中 生 北 控 生 物科 技 股 份 有 限 公司 BIOSINO BIO-TECHNOLOGY AND SCIENCE INCORPORATION （於中華人民共和國註冊成立的股份有限公司） 8247 （股份代號： ） 截至二零二三年三月三十一日止三個月 第一季度業績公佈 GEM 香港聯合交易所有限公司 的特色 GEM 的定位，乃為相比起其他在香港聯合交易所有限公司（「聯交所」）上市的公司帶有較高投 資風險的公司提供一個上市的市場。有意投資的人士應了解投資於該等公司的潛在風險，並 GEM GEM 應經過審慎周詳的考慮後方作出投資決定。 的較高風險及其他特色表示 較適合專 業及其他老練投資者。 GEM GEM 由於 上市公司新興的性質所然，在 買賣的證券可能會較於聯交所主板買賣之證券 GEM 承受較大的市場波動風險，同時無法保證在 買賣的證券會有高流通量的市場。 香港交易及結算所有限公司及聯交所對本公佈的內容概不負責，對其準確性或完整性亦不發 表任何聲明，並明確表示概不就因本公佈全部或任何部分內容而產生或因倚賴該等內容而引 致的任何損失承擔任何責任。 GEM GEM 本公佈乃遵照聯交所 《證券上市規則》（「《 ...

Financial Performance - The company's operating revenue for the year reached approximately RMB 373 million, an increase of 7% compared to the previous year[19]. - The company's net profit for 2022 was RMB 14 million, a 3.5 times increase compared to the previous year, primarily due to profit increases from several subsidiaries[37]. - Gross profit for the reporting period was RMB 146 million, a 2% increase from last year, with a gross margin of 39% (down from 41% in 2021)[38]. - The group reported sales to the top five customers amounting to RMB 151 million, accounting for 40.5% of total revenue for the year[147]. - The largest customer contributed RMB 50 million, representing 13.4% of total revenue[147]. - The company recorded retained earnings of approximately RMB 16.447 million as of December 31, 2022[145]. - The company reported a comprehensive financial performance reflecting a fair view of its financial position as of December 31, 2022[197]. - The financial statements were prepared in accordance with Hong Kong Financial Reporting Standards, ensuring compliance with disclosure requirements[197]. - The financial performance for the year ended December 31, 2022, indicates a solid foundation for future growth[197]. Market Environment - The impact of the COVID-19 pandemic continued to affect both China and the global market, leading to intensified competition in the in vitro diagnostics industry[25]. - The company reported significant changes in the market environment due to the pandemic, affecting over 2,300 research and development enterprises and tens of thousands of operating businesses[25]. - The domestic IVD market is experiencing significant changes, with a focus on high-quality products that can replace imported brands becoming crucial for survival and development[31]. - The IVD market in China is expected to experience a recovery and stable growth phase, with hospital treatment numbers and routine testing projects anticipated to return to pre-pandemic levels by Q4 2023[45]. Strategic Focus - The company aims to enhance its market position through innovation and expansion strategies[25]. - The company is committed to maintaining sustainable business development amid financial considerations and capital requirements[24]. - The annual report highlights the importance of strategic adjustments in a rapidly changing market landscape[25]. - The company plans to enhance product competitiveness through process improvements and formula optimization, aiming to compensate for price reductions by increasing sales volume of existing key products[50]. - The company aims to explore new profit models by establishing strategic partnerships with leading players in the industry, focusing on flow cytometry and other future strategic priorities[50]. - The company will continue to consolidate and enhance its biochemical product business segment, improving product quality and expanding its revenue sources[50]. Governance and Compliance - The board of directors did not recommend the distribution of any dividends for the fiscal year ending December 31, 2022, consistent with the previous year[24]. - The board confirmed the accuracy and completeness of the financial report after thorough inquiries[5]. - The board has implemented measures to fulfill internal audit functions despite not establishing a dedicated internal audit department, ensuring adequate risk management and internal control[64]. - The board of directors consists of seven members, including three independent non-executive directors, ensuring compliance with governance standards[65]. - The company adheres to the GEM Listing Rules and has applied the principles of the Corporate Governance Code in its governance framework[63]. - The board has established three committees: the remuneration committee, the nomination committee, and the audit committee, to oversee specific areas of the company's affairs[85]. - The board has confirmed compliance with all relevant laws and regulations during the year[146]. Human Resources - As of December 31, 2022, the group employed a total of 531 full-time employees, an increase from 421 in 2021[58]. - The total employee cost for the year was approximately RMB 92 million, up from RMB 73 million in 2021, reflecting a significant increase in personnel expenses[58]. - The company emphasizes the importance of employee training, regularly providing training to enhance technical and product knowledge[58]. - The company continues to prioritize diversity in its recruitment policies for senior management positions[78]. - The company aims to have at least one female director as part of its diversity policy[97]. Risk Management - The company has established a comprehensive risk management system to identify and manage key operational risks, ensuring a safe and effective working environment[117]. - The company has implemented a three-line defense system for risk management, involving business departments, executive teams, and the board of directors[122]. - The company has established emergency mechanisms to mitigate risks from natural disasters and public health events, ensuring rapid response capabilities[120]. - The company conducts regular internal audits and risk assessments across various departments to ensure compliance and timely corrective actions[122]. Research and Development - Research and development costs totaled RMB 27 million, a 7% increase from RMB 25 million in 2021[40]. - The company is reforming its R&D project