Summary of Nanobiotix Conference Call Company Overview - **Company**: Nanobiotix (NasdaqGS:NBTX) - **Industry**: Healthcare, specifically focused on oncology and CNS disorders through nanophysics-based therapeutics [1][2] Core Points and Arguments Nanobiotix's Unique Approach - Nanobiotix is pioneering nanophysics for healthcare, developing small objects that can trigger physical effects at the cellular level, impacting treatments for oncology and CNS disorders [2][3] - The company has three platforms: one for oncology, one for rethinking drug development, and one for CNS disorders [3] NBTXR3 Program - NBTXR3 is the most advanced program, currently in a Phase 3 study for head and neck cancer, with a partnership with Johnson & Johnson (J&J) [4] - The focus is on early-stage cancer treatment, where the majority of patients have local disease, representing a significant market opportunity [5][6] - NBTXR3 aims to enhance radiation therapy by improving the dose delivered to tumors while minimizing damage to surrounding healthy tissue [6][7] Market Opportunity - Approximately 60% of all cancer patients receive radiation therapy, with significant potential for NBTXR3 to impact around 160,000 patients in the EU5 and US for the initial indications [7][8] - The potential market size for NBTXR3 is estimated between $5 billion and $10 billion based on addressing 20% of the patient population [8] Partnership with J&J - The deal with J&J includes $2.6 billion in milestones and royalties ranging from low teens to low twenties percentage [8] - J&J is responsible for running three trials for NBTXR3, with the aim of broad commercialization [7][8] Clinical Data and Efficacy - In a Phase 1 study, NBTXR3 showed an 81% overall response rate and a 63% complete response rate among treated patients, with a median overall survival of 23 months [17][18] - The ongoing Phase 3 trial aims to improve progression-free survival (PFS) from nine months to 13 months, which could serve as registration data for the FDA [25] Future Directions - J&J has initiated a Phase 1 study for cisplatin-eligible head and neck cancer patients, indicating confidence in expanding the use of NBTXR3 [26] - The company is also exploring the use of NBTXR3 in lung cancer, where radiation therapy is widely used [29][30] Additional Important Content Other Platforms - Nanobiotix is developing Curadigm, a technology aimed at improving the delivery of various therapies by preventing their capture by the liver, thus enhancing systemic distribution [39][40] - The company is positioned to leverage its nanophysics-based approach beyond oncology, indicating potential for significant business development opportunities [39][40] Regulatory and Market Readiness - The transfer of the Phase 3 trial to J&J was completed in September 2025, with expected interim data in H1 2027 [24] - The company anticipates significant revenue from the J&J partnership, with plans for commercialization and recurrent revenue from royalties [38] This summary encapsulates the key points discussed during the Nanobiotix conference call, highlighting the company's innovative approach, market potential, partnership dynamics, and future directions in research and development.

Summary of Nanobiotix FY Conference Call Company Overview - **Company**: Nanobiotix (NasdaqGS:NBTX) - **Focus**: Development of innovative cancer therapies using physics-based approaches, particularly through the use of nanoparticles Key Technologies - **Platforms**: Nanobiotix has developed three different platforms aimed at treating cancer through physical mechanisms rather than traditional biological or chemical methods [3][4] - **NBTXR3**: A nanoparticle designed to enhance radiation therapy by being injected directly into tumors, allowing for higher doses of radiation to be delivered specifically to cancer cells while minimizing damage to surrounding healthy tissue [9][10] Market Opportunity - **Local Disease Focus**: Approximately 77% of cancer patients present with local disease at diagnosis, highlighting the importance of local treatment options [8] - **Radiation Therapy**: About 60% of all cancer patients receive radiation therapy, which has limitations due to damage to healthy tissue surrounding tumors [8][9] - **Head and Neck Cancer**: Initial focus on head and neck cancers due to 90% of patients having local disease at diagnosis, making it a critical area for intervention [14][15] - **Potential Patient Population**: Estimated 30,000 patients in the EU-5 and North America for head and neck cancer, with a total of 160,000 patients when including lung stage III and cisplatin-eligible populations [16][17] Strategic Partnerships - **Johnson & Johnson (J&J)**: Partnered for the commercial development of NBTXR3, aligning with J&J's interventional oncology strategy [12][13] - **Phase III Study**: J&J is conducting a Phase III study for head and neck cancers and a Phase II study for lung stage III cancer [15][28] Financial Aspects - **Royalty Financing**: Recently secured $71 million in royalty financing, extending the company's financial runway into 2028 [32][33] - **Reimbursement Terms**: The financing will be reimbursed at 1.75 to 2.5 times the amount, depending on the timing of reimbursement [35] Clinical Development - **PFS Interim Analysis**: The interim analysis for the Phase III study has been pushed to 2027 due to the complexity of transferring the trial to J&J [26][27] - **Response Rates**: Previous trials showed an 81% overall response rate and a 63% complete response rate in frail populations, indicating strong potential for improving patient outcomes [27] Future Milestones - **Upcoming Data Releases**: Anticipated updates on the second platform, interim readout of the Phase III study, and results from various trials including lung stage III and pancreatic cancer [38] Additional Insights - **Material Choice**: Hafnium oxide was selected for NBTXR3 due to its stability and effectiveness as a super X-ray absorber, minimizing systemic toxicity [11] - **Universal Application**: Data from trials in various cancers (e.g., esophageal, melanoma) support the hypothesis that NBTXR3 could be applicable across many solid tumors [37] This summary encapsulates the key points discussed during the Nanobiotix FY Conference Call, highlighting the company's innovative approach to cancer treatment, strategic partnerships, market opportunities, and future clinical developments.

