Summary of Pelthos Therapeutics FY Conference Call (March 23, 2026) Company Overview - **Company**: Pelthos Therapeutics (NYSEAM:PTHS) - **Lead Product**: ZELSUVMI, a topical nitric oxide releasing product for treating molluscum contagiosum in patients aged one year and older [5][7] Key Points Company Background and Capitalization - Pelthos was formed from a merger with Channel Therapeutics on July 1, 2025, after raising $50 million through a PIPE [5] - The company trades on the NYSE under the ticker PTHS, with a current market cap of approximately $200 million [6] Product Information - **ZELSUVMI**: - First FDA-approved at-home treatment for molluscum contagiosum, allowing for daily application over 12 weeks [8] - Addresses a significant unmet need as traditional treatments involve painful procedures [7][10] Financial Performance - Prescription volume increased by 129% from Q3 to Q4, with net revenue rising from $7.1 million in Q3 to $9.1 million in Q4 [13][14] - The company has over 4,200 unique prescribers since the product launch [14] - Payer access is favorable, with 70% of prescriptions covered by commercial insurance and 99% by Medicaid [15][16] - Gross to net ratio improved from 25.3% in Q3 to 28.7% in Q4, with expectations to reach mid- to upper 30s% in 2026 [18] Sales Strategy and Market Access - The sales force is approximately 64 representatives, focusing on both dermatologists and pediatricians [19] - The company plans to leverage existing sales channels for new products, Xepi and Xeglyze, which target pediatric conditions [20][25] New Product Acquisitions - **Xepi**: - Targets impetigo, with a significant market need due to resistance to current treatments [21] - Expected to launch in early 2027 [24] - **Xeglyze**: - Aimed at treating head lice, with a unique dual-action formula [22] - Planned launch in the latter half of Q2 2027 [25] Future Outlook - Revenue guidance for ZELSUVMI is projected at $175 million by 2028, with a current consensus estimate of just over $60 million for the year [57] - The company is comfortable with its cash position, having raised $50 million in equity and additional funds through convertible debt [55][56] Intellectual Property and Market Exclusivity - ZELSUVMI has patent protection until 2035, with potential extensions into 2037 [40] - Xepi and Xeglyze have exclusivity until early 2032 and 2034, respectively [41] Strategic Focus - The primary focus remains on successfully launching ZELSUVMI, with plans to evaluate additional indications for the NITRICIL platform in the future [47][49] Additional Insights - The company emphasizes the importance of executing its current business plan before pursuing further acquisitions or expansions [47] - There is a noted prevalence of "super lice," which enhances the market potential for Xeglyze [22]

Summary of Pelthos Therapeutics FY Conference Call Company Overview - **Company Name**: Pelthos Therapeutics (NYSEAM:PTHS) - **Industry**: Biopharmaceuticals, specifically focused on pediatric cutaneous infectious diseases - **Ticker Symbol**: PTHS - **Market Capitalization**: Approximately $200 million [4] - **Shares Outstanding**: 8.9 million common shares [4] Key Products and Developments - **Lead Product**: ZELSUVMI, launched in July 2025, indicated for the treatment of molluscum contagiosum in patients aged 1 year and older [3][7] - **Recent Acquisitions**: - **Xepi**: Acquired in late 2025, expected launch in late 2026, treats impetigo [3][29] - **Xeglyze**: Acquired for $1.8 million, FDA-approved for head lice treatment, expected launch in mid-2027 [30][31] Financial Highlights - **Cash Position**: $14.2 million at Q3 close, raised an additional $18 million in a convertible note [4] - **Revenue Generation**: - Q3 2025: 2,700 units of ZELSUVMI dispensed, generating $7.1 million in net revenue [24] - Q4 2025: 129% growth in units quarter-over-quarter [24] - Anticipated gross-to-net (GTN) in Q4 expected to rise to the high 30% range [25] Market Strategy and Sales Performance - **Sales Force**: Initially launched with 50 representatives, expanded to 64 territories by March [21][22] - **Target Audience**: Focus on dermatologists, pediatric dermatologists, and pediatricians, covering approximately 10,000 top molluscum treaters [22] - **Digital Marketing**: Successful YouTube promotional video with over 3.5 million views [23] Clinical Insights and Product Efficacy - **ZELSUVMI Efficacy**: - B-SIMPLE4 trial showed about one-third of patients achieved complete clearance at 12 weeks [19] - 80% of parents found the treatment clinically meaningful even without complete clearance [20] - **Safety Profile**: Common side effects include mild application site pain (12%) and moderate pain (6%) [17] Market Challenges and Opportunities - **Molluscum Contagiosum**: High prevalence among children, with 73% of affected children going untreated [10] - **Treatment Landscape**: Traditional treatments often require multiple painful office visits; ZELSUVMI offers a home-based solution [16][17] - **Resistance Issues**: Concerns over mupirocin resistance in treating impetigo, presenting an opportunity for Xepi [30] Management Team and Experience - **CEO**: Over 30 years in the pharmaceutical industry, with a history of successful exits [5] - **Board Composition**: Includes experienced executives from various pharmaceutical companies, enhancing strategic direction [6] Future Outlook - **Product Pipeline**: Focus on maximizing ZELSUVMI's market potential before launching Xepi and Xeglyze [32] - **Potential Collaborations**: Opportunities to work with Ligand on clinical stage programs for the NITRICIL platform [37] - **Financial Position**: Strong capital position to support growth and potential acquisitions [36] Conclusion Pelthos Therapeutics is positioned for growth with its innovative product ZELSUVMI, a strong management team, and strategic acquisitions. The company is focused on addressing unmet needs in pediatric infectious diseases while navigating market challenges and leveraging digital marketing strategies for enhanced outreach.

Financial Performance - Ligand Pharmaceuticals reported total GAAP revenue of $268 million for 2025, up from $167 million in 2024, with core revenue at $240 million reflecting a 43% year-over-year growth [15][16] - Full-year royalty revenue grew to $161 million, an increase of 48% year-over-year, driven by products such as FILSPARI, Ohtuvayre, CAPVAXIVE, and QARZIBA [15][16] - Adjusted EPS increased to $8.13, up 42% year-over-year, indicating strong operating leverage and higher royalty contributions [15][16] Business Line Performance - FILSPARI's U.S. net sales reached $103 million in Q4, representing 108% growth year-over-year, with total global sales of approximately $355 million for 2025 [16][17] - Ohtuvayre reported net sales of $178 million in Q4, with full-year sales of $506 million, marking a strong launch in COPD history [17][34] - CAPVAXIVE's net sales were $279 million in Q4 and $755 million for the full year, nearing blockbuster status [17][18] Market Performance - Ligand's royalty portfolio is expected to see a 23% compound annual growth rate in royalty receipts from 2025 through 2030, driven by contributions across the entire portfolio [12][13] - The company anticipates significant commercial opportunities in Japan for FILSPARI, with a sizable market for IgAN [71] Company Strategy and Industry Competition - Ligand is focusing on disciplined investments to create new royalty streams and enhance long-term shareholder value, with a systematic portfolio management strategy to drive value across partnerships [9][10][22] - The demand for royalty financing has doubled over the last five years, positioning Ligand favorably within the biopharmaceutical royalty financing sector [10][11] Management Commentary on Operating Environment and Future Outlook - Management expressed confidence in the company's growth trajectory, citing strong trial results for QTORIN rapamycin and the successful partnership with Leona Bio for lasofoxifene [36] - The company is optimistic about the upcoming year, expecting multiple catalysts from its late-stage development pipeline [36][31] Other Important Information - Ligand ended 2025 with $734 million in cash equivalents and short-term investments, totaling over $1 billion in deployable capital [20] - The company reaffirmed its 2026 financial guidance, expecting adjusted EPS of approximately $8-$9 per share and royalty revenue of $200 million-$225 million [20][21] Q&A Session Summary Question: Clinical update expectations for late-stage royalty portfolio - Management highlighted several active late-stage programs, including QARZIBA and TZIELD, with robust updates expected in the coming quarters [39][40] Question: Update on monetizing older assets in the portfolio - Management confirmed active engagement in 5 to 10 opportunities for older assets, with potential announcements expected by year-end [43][44] Question: Larger opportunity for TZIELD and peak sales size - Management acknowledged TZIELD's low royalty but emphasized its potential blockbuster status, particularly with the upcoming Stage 3 indication [48][50] Question: Impact of FSGS approval delay on 2026 outlook - Management indicated that the FSGS contribution to 2026 guidance is modest, with a risk-adjusted estimate of $4 million [53][55] Question: Changes in selection criteria for potential partnerships - Management noted that as the portfolio value grows, the average deal size will increase, focusing on high clinical value assets [58][59]

