Salt Lake City, Jan. 06, 2026 (GLOBE NEWSWIRE) -- Recursion (Nasdaq: RXRX), a leading clinical stage TechBio company decoding biology to radically improve lives, announced today its CEO & President, Najat Khan, Ph.D., will present Tuesday, January 13, 10:30am PT at the upcoming 44th Annual J.P. Morgan Healthcare Conference in San Francisco. Management will also participate in the following upcoming investor conference: 28th Annual Needham Growth Conference - Friday, January 16, 2026 Webcasts may be found ...

The company appears to be on track to develop a commercialized product through its drug discovery system.Recursion Pharmaceuticals (RXRX +2.33%) was in the headlines on Monday, and for the right reason. One of the biotech company's investigational drugs did well in a clinical trial, and investors rewarded the company by trading its stock more than 2% higher on the news. A very encouraging trialBefore market open, Recursion divulged that its REC-4881 demonstrated notable efficacy in a phase 1b/2 trial. The d ...

Recursion Pharmaceuticals (NasdaqGS:RXRX) Update Summary Company Overview - **Company**: Recursion Pharmaceuticals - **Focus**: Development of REC-4881 for Familial Adenomatous Polyposis (FAP) - **Key Personnel**: Najat Khan (Chief R&D and Commercial Officer, incoming CEO), Dr. Beth Bruckheimer (FAP clinical lead), Dr. David Mauro (Chief Medical Officer) Industry Context - **Disease**: Familial Adenomatous Polyposis (FAP) - **Patient Population**: Over 50,000 patients in the U.S. and EU5 affected by FAP - **Current Treatment Landscape**: No approved pharmacotherapies for FAP; patients undergo frequent surgeries and interventions Core Findings and Insights 1. **Unmet Need**: FAP is a progressive disease with no approved treatments, leading to severe interventions and surgeries, including the Whipple procedure [2][15][18] 2. **Mechanism of Action**: REC-4881 is a selective MEK1/2 inhibitor that targets the underlying biology of FAP by addressing the loss of APC gene function [3][20] 3. **Clinical Study Results**: - Phase 1b/2 TUPELO study shows that 75% of patients experienced a reduction in polyp burden by week 13, with a median reduction of 43% [25][31] - Durable effects observed, with 82% of patients maintaining a response at week 25, showing a median reduction of 53% [27][29][32] 4. **Safety Profile**: Consistent with MEK inhibitor class expectations; primarily grade 1-2 adverse events, with no grade 4-5 events reported [4][25][31] Additional Insights 1. **Real-World Evidence**: The ClinTECH platform analyzed over 1,000 FAP patients, revealing the relentless progression of polyp growth and the need for effective therapies [10][11][17] 2. **Regulatory Engagement**: Plans to engage with the FDA in the first half of 2026 to discuss a potential registrational pathway for REC-4881 [5][33] 3. **Partnerships and Financials**: Over $500 million generated from collaborations, indicating strong partnership momentum [7][8] Future Directions - **Expansion of Patient Population**: Broadening eligibility from patients over 55 to those over 18 years old [5][33] - **Dosing Optimization**: Exploring alternative dosing regimens to enhance the benefit-risk profile of REC-4881 [33] - **Long-term Goals**: Aim to provide a much-needed therapeutic option that can significantly improve the quality of life for FAP patients [15][33] Conclusion - REC-4881 represents a significant advancement in the treatment of FAP, with promising efficacy and safety data, addressing a critical unmet need in a patient population that currently lacks effective pharmacotherapy options [31][33]

REC-4881 (4 mg QD) achieved rapid clinical activity, with 75% of evaluable patients showing reductions in total polyp burden and a 43% median reduction after 12 weeks of treatment (n=12)After 12 weeks off therapy (week 25 of the study), 82% of evaluable patients (9 of 11) maintained a durable reduction in total polyp burden, with a 53% median reduction observed from baselineNatural history analysis showed that 87% of untreated FAP patients - who resembled the inclusion criteria of TUPELO - had annualized po ...

