香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性或完整性亦 不發表任何聲明，並明確表示，概不對因本公告全部或任何部分內容而產生或因倚賴該等內容而引致的任 何損失承擔任何責任。 自願公告 重組抗人 IL-17A/F 人源化單克隆抗體注射液Ⅲ期臨床試驗 達到主要研究終點 近日，麗珠醫藥集團股份有限公司 Livzon Pharmaceutical Group Inc.*（「本公司」）控股附 屬公司珠海市麗珠單抗生物技術有限公司（「麗珠單抗」）與北京鑫康合生物醫藥科技 有限公司聯合開發的"重組抗人IL-17A/F人源化單克隆抗體注射液"（「LZM012」或「本 品」）的Ⅲ期臨床試驗達到主要研究終點。現將有關詳情公告如下： 一、藥品基本情況 藥品名稱：重組抗人IL-17A/F人源化單克隆抗體注射液 英文名/拉丁名：Recombinant anti-human IL-17A/F Humanized Monoclonal Antibody Injection 劑型：注射劑 註冊分類：治療用生物製品1類 規格：160 mg（1.6mL）/瓶 上市申請人：珠海市麗珠單抗生物技術有限公司 本公司 ...

证券代码：000513、01513 证券简称：丽珠集团、丽珠医药 公告编号：2025-050 丽珠医药集团股份有限公司 关于重组抗人IL-17A/F人源化单克隆抗体注射液Ⅲ期临床试验 达到主要研究终点的提示性公告 本公司及董事会全体成员保证信息披露内容真实、准确、完整，没有虚假记 载、误导性陈述或重大遗漏。 丽珠医药集团股份有限公司（以下简称"本公司"）控股附属公司珠海市丽珠 单抗生物技术有限公司（以下简称"丽珠单抗"）与北京鑫康合生物医药科技有限 公司联合开发的"重组抗人 IL-17A/F 人源化单克隆抗体注射液"（以下简称 "LZM012"或"本品"）的Ⅲ期临床试验达到主要研究终点。现将有关详情公告如 下： 一、药品基本情况 药品名称：重组抗人 IL-17A/F 人源化单克隆抗体注射液 英文名/拉丁名：Recombinant anti-human IL-17A/F Humanized Monoclonal 剂型：注射剂 规格：160 mg（1.6mL）/瓶 注册分类：治疗用生物制品 1 类 上市申请人：珠海市丽珠单抗生物技术有限公司 二、临床试验相关情况 该Ⅲ期临床研究是一项在中重度斑块型银屑病患者中开展 ...

Market Overview - Hong Kong stocks experienced a pullback after an initial rise, with the Hang Seng Index closing down 0.29% at 24,517.76 points and a total trading volume of 258.95 billion HKD [1] - The Hang Seng China Enterprises Index fell 0.18% to 8,861.39 points, while the Hang Seng Tech Index decreased by 0.24% to 5,418.4 points [1] - Shenwan Hongyuan remains optimistic about investment opportunities in Hong Kong and A-share markets, predicting that Hong Kong will play a crucial role in the restructuring of the global financial order [1] Blue Chip Performance - Anta Sports (02020) led blue-chip stocks, rising 2.28% to 91.85 HKD, contributing 4.55 points to the Hang Seng Index [2] - Other notable performers included Kuaishou-W (01024) up 2.13% and Trip.com Group-S (09961) up 1.59%, while Shenzhou International (02313) and Zhongsheng Holdings (00881) saw declines of 2.75% and 2.67%, respectively [2] Sector Highlights - Large tech stocks showed mixed results, with Kuaishou rising over 2% and Baidu nearly 1%, while Tencent fell 0.19% [3] - The humanoid robot sector is gaining traction, with Shengye rising nearly 15% following positive developments [3] - The innovative drug sector remains active, with Lijun Pharmaceutical rising 13% amid ongoing interest in new drug procurement [4][5] Innovative Drug Sector - The 11th batch of national drug procurement has started, focusing on mature "old drugs" while excluding innovative drugs [5] - Analysts believe that the current innovative drug market is driven by value reassessment, with domestic investors increasing their positions through Hong Kong Stock Connect [5] Stablecoin Activity - China San San Media (08087) surged 72.73% after announcing plans to apply for a stablecoin license in Hong Kong, which will officially take effect on August 1 [6] - The global regulatory framework for stablecoins is expected to lead to significant industry growth [6] New Consumption Trends - New consumption stocks showed varied performance, with Guoquan (02517) up 7.29% and Hu Shang Ayi (02589) up 1.99%, while Gu Ming (01364) fell 4.26% [7] - Guoquan expects a net profit of approximately 180 to 210 million RMB for the first half of 2025, representing a year-on-year increase of 111% to 146% [7] Notable Stock Movements - Weiyali (00854) saw a dramatic increase of 288.34% after resuming trading, reaching a peak of 33.2 HKD [8] - Chongqing Machinery (02722) rose 14.06% following news of NVIDIA resuming sales of its H20 chip in China [9] - Jiufang Zhitu Holdings (09636) increased by 10.06% as it plans to issue shares for strategic investments [10] - Quzhi Group (00917) fell 12.06% after announcing a share placement at a discount to its market price [11]