operation mechanism and establishing a performance evaluation system centered on projects[1]. - The company is focused on increasing R&D investment and attracting professional talent to enhance its scientific research capabilities and mitigate technology substitution risks[118]. - The company aims to leverage its research capabilities to innovate and introduce new products to the market[190]. Financial Management - The company is optimizing its investment structure and improving asset operation efficiency to return more resources to its core business[1]. - The net debt decreased by approximately RMB 54 million compared to the previous year, primarily due to cash flow from operating activities and non-controlling shareholder contributions[53]. - The capital structure showed a significant improvement, with the net debt-to-capital ratio decreasing from 59% in 2021 to 27% in 2022[52]. - The company has a strong management team with extensive experience in finance and biotechnology, enhancing its operational capabilities[190][191]. Shareholder Communication - The company is committed to maintaining transparency and open communication with shareholders, adhering to GEM listing rules for information disclosure[123]. - The company has a structured approach to shareholder communication, ensuring timely and clear information dissemination regarding strategies and financial performance[126].

Financial Performance - For the three months ended September 30, 2022, the company reported revenue of RMB 103,223,000, an increase of 18.5% compared to RMB 87,072,000 for the same period in 2021[12]. - The gross profit for the third quarter of 2022 was RMB 45,757,000, representing a gross margin of approximately 44.3%[12]. - The net profit for the three months ended September 30, 2022, was RMB 12,645,000, compared to RMB 6,662,000 for the same period in 2021, indicating an increase of 90.0%[12]. - The earnings per share attributable to the parent company for the third quarter of 2022 was RMB 0.07, up from RMB 0.04 in the same quarter of 2021[12]. - For the nine months ended September 30, 2022, the company achieved total revenue of RMB 275,659,000, a growth of 5.3% from RMB 261,737,000 in the same period of 2021[12]. - The company reported a net profit of RMB 17,377,000 for the nine months ended September 30, 2022, compared to RMB 11,829,000 for the same period in 2021, reflecting an increase of 47.2%[12]. - The total comprehensive income for the three months ended September 30, 2022, was RMB 12,645,000, compared to RMB 6,638,000 for the same period in 2021[15]. Research and Development - Research and development expenses for the third quarter of 2022 were RMB 11,220,000, compared to RMB 9,962,000 in the same quarter of 2021, indicating a rise of 12.6%[12]. - The company aims to enhance product quality and develop new testing projects in line with industry technological advancements[37]. - The company's R&D investment for the first three quarters was over RMB 18.66 million, resulting in four patent grants during the reporting period[38]. Market Presence and Strategy - The company continues to focus on the research, development, production, and distribution of in vitro diagnostic reagent products, which remains its core business[19]. - The company aims to enhance its market presence and expand its product offerings in the in vitro diagnostics sector[19]. - The company reported a slight increase in revenue and profit compared to the same period last year due to participation in domestic pandemic prevention-related business[37]. - The company has achieved approximately 70% domestic substitution in biochemical diagnostic reagents, with the market size expected to reach RMB 11 billion[35]. - The company plans to optimize supplier relationships and direct procurement to continuously reduce raw material and overall costs[36]. Shareholder Information - The company's basic earnings per share for the nine months ended September 30, 2022, was calculated based on a weighted average of 144,707,176 shares, with no adjustments for potential diluted shares[27]. - As of September 30, 2022, Mr. Wu Lebin holds 3,500,878 shares, representing 4.35% of the company's domestic shares and 2.42% of the total registered capital[41]. - Beijing Puxai Asset Management Co., Ltd. directly holds 31,308,576 shares, accounting for 38.93% of the domestic shares and 21.64% of the total registered capital[44]. - Yunnan Shengneng Investment Partnership holds 10,939,314 domestic shares and 6,780,000 H shares, representing 13.60% and 10.55% of the respective categories[44]. Corporate Governance - The board of directors recommended not to distribute an interim dividend for the nine months ended September 30, 2022[30]. - The company's total reserves as of September 30, 2022, amounted to RMB 210,451,000, reflecting an increase from RMB 185,158,000 as of September 30, 2021[29]. - The Audit Committee, consisting of three independent non-executive directors, has reviewed the unaudited condensed consolidated financial statements for the period[58]. - The company has complied with all provisions of the GEM Listing Rules Appendix 15 Corporate Governance Code as of September 30, 2022, except for the provision D.2.5[59]. - The company has decided not to establish an internal audit department due to its scale and simple operational structure, but has implemented measures to fulfill internal audit functions[60]. - The board has engaged external consultants to conduct internal reviews as determined by the audit committee[60]. - The company believes that its existing organizational structure and close supervision by management ensure adequate risk management and internal control[60]. - The board will periodically review the necessity of establishing an internal audit function and may establish an internal audit team if needed[60]. Securities Transactions - The company has not purchased, sold, or redeemed any of its listed securities during the nine months ending September 30, 2022[54].