Financial Data and Key Metrics Changes - Full-year adjusted EPS exceeded original 2025 guidance by more than 30%, with a 42% increase year-over-year [6][7] - Total GAAP revenue for 2025 was $268 million, up from $167 million in 2024, with core revenue reflecting a 43% year-over-year growth at $240 million [15][16] - Royalty revenue grew to $161 million, an increase of 48% year-over-year, driven by products like FILSPARI, Ohtuvayre, CAPVAXIVE, and QARZIBA [15][16] Business Line Data and Key Metrics Changes - FILSPARI's U.S. net sales reached $103 million in Q4, representing 108% growth year-over-year, with total annual sales of $322 million [16][17] - Ohtuvayre reported U.S. net sales of $506 million for the full year 2025, with Q4 sales just under $200 million [17] - CAPVAXIVE's net sales were $279 million in Q4 and $755 million for the full year, nearing blockbuster status [17] Market Data and Key Metrics Changes - The royalty funding market has doubled over the last five years, indicating a growing demand for royalty capital [10][11] - Ligand expects a 23% compound annual growth rate in royalty receipts from 2025 through 2030, driven by contributions across the entire portfolio [12][13] Company Strategy and Development Direction - Ligand is focused on disciplined investments to create new, clinically differentiated product royalty streams and enhance long-term shareholder value [8][9] - The company launched a systematic portfolio management strategy to proactively communicate with partners and identify new investment opportunities [22][23] - Ligand aims to expand its business development efforts and deepen its pipeline, with a strong capital base to support growth initiatives [10][11] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the continued momentum of the royalty portfolio and disciplined capital deployment approach, positioning the company for sustained long-term growth [12][13] - The company anticipates significant commercial upside from products like FILSPARI and Ohtuvayre, with ongoing efforts to engage with regulatory bodies for approvals [34][35] Other Important Information - Ligand ended 2025 with $734 million in cash equivalents and short-term investments, totaling over $1 billion in deployable capital [20] - The company is optimistic about the potential of lasofoxifene and QTORIN rapamycin, with significant market opportunities projected [24][29] Q&A Session Summary Question: Clinical update expectations for late-stage royalty portfolio - Management highlighted several active late-stage programs, including QARZIBA and TZIELD, with robust updates expected in the coming quarters [39][40] Question: Update on monetizing older assets in the portfolio - Management confirmed active engagement in 5 to 10 opportunities for older assets, with potential announcements expected by year-end [43][44] Question: Larger opportunity for TZIELD and peak sales size - Management acknowledged TZIELD's low royalty but emphasized its potential blockbuster status, particularly with the upcoming Stage 3 indication [48][49] Question: Impact of FSGS approval delay on 2026 outlook - Management indicated that the FSGS contribution to 2026 guidance is modest, with a risk-adjusted estimate of $4 million [53][55] Question: Changes in selection criteria for potential partnerships - Management noted that as the portfolio value grows, the average deal size sought will increase, focusing on high clinical value assets [58][59] Question: Market size opportunity for FILSPARI in IgAN and FSGS - Management estimated consensus market size for both indications at around $1 billion, with potential royalties of approximately $90 million for each [70][71]

Financial Performance - In 2025, Ligand Pharmaceuticals achieved total GAAP revenue of $268 million, up from $167 million in 2024, with core revenue at $240 million reflecting a 43% year-over-year growth [12][13] - Full-year adjusted EPS increased to $8.13, a 42% rise year-over-year, driven by strong operating leverage and higher royalty contributions [13][10] - Royalty revenue grew to $161 million, marking a 48% increase year-over-year, primarily from FILSPARI, Ohtuvayre, CAPVAXIVE, and QARZIBA [12][5] Business Line Performance - FILSPARI's U.S. net sales reached $103 million in Q4, representing 108% growth year-over-year, with total global sales of approximately $355 million for 2025 [13][14] - Ohtuvayre reported U.S. net sales of $506 million for the full year 2025, with Q4 sales of nearly $200 million [14] - CAPVAXIVE's net sales were $279 million in Q4 and $755 million for the full year, nearing blockbuster status [15] Market Data - The royalty financing market has doubled over the last five years, indicating a growing demand for royalty capital [9] - Ligand