Key Points - A total of 133 stocks reached their 52-week highs as of July 16, with notable performers including 威雅利 (00854) at 909.12%, 绿心集团股权 (02999) at 135.29%, and 首都金融控股 (08239) at 65.22% [1] - 威雅利 (00854) closed at 12.660, with a peak price of 33.200, marking a significant increase of 909.12% [1] - 绿心集团股权 (02999) had a closing price of 0.020 and reached a high of 0.040, reflecting a growth of 135.29% [1] - 首都金融控股 (08239) closed at 1.590, with a maximum price of 1.900, indicating a rise of 65.22% [1] - Other notable stocks include 中国三三传媒 (08087) with a 59.54% increase, and 云能国际 (01298) with a 41.23% increase [1] - The report also lists stocks that reached their 52-week lows, with 百利达集团控股 (08179) at -7.14% and 昊天国际建投 (01341) at -6.28% [5]

Group 1 - The core viewpoint of the news is the significant performance and growth of the Hong Kong Innovative Drug ETF, which has seen a cumulative increase of over 100% in the past year, reflecting strong investor interest in the innovative drug sector [1][2] - As of July 15, 2025, the Hong Kong Innovative Drug ETF has a net asset value increase of 108.39% over the past year, ranking 1st out of 122 QDII equity funds, indicating its strong performance relative to peers [2] - The Hong Kong Innovative Drug ETF closely tracks the CSI Hong Kong Innovative Drug Index, which includes up to 50 listed companies primarily engaged in innovative drug research and development, providing a comprehensive view of the sector's performance [2] Group 2 - Recent measures introduced by the National Healthcare Security Administration and the National Health Commission aim to support the high-quality development of innovative drugs, including increased R&D support and inclusion in insurance directories [3] - The current market rally in Hong Kong's innovative drug sector is driven by a revaluation of value, with expectations for a new commercial insurance directory for innovative drugs to be launched in 2025, potentially creating a more favorable pricing environment [3] - The Hong Kong Innovative Drug ETF supports T+0 trading, enhancing liquidity and allowing investors to conduct multiple transactions within a trading day, thereby improving capital efficiency [3]

Group 1 - The Hong Kong pharmaceutical sector is experiencing positive momentum, with notable stock increases for companies such as Lijun Pharmaceutical (up over 13%), Green Leaf Pharmaceutical, and Fosun Pharmaceutical (both up over 8%) [1] - The State Medical Insurance Administration and the National Health Commission have introduced measures to support the high-quality development of innovative drugs, focusing on issues faced by the innovative drug sector and proposing 16 measures across five areas [1] - The measures aim to provide comprehensive support for the entire chain of innovative drug development, including research, market access, hospital usage, and diversified payment methods, emphasizing genuine support for innovation [1] Group 2 - Guoyuan Securities highlights the importance of increasing the commercial insurance innovative drug directory, indicating a strengthened role for commercial insurance in the multi-tiered medical security system, which is a significant step for market access [2] - The ongoing reform of medical insurance payment methods by the National Medical Insurance Administration is expected to create broader opportunities for commercial insurance, enhancing its flexibility and supplementary role in supporting high-priced innovative drugs and medical devices [2] - The aging population in China is driving a rigid growth in demand for pharmaceuticals and healthcare services, particularly among the elderly who face multiple chronic diseases, thus expanding the pharmaceutical market [2] Group 3 - The Chinese pharmaceutical industry has maintained steady growth, demonstrating resilience even during challenging economic conditions, with a notable anti-cyclical consumption pattern [3] - The increasing elderly population is not only raising the demand for basic medications but also creating a need for specialized treatments, rehabilitation care, and health monitoring services, providing ample opportunities for the development of niche markets within the pharmaceutical sector [3] - The demand growth driven by demographic changes is characterized by long-term stability, serving as a core driver for the sustained development of the pharmaceutical industry [3]

