Financial Data and Key Metrics Changes - Revenue grew 5% in Q3 to $11.12 billion, with adjusted operating income increasing 9% to $2.59 billion [5][21] - Adjusted operating margin expanded by 100 basis points to 23.3%, and adjusted EPS grew 10% to $5.79 per share [5][21] - Full-year revenue guidance raised to a range of $44.1 billion to $44.5 billion, with adjusted EPS guidance increased to $22.60 to $22.86 per share [17][27] Business Line Data and Key Metrics Changes - In pharma and biotech, mid-single-digit growth was achieved, driven by bioproduction and analytical instruments [6] - Academic and government revenue declined in the low single digits, showing modest improvement [6] - Industrial and applied revenue grew in the mid-single digits, led by electron microscopy [6] - Diagnostics and healthcare revenue growth improved but remained down low single digits, primarily due to conditions in China [6][45] Market Data and Key Metrics Changes - North America grew low single digits, while Europe and Asia-Pacific both grew mid-single digits; China experienced a mid-single-digit decline [21] - The diagnostics market in China faced weak conditions due to pricing and reimbursement challenges, but the impact on the overall business was modest [45][70] Company Strategy and Development Direction - The growth strategy focuses on high-impact innovation, trusted partner status with customers, and a strong commercial engine [7][10] - Collaborations with OpenAI aim to enhance product development and operational efficiency [11][13] - Recent acquisitions, including a filtration and separation business and a Sterile Fill Finish site, are expected to strengthen the company's capabilities in bioprocessing and drug product manufacturing [14][15] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in navigating government policies and reshoring activities, which are expected to benefit the company [33][34] - The company anticipates a stable funding environment in the academic and government sectors, which could remove headwinds over time [38] - Overall, management remains optimistic about midterm and long-term growth prospects, maintaining a 3% to 6% organic growth outlook [53][54] Other Important Information - The company repurchased $1 billion of shares in Q3, bringing total repurchases for the year to $3 billion [15][22] - Free cash flow for the year is expected to be around $7 billion, with net capital expenditures projected between $1.4 billion and $1.7 billion [29] Q&A Session Summary Question: Market conditions and customer conversations in pharma - Management noted excitement around scientific breakthroughs and confidence in pipelines, with customers looking to navigate government policies effectively [33][34] Question: Update on academic and government market conditions - Management indicated slight improvement in Europe and stable conditions in the U.S., with potential delays in expenditures due to the government shutdown [37][38] Question: Strengths in analytical instruments - Growth was driven by electron microscopy and chromatography, with a strong underlying health of the business despite headwinds in some segments [44] Question: Impact of China on diagnostics - The company has a smaller presence in China, and while conditions are weak, the impact on overall business is modest [45][70] Question: Demand from small and emerging biotech - There was positive momentum in clinical research and early activities in pharma services, indicating a potential reinvestment cycle [66][67] Question: Onshoring announcements and CapEx implications - Management highlighted incremental demand from new facilities and equipment, but noted that overall drug volumes would remain stable [73][74] Question: Tariff impacts on EPS - The impact of tariffs in Q3 was favorable, with expectations for Q4 to hold steady without significant changes [76][77]

Financial Data and Key Metrics Changes - Revenue grew 5% in Q3 to $11.12 billion, with adjusted operating income increasing 9% to $2.59 billion [5][21] - Adjusted operating margin expanded by 100 basis points to 23.3% [5][21] - Adjusted EPS increased by 10% to $5.79 per share [5][20] Business Line Data and Key Metrics Changes - **Pharma and Biotech**: Mid-single-digit growth driven by bioproduction and analytical instruments [6] - **Academic and Government**: Revenue declined in low single digits, showing modest improvement [6] - **Industrial and Applied**: Revenue grew in mid-single digits, led by electron microscopy [6] - **Diagnostics and Healthcare**: Revenue growth improved but remained down low single digits, primarily due to conditions in China [6][25] Market Data and Key Metrics Changes - North America grew low single digits, Europe and Asia-Pacific grew mid-single digits, while China declined mid-single digits [21] - Total company adjusted gross margin was 41.9%, reflecting strong productivity [21] Company Strategy and Development Direction - The growth strategy focuses on high-impact innovation, trusted partner status, and a strong commercial engine [7][10] - Recent innovations include FDA-approved diagnostic tests and new electron microscopes [8][9] - Strategic collaborations, such as with OpenAI and AstraZeneca, aim to enhance product offerings and drive innovation [10][13] Management Comments on Operating Environment and Future Outlook - Management expressed confidence in navigating government policies and reshoring activities in the U.S. [33][34] - The company raised its full-year revenue guidance to $44.1 billion to $44.5 billion and adjusted EPS guidance to $22.60 to $22.86 [17][27] - Management remains optimistic about midterm and long-term growth prospects, expecting organic growth of 3% to 6% [54] Other Important Information - The company completed significant acquisitions, including a filtration and separation business and a sterile fill-finish site, enhancing its capabilities [14][15] - Share repurchases totaled $1 billion in Q3, bringing the total for the year to $3 billion [15][23] Q&A Session Summary Question: Market conditions and customer conversations - Management noted excitement among pharma and biotech customers regarding scientific breakthroughs and confidence in their pipelines [33][34] Question: Academic and government funding outlook - Management indicated a more stable funding environment is expected, despite the ongoing government shutdown adding some uncertainty [37][38] Question: Analytical instruments performance - Growth was driven by strong demand in electron microscopy and chromatography, with expectations for continued momentum [44] Question: Diagnostics in China - Management acknowledged weak conditions in China but noted a modest improvement relative to the previous quarter [45][46] Question: Biopharma demand from small biotech - There was positive momentum in clinical research and early activities in pharma services, indicating a potential reinvestment cycle [66][67] Question: Onshoring impact on capacity and volumes - Management discussed incremental demand from new facilities and equipment, but noted that overall drug volumes would remain stable [73][74]

