Core Insights - The study identifies multiple members of the low-density lipoprotein receptor (LDLR) family, specifically LRP1, LRP4, and VLDLR, as key receptors for the entry of the yellow fever virus (YFV) into human cells [2][6] - The research demonstrates that the soluble LRP4-Fc bait receptor can effectively neutralize YFV infection and reduce viral load in vivo [5][6] - The findings suggest that targeting LDLR family members could be significant for developing therapeutic strategies against YFV and other emerging viruses in the Orthoflavivirus genus [6] Summary by Sections - **Research Findings**: The study published in Nature reveals that LRP4 is a candidate receptor for YFV, and its knockout inhibits YFV infection, while its expression enhances it [5] - **Mechanism of Action**: LRP4 interacts with the viral envelope protein, facilitating YFV entry into cells. Other LDLR family members, LRP1 and VLDLR, also mediate YFV entry [5][6] - **Implications for Treatment**: The research indicates that LRP1-Fc, LRP4-Fc, and VLDLR-Fc bait proteins can protect mice from YFV and reduce liver damage, highlighting their potential in therapeutic applications [6]