Gilead Sciences, Inc. (GILD), founded in 1987, has long stood as one of America’s most influential biopharmaceutical powerhouses, a company that built its legacy by tackling humanity’s most complex diseases. Headquartered in Foster City, California, it carved its name through breakthroughs in HIV/AIDS treatments, transformed global outcomes in hepatitis B and C, and stepped up during the COVID-19 crisis with Veklury. Today, oncology and inflammatory diseases form Gilead’s next frontiers, expanding the comp ...

Core Insights - Gilead Sciences, Inc. (GILD) reported a 3% year-over-year growth in total revenues for Q3 2025, driven by higher royalty, contract, and other revenues, alongside strong product sales from its HIV franchise and liver disease drug Livdelzi [1][10] Revenue Breakdown - Total revenues include product sales and royalty, contract, and other revenues [1] - Excluding Veklury, product sales increased by 4% to $7.1 billion [2] HIV Franchise Performance - Gilead's HIV franchise remains strong, with flagship therapies Biktarvy and Descovy contributing significantly to revenue growth [3] - Biktarvy sales rose 6% year-over-year to $3.7 billion, capturing over 52% of the U.S. treatment market [4] - Descovy sales increased by 20% year-over-year to $701 million, with approximately 75% of sales for HIV prevention [6] - Newly approved Yeztugo generated $39 million in sales, achieving a 75% coverage goal ahead of schedule [7] - Gilead anticipates approximately 5% HIV revenue growth in 2025, despite challenges from Medicare Part D redesign [7] Liver Disease Portfolio - Sales from the liver disease portfolio increased by 12% to $819 million, primarily due to demand for Livdelzi [9] - Livdelzi surpassed $100 million in quarterly sales for the first time and is now the first-line treatment for second-line PBC in the U.S. [10][11] Cell Therapy Franchise - Sales from the Cell Therapy franchise decreased by 11% to $432 million, missing consensus estimates [12] - Yescarta sales fell by 10% to $349 million, while Tecartus sales decreased by 15% to $83 million due to lower demand [12] Overall Performance and Market Position - Despite declines in Veklury and Cell Therapy sales, the strong performance of the HIV franchise and Livdelzi supports future growth [10][14] - Gilead's shares have surged 32.2% year-to-date, outperforming the industry growth of 12.1% [14]

Core Insights - Gilead Sciences is experiencing mixed results in its product sales, with a notable decline in Veklury sales impacting overall performance, while HIV treatment sales, particularly Biktarvy, show positive growth [6][7][8]. Sales Performance - Gilead's total product sales reached $7.35 billion, slightly below the expected $7.43 billion, marking a decline of over 2% year-over-year [6]. - Veklury, Gilead's COVID treatment, saw a significant drop in sales by 60% to $277 million, missing the $333 million estimate due to lower hospitalization rates [7]. - Excluding Veklury, product sales increased by 4% to $7.1 billion, aligning with analysts' forecasts [7]. HIV Treatment Insights - Biktarvy generated $3.69 billion in sales, surpassing the forecast of $3.67 billion, and accounting for approximately half of Gilead's total product sales, with a year-over-year increase of 6% [8]. - Overall sales from Gilead's HIV treatment franchise rose 4% to $5.28 billion, including $701 million from Descovy, which grew nearly 20% [9]. Yeztugo Performance - Yeztugo, Gilead's newly approved HIV prevention shot, generated $39 million in sales during Q3, exceeding sell-side expectations of $35 million but falling short of buy-side forecasts of $40 million to $45 million [2]. - Gilead achieved 75% insurance coverage for Yeztugo in the U.S. ahead of schedule, with about 80% of patients having $0 co-pays [3]. Guidance and Future Outlook - Gilead raised the low end of its 2025 product sales outlook to $27.4 billion to $28.7 billion, which aligns with analysts' consensus of $28.71 billion [12]. - The company also increased its full-year earnings guidance to a range of $8.05 to $8.25 per share, surpassing the analysts' expectation of $8.04 [12].

Valued at $147.4 billion by market cap, Gilead Sciences, Inc. (GILD) is a leading U.S. biopharmaceutical company headquartered in Foster City, California. The company specializes in treatments for HIV/AIDS, hepatitis B and C, COVID-19, and other serious infectious diseases, along with oncology and inflammatory diseases as growing focus areas. Shares of this HIV giant have outperformed the broader market over the past year. GILD has gained 34.2% over this time frame, while the broader S&P 500 Index ($SPX) ...

By Deena Beasley (Reuters) -Gilead Sciences said on Thursday its HIV drug sales rose 4% to $5.3 billion in the third quarter including $39 million for its new prevention drug Yeztugo, helping to boost its profit. The company's overall product sales, however, fell 2% to $7.3 billion due to lower COVID-19 and cell therapy sales. Shares of Gilead, which closed down a fraction, were down 3.5% at $114.30 in after-hours trading. Wall Street expected sales of Yeztugo, which has an annual U.S. list price of ab ...