Financial Data and Key Metrics Changes - Revenue grew 5% in Q3 2025 to $11.12 billion [6][26] - Adjusted operating income increased 9% to $2.59 billion [6][27] - Adjusted operating margin expanded by 100 basis points to 23.3% [6][27] - Adjusted EPS rose 10% to $5.79 per share [6][26] Business Line Data and Key Metrics Changes - **Pharma and Biotech**: Mid single-digit growth, driven by bioproduction and analytical instruments [6][7] - **Academic and Government**: Revenue declined in low single digits, showing slight improvement [7][52] - **Industrial and Applied**: Revenue grew in mid single digits, led by electron microscopy [8][32] - **Diagnostics and Healthcare**: Revenue growth improved but remained down low single digits, primarily due to conditions in China [8][64] Market Data and Key Metrics Changes - North America grew low single digits; Europe and Asia Pacific grew mid single digits; China declined mid single digits [26][27] - Total company adjusted gross margin was 41.9%, up 10 basis points year-over-year [28] Company Strategy and Development Direction - The growth strategy focuses on high-impact innovation, trusted partner status, and a strong commercial engine [9][13] - Collaborations with OpenAI aim to enhance product offerings and operational efficiency [14][15] - Strategic partnerships, such as with AstraZeneca, are intended to drive innovation in life sciences [16] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in navigating government policies and the potential for reshoring in the pharma sector [46][49] - The company raised its full-year revenue guidance to $44.1 billion to $44.5 billion and adjusted EPS guidance to $22.6 to $22.86 [22][36] Other Important Information - The company repurchased $1 billion of shares in Q3, totaling $3 billion for the year [20][30] - The integration of recent acquisitions is progressing smoothly, with positive early feedback from customers [18][19] Q&A Session Summary Question: Market conditions and customer conversations - Management noted excitement around scientific breakthroughs and confidence in customer pipelines, with a focus on reshoring and navigating government policies [46][49] Question: Academic and government funding outlook - Management indicated a more stable funding environment is expected, despite the government shutdown adding some uncertainty [53][55] Question: Analytical instruments performance - Growth was driven by strong demand in electron microscopy and chromatography, with a positive outlook for the fourth quarter [60][62] Question: Diagnostics in China - Weak conditions were noted in China, but the company remains well-positioned for long-term growth despite current pressures [64][92] Question: 2026 growth outlook - Management remains confident in a 3% to 6% organic growth range, with expectations for improved market conditions over time [68][70] Question: Clinical research business trends - The clinical research business is performing well, with strong authorization rates and innovative approaches to improve drug development efficiency [78][80] Question: Demand from small and emerging biotech - There is a positive trend in demand from small biotech firms, supported by recent M&A activity in the sector [87]

Financial Data and Key Metrics Changes - Revenue grew 5% in Q3 2025 to $11.12 billion, with adjusted operating income increasing 9% to $2.59 billion [5][21] - Adjusted operating margin expanded by 100 basis points to 23.3%, and adjusted EPS rose 10% to $5.79 per share [5][21] - Full-year revenue guidance raised to a range of $44.1 billion to $44.5 billion, with adjusted EPS guidance increased to $22.60 to $22.86 [17][27] Business Line Data and Key Metrics Changes - **Pharma and Biotech**: Mid-single-digit growth driven by bioproduction and analytical instruments [6] - **Academic and Government**: Revenue declined in low single digits, showing slight improvement from the previous quarter [6] - **Industrial and Applied**: Revenue grew in mid-single digits, led by electron microscopy [6] - **Diagnostics and Healthcare**: Revenue growth improved but remained down low single digits, primarily due to conditions in China [6][46] Market Data and Key Metrics Changes - North America grew low single digits, while Europe and Asia-Pacific both grew mid-single digits; China declined mid-single digits [20] - Adjusted gross margin was 41.9%, reflecting strong productivity [21] Company Strategy and Development Direction - The growth strategy focuses on high-impact innovation, trusted partner status, and a strong commercial engine [7][11] - Collaborations with OpenAI aim to enhance product development and operational efficiency [12][13] - Recent acquisitions, including the filtration and separation business from Solventum and a Sterile Fill Finish site from Sanofi, are expected to strengthen the company's capabilities [14][15] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in navigating government policies and reshoring activities, which are expected to benefit the company [34][36] - The company anticipates a stable funding environment in the academic and government sectors, which may remove headwinds over time [39] - The outlook for 2026 remains positive, with expectations of 3% to 6% organic growth [50][51] Other Important Information - The company repurchased $1 billion of shares in Q3, totaling $3 billion for the year [15][22] - Free cash flow for the year is expected to be around $7 billion [30] Q&A Session Summary Question: Market conditions and customer conversations - Management noted excitement among pharma and biotech customers regarding scientific breakthroughs and confidence in their pipelines [34] Question: Academic and government funding outlook - Management indicated that while conditions were muted, there is a consensus around a relatively flat budget, which could stabilize the market [39] Question: Analytical instruments performance - Growth was driven by strong demand in electron microscopy and chromatography, with expectations for continued momentum [44][45] Question: China diagnostics market conditions - Management acknowledged weak conditions in China but noted a modest improvement relative to the prior quarter [46] Question: Demand from small and emerging biotech - There was positive momentum in clinical research business, with expectations for increased reinvestment in the market [61] Question: Onshoring impact on demand - Management highlighted that onshoring will create incremental demand for new equipment and facilities, although overall drug volumes may not change significantly [68]