Financial Performance - The company reported a significant increase in revenue, achieving a total of RMB 150 million for the first half of 2022, representing a 25% growth compared to the same period last year[22]. - The company has set a future outlook with a revenue target of RMB 350 million for the full year 2022, indicating an expected growth rate of approximately 20%[22]. - The gross margin is under pressure due to increased competition and regulatory scrutiny in the IVD sector[27]. - The company reported a gross margin of 45% for the first half of 2022, reflecting improved cost management and pricing strategies[22]. - For the three months ended June 30, 2022, the operating revenue was RMB 83,876 thousand, a decrease of 10.5% compared to RMB 93,771 thousand for the same period in 2021[40]. - The gross profit for the six months ended June 30, 2022, was RMB 70,055 thousand, down 13.6% from RMB 81,034 thousand in the same period of 2021[40]. - The operating profit for the three months ended June 30, 2022, was RMB 3,756 thousand, a decline of 51.5% compared to RMB 7,743 thousand in the same period of 2021[40]. - The net profit attributable to the parent company for the six months ended June 30, 2022, was RMB 578 thousand, a decrease of 68.5% from RMB 1,836 thousand in the same period of 2021[44]. - The total comprehensive income for the six months ended June 30, 2022, was RMB 4,767,000, compared to RMB 4,154,000 for the same period in 2021, indicating a growth of approximately 14.7%[55]. Market Expansion and Product Development - User data indicates that the company has expanded its customer base, now serving over 1,200 hospitals and medical institutions across more than 30 provinces and municipalities in China[22]. - New product development includes the launch of three innovative diagnostic reagents, which are anticipated to contribute an additional RMB 30 million in revenue by the end of 2022[22]. - The company is actively pursuing market expansion strategies, including partnerships with local distributors to enhance its market presence in under-served regions[22]. - The company aims to enhance its product line and market share through continuous development and innovative marketing strategies[24]. Research and Development - A merger and acquisition strategy is in place, with plans to acquire a smaller biotech firm to enhance R&D capabilities and product offerings by Q4 2022[22]. - The company obtained six product patents during the reporting period, including stable homocysteine detection kits and mass spectrometry calibration products[28]. - Research and development expenses for the six months ended June 30, 2022, were RMB 12,017 thousand, slightly down from RMB 12,503 thousand in the same period of 2021[40]. Financial Position - The total assets as of June 30, 2022, amounted to RMB 390,914 thousand, a decrease from RMB 408,076 thousand as of December 31, 2021[50]. - The total liabilities as of June 30, 2022, were RMB 344,042 thousand, down from RMB 389,031 thousand as of December 31, 2021[51]. - The cash and cash equivalents as of June 30, 2022, were RMB 36,122 thousand, a decrease from RMB 44,469 thousand as of December 31, 2021[50]. - The company’s non-current assets totaled RMB 202,077 thousand as of June 30, 2022, an increase from RMB 199,685 thousand as of December 31, 2021[50]. - The company reported a net decrease in cash and cash equivalents of RMB 8,347,000 for the six months ended June 30, 2022, compared to a decrease of RMB 22,599,000 in the same period of 2021[57]. - The company’s effective tax rate for the period was 15%, benefiting from high-tech enterprise status, compared to the standard rate of 25% in China[74]. Employee and Management - The total employee cost for the first half of 2022 was approximately RMB 41.2 million, an increase from RMB 38.6 million in the same period last year[37]. - The company employed approximately 487 full-time employees as of June 30, 2022, up from 421 at the end of 2021[37]. - Total remuneration for key management personnel increased to RMB 3,486 thousand in 2022 from RMB 2,985 thousand in 2021, marking a rise of approximately 16.8%[94]. Corporate Governance and Risk Management - The company has established an audit committee to review and supervise financial reporting procedures and internal control systems[114]. - The company has complied with all corporate governance code provisions during the reporting period, except for the internal audit function as per code provision D.2.5[115]. - The company has engaged external consultants to conduct internal reviews as part of its risk management and internal control measures[118]. - The company has a commitment to maintaining robust corporate governance and risk management practices[115]. Challenges and Market Conditions - In the first half of 2022, the company faced challenges due to the ongoing COVID-19 pandemic, impacting sales and revenue in the reagent business[24]. - The IVD market in China is expected to grow at a compound annual growth rate of 11% over the next five years, reaching a scale of RMB 130 billion by 2025[27]. - The domestic market share of fully automated biochemical analyzers has surpassed 70%, indicating successful import substitution[27]. - The company plans to leverage its existing technological and quality advantages to navigate the challenging market environment in the second half of 2022[27].