Core Insights - Gilead Sciences is set to present new antiviral research data at IDWeek 2025, focusing on HIV, viral hepatitis, and respiratory diseases, highlighting its leadership in antiviral science and commitment to innovative solutions for affected communities [1][2]. HIV Prevention Research - New data from the Phase 3 PURPOSE trials reinforce the safety profile of Yeztugo (lenacapavir) as a twice-yearly pre-exposure prophylaxis (PrEP) option, showing no significant drug-drug interactions with commonly used hormonal contraceptives and gender-affirming hormone therapy [3][4]. - The PURPOSE 2 trial indicates that Yeztugo is a viable PrEP option for gender-diverse populations and those affected by substance use, emphasizing its inclusivity [4]. HIV Treatment Research - Gilead's data at IDWeek emphasizes the strong clinical profile of Biktarvy (bictegravir/emtricitabine/tenofovir alafenamide) as a preferred treatment for HIV, with patients reporting higher satisfaction after switching from intramuscular cabotegravir + rilpivirine to Biktarvy [5][6]. - A 12-week interim analysis of the Phase 4 EMPOWER study shows that individuals switching to Biktarvy maintained viral suppression without serious adverse events and reported increased treatment satisfaction [6]. Respiratory Viruses / COVID-19 Research - Gilead will present findings on the effectiveness of Veklury (remdesivir) in high-risk COVID-19 populations, including those with renal impairment and solid organ transplant recipients, reinforcing its role as a standard of care [9][17]. - New analyses indicate that Veklury retains antiviral activity against recent SARS-CoV-2 variants, with significant data on treatment patterns among immunocompromised individuals [18][19]. Overview of Scientific Presentations - Gilead's presentations will cover a wide range of topics, including adherence and safety of HIV prevention methods, treatment satisfaction among HIV patients, and the effectiveness of antiviral treatments for respiratory viruses [7][10].

Core Viewpoint - Analysts expect Gilead Sciences (GILD) to report quarterly earnings of $1.95 per share, reflecting a year-over-year decline of 3%, with revenues projected at $6.95 billion, down 0.1% from the previous year [1]. Earnings Estimates - The consensus EPS estimate has been revised 1.1% higher in the last 30 days, indicating a collective reevaluation by analysts [1][2]. - Changes in earnings estimates are crucial for predicting investor reactions, as empirical studies show a strong correlation between earnings estimate revisions and short-term stock performance [2]. Revenue Projections - Analysts project 'Revenues- Royalty contract and other revenues' to reach $38.09 million, indicating a decline of 7.1% year-over-year [3]. - The average prediction for 'Total product sales- Total' is $6.91 billion, showing no change from the prior year [4]. Product Sales Estimates - 'Product Sales- Oncology- Cell Therapy- Tecartus- Total' is estimated at $92.76 million, reflecting a decrease of 13.3% from the previous year [4]. - 'Product Sales- Veklury- Total' is expected to be $211.34 million, down 1.2% year-over-year, while 'Product Sales- HIV- Odefsey- U.S.' is projected at $215.50 million, down 7.5% [5]. - 'Product Sales- Other- Other- U.S.' is anticipated to be $54.28 million, indicating a significant decline of 44.6% [5]. - 'Product Sales- HIV- Descovy- U.S.' is expected to reach $509.35 million, reflecting a growth of 17.4% year-over-year [6]. - 'Product Sales- Oncology- Trodelvy- U.S.' is projected at $224.58 million, showing a slight increase of 0.3% [6]. - 'Product Sales- Oncology- Cell Therapy- Tecartus- U.S.' is estimated at $49.56 million, down 21.3% year-over-year [7]. - 'Product Sales- Liver Disease- Sofosbuvir / Velpatasvir- U.S.' is expected to be $225.96 million, down 15.4% [7]. - 'Product Sales- HIV- Genvoya- U.S.' is projected at $333.57 million, reflecting a decline of 10.3% [8]. - 'Product Sales- Veklury- U.S.' is expected to reach $69.13 million, down 9% year-over-year [8]. Market Performance - Gilead shares have increased by 1.3% over the past month, compared to a 0.6% increase in the Zacks S&P 500 composite [8].

