue of poor bioavailability that has hindered regulatory approval [9] - Nugevia leverages the same clinically validated delivery technology as JOTROL, offering targeted support for cognitive health, skin vitality, and cellular energy [10]

Core Insights - Jupiter Neurosciences, Inc. has appointed Jean Fallacara as the brand ambassador for its new consumer longevity supplement line, Nugevia, which aims to enhance clinical and scientific integrity in the longevity market [2][4][5] - Nugevia is built on the JOTROL platform, a patented resveratrol-based micellar delivery system that significantly improves bioavailability, supporting the company's clinical-stage CNS therapies [5][11] - The longevity market is projected to reach $8 trillion by 2030, and Nugevia's consumer-facing strategy is expected to create a revenue stream that supports ongoing clinical development and enhances long-term shareholder value [6][8] Company Overview - Jupiter Neurosciences is a clinical-stage pharmaceutical company focused on addressing neuroinflammation and promoting healthy aging through a dual-path strategy, which includes advancing therapeutics for CNS disorders and expanding into the consumer longevity market with Nugevia [8] - The company’s therapeutic pipeline includes a Phase IIa trial for Parkinson's disease and targets other CNS disorders such as Alzheimer's Disease and Friedreich's Ataxia [8][10] - JOTROL, the foundation for both therapeutic and consumer products, has demonstrated over nine times higher bioavailability compared to earlier resveratrol products, addressing the issue of poor absorption that has historically limited the effectiveness of resveratrol [9][10][11] Product Details - Nugevia's initial formulations—GLO, MND, and PWR—are designed to support cellular resilience through synergistic ingredients optimized for absorption via the JOTROL system [5][11] - The brand emphasizes the importance of real science in wellness innovation, aiming to make human longevity accessible to a broad audience, including athletes and entrepreneurs [5][6]

Core Insights - Jupiter Neurosciences, Inc. is launching its Nugevia e-commerce platform and three nutraceutical supplements, marking a significant expansion into the longevity market valued at $8 trillion [2][3][4] - The Nugevia product line utilizes the patented JOTROL resveratrol delivery platform, which has shown a nine-fold increase in bioavailability, aiming to bring pharmaceutical-grade science to the consumer health sector [3][11] - The launch is seen as a pivotal moment for the company, establishing a new revenue stream that supports ongoing research and development while enhancing financial flexibility [4][5] Company Strategy - Jupiter Neurosciences is executing a dual-path business model that focuses on both CNS therapeutic programs and the consumer longevity market [3][8] - The introduction of Nugevia is intended to create a capital-efficient growth engine, allowing the company to leverage its clinical research for consumer products [4][5] - The company aims to build a diversified and sustainable business that complements its pharmaceutical pipeline [4] Product Details - The Nugevia product line includes Nugevia GLO for skin vitality, Nugevia PWR for mitochondrial health, and Nugevia MND for cognitive support, all utilizing the JOTROL technology [9][12] - Pre-orders for the products are available on the Nugevia website, with shipping expected to start in Fall 2025 [7] Brand Ambassadors - Annika Sörenstam and Chris Webber have been appointed as the first brand ambassadors for Nugevia, enhancing the brand's visibility and credibility [6]

Core Insights - Jupiter Neurosciences, Inc. has launched Nugevia MND, a supplement aimed at enhancing cognitive function and supporting brain health, tapping into the $8 trillion longevity and wellness markets [1][4] - Nugevia MND combines JOTROL, a proprietary resveratrol-based platform, with NovaSOL Curcumin to target neuroprotective pathways and improve cognitive resilience [2][4] - The product is positioned to generate high-margin revenue by appealing to aging populations concerned about cognitive decline, while also complementing Jupiter's pharmaceutical pipeline [4][8] Product Details - Nugevia MND is designed to improve memory, clarity, executive function, and support mitochondrial function in brain cells, while reducing neuroinflammation and oxidative stress [7][8] - The supplement will be available through direct-to-consumer e-commerce platforms starting Fall 2025, with a recommended daily regimen of two capsules [4] Strategic Importance - The launch of Nugevia MND represents a strategic move for Jupiter to leverage its expertise in central nervous system (CNS) therapeutics within the consumer health market [3][4] - Insights gained from consumer use of MND and biomarker data from ongoing clinical trials will inform future cognitive health programs [3][4] Scientific Foundation - JOTROL has demonstrated over nine times higher bioavailability compared to traditional resveratrol products, addressing previous issues of poor absorption and gastrointestinal side effects [9][10] - The product line aims to bring clinical-grade science into the wellness space, supporting mental clarity and cellular energy [11]

Core Insights - Jupiter Neurosciences, Inc. is advancing its proprietary resveratrol-based platform, JOTROL, which offers significant advantages over traditional resveratrol formulations [1][3][10] - JOTROL has demonstrated a nine-fold increase in bioavailability compared to conventional resveratrol, while avoiding gastrointestinal side effects [3][7][10] - The company is progressing JOTROL towards a Phase IIa trial for Parkinson's Disease, supported by promising preclinical data [4][8][10] Scientific and Clinical Advantages - Resveratrol is known for its antioxidant, mitochondrial, and anti-inflammatory properties, but its therapeutic use has been limited due to poor bioavailability and GI side effects [2][9] - JOTROL promotes mitochondrial biogenesis and reduces neuroinflammation, addressing key factors in neurodegenerative diseases and aging [5][6] Product Development and Market Strategy - JOTROL is not only aimed at pharmaceutical applications but also serves as the foundation for the Nugevia consumer product line, targeting cognitive health, mitochondrial energy, and skin vitality [4][11] - The Nugevia product line is set to launch in Q3 2025, leveraging the same delivery technology as JOTROL to provide clinical-grade bioavailability in the wellness market [11] Intellectual Property and Market Potential - The company has secured intellectual property rights for JOTROL in major markets including the U.S., EU, China, Japan, and Hong Kong, valid through 2036 [7] - JOTROL's ability to cross the blood-brain barrier positions it as a potential treatment for CNS disorders such as Parkinson's and Alzheimer's [7][8]

Core Points - Jupiter Neurosciences, Inc. has regained compliance with Nasdaq's minimum share price requirement, confirming an average closing share price of at least $1.00 for 13 consecutive days [1][2] - The company is focused on developing JOTROL, a patented resveratrol-based platform, targeting neuroinflammation and promoting healthy aging [3] Company Overview - Jupiter Neurosciences is a clinical-stage pharmaceutical company with a dual-path strategy addressing central nervous system (CNS) disorders and rare diseases, while also entering the consumer longevity market with its Nugevia product line [3] - The therapeutic pipeline includes a Phase IIa trial for Parkinson's disease and targets conditions such as Alzheimer's Disease, Mucopolysaccharidoses Type I, Friedreich's Ataxia, and MELAS [3]