规模方面，截止11月10日，港股创新药ETF（159567）最新份额为96.75亿份，最新规模为80.15亿元。 回顾2024年12月31日，港股创新药ETF（159567）份额为3.95亿份，规模为3.78亿元。即该基金今年以 来份额增加2347.04%，规模增加2021.31%。 流动性方面，截止11月11日，港股创新药ETF（159567）近20个交易日累计成交金额249.64亿元，日均 成交金额12.48亿元；今年以来，207个交易日，累计成交金额2445.56亿元，日均成交金额11.81亿元。 来源：新浪基金∞工作室 11月11日，港股创新药ETF（159567）收盘跌0.48%，成交额8.54亿元。 港股创新药ETF（159567）成立于2024年1月3日，基金全称为银华国证港股通创新药交易型开放式指数 证券投资基金，基金简称为港股创新药ETF。该基金管理费率每年0.50%，托管费率每年0.10%。港股创 新药ETF（159567）业绩比较基准为国证港股通创新药指数收益率(经估值汇率调整)。 最新定期报告显示，港股创新药ETF（159567）重仓股包括百济神州、康方生物、信达生物、中国生物 制药、 ...

公司名稱: 吉輝控股有限公司 呈交日期: 2025年11月5日 I. 法定/註冊股本變動 股份發行人及根據《上市規則》第十九B章上市的香港預託證券發行人的證券變動月報表 | | | 致：香港交易及結算所有限公司 | 1. 股份分類 | 普通股 | 股份類別 | 不適用 | | 於香港聯交所上市 (註1) | | 是 | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 證券代號 (如上市) | 08027 | 說明 | 普通股 | | | | | | | | | 法定/註冊股份數目 | | | 面值 | | 法定/註冊股本 | | | 上月底結存 | | | 1,600,000,000 | HKD | | 0.03125 HKD | | 50,000,000 | | 增加 / 減少 (-) | | | | | | HKD | | | | 本月底結存 | | | 1,600,000,000 | HKD | | 0.03125 HKD | | 50,000,000 | 本月底法定/註冊股本總額： HKD 50,000,000 FF301 第 1 ...

Core Viewpoint - The Hong Kong Innovative Drug ETF (159567) has shown significant growth in both share volume and fund size since its inception, indicating strong investor interest and market performance [1][2]. Group 1: Fund Performance - As of October 31, 2024, the Hong Kong Innovative Drug ETF (159567) closed with a gain of 5.46% and a trading volume of 3.327 billion yuan [1]. - The fund's share volume increased by 1968.65% from 3.95 million shares at the end of 2023 to 81.79 million shares by October 30, 2024 [1]. - The fund's size grew by 1650.00%, from 378 million yuan to 6.612 billion yuan during the same period [1]. Group 2: Liquidity - Over the last 20 trading days, the cumulative trading amount for the fund reached 23.202 billion yuan, with an average daily trading amount of 1.16 billion yuan [1]. - Year-to-date, the cumulative trading amount for the fund is 234.346 billion yuan, averaging 1.172 billion yuan per day over 200 trading days [1]. Group 3: Fund Management - The current fund manager, Ma Jun, has managed the Hong Kong Innovative Drug ETF (159567) since its inception, achieving a return of 64.72% during the management period [2]. - The fund's top holdings include companies such as BeiGene, CanSino Biologics, Innovent Biologics, and others, with significant percentages of the portfolio allocated to these stocks [2].

Core Insights - The Hong Kong Innovative Drug ETF (159567) closed down 1.32% with a trading volume of 588 million yuan on October 28, 2024 [1] - The fund was established on January 3, 2024, with an annual management fee of 0.50% and a custody fee of 0.10% [1] - As of October 27, 2024, the fund's latest share count was 8.177 billion shares, with a total size of 6.823 billion yuan, reflecting a significant increase in both share count and size compared to the previous year [1] Fund Performance - The fund's share count increased by 1968.15% and its size increased by 1706.06% from December 31, 2023, when it had 395 million shares and a size of 378 million yuan [1] - The fund has recorded a total trading amount of 22.001 billion yuan over the last 20 trading days, averaging 1.1 billion yuan per day [1] - Year-to-date, the cumulative trading amount is 229.668 billion yuan, with an average daily trading amount of 1.166 billion yuan [1] Fund Management - The current fund manager is Ma Jun, who has managed the fund since its inception, achieving a return of 66.90% during the management period [2] - The top holdings of the fund include companies such as BeiGene, CanSino Biologics, Innovent Biologics, and others, with significant percentages of the portfolio allocated to these stocks [2] - The largest holding is BeiGene, accounting for 10.62% of the portfolio, followed by CanSino Biologics at 10.55% and Innovent Biologics at 10.21% [2]