expects a compound annual growth rate of 23% in royalty receipts from 2025 through 2030, driven by contributions across its portfolio [10] Company Strategy and Industry Competition - Ligand is focusing on disciplined investments to create new royalty streams and enhance long-term shareholder value, with a strong emphasis on proactive portfolio management [6][19] - The company is positioned uniquely within the biopharmaceutical royalty financing sector, capitalizing on high demand for capital [9] Management Commentary on Operating Environment and Future Outlook - Management expressed confidence in the continued momentum of the royalty portfolio and the disciplined capital deployment approach, which positions the company for sustained long-term growth [11][33] - The company anticipates a strong pipeline of late-stage development programs and is optimistic about upcoming regulatory decisions and market expansions [33][27] Other Important Information - Ligand ended 2025 with $734 million in cash equivalents and short-term investments, totaling over $1 billion in deployable capital [17] - The company is actively engaged in monetizing older assets and exploring new investment opportunities across its portfolio [41][42] Q&A Session Summary Question: Clinical update expectations for late-stage royalty portfolio - Management highlighted several active late-stage programs, including QARZIBA and Lasofoxifene, with robust updates expected in the coming quarters [37] Question: Update on monetizing older assets - Management confirmed ongoing engagement with 5 to 10 opportunities for monetization and expects announcements by year-end [41] Question: Market opportunity for TZIELD - Management acknowledged the low royalty but emphasized the potential blockbuster opportunity with Sanofi's TZIELD, particularly in Stage 3 Type 1 diabetes [46] Question: Impact of FSGS approval delay on 2026 outlook - Management indicated that the FSGS approval delay would have a negligible impact on the 2026 guidance, with a modest $4 million contribution assumed [51][63] Question: Differentiation of Castle Creek technology - Management discussed the potential advantages of the Castle Creek treatment over competitors, emphasizing its injectable nature and broader application [58]

Core Insights - Pelthos Therapeutics Inc. reported strong commercial performance for ZELSUVMI, generating $7.1 million in net revenues during its first quarter of operations [1][5] - The company has successfully launched ZELSUVMI, the first FDA-approved at-home treatment for molluscum contagiosum, with 2,716 units prescribed by 1,169 unique prescribers in Q3 2025 [1][5] - The acquisition of XEPI adds a complementary product to Pelthos' portfolio, targeting the same pediatric market as ZELSUVMI, enhancing revenue potential [3][5] Financial Performance - For the three months ended September 30, 2025, Pelthos reported total revenue of $7.4 million, with net product revenues from ZELSUVMI at $7.1 million [10] - The company incurred a net loss of $16.2 million, translating to a loss of $5.30 per share [9][10] - Cash and cash equivalents as of September 30, 2025, stood at $14.2 million, reflecting a significant increase from $513,000 in December 2024 [7] Operational Highlights - The commercial launch of ZELSUVMI exceeded expectations, with strong market uptake and continued growth anticipated in Q4 2025 [3][5] - The company completed a merger to form Pelthos Therapeutics and raised $50.1 million in an equity private placement to support ZELSUVMI's launch [5] - An additional $18 million in private convertible notes financing was closed in November 2025 to facilitate the purchase and relaunch of XEPI and expedite ZELSUVMI's commercial rollout [5] Market Context - ZELSUVMI addresses a significant unmet need in treating molluscum contagiosum, primarily affecting children, while XEPI targets antibiotic-resistant skin infections, further solidifying Pelthos' position in the pediatric dermatology market [3][5] - The combined addressable markets for ZELSUVMI and XEPI present substantial revenue opportunities for Pelthos, leveraging existing commercial relationships and infrastructure [3][5]