Core Insights - Nanobiotix (NBTX) is a clinical-stage nanomedicine company valued at $1.3 billion, focusing on innovative cancer treatment approaches with proprietary technology including NBTXR3 [1] Stock Performance - NBTX has shown exceptional price momentum, gaining 440% over the past year and 200.78% since a "Buy" signal was issued on August 27 [2][6] - The stock reached an all-time high of $27.77 in intraday trading on October 8 [4] - NBTX has made 13 new highs and gained 198.02% in the last month, with a Relative Strength Index (RSI) of 82.55 [7] Technical Indicators - Barchart indicates a 100% "Buy" opinion for NBTX, with a Weighted Alpha of +470.88 [7] - The stock has a technical support level around $25.96 [7] Revenue and Earnings Projections - Revenue is projected to grow by 643.31% this year and an additional 89.01% next year [7] - Earnings are estimated to increase by 79.86% this year and 235.61% next year [7]

Summary of Nanobiotix Conference Call on Melanoma Study Results Company and Industry - **Company**: Nanobiotix - **Industry**: Oncology, specifically focused on melanoma treatment Core Points and Arguments 1. **Study Overview**: The conference call discussed new data from the third cohort of the Phase I 1100 study in melanoma, presented at the ImmunoRad Conference in Paris [2][4] 2. **Product Focus**: NBTXR3 is designed for patients receiving radiation therapy, which constitutes around 60% of cancer patients. The product aims to address unmet medical needs in patients who have failed multiple lines of treatment [4][5] 3. **Patient Recruitment**: A total of 21 patients were recruited for the study, with 19 evaluable for efficacy. The majority of these patients were advanced stage III and IV melanoma patients who had failed PD-1 and other treatments [6][8] 4. **Efficacy Results**: The study reported an overall response rate of 47%, with 9 out of 19 patients achieving complete response (CR) or partial response (PR). The disease control rate (DCR) was noted to be 78% [9][15] 5. **Safety Profile**: No grade four or five adverse events were reported related to NBTXR3, and the safety profile was consistent with previous trials [7][15] 6. **Overall Survival**: The median overall survival (OS) was reported at 14.6 months, with a confidence interval ranging from 11.6 months to non-reach [11][12] 7. **Immune Response**: There is a potential for NBTXR3 to prime an immune response, particularly in patients who have exhausted other treatment options. This was suggested by the correlation between injected irradiated lesions and systemic responses [11][20] 8. **Future Development Plans**: The company is considering further development of NBTXR3 in earlier treatment settings for melanoma and potentially in combination with other therapies [25][27] Additional Important Content 1. **Regulatory Considerations**: Future trials will need to be discussed with regulatory agencies like the FDA, especially regarding the control arm for randomized trials [21][22] 2. **Comparative Context**: The median OS of 14.6 months compares favorably to historical data for similar patient populations, where median OS after failure of PD-1 treatments is around 6.8 months [44][45] 3. **Pipeline Strategy**: Nanobiotix is exploring multiple indications for NBTXR3, with ongoing trials in head and neck cancer and lung cancer being run by Janssen [27][49] 4. **Patient Characteristics**: The study did not find significant baseline characteristics that influenced treatment outcomes, indicating a broad applicability of NBTXR3 across different patient profiles [33][39] This summary encapsulates the key findings and discussions from the Nanobiotix conference call, highlighting the potential of NBTXR3 in treating advanced melanoma and the company's strategic direction moving forward.

Immunorad September 2025 Data on Phase 1 Trial Safety and preliminary efficacy of NBTXR3/SBRT in combination with Immune Checkpoint Inhibitors in anti-PD-1 resistant patients with melanoma treated in the phase I trial Study 1100 Cohort 3 – Melanoma Subgroup Analysis Jason W. Chan, MD, Ari Rosenberg, MD, Alexander Lam, MD, James Lee, MD, Adil Daud, MD, William A. Stokes, MD,Nabil F. Saba, MD, Frances Collichio, MD, Hyeon Yu, MD, Priya Mody, MD, Jared Weiss, MD, Stergios Moschos, MD,Steven Powell, MD, Shannon ...