Core Insights - The fourth-quarter 2025 reporting cycle for the Medical sector is commencing, with major firms expected to release earnings results in the coming weeks, primarily in the pharma/biotech and medical device segments [1] - Johnson & Johnson's strong performance has set a positive tone, while Roche faced challenges due to unfavorable foreign-exchange impacts, particularly from a weak U.S. dollar [1] - Sanofi reported mixed results, beating earnings estimates but slightly missing sales expectations [1] Earnings Trends - As of January 28, 11.7% of Medical sector companies, representing 26% of the sector's market capitalization, have reported quarterly earnings, with 42.9% beating both earnings and revenue estimates [2] - Year-over-year earnings decreased by 15.5%, while revenues increased by 10.3% [2] - Overall, fourth-quarter earnings for the Medical sector are expected to decrease by 2.4%, while sales are projected to rise by 8.7% compared to the previous year [3] Company Highlights - **Zoetis (ZTS)**: Expected to report earnings on February 12, with a consensus estimate of $1.40 per share and revenues of $2.37 billion. The company has an Earnings ESP of +0.84% and a Zacks Rank of 3. Recent performance has been driven by strong demand for companion animal products, although sales of certain monoclonal antibody products may have declined [7][8] - **Pacira BioSciences (PCRX)**: Anticipated to report earnings soon, with a consensus estimate of 85 cents per share and revenues of $196.99 million. The company has an Earnings ESP of +7.38% and a Zacks Rank of 2. Revenue growth is expected from its pain-management product, Exparel, and other products [9][10] - **Apellis Pharmaceuticals (APLS)**: Expected to report earnings soon, with a consensus estimate of a loss of 41 cents per share and revenues of $194.37 million. The company has an Earnings ESP of +4.52% and a Zacks Rank of 3. Revenue growth is likely driven by its geographic atrophy drug, Syfovre [11][12] - **Acadia Pharmaceuticals (ACAD)**: Set to report earnings soon, with a consensus estimate of 12 cents per share and revenues of $292.64 million. The company has an Earnings ESP of +14.92% and a Zacks Rank of 3. Revenue growth is expected from its lead drug, Nuplazid, and its second product, Daybue [13][14] - **Denali Therapeutics (DNLI)**: Expected to report a loss of 75 cents per share and revenues of $18.47 million. The company has an Earnings ESP of +6.11% and a Zacks Rank of 3. Revenue expectations are based on collaboration revenues, with updates on pipeline programs anticipated [15][16]

Summary of Pacira BioSciences FY Conference Call (January 14, 2026) Company Overview - **Company**: Pacira BioSciences (NasdaqGS:PCRX) - **Mission**: Deliver innovative, non-opioid pain management therapies to transform lives [2][3] - **Sales**: Reported unaudited sales of $726 million for the previous year [2] - **Employees**: Over 800 engaged employees [2] - **Patients Served**: More than 18 million patients helped to date [2] Product Portfolio - **Key Products**: - **Exparel**: Flagship product for nerve block - **Zilretta**: Long-acting corticosteroid for osteoarthritis pain - **Iovera**: Medical device using cryoneurolysis for pain management [3] Strategic Developments - **5x30 Strategy**: Aims to help over 3 million patients by 2030, achieve double-digit top-line growth, expand profitability by five points, add five new programs to the pipeline, and establish five partnerships [6][7] - **Partnerships**: - **Johnson & Johnson MedTech**: Triples reach for Zilretta [9] - **LG Chem**: Gains commercial rights for Exparel in Asia-Pacific, with potential for Zilretta sales [10] - **Intellectual Property**: Strong IP estate with 21 patents, providing robust defense against future Paragraph IV filers [5][12] Financial Performance - **Stock Performance**: 40% increase in stock price from January to December [5] - **Profitability**: Expected margins of 80%-82% for the current year [7] - **Share Buyback**: $150 million worth of stock repurchased, reducing outstanding shares to 41 million [11] Pipeline and Data Catalysts - **Upcoming Data Catalysts**: - **PCRX201**: Local gene therapy with promising phase one results [8][22] - **Iovera Spasticity**: Interim readout expected in the first half of the year [21] - **Zilretta for OA of the Shoulder**: Registrational study readout anticipated [21] Market Access and Growth Strategy - **NOPAIN Legislation**: Aimed at reducing opioid prescriptions; 102 million lives covered by the end of the year [19] - **Market Access**: Over 90% of business contracted, with ongoing efforts to educate stakeholders [20][44] - **Volume Growth**: Notable growth in the second half of the year, with 9% and 7% volume growth in Q3 and Q4 respectively [36] Challenges and Future Outlook - **Behavior Change**: Ongoing efforts to drive behavior change among healthcare professionals regarding non-opioid pain management [31] - **Market Education**: Continued focus on educating physicians and patients about the benefits of non-opioid options [41][43] - **Long-term Potential**: Exploration of additional indications for PCRX201, including potential for repeat dosing and expansion to other joints [33][35] Conclusion - **Overall Sentiment**: The company is optimistic about its growth trajectory, driven by a strong product pipeline, strategic partnerships, and a commitment to transforming pain management [28][30]