Core Points - The Hong Kong Innovative Drug ETF (159567) closed down 0.12% with a trading volume of 797 million yuan on October 24, 2024 [1] - The fund was established on January 3, 2024, with a management fee of 0.50% and a custody fee of 0.10% [1] - As of October 23, 2024, the fund's latest share count was 8.225 billion shares, with a total size of 6.801 billion yuan, reflecting a year-to-date increase of 1980.29% in shares and 1700.12% in size [1] Fund Performance - The current fund manager is Ma Jun, who has managed the fund since its inception, achieving a return of 65.38% during the tenure [2] - The fund's performance benchmark is the National Index for Hong Kong Innovative Drugs, adjusted for valuation exchange rates [1] Liquidity and Trading Activity - Over the last 20 trading days, the ETF has accumulated a trading amount of 22.849 billion yuan, with an average daily trading amount of 1.142 billion yuan [1] - Since the beginning of the year, the ETF has recorded a total trading amount of 227.996 billion yuan over 195 trading days, averaging 1.169 billion yuan per day [1] Top Holdings - The ETF's top holdings include: - Innovent Biologics (9.52% holding, 26 million yuan market value) - WuXi Biologics (9.47% holding, 25.8 million yuan market value) - BeiGene (8.73% holding, 23.8 million yuan market value) - CanSino Biologics (7.62% holding, 20.8 million yuan market value) - China National Pharmaceutical Group (7.17% holding, 19.6 million yuan market value) [2]

Core Insights - The Hong Kong Innovative Drug ETF (159567) closed down 0.46% on October 20, with a trading volume of 907 million yuan [1] - The fund was established on January 3, 2024, with an annual management fee of 0.50% and a custody fee of 0.10% [1] - As of October 17, 2024, the fund's shares totaled 8.134 billion, with a total size of 6.968 billion yuan, reflecting a significant increase in both shares and size compared to the previous year [1] Fund Performance - The fund has seen a remarkable increase of 1957.27% in shares and 1744.35% in size since December 31, 2023 [1] - The fund's cumulative trading amount over the last 20 trading days reached 27.487 billion yuan, with an average daily trading amount of 1.374 billion yuan [1] - Year-to-date, the cumulative trading amount is 224.063 billion yuan, averaging 1.173 billion yuan per day over 191 trading days [1] Fund Management - The current fund manager is Ma Jun, who has managed the fund since its inception, achieving a return of 71.34% during the management period [2] - The fund's top holdings include companies such as Innovent Biologics, WuXi Biologics, BeiGene, and others, with significant percentages of the portfolio allocated to these stocks [2]

Core Insights - The Hong Kong Innovative Drug ETF (159567) closed with a gain of 2.42% on October 16, with a trading volume of 1.486 billion yuan [1] - The fund was established on January 3, 2024, with an annual management fee of 0.50% and a custody fee of 0.10% [1] - As of October 15, 2024, the fund's shares reached 8.213 billion, with a total size of 7.102 billion yuan, reflecting a significant increase of 1977.25% in shares and 1779.88% in size compared to December 31, 2023 [1] Fund Performance - The current fund manager, Ma Jun, has achieved a return of 68.94% since taking over the fund on January 3, 2024 [2] - The ETF's top holdings include companies such as Innovent Biologics, WuXi Biologics, BeiGene, and others, with significant percentages of the portfolio allocated to these stocks [2] Trading Activity - Over the last 20 trading days, the ETF recorded a cumulative trading amount of 30.962 billion yuan, averaging 1.548 billion yuan per day [1] - Since the beginning of the year, the ETF has seen a total trading amount of 222.219 billion yuan over 189 trading days, averaging 1.176 billion yuan per day [1]