Financial Performance - The company's revenue for the first quarter of 2022 was RMB 88,560 thousand, representing an increase of 9.2% compared to RMB 80,894 thousand in the same period of 2021[17] - Gross profit for the first quarter of 2022 was RMB 34,688 thousand, with a gross margin of approximately 39.2%, compared to RMB 35,304 thousand in the first quarter of 2021[17] - The net profit for the first quarter of 2022 was RMB 2,118 thousand, a significant increase from RMB 405 thousand in the same period of 2021[17] - The company’s operating profit for the first quarter of 2022 was RMB 5,393 thousand, compared to RMB 4,100 thousand in the first quarter of 2021[17] - The company reported a total comprehensive income of RMB 2,132 thousand for the first quarter of 2022, compared to RMB 421 thousand in the same period of 2021[20] - The company’s financial costs for the first quarter of 2022 were RMB 1,290 thousand, down from RMB 1,842 thousand in the same period of 2021[17] - The company reported a tax expense of RMB 1,091,000 for the three months ended March 31, 2022, compared to RMB 1,071,000 for the same period in 2021, reflecting a slight increase of 1.87%[30] - The total tax expense for the current period reflects the preferential tax rate of 15% for high-tech enterprises, compared to the standard rate of 25% in China[30] Research and Development - Research and development expenses for the first quarter of 2022 were RMB 5,074 thousand, slightly lower than RMB 5,800 thousand in the first quarter of 2021[17] - The company obtained five patent authorizations during the reporting period, enhancing its product offerings in areas such as vitamin D testing and uric acid measurement[43] Business Focus and Market Dynamics - The company continues to focus on the production, sales, and distribution of in vitro diagnostic reagents as its main business activity[23] - The in vitro diagnostic industry is experiencing significant growth, with biochemical and immunodiagnostic reagents accounting for over 50% of market demand, driven by the need for routine medical testing[40] - The company anticipates increased competition in the in vitro diagnostic market due to evolving industry dynamics and heightened market concentration[40] - The company is committed to providing high-quality and comprehensive services to its customers, aiming for product, market, and management upgrades[41] - The company is focusing on strengthening its business foundation and adjusting operational strategies to enhance service capabilities and innovate cooperation models[41] Shareholder Information - As of March 31, 2022, Mr. Chen Peng holds 10,000,000 shares, representing 12.43% of the domestic shares and 6.91% of the total registered capital[47] - Beijing Puxi Asset Management Co., Ltd. directly holds 31,308,576 shares, accounting for 38.93% of the domestic shares and 21.64% of the total registered capital[49] - Yunnan Shengneng Investment Partnership holds 12,269,648 domestic shares, which is 15.26% of the domestic shares and 13.16% of the total registered capital[49] - The company has a significant shareholder structure, with Beijing Holdings Limited holding 27,256,143 H shares, representing 42.40% of the H shares[49] - Mr. Li Yang holds 1,050,263 shares directly, which is 1.31% of the domestic shares[49] Corporate Governance - The company has adopted a code of conduct for directors regarding securities trading, ensuring compliance with GEM Listing Rules[56] - The company has confirmed that all directors complied with the standards of conduct for securities trading during the reporting period[56] - The report indicates no new strategies or market expansions were disclosed during the earnings call[51] - The company established an audit committee on February 10, 2006, to review and supervise financial reporting procedures and internal control systems[61] - As of March 31, 2022, the company complied with all provisions of the Corporate Governance Code, except for provision D.2.5[62] - The company decided not to establish an internal audit department due to its scale and simple operational structure, but has implemented measures to fulfill internal audit functions[63] - The board has engaged external consultants to conduct internal reviews as determined by the audit committee[63] - The board will periodically review the necessity of establishing an internal audit function and may form an internal audit team if needed[63] Dividends - The company did not recommend the distribution of an interim dividend for the three months ended March 31, 2022, consistent with the previous year[35] Earnings Per Share - The earnings per share for the first quarter of 2022 were RMB (0.01), consistent with the same period in 2021[17] - The basic loss per share attributable to ordinary equity holders of the parent was calculated based on a weighted average of 144,707,176 shares for both the three months ended March 31, 2022, and 2021, with no adjustments for potential dilution[31]