Financial Data and Key Metrics Changes - Total revenue and other income for Q3 2025 on a GAAP basis was $115.5 million, up from $51.8 million in the same quarter last year, with core revenue growing 68% year over year to $86.9 million [26][34] - Royalty revenue rose 47% year over year to $46.6 million, and adjusted EPS increased 68% to $3.09 [26][34] - The company raised its full-year 2025 guidance, now expecting core revenue of $225-$235 million and adjusted EPS of $7.40-$7.65 [35][36] Business Line Data and Key Metrics Changes - Royalty revenue growth was driven by strong performances from products like Travere's Filspari, Merck's Ohtuvayre, and Capvaxive, with Filspari becoming the largest royalty-generating asset [30][31] - Filspari reported Q3 sales of $90.9 million, a 155% year-over-year increase, while O2VARE sales reached $136 million, a 32% sequential increase [30][31] - Capvaxive generated $244 million in sales, an 89% sequential increase, reinforcing its market position [31] Market Data and Key Metrics Changes - The company noted strong uptake of Zelsuvmi in its early launch phase, with expectations for continued momentum [7] - Ohtuvayre is tracking ahead of initial forecasts, with Q3 sales growing 32% sequentially, and projected sales of $2 billion by 2029 [10][11] - The FDA has assigned a PDUFA date of January 13, 2026, for Filspari's second indication, FSGS, which could significantly expand its market opportunity [18] Company Strategy and Development Direction - The company has focused on building a diversified portfolio of high-margin royalties and has successfully executed a convertible debt financing to support growth initiatives [5][6] - The strategic direction set in 2022 has led to significant growth across core revenue and adjusted EPS, with a long-term royalty growth outlook of 22% CAGR [9][10] - The company is actively pursuing high-quality investment opportunities and expanding its business development team to capitalize on its robust pipeline [27][29] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the strength of the commercial royalty portfolio and the potential for indication and geographic expansion of key products [36][37] - The company highlighted the positive developments in the FDA's approach to accelerating timelines for innovative treatments, which aligns with its investment strategy [16][49] - Management remains optimistic about the ongoing progress of the Pelthos team and the launch momentum of Zelsuvmi [37] Other Important Information - The company ended the quarter with approximately $1 billion in deployable capital, including cash and investments [7][27] - The Pelthos transaction resulted in a $53 million gain recognized in Q3, reflecting the strategic value of the spin-out [24][25] - The company has seen record-setting origination activity, reviewing over 130 investment opportunities in the first three quarters of the year [13] Q&A Session Summary Question: Opportunities and special situations related to Pelthos and Palvella - Management indicated a robust opportunity set in special situations, focusing on companies needing more than just capital [38][39] Question: Changes in investment opportunities and capital demands - Management noted that while the deal flow may shift with market conditions, the demand for royalty capital remains high, particularly for development-stage assets [44][45] Question: Insights on the ZELSUVMI launch and future expectations - Management provided limited additional information but indicated that more specifics would be available during the upcoming earnings call [50][51] Question: Competitive landscape for royalty assets - Management acknowledged potential future competition but noted that they have not yet seen significant changes in the competitive landscape [53][54] Question: Thoughts on the recent approval of Furoscix - Management expressed optimism about Furoscix's potential to provide a differentiated treatment option in the market [56]

Core Insights - Pelthos Therapeutics Inc. is set to launch ZELSUVMI™ for treating Molluscum contagiosum infections in July 2025, following the completion of a merger with Channel Therapeutics Corporation [1][2] - Ligand Pharmaceuticals has invested $18 million in Pelthos and will receive a 13% royalty on worldwide sales of ZELSUVMI [1][2] - Pelthos will begin trading on the NYSE American exchange under the ticker symbol "PTHS" on July 2, 2025 [1] Company Developments - The merger between Ligand's subsidiary LNHC, Inc. and Channel Merger Sub Inc. has been completed, forming Pelthos Therapeutics Inc. [1][2] - Pelthos raised $50.1 million in equity capital, with $32 million from a group of strategic investors and $18 million from Ligand [2] - The capital raised will support the commercial launch of ZELSUVMI and includes the cancellation of approximately $18.8 million in bridge capital previously advanced to Pelthos [2] Product Information - ZELSUVMI (berdazimer) is a topical gel approved for treating Molluscum contagiosum, a common skin infection affecting an estimated 16.7 million people in the U.S. [3] - It is the first and only prescription medication for this condition that can be administered at home by patients or caregivers [3] - Pelthos is also evaluating the development of Channel's existing NaV 1.7 programs for various types of chronic pain and post-surgical nerve blocks [3]