Developing Novel Integrin-Based Therapeutics DECEMBER 2025 © 2025 PLIANT THERAPEUTICS Disclaimers This presentation has been prepared by Pliant Therapeutics, Inc. ("we," "us," "our," "Pliant" or the "Company"). The information set forth herein does not purport to be complete or to contain all of the information you may desire. Statements contained herein are made as of the date of this presentation unless stated otherwise, and this presentation shall not under any circumstances create an implication that th ...

Financial Performance - Q2 Fiscal Year 2026 - Net sales for Fiscal 2Q'26 were $247 million[6], a 16% decrease compared to the $292.6 million in 2Q'25[18] - Adjusted EBITDA for Fiscal 2Q'26 was $18 million[6], while in 2Q'25 it was $26.7 million[19] - Free cash flow improved by $47 million in 2Q'26 compared to the prior year[6] - Net debt reduced by $29.6 million, a 12% year-over-year decrease[25] Financial Performance - 1H Fiscal Year 2026 - Net sales for Fiscal 1H'26 were $487 million[6] - Adjusted EBITDA for Fiscal 1H'26 was $33 million[6] - Free cash flow for Fiscal 1H'26 was +$6 million[6] Guidance and Outlook - Fiscal year 2026 sales guidance reaffirmed at $900 million to $1 billion[7] - Fiscal year 2026 adjusted EBITDA guidance reaffirmed at $70 million to $80 million[7] - Capital expenditures are expected to be between $24 million and $29 million for fiscal year 2026[27] Strategic Focus - Aligning product portfolio with megatrends, including data centers and vehicle electrification[9] - Power Solutions offerings net sales increased from $116 million in FY22 to $252 million in FY25[13]

Financial Performance - Total revenues for Q4 2025 were $818 million, compared to guidance of $750-$850 million[11] - Adjusted homebuilding gross margin for Q4 2025 was 163%, within the guidance of 150%-165%[11] - Income from unconsolidated joint ventures was $13 million in Q4 2025, exceeding the guidance of $8-$12 million[11] - Adjusted EBITDA for Q4 2025 was $89 million, compared to guidance of $77-$87 million[11] - Adjusted income before income taxes for Q4 2025 was $49 million, compared to $126 million in Q4 2024[15] - Adjusted homebuilding gross margin decreased from 217% in Q4 2024 to 163% in Q4 2025[15] Contracts and Traffic - Contracts, including domestic unconsolidated joint ventures, decreased from 1,571 in Q4 2024 to 1,450 in Q4 2025[19] - The company's total liquidity was $2728 million in cash and cash equivalents, $63 million in restricted cash, and $1250 million available under a senior secured revolving credit facility as of October 31, 2025[8] - Total lots controlled were 38,742 as of October 31, 2025[49] - Option deposits as of October 31, 2025, were $3332 million[84]

Financial Performance - Adjusted revenue decreased by 1% to $422 million, but excluding divestitures and foreign exchange impacts, the decrease was driven by an 11% decline in Learning, offset by 5% growth in Research [38, 41] - Adjusted EPS increased by 12% to $1.10, driven by a 14% increase in Adjusted Operating Income [38, 41] - Adjusted EBITDA increased by 8% to $115 million, with the Adjusted EBITDA margin up 240 basis points to 273% [38, 41] Segment Performance - Research revenue increased by 5%, with Research Publishing up 7% and Research Solutions down 5% [41, 14, 42] - Learning revenue decreased by 11%, with Academic down 8% and Professional down 16% [41, 45] AI Initiatives - Secured a $6 million LLM training licensing agreement in Q2, bringing year-to-date AI revenue to $35 million [14] - Launched the AI Gateway, a content enrichment and distribution platform, and have over 30 publisher partners for the Nexus content licensing service [8, 14, 25] Operational Efficiency and Capital Allocation - Corporate expenses reduced by 18% in Q2 [8, 14, 52] - Share repurchases increased by 69% to $21 million in Q2, with a total of $73 million returned to shareholders YTD through dividends and repurchases [8, 54] Outlook - The company is on track to deliver full year Free Cash Flow outlook of $200M [56]

