Summary of Altimmune Fireside Chat Company Overview - **Company**: Altimmune - **Focus**: Development of pemvidutide, a GLP-1/glucagon dual receptor agonist for treating serious liver diseases, particularly NASH (Non-Alcoholic Steatohepatitis) [3][4] Core Points and Arguments Pemvidutide and NASH - Pemvidutide is designed to have direct effects on the liver and provide metabolic benefits, primarily through weight loss [3][4] - Approximately 80% of NASH patients are overweight or obese, indicating that addressing both liver health and weight is crucial for treatment [4] - The drug shows significant reductions in liver fat, inflammation, and fibrosis, alongside weight loss [4] - Currently in a 48-week phase 2b trial for NASH, with 24-week data recently reported [5][6] Trial Design and Results - The phase 2b trial enrolled 212 patients with three treatment arms: placebo, 1.2 mg, and 1.8 mg of pemvidutide [6][7] - Class-leading NASH resolution was observed at the 24-week biopsy endpoint, exceeding results from other compounds [7][8] - Non-invasive tests showed robust anti-inflammatory and anti-fibrotic activity, with results indicating potential for FDA approval based on these tests [8][9] - The company plans to meet with the FDA to discuss transitioning from biopsy-based endpoints to non-invasive test-based endpoints for phase 3 trials [10][12] FDA Engagement and Future Plans - The company aims to align with the FDA on trial design, dose regimens, and endpoints during the end-of-phase 2 meeting [12][13] - Pemvidutide has shown excellent tolerability with no adverse event discontinuations, a significant advantage over other NASH treatments [15][17] - The company is preparing for phase 3 trials in NASH, expected to start in 2026 [5][10] Broader Implications and Market Position - The treatment landscape for NASH is evolving, with recent approvals for other drugs like semaglutide, which primarily focuses on metabolic components [23][24] - The combination of direct liver effects and weight loss in pemvidutide is positioned as a unique advantage over existing therapies [24][25] - The company is also exploring the use of pemvidutide in treating Alcohol Use Disorder (AUD) and Alcoholic Liver Disease (ALD), with ongoing trials [34][36] Additional Important Insights - The FDA has accepted applications for non-invasive tests, indicating a shift towards less invasive methods for evaluating liver health [9][10] - Pemvidutide's weight loss efficacy at the 2.4 mg dose was reported at 15.6% over 48 weeks, with potential for greater weight loss over longer periods [26][27] - The drug's ability to preserve lean mass during weight loss is highlighted as a critical factor, especially for older patients [28][29] - The company has received fast track status for AUD, emphasizing its commitment to addressing serious conditions related to obesity [39] Conclusion Altimmune is strategically positioned in the NASH treatment landscape with pemvidutide, focusing on both liver health and weight loss. The upcoming phase 3 trials and FDA meetings are critical milestones for the company's future in addressing serious liver diseases and related conditions.

Core Insights - The article discusses Stephen's unique approach to analyzing healthcare and tech stocks using his proprietary "Dizzy Framework," which aims to mitigate common behavioral errors in investment decision-making [1] Group 1: Investment Framework - The "Dizzy Framework" is designed to counteract behavioral biases such as chasing market noise and adhering too rigidly to prior beliefs [1] - The framework emphasizes the importance of the quality and timing of information, promoting a patient and disciplined investment approach [1] - Stephen's analysis translates complex scientific and market dynamics into actionable investment theses [1] Group 2: Influences and Background - Stephen's background includes experience as a Registered Nurse (RN) and an MBA, which informs his investment analysis [1] - Influences on Stephen's investment philosophy include concepts from "Superforecasting" and "Fooled by Randomness," highlighting a probabilistic approach to predictions [1] Group 3: Personal Interests - In his personal time, Stephen enjoys family activities, managing a fantasy baseball team, and contemplating existential questions [1]

Altimmune (NasdaqGM:ALT) FY Conference September 09, 2025 08:30 AM ET Speaker0Back to h c Wainwright's twenty seventh annual global investor conference held on September 2025. My name is Patrick Trucchio. I'm a senior health care analyst at h c Wainwright. That said, it's my pleasure to introduce our next company, Altimmune, a late stage biopharmaceutical company focused on developing novel peptide based therapeutics for liver and cardiometabolic diseases. Company's lead program is pembidutide, a GLP-one gl ...