Core Insights - Recursion, a clinical stage TechBio company, will present new clinical data from the ongoing TUPELO Phase 1b/2 trial of REC-4881 for Familial Adenomatous Polyposis (FAP) during a webinar on December 8, 2025 [1][2] - The company utilizes a platform called Recursion OS, which integrates various technologies to create one of the largest proprietary biological and chemical datasets, enabling advanced drug discovery [3] Company Overview - Recursion is headquartered in Salt Lake City and is a founding member of BioHive, a collective for the Utah life sciences industry, with additional offices in Montréal, New York, London, and Oxford [4] - The company focuses on decoding biology to improve lives, leveraging machine-learning algorithms to analyze vast datasets and conduct millions of wet lab experiments weekly [3] Leadership and Presenters - The webinar will feature key personnel including Najat Khan, Ph.D. (Chief R&D and Chief Commercial Officer), David Mauro, M.D., Ph.D. (Chief Medical Officer), and other notable experts [6]

Financial Data and Key Metrics Changes - The company reported a pro forma cash balance of almost $800 million as of a few weeks ago, providing runway through the end of 2027 without additional financing [9][41] - The company achieved nearly $40 million in partnership inflows over the course of the year, contributing to over $500 million in total partnership inflows since inception [40][44] - The company reaffirmed its guidance for 2025 on an expense base of less than $450 million and for 2026, less than $390 million [41][42] Business Line Data and Key Metrics Changes - The collaboration with Roche and Genentech has resulted in the delivery of four whole genome phenomaps in GI oncology, generating over 100 billion GI oncology relevant cells [11] - The company earned a $30 million milestone payment from Roche and Genentech for the delivery of a whole genome neuromap, marking the second such milestone [10] Market Data and Key Metrics Changes - The company has identified numerous novel potential targets in both microglial and neuronal phenomaps, which are expected to lead to meaningful medicines in neuroscience [12][14] - The company is leveraging AI and machine learning techniques to enhance drug discovery and development processes, indicating a strong focus on technological advancement in the biotech sector [18][19] Company Strategy and Development Direction - The company aims to translate platform insights into repeatable clinical proof, focusing on both wholly owned programs and partnerships [7] - The strategic plan laid out in May allowed the company to hit multiple high-value milestones while reducing its expense base by 35% from 2024 [40][41] - The company is committed to maintaining deep, collaborative partnerships while being selective about new partnerships to ensure mutual value [60] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the company's strong position and the potential for significant advancements in the next 18 months [9] - The new CEO emphasized the importance of translating data and insights into tangible proof points that matter for patients and shareholders [64][66] - Management acknowledged the challenges of drug discovery but remains focused on disciplined execution and capital stewardship [66] Other Important Information - The company is in a robust financial position, having completed all restructuring associated with recent transactions and focusing on high-value projects [42][44] - The company is actively working on multiple programs, including CDK7 and REC-4881, with significant updates expected in the near future [46][49] Q&A Session Summary Question: Can you review expectations for cash burn through 2026 and how this works with runway expectations through 2027 without additional financing? - Management confirmed that the company has fully utilized the ATM and does not plan to open a new one, allowing for a cash balance that supports operations through the end of 2027 without additional financing [51][52] Question: How do you see platform utilization feeding into the quality or uniqueness of newer assets? - The new CEO highlighted that even older programs leverage the current platform significantly, and improvements in compounds continue throughout the development process [56][57] Question: Is Recursion looking to maintain current biopharma partnerships or expand to new partnerships in the near to midterm? - The company is focused on deepening existing partnerships while remaining open to new collaborations that can drive significant value [60]

Financial Status & Outlook - Recursion had approximately $785 million in cash as of October 9, 2025 [12, 72] - The company anticipates a cash runway through the end of 2027 without needing additional financing [12, 71] - Recursion projects its 2025 cash burn to be less than $450 million [73] - The company expects its 2026 cash burn to be less than $390 million [73] - Total cash inflows exceeding $500 million have been achieved across all partnerships and collaborations [15, 72] Pipeline & Platform Advancements - The company is anticipating multiple catalysts in the second half of 2025, including additional safety and efficacy data for REC-4881 in Familial Adenomatous Polyposis (FAP) [11, 79] - Recursion's platform has facilitated a $30 million milestone payment for delivering a second whole-genome neuro map [15, 72, 77] - In a Phase 1b/2 trial of REC-4881, 43% median reduction in total polyp burden was observed [61] - 6 out of 6 patients achieved >30% reduction in total polyp burden in REC-4881 Phase 1b/2 trial [62] - In Phase 1 monotherapy dose-escalation of REC-617, 90% of patients experienced treatment-related adverse events (TRAEs), with 28% being Grade ≥3 [48]

