Financial Performance - Worldwide sales for Q1 2025 reached $219 billion, a 24% increase compared to Q1 2024, with operational sales growth of 42%[52] - Adjusted earnings for Q1 2025 were $67 billion, resulting in adjusted EPS of $277, a 22% increase[54] - The company is increasing its 2025 operational sales guidance midpoint by $07 billion to 38% due to the Intra-Cellular Therapies (ITCI) acquisition[72] Innovative Medicine - Innovative Medicine achieved 42% operational sales growth in Q1 2025, driven by key brands growing in double digits[15] - Oncology sales reached $5678 million, demonstrating strong growth[57] - TREMFYA showed superiority versus STELARA in endoscopic endpoints in Crohn's disease, with 34% of patients achieving deep remission at 1 year[42] MedTech - MedTech reported 41% operational sales growth in Q1 2025, with strong performance across Abiomed, Shockwave, Vision, and Wound Closure[17, 59] - Cardiovascular sales increased by 177% operationally[60] - Orthopaedics experienced a (31)% operational decrease, impacted by one-time events[62] Pipeline and Milestones - RYBREVANT plus LAZCLUZE demonstrated a significant overall survival benefit in first-line EGFR-mutated non-small cell lung cancer, with a projected median OS improvement of more than 1 year[38] - Icotrokinra showed potential in treating plaque psoriasis, with 46% of patients achieving completely clear skin (IGA 0) and 75% among adolescents[49] - The company anticipates several milestones in 2025, including potential approvals for nipocalimab in gMG, RYBREVANT Sub-Q in NSCLC, and TREMFYA Sub-Q in UC[75]