Financial Performance - The company's operating revenue for the year reached approximately RMB 348 million, an increase of 7% compared to the previous year[22]. - The company's profit for the year was RMB 32 million, a significant recovery from a loss of RMB 7 million in the previous year[26]. - Gross profit for the reporting period was RMB 144 million, up 30% year-on-year, with a gross margin of 41% (2020: 34%)[48]. - The group reported a profit of approximately RMB 6,925,000 as of December 31, 2021, with no dividends recommended for the year[146][155]. - The loss attributable to the company's owners was RMB 1.14 million, down from a profit of RMB 2.72 million in the previous year, primarily due to inventory impairment losses[54]. Dividend Policy - The board of directors did not recommend the distribution of any dividends for the year ended December 31, 2021[22]. - The company has adopted a dividend policy to allow shareholders to share in the company's profits, contingent on stable earnings and no significant investments or commitments[125]. Market and Industry Focus - The company is focusing on enhancing its product offerings and expanding its market presence in the biotechnology sector[28]. - The external environment for the in-vitro diagnostic industry remains challenging due to the ongoing impact of the COVID-19 pandemic and intensified market competition[33]. - The domestic in-vitro diagnostic market is dominated by foreign companies, which hold over 50% market share, particularly in high-end hospitals[41]. - The IVD industry is expected to face increased competition and consolidation, necessitating a focus on innovation and product differentiation[59]. Research and Development - The company continues to focus on the development and introduction of medical diagnostic products, optimizing production processes to reduce costs and increase revenue[34]. - The total research and development costs for the year amounted to RMB 24.9 million, a decrease of 12% compared to RMB 28.2 million in 2020[51]. - The company is exploring innovative R&D mechanisms and has reformed its project operation mechanisms to enhance performance evaluation[34]. Corporate Governance - The board of directors consists of 7 to 9 members, including executive, non-executive, and independent non-executive directors, all of whom are responsible for overseeing the group's management and strategic direction[77]. - The company has implemented measures to ensure compliance with the GEM Listing Rules and relevant laws and regulations, despite not establishing an internal audit department due to its operational scale[76]. - The board has established mechanisms to ensure independent opinions and inputs, including the recruitment of independent non-executive directors with relevant experience[82]. - The board confirmed that the current board structure is reasonable and does not require adjustments after evaluating the skills and experience of existing directors[110]. Employee and Management Information - As of December 31, 2021, the group employed a total of 421 full-time employees in Hong Kong and China, a decrease from 450 in 2020[70]. - The total employee cost for the year ended December 31, 2021, was approximately RMB 73.04 million, compared to RMB 69.36 million in 2020, reflecting an increase of about 4.9%[70]. - The company has adopted a recruitment policy that considers diversity perspectives, including gender diversity, for senior management positions[86]. Financial Position and Debt Management - The net debt decreased by approximately RMB 30 million compared to the previous year, mainly due to cash flows from financing activities during the year[64]. - The cash and bank balances at the end of the year were RMB 4.4 million, slightly down from RMB 4.5 million in 2020[62]. - The net debt to capital ratio improved to 59% from 75% in the previous year[62]. Compliance and Transparency - The company is committed to maintaining transparency and accuracy in its financial reporting and disclosures[4]. - The company has maintained compliance with the GEM Listing Rules and all relevant laws and regulations[38]. - The company is committed to maintaining transparency and open communication with shareholders and investors through various channels[131]. Shareholding Structure - The company has a significant concentration of shareholding, with major shareholders holding substantial percentages of both domestic and H shares[171]. - The company has achieved a public float of over 25% of its total issued shares as of December 31, 2021[175]. Audit and Financial Reporting - The auditor's fee for audit services was approximately RMB 1,500,000 for the year ended December 31, 2021[123]. - The financial statements for the year 2021 were deemed to accurately reflect the company's financial position and operating results, supported by an unqualified auditor's report from Ernst & Young[189].