Core Insights - Pacira BioSciences (PCRX) has entered a partnership with LG Chem to enhance access to opioid-sparing postsurgical pain management in select Asia-Pacific markets, granting LG Chem exclusive rights to commercialize Exparel [1][6] Group 1: Partnership Details - The agreement includes an undisclosed upfront payment, a transfer price, and tiered royalties on future sales generated by LG Chem in the licensed markets [2] - Pacira will manufacture Exparel, while LG Chem will manage regulatory filings and approvals, with plans to submit marketing authorization applications in South Korea and Thailand within six months [2][6] Group 2: Strategic Rationale - The partnership aims to extend Exparel's reach into Asia-Pacific markets, supporting Pacira's long-term growth strategy by tapping into a large surgical patient base [3] - Exparel's extended duration of action addresses the demand for advanced postsurgical pain management solutions in Asian markets, where reliance on short-acting analgesics is prevalent [4] Group 3: Financial Implications - The collaboration is expected to expand Exparel's commercial footprint and create new revenue channels outside the United States, which is crucial as Pacira reported preliminary fourth-quarter revenues of $196.9 million, a 5% year-over-year increase but below market expectations [9] - Management is positioning the international expansion of Exparel as a key lever to drive incremental sales and improve overall revenue momentum [9] Group 4: Product Portfolio - In addition to Exparel, Pacira's marketed portfolio includes Zilretta, an extended-release therapy for osteoarthritis knee pain, and the iovera system, a device for delivering cold temperature to targeted nerves [10]

Core Insights - Pacira BioSciences (PCRX) reported preliminary, unaudited total revenues of $196.9 million for Q4 2025, missing the Zacks Consensus Estimate of $199 million, leading to a 9.6% decline in stock price [1][5] Group 1: Product Revenues - Exparel's net product sales reached $155.8 million in Q4 2025, a 5% increase from the previous year, slightly exceeding the Zacks Consensus Estimate of $155 million [3][5] - Zilretta's net product sales were reported at $33 million, remaining flat year over year and missing the Zacks Consensus Estimate of $34.4 million [6][7] - Iovera's net product sales amounted to $7 million, an 8% increase from the year-ago quarter, but fell short of the Zacks Consensus Estimate of $7.3 million [8] Group 2: Annual Performance - For the full year 2025, Pacira BioSciences reported total revenues of $726.4 million, a 4% increase year over year, but below the Zacks Consensus Estimate of $728.8 million [9]

Summary of Pacira BioSciences Conference Call Company Overview - **Company**: Pacira BioSciences (NasdaqGS:PCRX) - **Focus**: Musculoskeletal pain management - **Products**: - Exparel: Flagship nerve block product - Zilretta: Long-acting steroid for osteoarthritis - Iovera: Medical device using cryoneurolysis for pain relief - **Future Goals**: 5x30 initiative aiming for significant growth and development by 2030 [1][2] Financial Performance - **Revenue Projection**: Expected to be around $750 million for the year, with Exparel contributing over $500 million [4] - **EBITDA**: Anticipated to be around $200 million [4] - **Growth Drivers**: Exparel is the main growth driver, with ongoing investments in commercial medical market access [3][5] Exparel Growth Dynamics - **Reimbursement Catalyst**: Introduction of "no pain" reimbursement for Medicare patients, allowing separate reimbursement for Exparel [6] - **Volume Growth**: Year-over-year volume increases of 3%, 6%, and 9% in the first three quarters, respectively [7] - **Adoption Challenges**: Larger institutions are slower to adopt due to organizational complexities [12][13] Market Access and Sales Strategy - **GPO Contracts**: Over 80% of business contracted under Group Purchasing Organizations (GPOs) [10] - **Sales Force Structure**: Dedicated sales forces for Exparel, Zilretta, and Iovera to enhance focus and efficiency [17][18] - **Education Efforts**: Increased focus on educating payers and healthcare professionals about the benefits of Exparel [16] Pipeline and Future Products - **PCRX-201**: A gene therapy targeting osteoarthritis of the knee, with a completed Phase I program and a recently enrolled Phase 2A program [29][30] - **Market Potential**: Positioned as a gene therapy for the masses, with a focus on local administration and improved safety profiles [29][31] - **Phase 2 Program**: Aiming for transformative pain relief extending beyond the current standard of care [32] Manufacturing and Margins - **Manufacturing Improvements**: Transition to a 200-liter process has improved production reliability and reduced waste, leading to enhanced gross margins [26][27] - **Margin Guidance**: Expected to achieve at least a five-point margin improvement over five years [27] International Expansion - **Global Market Opportunities**: Plans to explore markets outside the U.S. without the need for additional clinical studies [24] Conclusion - **Outlook**: Anticipated continued growth driven by Exparel, Zilretta, and Iovera, alongside new product developments and strategic partnerships [21][23]