KPM HOLDING LIMITED 吉輝控股有限公司（「本公司」）董事（「董事」）會（「董事會」）宣佈本公司於香港之 主要營業地點已更改為香港中環皇后大道中18號新世界大廈1座5樓506室，自2025 年10月16日起生效。 承董事會命 香港交易及結算所有限公司及香港聯合交易所有限公司對本公佈的內容概不負責， 對其準確性或完整性亦不發表任何聲明，並明確表示概不就因本公佈全部或任何 部分內容而產生或因依賴該等內容而引致的任何損失承擔任何責任。 吉輝控股有限公 司* （於開曼群島註冊成立的有限公司） （股份代號：8027） 香港主要營業地點變動 香港，2025年10月16日 於本公佈日期，執行董事為陳添吉先生及林欣慧女士，而獨立非執行董事為劉木 根先生、肖來文先生及陸翹彥先生。 本公佈的資料乃遵照香港聯合交易所有限公司GEM證券上市規則而刊載，旨在提 供有關本公司的資料；各董事願就本公佈的資料共同及個別地承擔全部責任。各 董事在作出一切合理查詢後，確認就其所知及所信，本公佈所載資料在各重要方 面均屬準確完備，沒有誤導或欺詐成分，且並無遺漏任何其他事項，足以令致本公 佈或其所載任何陳述產生誤導。 本公佈將自其刊 ...

致：香港交易及結算所有限公司 股份發行人及根據《上市規則》第十九B章上市的香港預託證券發行人的證券變動月報表 | | | 公司名稱: 吉輝控股有限公司 呈交日期: 2025年10月6日 I. 法定/註冊股本變動 | 1. 股份分類 | 普通股 | 股份類別 | 不適用 | | 於香港聯交所上市 (註1) | | 是 | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 證券代號 (如上市) | 08027 | 說明 | 普通股 | | | | | | | | | 法定/註冊股份數目 | | | 面值 | | 法定/註冊股本 | | | 上月底結存 | | | 1,600,000,000 | HKD | | 0.03125 HKD | | 50,000,000 | | 增加 / 減少 (-) | | | | | | HKD | | | | 本月底結存 | | | 1,600,000,000 | HKD | | 0.03125 HKD | | 50,000,000 | 本月底法定/註冊股本總額： HKD 50,000,000 FF301 第 1 ...

Core Insights - The article discusses the increasing trend of antimetabolite drugs in China, highlighting the growth in the number of brands and sales volume in recent years [1][5][11] Antimetabolite Drug Industry Definition and Classification - Antimetabolite drugs interfere with normal cellular metabolism to inhibit cell growth and proliferation, primarily used in cancer treatment [4][6] - These drugs are classified into five categories based on their target mechanisms, including thymidylate synthase inhibitors and dihydrofolate reductase inhibitors [2][6] Current Development Status of Antimetabolite Drugs - The number of antimetabolite drug brands in China has increased to 121 in 2024, with a projected rise to 130 by the first quarter of 2025 [5] - The primary product in the market is capecitabine tablets, which accounted for 51.55% of the market share in 2024, with sales of 41,478 million tablets [5][9] Sales and Market Share of Antimetabolite Drugs - In 2024, the sales volume of capecitabine tablets was 41,478 million tablets, while methotrexate tablets and tegafur capsules had sales of 15,343 million tablets and 15,566 million capsules, respectively [5] - By the first quarter of 2025, capecitabine sales were 11,409 million tablets, maintaining a market share of 54.99% [5] Industry Chain of Antimetabolite Drugs - The upstream of the antimetabolite drug industry includes raw materials like methotrexate and fluorouracil, while the midstream focuses on drug development and production [6][8] - The downstream consists of sales and distribution channels, primarily through medical institutions and pharmacies [6] Competitive Landscape of the Antimetabolite Drug Industry - Major companies in the antimetabolite drug market include Qilu Pharmaceutical, Jiangsu Hengrui Medicine, and Shanghai Pharmaceutical, with Qilu holding a market share of 40.67% in 2024 [8][9] - Sales figures for Qilu Pharmaceutical in 2024 included 22,315 million capecitabine tablets and 10,415 million tegafur capsules [8] Development Trends in the Antimetabolite Drug Industry - The demand for antimetabolite drugs is expected to grow due to an aging population and rising chronic disease rates [11] - The industry is characterized by continuous innovation supported by advancements in biotechnology and molecular biology [11]