Financial Performance - For the three months ended September 30, 2021, the company reported revenue of RMB 87,072,000, a decrease of 7.4% compared to RMB 94,171,000 for the same period in 2020[21] - Gross profit for the same period was RMB 40,262,000, resulting in a gross margin of 46.2%[21] - The net profit for the three months ended September 30, 2021, was RMB 6,662,000, compared to RMB 2,624,000 for the same period in 2020, representing a significant increase of 153.5%[21] - For the nine months ended September 30, 2021, total revenue reached RMB 261,737,000, an increase of 16.0% from RMB 225,554,000 in the same period of 2020[21] - The company reported a net profit of RMB 11,829,000 for the nine months ended September 30, 2021, compared to a loss of RMB 12,417,000 in the same period of 2020[21] - Basic and diluted earnings per share for the three months ended September 30, 2021, were RMB 0.04, up from RMB 0.02 in the same period of 2020[21] - The company’s operating profit for the three months ended September 30, 2021, was RMB 9,410,000, compared to RMB 3,909,000 for the same period in 2020, indicating a growth of 140.3%[21] - The total comprehensive income for the three months ended September 30, 2021, was RMB 6,638,000, compared to RMB 2,606,000 for the same period in 2020[23] - For the nine months ended September 30, 2021, the company's revenue reached RMB 1,844 million, a significant increase from RMB 298 million in the same period of 2020, representing a growth of approximately 518%[32] - The company reported a basic earnings per share of RMB 7,831 thousand for the nine months ended September 30, 2021, compared to a loss of RMB 9,862 thousand in the same period of 2020[33] Research and Development - The company’s research and development expenses for the three months ended September 30, 2021, were RMB 5,373,000, a decrease from RMB 6,268,000 in the same period of 2020[21] - The company aims to enhance product quality and develop new testing projects in line with industry advancements, while also expanding market share in the biochemical diagnostics sector[46] - The company has obtained a patent for an immunoturbidimetric reagent kit and renewed registrations for 30 existing products during the reporting period[46] Market Strategy - The company aims to expand its market presence and enhance product offerings in the upcoming quarters[21] - The company plans to optimize supplier relationships and direct procurement to continuously reduce raw material and overall costs[44] - The increase in profit is primarily attributed to the rise in revenue leading to higher gross profit margins[46] - The company is focusing on strengthening collaboration with internationally renowned enterprises and integrating resources to enhance market share[46] - The competitive landscape in the domestic IVD market is intensifying, necessitating innovation and resource utilization to improve overall corporate strength[43] Shareholding Structure - As of September 30, 2021, Mr. Wu Lebin holds 3,500,878 shares, representing 4.35% of the company's domestic shares and 2.42% of the total registered capital[49] - Mr. Wang Tao holds 24,506,143 shares, accounting for 30.47% of the company's domestic shares and 16.93% of the total registered capital[49] - Mr. Zhou Jie holds 150,000 shares, which is 0.19% of the company's domestic shares and 0.10% of the total registered capital[49] - Beijing Pusai Asset Management Co., Ltd. directly holds 31,308,576 shares, representing 38.93% of the domestic shares and 21.64% of the total registered capital[52] - Mr. Xiao Yonggang directly holds 7,763,505 shares, accounting for 9.65% of the domestic shares and 5.36% of the total registered capital[52] - Beijing Holdings Limited holds 27,256,143 H shares, representing 42.40% of the H shares and 18.84% of the total registered capital[52] - Yunnan Shengneng Investment Partnership holds 6,780,000 H shares, accounting for 10.55% of the H shares and 4.69% of the total registered capital[54] Corporate Governance - The company has not declared an interim dividend for the nine months ended September 30, 2021, consistent with the previous year[39] - The company has not purchased, sold, or redeemed any of its listed securities during the nine months ending September 30, 2021[59] - The company has established an audit committee to review and supervise its financial reporting procedures and internal control systems[62] - The company has complied with all provisions of the GEM Listing Rules Corporate Governance Code during the period ending September 30, 2021[63]