NEW YORK , Sept. 8, 2025 /PRNewswire/ -- The Gross Law Firm issues the following notice to shareholders of Altimmune, Inc. (NASDAQ: ALT). ...

Core Viewpoint - A class action securities lawsuit has been filed against Altimmune, Inc. due to alleged securities fraud that negatively impacted investors between August 10, 2023, and June 25, 2025 [1][2]. Group 1: Lawsuit Details - The lawsuit was initiated following Altimmune's announcement on June 26, 2025, regarding the topline results from the IMPACT Phase 2b MASH trial of Pemvidutide, which failed to achieve statistical significance in its primary endpoint of fibrosis reduction [2]. - The company's stock price plummeted from $7.71 per share on June 25, 2025, to $3.61 per share on June 26, 2025, marking a significant decline of 53.2% in just one day [2]. Group 2: Investor Information - Investors who suffered losses during the specified timeframe have until October 6, 2025, to request appointment as lead plaintiff, although participation in any recovery does not require serving in this role [3]. - Class members may be entitled to compensation without incurring any out-of-pocket costs or fees [3]. Group 3: Legal Firm Background - Levi & Korsinsky, LLP has a strong track record in securities litigation, having secured hundreds of millions of dollars for shareholders over the past 20 years [4]. - The firm has been recognized in ISS Securities Class Action Services' Top 50 Report for seven consecutive years as one of the leading securities litigation firms in the United States [4].

Core Viewpoint - Rosen Law Firm is reminding investors who purchased Altimmune, Inc. securities between August 10, 2023, and June 25, 2025, about the October 6, 2025, deadline to become a lead plaintiff in a class action lawsuit [1]. Group 1: Class Action Details - A class action lawsuit has been filed against Altimmune, and investors may be entitled to compensation without any out-of-pocket fees through a contingency fee arrangement [1][2]. - To join the class action, investors can submit a form online or contact the law firm directly for more information [2][5]. - The lawsuit claims that Altimmune misrepresented the results of its IMPACT Phase 2b MASH trial, failing to meet a key statistical significance marker for fibrosis reduction [4]. Group 2: Legal Representation - Investors are encouraged to select qualified legal counsel with a proven track record in securities class actions, as many firms may not have the necessary experience or resources [3]. - The Rosen Law Firm has a history of successful settlements, including the largest securities class action settlement against a Chinese company at the time, and has recovered hundreds of millions of dollars for investors [3]. Group 3: Case Specifics - The lawsuit alleges that Altimmune created a false impression regarding the reliability of its trial results, which ultimately led to investor damages when the true results were revealed [4].

Core Viewpoint - Altimmune, Inc. is facing a class action securities lawsuit due to alleged securities fraud that affected investors between August 10, 2023, and June 25, 2025 [1] Group 1: Lawsuit Details - The lawsuit was initiated following Altimmune's announcement on June 26, 2025, regarding the topline results from the IMPACT Phase 2b MASH trial of Pemvidutide, which failed to achieve statistical significance in its primary endpoint of fibrosis reduction [2] - The company's stock price plummeted from $7.71 per share on June 25, 2025, to $3.61 per share on June 26, 2025, marking a decline of 53.2% in just one day [2] Group 2: Next Steps for Investors - Investors who suffered losses during the specified timeframe have until October 6, 2025, to request the Court to appoint them as lead plaintiff, although participation in any recovery does not require serving as a lead plaintiff [3] - Class members may be entitled to compensation without any out-of-pocket costs or fees [3] Group 3: Firm Background - Levi & Korsinsky, LLP has a strong track record in securities litigation, having secured hundreds of millions of dollars for shareholders over the past 20 years [4] - The firm has been recognized in ISS Securities Class Action Services' Top 50 Report for seven consecutive years as one of the leading securities litigation firms in the United States [4]