Financial Performance - SAIC's FY26 3Q revenue was $1.866 billion, a decrease compared to $1.976 billion in FY25 [13, 14] - Adjusted EBITDA for FY26 3Q was $185 million, representing 9.9% of revenue, compared to $197 million, or 10.0% of revenue, in FY25 [14] - Adjusted diluted EPS for FY26 3Q was $2.58, slightly lower than $2.61 in FY25 [15] - Free cash flow for FY26 3Q was $135 million, compared to $143 million in FY25 [18] Guidance and Targets - FY26 revenue guidance is $7.275 billion - $7.325 billion, with an organic growth rate of -2% to -3% [19] - Adjusted EBITDA guidance for FY26 is approximately $695 million, with a margin of approximately 9.5% [19] - Adjusted diluted EPS guidance for FY26 is $9.80 - $10.00 [19] - Free cash flow guidance for FY26 is greater than $550 million [19] Business Development - The TCV (Total Contract Value) of submitted bids for FY27 is projected to be greater than $30 billion [8] - The company has identified over $100 million of annual savings to reallocate to drive growth and improve margins [5] Capital Deployment - The majority of capital deployment is expected to be allocated to the share repurchase program [5] - Approximately $500 million is allocated to share repurchases for FY26 [22]

Q3 2025 Performance - Identical sales (excluding fuel) increased by 2.6%[5] - E-commerce sales grew by 17% year-over-year[5,6] - GAAP operating profit was $(1,541) million, including $2.6 billion in impairment and related charges for the automated fulfillment network[5] - Adjusted FIFO operating profit reached $1,089 million[5] - GAAP EPS was $(2.02), while adjusted EPS showed a 7% growth[5] Financial Position and Guidance - The company reaffirms its full-year 2025 guidance for identical sales without fuel to be between 2.8% and 3.0%[9] - The company expects operating profit to be in the range of $4.8 billion to $4.9 billion[9] - EPS is projected to be between $4.75 and $4.80[9] - Free cash flow is expected to be between $2.8 billion and $3.0 billion[9] - Capital expenditures are anticipated to be between $3.6 billion and $3.8 billion[9]

Financial Performance - Reported net income was $3.3 billion, with an EPS of $1.82[9] - Adjusted net income reached $3.9 billion, with an EPS of $2.18, a 27% year-over-year increase[9] - Pre-tax, pre-provision earnings (PTPP) stood at $6.7 billion[9] - Adjusted PTPP was $5.4 billion, up 25% year-over-year, excluding specific items[9] - The bank's CET1 ratio was 14.7%[9] Business Segment Highlights - Canadian Personal & Commercial Banking saw revenue increase by 5% year-over-year[40] - U S Retail net income increased 29% year-over-year[45] - Wealth Management & Insurance net income doubled year-over-year[48] - Wholesale Banking revenue increased by 24% year-over-year[52] Strategic Initiatives - The bank implemented approximately 75 AI use cases in F'25, generating $170 million in value, with expectations of $200 million in F'26[7] - Fraud losses decreased by 26% year-over-year due to investments in fraud modernization[8] - The bank is undergoing a restructuring program expected to yield annual cost savings of approximately $750 million pre-tax, involving a workforce reduction of around 3%[37]