Strategic Transformation & Growth - Gilead is making meaningful progress on strategic transformation with a strong 2023 execution, leading to a catalyst-rich 2024[5, 11, 28, 65] - The company's pipeline has grown by 88% since 2019, positioning it to deliver 10+ new transformative therapies by the end of 2030[18, 19] - Gilead's base business has returned to consistent growth, with an expected 7-8% year-over-year growth in 2023 driven by HIV and Oncology[21, 22] Oncology - Gilead is accelerating its oncology business, aiming for >$3 billion/year[7, 13, 30, 67] - Oncology revenue has grown significantly, reaching ~$3 billion in FY23, representing ~12% of total revenue compared to 2% in FY19[36] - Trodelvy programs reinforce pan-tumor potential, with >30 active or planned trials and >30,000 patients treated[40, 41] - In 1L mNSCLC, Trodelvy plus pembrolizumab demonstrated a strong 69% ORR in PD-L1 TPS>50% and 44% ORR in PD-L1 TPS<50% in the Phase 2 EVOKE-02 trial[48] - Yescarta is the 1 cell therapy in 2L+ LBCL with long-term, 5-year OS of 43% in 3L LBCL and delivered >6,000 cell therapies to patients in 2023[54] HIV - Gilead has a leading HIV portfolio poised for durable growth[9, 15, 32, 69] - Biktarvy is a global leader in HIV treatment, with >47% U S market share in Q3 2023 and projected U S and EU LOE in 2033[72, 73] - The company has an industry-leading HIV development portfolio with 10 clinical programs with lenacapavir[75, 76] - Gilead anticipates 5 potential new HIV product launches by 2030 in treatment & PrEP[17, 71, 78]

Commercial Execution & Market Opportunity - Kite has a broad global ATC footprint with unrivaled patient reach across 420+ ATCs in 25+ countries[14, 34] - The cell therapy market has significant untapped potential, with opportunities to drive market growth in Europe, where 2L+ class share is approximately 20%[38, 41] - Kite's global commercial strategy aims to grow class share by bringing treatment closer to patients and breaking down referral barriers[43] - The company is advancing its portfolio into $40 billion+ markets, including lymphoma & leukemia ($10B-$12B), multiple myeloma ($15B-$20B), and autoimmune diseases ($15B-$20B)[20, 21] Manufacturing Excellence - Kite boasts an industry-leading 14-day turnaround time in the U S for Yescarta and a 96% manufacturing success rate[14, 10] - The company has >24,000 manufacturing capacity by 2026 and >1 million square feet of manufacturing and R&D space[103, 104] - Kite is targeting a biologics product gross margin of approximately 80% in the U S by 2030 through operational excellence and cost improvements[136] - Plans are rapidly advancing for anito-cel manufacturing, leveraging Kite's existing capabilities to achieve similar turnaround times and success rates to Yescarta[137, 140] Clinical Development & Pipeline - Yescarta demonstrates statistically significant overall survival (OS) vs Salvage ± HDCT + ASCT in 2L LBCL, with 43% of patients alive at 5 years in 3L+ LBCL[47] - In ZUMA-7, Yescarta showed a 27% reduction in the risk of death (OS HR 0 726, p=0 0168) and a >4x median EFS in 2L LBCL[197] - The company is developing KITE-753, a CD19/CD20 dual-targeting CAR T with a rapid manufacturing process (3 days) to preserve T cell stemness[228, 231]

Core Viewpoint - Investing in dividend stocks requires attention to a company's underlying operations rather than just high yields, with AbbVie and Gilead Sciences being highlighted as strong candidates for income investors [1][2]. Group 1: AbbVie - AbbVie is recognized as a "Dividend King," having raised its payouts for 53 consecutive years, making it a strong consideration for income investors [4]. - The company is well-known for its immunology drugs, particularly Skyrizi and Rinvoq, which have shown unexpectedly rapid sales growth [5][6]. - Following the loss of patent exclusivity for Humira, AbbVie has successfully returned to top-line growth, with a revised 2027 sales guidance for Skyrizi and Rinvoq exceeding $31 billion, up from $27 billion [6]. - AbbVie has a robust pipeline with numerous programs that are expected to lead to further approvals and label expansions, supporting its strong business fundamentals [8]. - The forward yield for AbbVie is over 3.5%, significantly higher than the S&P 500 average of 1.3%, indicating its potential as a long-term dividend stock [8]. Group 2: Gilead Sciences - Gilead Sciences is a leading drugmaker, particularly known for its dominance in the HIV market, with a revenue of $6.7 billion in the first quarter, despite flat overall sales due to lower Veklury sales [9]. - The HIV segment grew by 6% year-over-year, generating $4.6 billion, with Biktarvy being the top prescribed regimen in the U.S. [10]. - Gilead is diversifying its portfolio beyond HIV, with a focus on oncology, where over a third of its 58 pipeline programs are concentrated [12]. - The forward yield for Gilead is 3.2%, and the company has increased its dividends by nearly 84% over the past decade, making it an attractive option for long-term income-seeking investors [13].