Core Insights - Recursion reported business updates and financial results for Q3 2025, highlighting progress in its internal pipeline and strategic partnerships, with a strong cash position extending through the end of 2027 [1][3][19] Business Highlights - The company achieved over $500 million in upfront and milestone payments from partnerships, including a recent $30 million milestone from Roche and Genentech for a whole-genome map of microglial immune cells [3][8][12] - Recursion's internal pipeline includes several programs in oncology and rare diseases, with notable candidates such as REC-617 for advanced solid tumors and REC-7735 for HR+ breast cancer [4][6][13] - The company is advancing its clinical programs, with REC-4881 in the TUPELO study and REC-617 entering combination studies [6][13] Financial Performance - Total revenue for Q3 2025 was $5.2 million, a decrease from $26.1 million in Q3 2024, primarily due to the timing of milestone payments [19][24] - Research and development expenses increased to $121.1 million in Q3 2025 from $74.6 million in Q3 2024, driven by acquisitions and business combinations [19][20] - The net loss for Q3 2025 was $162.3 million, compared to a net loss of $95.8 million in Q3 2024, reflecting increased operational costs [25][26] Cash Position - As of October 9, 2025, Recursion had approximately $785 million in cash and cash equivalents, providing a runway through the end of 2027 without additional financing [8][19] - The company reported a cash position of $667.1 million as of September 30, 2025, an increase from $603.0 million at the end of 2024 [19][28] Strategic Partnerships - Recursion's collaboration with Roche and Genentech focuses on neuroscience and oncology, with ongoing projects and milestones expected to exceed $10 billion in potential future payments [12][18] - The partnership with Sanofi aims to develop up to 15 best-in-class programs across oncology and immunology, with significant milestone payment potential [18][19]

Core Insights - Recursion has announced a leadership transition plan, effective January 1, 2026, with Chris Gibson transitioning to Chairman of the Board and Najat Khan appointed as the new CEO and President [1][2][4] Leadership Transition - The Board of Directors unanimously approved the transition, emphasizing continuity and collaboration for Recursion's future [1][2] - Chris Gibson has led the company for twelve years, transforming it into a pioneer in the TechBio sector, and will continue to provide guidance as Chairman [2][4] - Najat Khan, currently Chief R&D and Commercial Officer, has been recognized for her strategic insight and leadership, having worked closely with Gibson for the past 18 months [2][5] Najat Khan's Background - Dr. Najat Khan has a strong background in biopharma, with experience in integrating scientific discovery, data, and business strategy [3][6] - Prior to joining Recursion, she held significant roles at Johnson & Johnson, where she tripled pipeline value and advanced AI integration in R&D [6] - Khan holds a Ph.D. in Organic Chemistry and has certifications in AI/ML from MIT, showcasing her expertise in both science and technology [7] Recursion's Mission and Vision - Recursion aims to decode biology to radically improve patients' lives, leveraging its OS platform that combines biology, chemistry, and AI [8] - The company operates one of the largest proprietary biological and chemical datasets, utilizing advanced machine-learning algorithms for drug discovery [8] - Recursion's operational scale includes conducting millions of wet lab experiments weekly and managing one of the most powerful supercomputers globally [8]

Core Insights - Recursion will host a public earnings call on November 5, 2025, at 8:00 am ET to provide business updates and report its Q3 2025 financial results [1][2] Company Overview - Recursion (NASDAQ: RXRX) is a clinical stage TechBio company focused on decoding biology to improve lives, utilizing its Recursion OS platform to generate extensive biological and chemical datasets [3] - The company employs advanced machine-learning algorithms to analyze trillions of relationships in biology and chemistry, operating at a large experimental scale with millions of wet lab experiments weekly [3] - Recursion is headquartered in Salt Lake City and is a founding member of BioHive, with additional offices in Montréal, New York, London, and the Oxford area [4]