Core Viewpoint - Kodiak Sciences Inc. is set to present first-time end-of-study clinical results from the Phase 1b APEX study for KSI-101 at the Angiogenesis annual meeting, highlighting the drug's potential as a first-line therapy for macular edema secondary to inflammation (MESI) [4]. Company Overview - Kodiak Sciences Inc. is a precommercial biotechnology company focused on developing transformative therapeutics for retinal diseases, with a commitment to addressing leading causes of blindness globally [9]. - The company is advancing a portfolio of three late-stage clinical programs, including KSI-101, which targets a new market segment separate from the established anti-VEGF market [6][9]. Clinical Study Insights - The APEX study has shown that KSI-101 provides significant visual and anatomical improvements in patients with MESI, regardless of the inflammation's location or specific etiology [4][7]. - The study has completed enrollment and demonstrated that KSI-101 is well tolerated, with meaningful treatment responses observed in the MESI population [7]. - The top two dose levels from the APEX study have been selected for advancement into the Phase 3 PEAK and PINNACLE studies, which are currently enrolling patients [8]. Drug Profile - KSI-101 is a bispecific protein targeting IL-6 and VEGF, developed for patients with MESI, a condition characterized by retinal fluid and visual impairment due to inflammation [5]. - Currently, there are no available intravitreal biologic therapies addressing the spectrum of MESI diseases, indicating a significant market opportunity for KSI-101 [6]. Upcoming Events - The presentation of the APEX study results will be available on Kodiak's website at the start of the Angiogenesis meeting on February 7, 2026 [3].

Kodiak®, Kodiak Sciences®, ABC®, ABC Platform , and the Kodiak logo are registered trademarks or trademarks of Kodiak Sciences Inc. in various global jurisdictions. THE OPHTHALMOLOGY MEDICINES COMPANY 44th Annual J.P. Morgan Healthcare Conference January 12, 2026 1 Forward-Looking Statements This presentation may contain forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 and other federal securities laws, including statements regarding Kodiak's plans, commi ...

Core Insights - Kodiak Sciences Inc. is a precommercial biotechnology company focused on developing transformative therapeutics for retinal diseases [3] Company Overview - Kodiak Sciences is dedicated to researching, developing, and commercializing next-generation retinal medicines aimed at preventing and treating leading causes of blindness globally [3] - The company is developing a portfolio of three late-stage clinical programs targeting the $15 billion anti-VEGF marketplace [3] - Two drug candidates, Tarcocimab and KSI-501, are in Phase 3 studies with topline data readouts expected in 1Q 2026 and 3Q 2026 respectively [3] - KSI-101, a bispecific protein, is also in two Phase 3 studies with topline data readouts expected in 4Q 2026 and 2Q 2027 [3] Upcoming Events - Senior management will present at the 44th Annual J.P. Morgan Healthcare Conference on January 12, 2026, at 1:30 p.m. Pacific Time [1] - A live webcast of the presentation will be available on Kodiak's website and will remain accessible for a limited time after the event [2]

Core Insights - Kodiak Sciences Inc. successfully closed a public offering of 8,000,000 shares at a price of $23.00 per share, generating approximately $184 million in gross proceeds before expenses [1][3]. Company Overview - Kodiak Sciences is a precommercial biotechnology company focused on developing transformative therapeutics for retinal diseases, utilizing its proprietary ABC® Platform for next-generation retinal medicines [5]. Financial Position - The completion of the public offering strengthens Kodiak's financial position as it prepares for important Phase 3 topline readouts for its late-stage clinical assets: KSI-101, KSI-501, and tarcocimab [3]. Clinical Programs - Kodiak is advancing three late-stage clinical programs, with tarcocimab and KSI-501 in two BLA-facing Phase 3 studies for retinal vascular diseases, and KSI-101 being explored in two Phase 3 studies for Macular Edema Secondary to Inflammation (MESI) [5]. Underwriters - The offering was managed by J.P. Morgan, Jefferies, Evercore ISI, and UBS Investment Bank as joint book-running managers [2].

Core Viewpoint - Kodiak Sciences Inc. has announced an upsized underwritten public offering of 6,956,522 shares at a price of $23.00 per share, aiming to raise approximately $160 million in gross proceeds before expenses [1]. Company Overview - Kodiak Sciences is a precommercial biotechnology company focused on retinal therapeutics, utilizing its ABC® Platform to develop next-generation retinal medicines aimed at preventing and treating blindness [5]. - The company is currently advancing three late-stage clinical programs, including Tarcocimab and KSI-501 in Phase 3 studies for retinal vascular diseases, and KSI-101 in Phase 3 studies for Macular Edema Secondary to Inflammation [5]. Offering Details - The public offering is expected to close on or about December 18, 2025, subject to customary closing conditions [1]. - Kodiak Sciences has granted underwriters a 30-day option to purchase an additional 1,043,478 shares at the public offering price [1]. - The offering is conducted under a shelf registration statement previously filed with the SEC, which was declared effective on June 2, 2023 [3].