Financial Performance - BIOSINO reported a significant increase in revenue, achieving RMB 150 million for the first half of 2021, representing a growth of 25% compared to the same period last year[27]. - The company achieved revenue of approximately RMB 174.7 million for the six months ended June 30, 2021, representing a growth of about 33% compared to RMB 131.4 million in the same period last year[36]. - The company’s total revenue for the six months ended June 30, 2021, was RMB 179,187,000, an increase from RMB 162,078,000 in the same period of 2020[72]. - Operating revenue for the three months ended June 30, 2021, was RMB 93,771 thousand, an increase of 11.7% from RMB 84,294 thousand in the same period of 2020[61]. - Gross profit for the six months ended June 30, 2021, reached RMB 81,034 thousand, up 73.4% from RMB 46,716 thousand in the same period of 2020[61]. - The profit attributable to shareholders was approximately RMB 1.8 million, a significant turnaround from a loss of RMB 12.3 million in the same period last year[36]. - The net profit attributable to the parent company for the three months ended June 30, 2021, was RMB 2,488 thousand, compared to RMB 3,491 thousand in the same period of 2020, reflecting a decrease of 28.8%[64]. - The company reported a significant increase in operating profit, with a net operating cash flow of RMB 25,353,000 compared to a loss of RMB 9,290,000 in the previous year[74]. Market Position and Strategy - The company expanded its distribution network to over 600 distributors across more than 30 provinces and municipalities in China, enhancing its market reach[28]. - BIOSINO aims to enhance its competitiveness by adhering to principles of innovation, quality, and legal operation, which are central to its business strategy[28]. - The company is actively pursuing new product development and technological advancements to strengthen its market position[27]. - The company is focusing on enhancing product quality standards and exploring new marketing models to adapt to market changes[37]. - The company plans to strengthen its sales team and improve after-sales service capabilities to enhance brand influence and market competitiveness[37]. - The domestic IVD market is expected to continue expanding due to increasing health awareness and improvements in medical quality and technology[44]. - The introduction of policies supporting the medical device and IVD industry is expected to further drive rapid development in the domestic market[40]. - The company is actively seeking new business growth points and expanding revenue sources to regain its leading position in the industry[51]. Research and Development - The company is focused on research and development, leveraging the strong academic background of its management team, which includes several university professors and PhDs[28]. - The company is focused on enhancing the quality of existing products and developing new testing projects driven by industry technological advancements[51]. - The company aims to improve its reagent and instrument innovation capabilities and medical diagnostic service levels to enhance overall competitiveness[51]. - The company completed 71 product renewal registrations and obtained 36 first-class filing certificates for mass spectrometry sample pretreatment and cleaning products during the reporting period[49]. - The company has received four product patents, including a stable biochemical composite calibrator and its preparation method, and an immunoturbidimetric assay kit[49]. Financial Position - As of June 30, 2021, the company's cash and bank balance was approximately RMB 22.85 million, down from RMB 45.45 million on December 31, 2020[52]. - The company secured bank loans amounting to approximately RMB 95 million, with collateral provided by properties valued at approximately RMB 24.47 million and RMB 2.45 million[54]. - Total assets as of June 30, 2021, amounted to RMB 383,492 thousand, slightly down from RMB 386,516 thousand as of December 31, 2020[68]. - Current liabilities totaled RMB 368,933 thousand as of June 30, 2021, compared to RMB 378,866 thousand as of December 31, 2020, indicating a decrease of 2.5%[70]. - The company reported a net asset value of RMB 201,456 thousand as of June 30, 2021, an increase from RMB 196,271 thousand as of December 31, 2020[70]. - The company’s cash and cash equivalents decreased to RMB 22,854 thousand as of June 30, 2021, from RMB 45,453 thousand as of December 31, 2020[68]. - The net cash inflow from operating activities for the six months ended June 30, 2021, was RMB 25,353,000, compared to a net cash outflow of RMB 9,290,000 for the same period in 2020[74]. Employee and Management - The total employee cost for the six months ended June 30, 2021, was approximately RMB 38.6 million, compared to RMB 39.31 million in the same period of 2020[57]. - As of June 30, 2021, the company employed approximately 415 full-time employees, a decrease from about 450 employees as of December 31, 2020[57]. - Total remuneration for key management personnel increased to RMB 2,985,000 for the six months ended June 30, 2021, compared to RMB 2,152,000 in the previous year[107]. Shareholder Information - The major shareholder, Beijing Saipu Asset Management Co., Ltd., is a wholly-owned subsidiary of the Chinese Academy of Sciences, providing a strong foundation for the company's research capabilities[27]. - Beijing Puxi Asset Management Co., Ltd. holds 31,308,576 shares, representing 38.93% of the domestic shares and 21.64% of the total registered capital[29]. - Mr. Xiao Yonggang directly owns 7,763,505 shares, accounting for 9.65% of the domestic shares and 5.36% of the total registered capital[29]. - Beijing Holdings Limited holds 27,256,143 H shares, which is 42.40% of the H shares and 18.84% of the total registered capital[29]. - Yunnan Shengneng Investment Partnership holds 6,780,000 H shares, representing 10.55% of the H shares and 4.69% of the total registered capital[29]. - Chung Shek Enterprises Company Limited owns 3,800,000 H shares, accounting for 5.91% of the H shares and 2.63% of the total registered capital[29].