Transaction Overview - Vodacom Group intends to acquire a 15% stake in Safaricom PLC from the Government of Kenya (GOK) and a 5% stake from Vodafone Plc, increasing Vodacom's shareholding to 55%[19] - The price is KES 34 per share for 80 billion shares in Safaricom, totaling ZAR 36 billion, which will be debt-funded[11] - Deloitte has provided an independent fairness opinion on the transaction, which is expected to be completed in the first quarter of calendar year 2026[12] Safaricom Key Metrics - Safaricom has a population footprint of 190 million and 62 million customers[13] - The company boasts over 110 million daily M-Pesa transactions and a revenue CAGR of 10% from FY21-25[13] - Safaricom's EBITDA margin is 49.5%, with 57.3% in Kenya, and it has a net debt to EBITDA ratio of 0.38x[13] - Annualized EBITDA for the six months ended 30 September 2025 is $16 billion[13] Financial Performance & Impact - Safaricom has invested KES 18 billion over five years in education, health, environment, and economic empowerment, impacting over 13 million lives[15] - M-Pesa is the largest revenue component, with service revenue progression showing an 18% CAGR from FY21-25[15] - Vodacom's average cost for the 549% stake is KES 28/share, implying a FY26 EV/EBITDA multiple of 58x[19] Vodacom Group Impact - Vodacom will have 95 million financial services customers, extending its leading fintech position[25] - The combined Vodacom and Safaricom revenue is ZAR 2200 billion, with service revenue at ZAR 1871 billion and financial services revenue at ZAR 405 billion[25] - The illustrative EBITDA split for Vodacom plus Safaricom shows South Africa contributing approximately 45%, Egypt 31%, and International Business (IB) 19%[25]

Financial Performance - Revenues increased by 14% to CA$2,250 million in FY26 Q3 compared to CA$1,974 million in FY25 Q3[13] - Normalized diluted earnings per share increased by 33% to CA$1.59 in FY26 Q3 from CA$1.20 in FY25 Q3[13] - Free cash flow generation increased by 268% to CA$320 million[16] - The company raised full-year Normalized Diluted EPS guidance from "$4.25 to $4.75" to approximately "$5.00"[15] Retail Sales and Market Trends - North American Powersports retail sales declined by 4%[16] - North American network inventory decreased by 17%[16] - Year-Round Products revenues increased by 22%[33] - Seasonal Products revenues decreased by 2%[42] Market Share and Product Performance - Can-Am SSV gained over 4 percentage points of market share in the Utility segment[37] - Can-Am ATV gained over 11 percentage points of market share in current units[37] - Sea-Doo PWC ended the North American 2025 season as the 1 market leader[46]

Financial Position & Liquidity - DPM Metals ended Q3 2025 with $414 million in cash after spending $399 million for the Adriatic transaction, $136 million to retire Adriatic's debt, and $137 million of capital returned to investors [12] - The company's total liquidity as of September 30, 2025, was $564 million [11] Chelopech Mine Exploration - A new high-grade mineralization zone (Wedge Zone Deep Discovery) was discovered on the north flank of the Chelopech mine concession, with results including 68.3 meters @ 7.42 g/t AuEq and 48.1 meters @ 9.41 g/t AuEq [18] - An ongoing 10,000-meter exploration program aims to infill and delineate the WZD target [20] - Chelopech has a strong Mineral Resource base of 1.1 million ounces of gold, 4.4 million ounces of silver, and 242 million pounds of copper [23] Čoka Rakita Feasibility Study - Mineral Reserves increased to 7.34 million tonnes at 6.44 g/t gold [33, 36] - The Mineral Resource Estimate includes 0.53 million tonnes Indicated at 3.94 g/t gold and 0.09 million tonnes Inferred at 3.60 g/t gold [32] - The project is expected to have a Life of Mine (LOM) average gold grade of 6.44 g/t and a top decile all-in sustaining cost of $644/oz gold sold [47] - The initial capital expenditure is estimated at $448 million [55] - Average annual gold production is projected at 189,000 ounces for the first five years [65] Rakita Camp Potential - An Inferred Mineral Resource Estimate establishes a district-scale platform with 2.6 million ounces of gold and 1.9 billion pounds of copper [86] - Dumitru Potok contains a significant higher-grade core of the mineral resource with 2.4 million ounces of gold and 1.7 billion pounds of copper [86] Vareš Mine Ramp-Up - Vareš is expected to have an average grade processed of 9.2 g/t AuEq and total payable production of 1.8 million ounces AuEq over its 15-year initial operating life [92] - The post-tax NPV5% is estimated at $1,585 million [92]