AnaptysBio (ANAB) FY 2025 Conference September 04, 2025 11:00 AM ET Speaker0All right. Thank you, sir. Appreciate you. Alright. We'll do that again.So thanks everyone for joining the next fireside here. My name is Derek Archila. I'm with Wells Fargo. We're very excited to have Anaptis Bio here. We got the CEO, Dan Vega.Dan, great to have you here.Speaker1Thank you very much.Speaker0Good to see you. All right. Well, let's get started. Maybe kind of just level set us here. It's been a busy year already.Maybe ...

AnaptysBio (ANAB) 2025 Conference September 03, 2025 08:00 AM ET Company ParticipantsPrakhar Agrawal - Managing DirectorDaniel Faga - President & CEOPrakhar AgrawalAll right. Hello, everyone. Good morning. Welcome to day one of the CANTER Global Healthcare Conference. For the first session today, we have AnaptysBio. My name is Prakhara Gurwal. I'm a biotech analyst on CANTER. Joining us from AnaptysBio, we have Dan Faga, President and Chief Executive Officer. Dan, thank you for coming to us.Daniel FagaGood ...

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ Quarterly Report pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the quarterly period ended June 30, 2025 OR ☐ Transition report pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the transition period from to . Commission File Number: 001-37985 ANAPTYSBIO, INC. (Exact name of registrant as specified in its charter) Delaware 20-3828755 (State or other jurisdiction of incorpo ...

PORTFOLIO UPDATES Anaptys Announces Second Quarter 2025 Financial Results and Provides Business Update SAN DIEGO, August 6, 2025 — AnaptysBio, Inc. (Nasdaq: ANAB), a clinical-stage biotechnology company focused on delivering innovative immunology therapeutics, today reported financial results for the second quarter ended June 30, 2025, and provided a business update. "Rosnilimab's Phase 2b data in rheumatoid arthritis (RA) delivered a compelling safety and tolerability profile and JAK- like efficacy through ...

Core Insights - AnaptysBio reported positive Phase 2b data for rosnilimab in rheumatoid arthritis, demonstrating a favorable safety profile and JAK-like efficacy, with durable responses observed for at least 12-14 weeks off-drug [2][5] - The company completed enrollment for a Phase 2 trial of rosnilimab in ulcerative colitis, with top-line data expected in Q4 2025 [4][9] - AnaptysBio plans to initiate a Phase 1b trial for ANB033, a CD122 antagonist targeting celiac disease, by Q4 2025 [2][4] Financial Updates - As of June 30, 2025, AnaptysBio reported cash and investments totaling $293.7 million, down from $420.8 million at the end of 2024, primarily due to operating activities and share repurchases [13] - Collaboration revenue for Q2 2025 was $22.3 million, compared to $11.0 million in Q2 2024, driven by increased royalties from Jemperli [13] - The net loss for Q2 2025 was $38.6 million, an improvement from a net loss of $46.7 million in Q2 2024, with a net loss per share of $1.34 compared to $1.71 in the prior year [13][19] Pipeline Developments - Rosnilimab's Phase 2b trial for rheumatoid arthritis involved 424 patients and showed a best-in-disease profile with monthly dosing [5] - The company is assessing different dosing levels for rosnilimab in the ulcerative colitis trial, with a primary endpoint focused on the modified Mayo score [9] - Ongoing Phase 1 trials for ANB033 and ANB101 are in healthy volunteers, with plans for further updates on ANB033 at a dedicated R&D event later this year [4][6] Collaboration and Milestones - AnaptysBio anticipates a $75 million milestone payment from GSK in 2025 once Jemperli achieves $1 billion in worldwide net sales [4][10] - GSK reported strong sales performance for Jemperli, with Q2 2025 sales of $262 million, reflecting over 19% quarter-over-quarter growth [10]

Rosnilimab (PD-1 depleter and agonist) in Rheumatoid Arthritis (RA) - Rosnilimab is well-positioned for the ~$20 billion U S RA market, which hasn't had a new mechanism approved since 2012[14] - In b/tsDMARD-naïve patients, Rosnilimab shows JAK-like efficacy, with 64% achieving CDAI LDA, 48% achieving ACR50, and 23% achieving ACR70[28] - In b/tsDMARD-experienced patients, Rosnilimab surpassed the 6-month Target Product Profile (TPP) and is comparable at mid/high dose to JAKs in all-active H2H study[30] - 83% of Week 28 CDAI LDA responders were still in response at Week 34, demonstrating durable responses for at least 2-months off-drug[33] - Synovial biopsies show ~90% reduction of PD-1+ T cells in the target issue with 400mg/600mg doses[39, 40] Rosnilimab in Ulcerative Colitis (UC) - Initial Phase 2 data for Rosnilimab in Ulcerative Colitis is expected in Q4 2025[2, 78] - Enrollment is ongoing in the Phase 2 trial for moderate-to-severe UC, with interim 6-month data expected in Q4 2025[60] - The primary endpoint of the UC trial is the change in modified Mayo score (mMS) vs placebo at Week 12[62] ANB033 (CD122 antagonist) - Phase 1 trial of ANB033 in healthy volunteers has been initiated, with an R&D event planned for H2 2025[63, 78] - ANB033 is designed to reduce pathogenic T cells and NK Cells by potently inhibiting IL-15 and IL-2 biology[63, 65, 66] Financial Position - The company has a strong capital position with ~$383 million in cash as of Q1 2025, expected to provide a cash runway through YE 2027[7, 69, 76]

