Core Insights - Regeneron Pharmaceuticals reported second-quarter 2025 adjusted earnings per share (EPS) of $12.89, significantly surpassing the Zacks Consensus Estimate of $8.03, marking a 12% increase from $11.56 in the same quarter last year [1][7] - Total revenues grew by 4% year over year to $3.7 billion, driven by higher sales of Eylea HD and increased profits from Dupixent, exceeding the Zacks Consensus Estimate of $3.3 billion [2][7] Revenue Breakdown - Eylea's sales in the U.S. decreased by 39% year over year to $754 million, primarily due to increased competition and market share loss, although it still beat the Zacks Consensus Estimate of $686 million [3][5] - Eylea HD generated revenues of $393 million in the U.S., up 29% year over year, driven by higher sales volumes, surpassing the Zacks Consensus Estimate of $320 million [5][7] - Dupixent sales rose by 22% year over year to $4.3 billion globally, contributing significantly to collaboration revenues of $1.9 billion, which increased by 22.1% from the previous year [8][9] Collaboration Revenues - Sanofi's collaboration revenues increased by 26% to $1.44 billion, driven by higher Dupixent sales, exceeding the Zacks Consensus Estimate of $1.36 billion [9] - Bayer's collaboration revenues totaled $415 million, reflecting an 11% year-over-year increase [9] Product Performance - Total Libtayo sales reached $376.5 million, up 27% year over year, beating the Zacks Consensus Estimate of $322 million [10] - Praluent's net sales in the U.S. were $65.8 million, while Kevzara recorded global sales of $152.2 million, up 39% from the previous year [11] Expense Management - Adjusted R&D expenses increased by 20% year over year to $1.3 billion, reflecting advancements in the company's pipeline, while adjusted SG&A expenses decreased by 19% to $542 million [12] Regulatory Updates - The FDA approved a label expansion of Dupixent for treating adults with bullous pemphigoid, with additional applications under review in the EU and Japan [13] - The FDA granted accelerated approval to Lynozyfic for treating adults with relapsed or refractory multiple myeloma [15] - A complete response letter was issued for the BLA for odronextamab due to site inspection issues [16] Strategic Developments - Regeneron entered into an in-licensing agreement with Hansoh Pharmaceuticals for an obesity drug, HS-20094, expanding its clinical-stage obesity portfolio [17] - The company has initiated a share repurchase program, repurchasing shares worth $1.07 billion in Q2 2025 [12]

Industry Overview - The bear market caused by the Federal Reserve's monetary tightening ended in 2023, but the biotech sector continues to lag behind the broader market, with the SDPR S&P Biotech ETF trading at levels similar to 2017 [1] - Despite the skepticism surrounding biotech stocks post-COVID-19 pandemic, there are signs of potential recovery in 2025, driven by companies making progress on new drugs and innovative therapies [2] Company Highlights Vertex Pharmaceuticals - Vertex Pharmaceuticals has been a leader in developing cystic fibrosis treatments, including Kalydeco and Trikafta, and has recently gained FDA approval for Journavx, a novel non-opioid pain medication [6][7] - Despite a recent 15% stock decline and an earnings miss, Vertex is still rated as a Moderate Buy with an average price target of $515, indicating potential upside [8] Regeneron Pharmaceuticals - Regeneron Pharmaceuticals, known for its blockbuster drug Eyelea, reported over $14 billion in sales last year and has expanded its portfolio with drugs like Dupixent and Kevzara [9][10] - Although Regeneron's stock has dropped over 45% in the past year, analysts maintain a consensus Moderate Buy rating with an average price target of $892, suggesting significant upside potential [12] Akero Therapeutics - Akero Therapeutics focuses on liver disease treatments, particularly efruxifermin for metabolic dysfunction-associated steatohepatitis (MASH), currently in Phase 3 trials [13][14] - The stock saw a significant increase in January following positive Phase 2 trial results, and analysts unanimously rate it as a Buy, with a consensus price target of $76, indicating over 90% upside potential [14]

Core Viewpoint - Regeneron Pharmaceuticals is expected to report first-quarter 2025 results on April 29, 2025, with revenue estimates at $3.25 billion and earnings at $8.76 per share. The company has a mixed earnings surprise history, with an average surprise of 3.23% over the last four quarters [1][2]. Financial Performance - The Earnings Surprise Prediction Model indicates a negative Earnings ESP of -0.94%, suggesting a lower likelihood of an earnings beat this quarter [3]. - The Zacks Rank for Regeneron is currently 4 (Sell), indicating a bearish outlook [3]. Product Sales Overview - Eylea, Regeneron's leading drug, is facing sales pressure due to competition from Vabysmo, with expected sales in the U.S. pegged at $1.2 billion for the first quarter [4][5][6]. - The introduction of Eylea HD is anticipated to have positively impacted total Eylea franchise sales due to strong demand [6]. - Dupixent is another significant revenue driver, with sales estimates at $3.7 billion, bolstered by strong prescription trends and recent label expansions [7][8]. - Libtayo's sales are projected at $346 million, driven by increased demand in non-melanoma skin indications and lung cancer treatments [10]. Regulatory and Pipeline Updates - Regeneron received European Commission approval for odronextamab, enhancing its oncology portfolio [11]. - The FDA approved a label expansion for Dupixent, while a complete response letter was issued regarding the extended dosing intervals for Eylea HD [14][15][16]. - The FDA accepted a supplemental biologics license application for Eylea HD, with a target action date set for August 19, 2025 [17]. Shareholder Returns - In February 2025, Regeneron initiated a quarterly cash dividend program at $0.88 per share and authorized a $3.0 billion share repurchase program, totaling approximately $4.5 billion [13]. Market Performance - Regeneron's shares have declined by 21.1% year-to-date, compared to a 7.8% decline in the industry [18].