Financial Data and Key Metrics Changes - Revenue grew 5% in Q3 2025 to $11.12 billion [6][26] - Adjusted operating income increased 9% to $2.59 billion [6][27] - Adjusted operating margin expanded by 100 basis points to 23.3% [6][27] - Adjusted EPS rose 10% to $5.79 per share [6][26] Business Line Data and Key Metrics Changes - **Pharma and Biotech**: Mid single-digit growth, driven by bioproduction and analytical instruments [6][7] - **Academic and Government**: Revenue declined in low single digits, showing slight improvement [7][52] - **Industrial and Applied**: Revenue grew in mid single digits, led by electron microscopy [8][32] - **Diagnostics and Healthcare**: Revenue growth improved but remained down low single digits, primarily due to conditions in China [8][64] Market Data and Key Metrics Changes - North America grew low single digits; Europe and Asia Pacific grew mid single digits; China declined mid single digits [26][27] - Total company adjusted gross margin was 41.9%, up 10 basis points year-over-year [28] Company Strategy and Development Direction - The growth strategy focuses on high-impact innovation, trusted partner status, and a strong commercial engine [9][13] - Collaborations with OpenAI aim to enhance product offerings and operational efficiency [14][15] - Strategic partnerships, such as with AstraZeneca, are intended to drive innovation in life sciences [16] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in navigating government policies and the potential for reshoring in the pharma sector [46][49] - The company raised its full-year revenue guidance to $44.1 billion to $44.5 billion and adjusted EPS guidance to $22.6 to $22.86 [22][36] Other Important Information - The company repurchased $1 billion of shares in Q3, totaling $3 billion for the year [20][30] - The integration of recent acquisitions is progressing smoothly, with positive early feedback from customers [18][19] Q&A Session Summary Question: Market conditions and customer conversations - Management noted excitement around scientific breakthroughs and confidence in customer pipelines, with a focus on reshoring and navigating government policies [46][49] Question: Academic and government funding outlook - Management indicated a more stable funding environment is expected, despite the government shutdown adding some uncertainty [53][55] Question: Analytical instruments performance - Growth was driven by strong demand in electron microscopy and chromatography, with a positive outlook for the fourth quarter [60][62] Question: Diagnostics in China - Weak conditions were noted in China, but the company remains well-positioned for long-term growth despite current pressures [64][92] Question: 2026 growth outlook - Management remains confident in a 3% to 6% organic growth range, with expectations for improved market conditions over time [68][70] Question: Clinical research business trends - The clinical research business is performing well, with strong authorization rates and innovative approaches to improve drug development efficiency [78][80] Question: Demand from small and emerging biotech - There is a positive trend in demand from small biotech firms, supported by recent M&A activity in the sector [87]

Group 1 - The core viewpoint of the article highlights the performance of the CSI Hong Kong Stock Connect Innovative Drug Index, which rose by 4.76% to 707.89 points, with a trading volume of 12.439 billion yuan [1] - The index has experienced a decline of 1.15% over the past month, an increase of 24.35% over the past three months, and a year-to-date increase of 16.18% [1] - The index comprises 50 listed companies involved in innovative drug research and development, reflecting the overall performance of innovative drug companies within the Hong Kong Stock Connect framework [1] Group 2 - The top ten weighted companies in the index include Innovent Biologics (11.06%), BeiGene (10.75%), CanSino Biologics (9.99%), WuXi Biologics (9.97%), CSPC Pharmaceutical Group (7.52%), China National Pharmaceutical Group (6.75%), Hansoh Pharmaceutical (4.33%), Zai Lab (4.23%), 3SBio (3.94%), and WuXi AppTec (3.28%) [1] - The index's holdings are entirely composed of companies listed on the Hong Kong Stock Exchange, with a sector breakdown showing 49.06% in biopharmaceuticals, 29.71% in chemical drugs, 19.95% in pharmaceutical and biotechnology services, and 1.28% in medical commerce and services [2] - The index samples are adjusted biannually, with adjustments occurring on the next trading day following the second Friday of June and December each year [2]