Core Viewpoint - Kodiak Sciences Inc. has initiated an underwritten public offering of 6,000,000 shares of its common stock, with an option for underwriters to purchase an additional 900,000 shares [1][2]. Company Overview - Kodiak Sciences is a precommercial biotechnology company focused on retinal therapeutics, aiming to develop transformative treatments for leading causes of blindness globally [5]. - The company utilizes its ABC® Platform, which integrates protein-based and chemistry-based therapies, to advance its research and development efforts [5]. - Kodiak is currently developing three late-stage clinical programs, including Tarcocimab and KSI-501 in Phase 3 studies for retinal vascular diseases, and KSI-101 for Macular Edema Secondary to Inflammation [5]. Offering Details - The proposed public offering is subject to market conditions, and there are no guarantees regarding its completion or the final terms [1]. - The shares are being offered under a shelf registration statement that was declared effective by the SEC on June 2, 2023 [3].

Core Insights - Kodiak Sciences Inc. is a precommercial biotechnology company focused on developing transformative therapeutics for retinal diseases [2][4] - The company is advancing three late-stage clinical programs targeting the $15 billion anti-VEGF market [2] - Recent data from the APEX study indicates that 90% of patients achieved absence of intraretinal and subretinal fluid through week 20 in macular edema secondary to inflammation [4][5] Company Overview - Kodiak Sciences is committed to researching, developing, and commercializing next-generation retinal medicines to prevent and treat leading causes of blindness globally [2] - The company's ABC Platform utilizes molecular engineering to integrate protein-based and chemistry-based therapies [2] Upcoming Events - CEO Victor Perlroth will present at the Jefferies Global Healthcare Conference on November 17, 2025, and at the Evercore Healthcare Conference on December 3, 2025 [5]

Core Insights - Kodiak Sciences Inc. announced new data from the APEX study of KSI-101, a novel therapy for macular edema secondary to inflammation (MESI), presented at the Retina Society Annual Scientific Meeting [1][2] Group 1: Study Findings - The APEX Phase 1b study showed that patients with MESI experienced clinically meaningful gains in best-corrected visual acuity (BCVA) and rapid retinal drying by Week 12 [2][5] - In the study, the proportion of patients achieving a 15-letter gain in BCVA was 31% at the 2.5 mg dose, 62% at the 5 mg dose, and 54% at the 10 mg dose [5] - The mean change in BCVA from baseline to Week 12 was +8.8 letters for 2.5 mg, +10.7 letters for 5 mg, and +12.1 letters for 10 mg [5] - Patients with diabetic macular edema (DME) also showed significant visual and anatomical improvements, gaining an average of 12.0 letters and reducing retinal thickness by 157 microns by Week 24 [5] Group 2: Mechanism and Safety - KSI-101 is a bispecific antibody targeting interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF), designed to treat MESI [4][10] - The therapy demonstrated a favorable safety profile, being well tolerated in both MESI and DME patients [6][12] - The drying effect of KSI-101 was reported to be comparable or superior to existing treatments like Ozurdex, without associated side effects [7] Group 3: Future Developments - Ongoing Phase 3 studies, PEAK and PINNACLE, are actively enrolling patients to further evaluate KSI-101 at the 5 mg and 10 mg dose levels [8][14] - The studies aim to cover a wide spectrum of MESI patients, with PEAK focusing on more severe cases and PINNACLE on milder cases [14] - Topline data readouts for KSI-101 are expected in late 2026 or early 2027, indicating a significant market opportunity for the treatment of MESI [17]

Core Insights - Kodiak Sciences Inc. reported a net loss of $57.5 million for Q1 2025, compared to a net loss of $43.0 million in Q1 2024, reflecting an increase in operational expenses and R&D investments [4][28]. - The company ended Q1 2025 with $138.9 million in cash and cash equivalents, which is expected to support operations into 2026 [3][29]. - Kodiak is focused on advancing its pipeline, particularly three Phase 3 assets, with topline data anticipated in 2026 [2][3]. Financial Results - The net loss for Q1 2025 was $57.5 million, or $1.09 per share, compared to a net loss of $43.0 million, or $0.82 per share, in Q1 2024 [4][28]. - R&D expenses increased to $43.6 million in Q1 2025 from $29.9 million in Q1 2024, driven by heightened clinical activities [5][28]. - General and administrative expenses decreased slightly to $15.4 million in Q1 2025 from $16.1 million in Q1 2024 [8][28]. Pipeline and Upcoming Events - Kodiak plans to host an Investor R&D Update on July 16, 2025, to discuss scientific, clinical, and commercial perspectives across its pipeline [3]. - The company is advancing its investigational therapies, including Tarcocimab, KSI-501, and KSI-101, with ongoing Phase 3 studies and new clinical trial data expected [7][19][21]. Product Development - Tarcocimab is being studied in two Phase 3 trials: GLOW2 for diabetic retinopathy and DAYBREAK for wet AMD, with both studies utilizing an enhanced formulation [11][19]. - KSI-501 is designed to target both IL-6 and VEGF, with a focus on treating wet AMD and is currently in the DAYBREAK study [17][20]. - KSI-101 is being evaluated in a Phase 1b study for diabetic macular edema and macular edema secondary to inflammation, with plans for dual Phase 3 studies [21][22].