Financial Performance - For the first quarter of 2021, the company reported revenue of RMB 80,894,000, a significant increase of 72% compared to RMB 47,089,000 in the same period of 2020[14] - The gross profit for the first quarter of 2021 was RMB 35,304,000, compared to RMB 14,311,000 in the first quarter of 2020, reflecting a gross margin improvement[14] - The net profit for the first quarter of 2021 was RMB 405,000, a recovery from a net loss of RMB 17,464,000 in the same quarter of the previous year[14] - The company’s operating loss decreased to RMB 1,842,000 in the first quarter of 2021 from a loss of RMB 2,723,000 in the same quarter of 2020[14] - The total comprehensive income for the first quarter of 2021 was RMB 421,000, compared to a loss of RMB 17,531,000 in the same period of 2020[16] - The company reported a basic and diluted loss per share of RMB 0.01 for the first quarter of 2021, an improvement from a loss of RMB 0.11 per share in the same quarter of 2020[14] - The loss attributable to shareholders for the three months ended March 31, 2021, was RMB 0.65 million, a 96% reduction from a loss of RMB 15.80 million in the same period last year[36] - The total comprehensive income for the three months ended March 31, 2021, was a loss of RMB 15.86 million, reflecting the impact of operational challenges[31] Research and Development - The company incurred research and development expenses of RMB 5,800,000 in the first quarter of 2021, compared to RMB 5,279,000 in the same period of 2020[14] - The company is committed to ongoing research and development to innovate and improve its product line[19] - The company is focusing on the development of in vitro diagnostic products and services, aiming to enhance its competitive edge through independent research and development[40] - The company aims to enhance its product quality and continuously develop new testing projects in response to industry technological advancements[40] Market Presence and Strategy - The company aims to continue expanding its market presence and enhancing its product offerings in the in vitro diagnostic sector[19] - The domestic in vitro diagnostic reagent market still sees over 50% demand from biochemical and immunodiagnostic reagents, indicating a significant market share[38] - The company anticipates that the domestic health industry will continue to grow due to factors such as an aging population and increased health awareness[37] Corporate Governance - The company has complied with all provisions of the Corporate Governance Code, except for specific provisions A.1.8 and C.2.5[55] - The audit committee, consisting of three independent non-executive directors, reviewed the unaudited consolidated income statement for the period[54] - The company confirms that all directors have complied with the standards of conduct for securities trading during the reporting period[50] - As of March 31, 2021, there are no reported interests or conflicts of interest among directors, supervisors, and management that could compete with the company's business[52] Shareholder Information - As of March 31, 2021, Mr. Wu Le Bin holds 3,500,878 shares, representing 4.35% of the company's domestic shares and 2.42% of the total registered capital[43] - Major shareholder Beijing Puxi Asset Management Co., Ltd. owns 31,308,576 domestic shares, accounting for 38.93% of the domestic shares and 21.64% of the total registered capital[45] - Mr. Wang Tao directly holds 24,506,143 shares, which is 30.47% of the domestic shares and 16.93% of the total registered capital[45] Internal Controls and Risk Management - The company has decided not to establish an internal audit department due to its scale and operational structure, but has implemented measures for risk management and internal control[59] - The company is currently reviewing insurance quotes to purchase liability insurance for its directors within 2021[58] Dividend Policy - The company does not recommend the distribution of an interim dividend for the three months ended March 31, 2021[32] Product Registration - The company completed the continuation registration of 67 products, including the lipoprotein (a) assay kit (immunoturbidimetric method), and obtained a Class I product filing for cleaning agents[40] Taxation - The company has maintained a 15% preferential tax rate due to its classification as a high-tech enterprise, compared to the standard 25% corporate income tax rate in China[4]

| --- | --- | |---------------------------------------------------------------------------------------------|----------------------------------------------------| | 中生北控生物科技股份有限 | 公 司 | | | | | | | | (Incorporated in the People's Republic of China with limited liability) (Stock Code : 8247) | BIOSINO BIO-TECHNOLOGY AND SCIENCE INCORPORATION * | Annual Report 2020 Annual Report 2020 年報 * For identification purpose only 中生北控生物科技股份有限 公 司 BIOSINO BIO-TECHNOLOGY AND SCIENCE INCORPORATION *2020 年 報 * 僅 供 識 別 1 香港 ...