Group 1: Market Performance - The innovative drug sector in both A-shares and Hong Kong stocks experienced significant gains, with A-shares seeing a surge in stock prices, including Lianhuan Pharmaceutical achieving six consecutive trading limits within eight days [1][4] - Notable A-share stocks include Guangshentang rising over 16% and Wuwei Biological increasing nearly 15% [1][2] - In the Hong Kong market, Lijuzhiyuan led with a rise of over 13%, while other companies like Green Leaf Pharmaceutical and Fosun Pharma also showed strong performance [2][3] Group 2: Policy Support - The recent surge in the innovative drug sector is attributed to favorable policy releases, particularly the exclusion of innovative drugs from the latest round of centralized procurement, which alleviated concerns about profit margins being squeezed [4][6] - The National Healthcare Security Administration's initiation of the 2025 medical insurance drug catalog adjustment, which includes a new commercial insurance catalog for innovative drugs, further supports the sector by broadening payment channels [6][7] Group 3: Financial Performance - Leading companies in the sector are reporting strong financial results, with WuXi AppTec expecting a revenue of approximately 20.8 billion yuan, a year-on-year increase of 20.64%, and a net profit of about 6.3 billion yuan, up 44.43% [7] - Other companies like Ganli Pharmaceutical and Zhongsheng Pharmaceutical are also projecting significant profit increases, with Ganli's net profit expected to rise by 100.73% to 114.12% [7][8] Group 4: International Expansion - Chinese innovative drug companies are accelerating their international expansion, with notable deals such as the $60.5 billion authorization agreement between 3SBio and Pfizer, highlighting the global competitiveness of Chinese innovative drugs [8][9] Group 5: Future Outlook - Institutions maintain an optimistic long-term outlook for the innovative drug market, with Goldman Sachs noting that the overall market capitalization of Chinese biotech companies is still only 14%-15% of their U.S. counterparts, indicating a potential for value re-evaluation [9] - The innovative drug sector is expected to continue its upward trend, supported by policy backing and increasing global competitiveness, with a focus on selecting stocks post-rebound [9]

Group 1 - The Hong Kong stock market for innovative drug concept stocks has seen a resurgence, with notable increases in share prices for several companies [1] - Lijun Pharmaceutical surged over 14%, while Green Leaf Pharmaceutical rose over 9%, and Fosun Pharma (600196) increased nearly 8% [1] - Other companies such as Kangfang Biotech and Lianbang Pharmaceutical also experienced gains of nearly 5% [1] Group 2 - Investors can buy Hong Kong stocks through A-share accounts without the need for the Hong Kong Stock Connect, allowing for T+0 trading [1]

Economic Overview - The domestic GDP for the first half of the year reached 660,536 billion yuan, showing a year-on-year growth of 5.3% [1] - The primary industry added value was 31,172 billion yuan, growing by 3.7%; the secondary industry added value was 239,050 billion yuan, with a growth of 5.3%; and the tertiary industry added value was 390,314 billion yuan, increasing by 5.5% [1] Market Performance - The CSI 500 Quality Growth Index (930939) increased by 0.17%, with notable stock performances including LIZHU Group (000513) up by 6.71% and KEDALI (002850) up by 6.43% [1] - The CSI 500 Quality Growth ETF (560500) is showing positive momentum, currently priced at 1 yuan [1] Policy Insights - Everbright Securities noted that domestic policies have shifted towards a focus on fundamentals and liquidity since September of last year, maintaining a positive stance despite some restraint [1] - The flexibility and foresight of policy measures are expected to stabilize market expectations and promote healthy capital market development [1] Investment Opportunities - According to Shenwan Hongyuan Securities, the A-share market is accumulating positive factors, with the CSI 500 Quality Growth Index's valuation at a historical low, with a latest price-to-book ratio (PB) of 1.9 times, below 88.94% of the past three years [2] - The CSI 500 Quality Growth Index selects 100 companies with high profitability, sustainable earnings, and strong cash flow from the CSI 500 Index, providing diverse investment options [2] Top Holdings - As of June 30, 2025, the top ten weighted stocks in the CSI 500 Quality Growth Index accounted for 20.42% of the index, including Dongwu Securities (601555) and Kaiying Network (002517) [2]

Core Insights - The Hong Kong pharmaceutical sector is experiencing a strong rally, with the China Securities Hong Kong Stock Connect Pharmaceutical and Health Comprehensive Index (930965) rising by 1.50% as of July 16, 2025, driven by significant gains in individual stocks such as Lijun Pharmaceutical (01513) up 11.16% and Green Leaf Pharmaceutical (02186) up 8.55% [1][2] - The introduction of a commercial health insurance innovative drug directory by the National Healthcare Security Administration on July 11, 2025, marks a significant development, allowing for the inclusion of high-innovation drugs that exceed basic insurance coverage [1][2] - The first innovative drug directory involving commercial insurance is expected to be launched within 2025, potentially creating a more favorable pricing environment compared to traditional medical insurance negotiations [2] Industry Summary - The Hong Kong Medical ETF (513700) has seen a 1.72% increase, marking its fourth consecutive rise, with the latest price reported at 0.65 yuan [1] - The index reflects the performance of 50 liquid and large-cap healthcare companies within the Hong Kong Stock Connect, with the top ten weighted stocks accounting for 59.44% of the index [2] - The commercial health insurance sector is anticipated to experience significant growth, with potential for premium and innovative drug payment scales to increase by several multiples in the long term [2]