Core Viewpoint - Altimmune, Inc. is facing a class action securities lawsuit due to alleged securities fraud that negatively impacted investors between August 10, 2023, and June 25, 2025 [1][2]. Group 1: Lawsuit Details - The lawsuit was initiated following Altimmune's announcement on June 26, 2025, regarding the topline results from the IMPACT Phase 2b MASH trial of Pemvidutide, which failed to achieve statistical significance in its primary endpoint of fibrosis reduction [2]. - The company's prior communications had created inflated expectations, but the trial results revealed a higher-than-expected placebo response, leading to a significant stock price drop [2]. - Following the announcement, Altimmune's stock plummeted from $7.71 per share on June 25, 2025, to $3.61 per share on June 26, 2025, marking a decline of 53.2% in one day [2]. Group 2: Next Steps for Investors - Investors who suffered losses during the specified timeframe have until October 6, 2025, to request appointment as lead plaintiff in the lawsuit [3]. - Participation in the lawsuit does not require serving as a lead plaintiff, and there are no out-of-pocket costs for class members [3]. Group 3: Firm Background - Levi & Korsinsky, LLP has a strong track record in securities litigation, having secured hundreds of millions of dollars for shareholders over the past 20 years [4]. - The firm has been recognized in ISS Securities Class Action Services' Top 50 Report for seven consecutive years, highlighting its expertise in complex securities litigation [4].

Core Viewpoint - Rosen Law Firm is reminding investors who purchased Altimmune, Inc. securities between August 10, 2023, and June 25, 2025, about the October 6, 2025, deadline to become a lead plaintiff in a class action lawsuit [1] Group 1: Class Action Details - A class action lawsuit has been filed against Altimmune, and investors may be entitled to compensation without any out-of-pocket fees through a contingency fee arrangement [1][2] - To participate in the class action, investors can submit a form or contact the law firm for more information [2][5] - The lawsuit claims that Altimmune misrepresented the results of its IMPACT Phase 2b MASH trial, leading to investor damages when the true results were revealed [4] Group 2: Law Firm Credentials - Rosen Law Firm has a strong track record in securities class actions, having achieved significant settlements, including the largest against a Chinese company at the time [3] - The firm has been consistently ranked among the top firms for securities class action settlements since 2013, recovering hundreds of millions for investors [3] - In 2019, the firm secured over $438 million for investors, showcasing its effectiveness in litigation [3]

Core Viewpoint - Altimmune, Inc. is facing a class action lawsuit following the announcement of disappointing results from its IMPACT Phase 2b MASH trial of Pemvidutide, leading to a significant drop in its stock price [3][4]. Group 1: Company Overview - Altimmune, Inc. is a biopharmaceutical company involved in developing treatments for liver diseases, specifically targeting MASH (Metabolic Dysfunction-associated Steatotic Liver Disease) [3]. - The company reported topline results from the IMPACT Phase 2b MASH trial on June 26, 2025, which failed to meet statistical significance for its primary endpoint related to fibrosis reduction [3]. Group 2: Stock Performance - Following the announcement of the trial results, Altimmune's stock price plummeted from $7.71 per share on June 25, 2025, to $3.61 per share on June 26, 2025, marking a decline of 53.2% in just one day [3]. Group 3: Legal Proceedings - The class period for the lawsuit is defined as August 10, 2023, to June 25, 2025, and shareholders are encouraged to register for potential recovery [3][4]. - The deadline for shareholders to seek lead plaintiff status is October 6, 2025, and there is no cost or obligation to participate in the case [4]. Group 4: Allegations - The complaint alleges that Altimmune provided inflated expectations regarding the trial results, which ultimately did not materialize due to a higher-than-expected placebo response [3]. - The company's response to the trial's failure was described as indifferent, attributing the results to the Phase 2 nature of the trial and expressing hope for better outcomes in the Phase 3 trial [3].