Summary of AnaptysBio (ANAB) FY Conference Call - June 11, 2025 Company Overview - AnaptysBio is focused on developing antibodies targeting overactive immune cells in autoimmune inflammatory diseases, with three clinical stage programs in development [3][5][20]. Key Programs and Data - **Rozanolimab**: Lead program targeting rheumatoid arthritis (RA) with promising Phase 2b data showing 70% of patients achieving low disease activity at three months [3][13]. - **Ozanelimab**: Ongoing trial for ulcerative colitis (UC) with initial data expected by the end of 2025 [4][8]. - **ANB033**: A CD123 antagonist that started Phase 1a in October 2024 [5]. - **AMB101**: A BTCA2 modulator with plans for an R&D event later in 2025 [5]. Financial Position - Company reported $383 million in cash at the end of Q1 2025 and has access to a significant royalty stream from GSK's drug JEMPRIRLY [5][6]. Upcoming Catalysts - Key upcoming catalysts include: - Phase 2b results for rozanolimab in RA [7]. - Initial data readout for ozanelimab in UC [4][8]. - Royalty readout from GSK's lung cancer trial involving cabolumab [8][11]. Market Dynamics - The RA market has not seen a new mechanism of action approved since 2012, indicating a potential opportunity for rozanolimab [12]. - The company believes the RA market is less crowded than perceived, with few competitors in Phase III development [12][20]. Efficacy and Safety Data - Rozanolimab demonstrated significant efficacy with over 80% of patients achieving ACR20 (20% improvement) [16]. - Safety profile appears favorable with no serious infections or malignancies reported in the Phase 2b trial [50][51]. - The drug targets PD-1 high expressing T cells, aiming to restore immune homeostasis without broadly depleting T cells [46][48]. Competitive Landscape - AnaptysBio's rozanolimab is positioned against other treatments like JAK inhibitors and biologics, with a focus on achieving deeper and more durable responses [17][56]. - The company views the discontinuation of competing PD-1 drugs by other firms as a positive indicator of its drug's potential [53][56]. Future Directions - The company is considering partnerships for further development in RA and UC, with a focus on maximizing the drug's potential in various autoimmune diseases [22][33]. - AnaptysBio is exploring additional indications beyond RA and UC, leveraging its PD-1 depleting mechanism [60][62]. Conclusion - AnaptysBio is well-positioned with a strong financial base, promising clinical data, and a strategic focus on autoimmune diseases, particularly RA and UC, with significant upcoming milestones that could enhance its market position [81].

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Group 1 - AnaptysBio, Inc. (NASDAQ: ANAB) reported positive results from its phase 2b study for a PD-1 depleter and agonist drug aimed at treating moderate-to-severe rheumatoid arthritis (RA) [2] - The study's results indicate potential for the drug to address significant unmet medical needs in the RA patient population [2] Group 2 - The Biotech Analysis Central service offers in-depth analysis of pharmaceutical companies, including a library of over 600 biotech investing articles and a model portfolio of small and mid-cap stocks [2]

Core Insights - AnaptysBio, Inc. has released updated data from the Phase 2b trial of rosnilimab, demonstrating significant efficacy in treating rheumatoid arthritis [1][2] - The drug showed durable responses and was well tolerated compared to standard biologics and JAK inhibitors [2][4] - Analyst Emily Bodnar upgraded AnaptysBio's rating from Neutral to Buy, raising the price target from $22 to $38 based on positive trial data [4] Efficacy and Safety - In a 424-patient trial, rosnilimab achieved JAK-like efficacy on multiple measures, including low disease activity (LDA) and remission on the Clinical Disease Activity Index (CDAI) [1] - At Week 12, all three doses of rosnilimab (100mg Q4W, 400mg Q4W, 600mg Q2W) showed statistically significant reductions in DAS-28 CRP and ACR20 compared to placebo [2] - By Week 12, 45% of patients achieved CDAI LDA, increasing to 69% by Week 14 across all doses [2] Patient Outcomes - Rosnilimab demonstrated clinically meaningful improvements in patient-reported outcomes, including pain visual analog scale (VAS) and HAQ-Disability Index [4] - As of the March 11, 2025 data cutoff, 83% of patients remained in LDA at Week 34, with a median CDAI of 13 for those not sustaining LDA [3] Competitive Landscape - Data from the SELECT-CHOICE trial indicated similar efficacy results for AbbVie’s Rinvoq and Bristol Myers Squibb’s Orencia, aligning with rosnilimab's outcomes [5] - In contrast, Eli Lilly's discontinued PD-1 agonist peresolimab showed a decline in CDAI LDA rates, highlighting rosnilimab's stronger performance [6] - Johnson & Johnson is expected to present early data for its PD-1 agonist at the upcoming EULAR conference, although its study is smaller than AnaptysBio's [6]