Core Viewpoint - DOMA Perpetual Capital Management LLC, a significant stockholder of Pacira BioSciences, Inc., is urging the Board to hire bankers and initiate a full sale process for the company due to perceived management underperformance and financial mismanagement [1][2][4]. Financial Performance and Management Concerns - Pacira's management has been criticized for excessive spending, with stock-based compensation projected to be approximately 6% of the company's market capitalization for 2025, exceeding the firm's entire operating income [2][6]. - Year-to-date sales of Zilretta have declined by 2% year over year through Q3, indicating poor business performance [3]. - Revenue growth has been modest at 3% year over year, while expenditures have surged, with R&D costs increasing by 36% and SG&A by 25% year over year [6]. Valuation and Sale Potential - A potential sale could yield a valuation of around $2.7 billion, translating to approximately $66 per share, which is three times the current stock price and represents a reasonable acquisition valuation [4][5]. - The cash flows from Pacira's assets, particularly Exparel, could exceed $10 billion through patent expiration, suggesting significant value under a larger owner [4]. Strategic Recommendations - The company should immediately pursue a sale process, with a target completion date before the end of Q1 2026 [7]. - Cost-cutting strategies must be implemented to enhance shareholder returns, and all new development programs should be put on hold until a sale is explored [12]. - Free cash flow should be prioritized for share buybacks, with a recommendation for a new $300 million buyback program following the completion of the current one [12]. Shareholder Relations and Governance - The Board's actions have been perceived as neglecting shareholder interests, with ongoing dilution of shareholder value through unapproved share issuances [10][11]. - DOMA has been in communication with the Board for over a year, advocating for a shareholder-friendly capital allocation framework, which has only recently begun to materialize [9].

Core Viewpoint - Pacira BioSciences reported first-quarter 2025 adjusted earnings of 62 cents per share, exceeding the Zacks Consensus Estimate of 57 cents, while total revenues of $168.9 million fell short of the expected $175 million [1][2] Financial Performance - Adjusted earnings for Q1 2025 were 62 cents per share, consistent with the same quarter last year [1] - Total revenues reached $168.9 million, a 1% increase year over year, but missed the Zacks Consensus Estimate [1] - Exparel's net product sales were $136.5 million, up 3% from the previous year, but below the consensus estimate of $140.2 million [2][4] - Zilretta's net product sales were $23.3 million, down 10% year over year, missing both the consensus and model estimates [4] - Iovera's net product sales were $5.1 million, a 2% increase year over year, but below the consensus estimate of $5.5 million [5] Expenses - Research and development (R&D) expenses (excluding stock-based compensation) increased by 41% to $23.1 million due to higher product development and clinical study costs [6] - Selling, general and administrative (SG&A) expenses (excluding stock-based compensation) rose 19% to $76.2 million, driven by increased investments in commercial and marketing activities [7] Guidance and Projections - For 2025, Pacira BioSciences expects total revenues between $725 million and $765 million, with an adjusted gross margin projected between 76% and 78% [8] - Adjusted R&D expenses are anticipated to be between $90 million and $105 million, while adjusted SG&A expenses are expected to range from $290 million to $320 million [10] Recent Developments - The company announced the dosing of the first patient in a mid-stage study for pipeline candidate PCRX-201, aimed at treating osteoarthritis of the knee [11] - A settlement agreement with Fresenius and others regarding Exparel patents protects sales from generic competition until at least 2030 [12] - A U.S. District Court ruling eliminated the obligation to pay a low single-digit royalty on Exparel sales, expected to enhance profitability and revenue growth [13]

Core Insights - The Medical sector is experiencing a robust first-quarter earnings season, with several drugmakers reporting results, and large caps like J&J, Merck, and Amgen exceeding earnings and sales estimates [1][2] - Overall, first-quarter earnings for the Medical sector are projected to rise by 40%, with revenues expected to increase by 8.3% [3] Earnings Performance - As of April 30, 45% of Medical sector companies, representing approximately 57.9% of the sector's market capitalization, have reported earnings, with 66.7% beating both earnings and revenue estimates [2] - Year-over-year earnings growth for the sector is reported at 60.5%, while revenues have increased by 7.8% [2] Company Highlights - **Novo Nordisk**: Expected to report earnings of 92 cents per share and revenues of $11.33 billion, with strong sales anticipated from diabetes and obesity care products [6][7] - **Pacira BioSciences**: Projected earnings of 57 cents per share and revenues of $174.96 million, driven by sales of its pain-management product Exparel [8][9] - **Ultragenyx Pharmaceuticals**: Expected to report a loss of $1.54 per share and revenues of $141.99 million, with growth driven by its lead drug Crysvita [10][11] - **Acadia Pharmaceuticals**: Anticipated earnings of 6 cents per share and revenues of $241.74 million, primarily from sales of Nuplazid for Parkinson's disease psychosis [12][13] - **Denali Therapeutics**: Expected loss of 71 cents per share and revenues of $8.3 million, with updates on pipeline programs anticipated during the earnings report [17][18] Earnings Surprise Potential - The Earnings ESP methodology indicates that stocks with a positive Earnings ESP and a Zacks Rank of 1, 2, or 3 have a high chance of delivering earnings surprises, with a success rate of up to 70% [4][5]