Core Insights - BioCryst Pharmaceuticals reported its strongest financial performance in history for Q2 2025, driven by significant revenue growth and operating profit from ORLADEYO [2][6][7] Financial Performance - ORLADEYO net revenue reached $156.8 million, reflecting a 45% year-over-year increase [6][7] - Total revenues for Q2 2025 were $163.4 million, up 50% from $109.3 million in Q2 2024 [7] - Operating profit for Q2 2025 was $29.8 million, a 239% increase year-over-year, while non-GAAP operating profit was $57.0 million, up 160% [10] Market Dynamics - New patient prescriptions for ORLADEYO were the highest ever in a quarter, exceeding the first quarter of the launch by over 10% [6][4] - The U.S. market contributed 89.5% of global ORLADEYO net revenues in Q2 2025 [6] Debt Management - The company made an additional $50 million paydown of term debt and plans to retire all remaining term debt with proceeds from the sale of its European ORLADEYO business [14] Pipeline Development - BioCryst is on track to submit a new drug application for ORLADEYO granules for children aged 2 to 11 by December 12, 2025 [5] - The company expects initial data from two clinical programs by the end of 2025 [2][15] Cash Flow and Outlook - Cash, cash equivalents, and investments totaled $287.1 million as of June 30, 2025, with net cash utilization of $30.4 million for the quarter [13] - The company maintains its full-year 2025 global net ORLADEYO revenue guidance between $580 million and $600 million, excluding European revenue [15][16]

Core Insights - BioCryst Pharmaceuticals (BCRX) is expected to report its Q2 2025 results on August 4, with revenue estimates of $148.85 million and earnings per share (EPS) of 3 cents [1][7] - The Zacks Consensus Estimate for BCRX's 2025 EPS has decreased from 16 cents to 13 cents over the past 60 days, while the 2026 EPS forecast has improved from 44 cents to 48 cents [2] Financial Performance - BCRX has shown mixed performance in the last four quarters, with two earnings beats, one match, and one miss, averaging an earnings surprise of 12.94% [5][6] - The last reported quarter saw a 100% earnings surprise [5] Upcoming Earnings Expectations - The company is likely to see increased sales from Orladeyo due to strong prescription trends, while SG&A costs are expected to rise due to global launch activities [7][10] - R&D expenses are anticipated to decline due to pipeline restructuring [13] Product and Pipeline Updates - Orladeyo is approved for preventing hereditary angioedema (HAE) attacks in patients aged 12 and older, with a label expansion application for younger patients currently under FDA review [10][11] - The FDA has cleared the investigational new drug application for BCX17725, targeting Netherton syndrome, with patient enrollment expected to begin soon [12] Market Position and Competition - BCRX has gained 9.3% year-to-date, outperforming the industry and S&P 500, but is trading below its 50 and 200-day moving averages [14] - The company faces competition from Ionis Pharmaceuticals and Intellia Therapeutics in the HAE treatment space, as well as from other companies in the Netherton syndrome indication [22][23] Strategic Focus - BioCryst aims to expand Orladeyo's market presence through increased global commercial activities and is looking to diversify its pipeline for other rare diseases [24]

RESEARCH TRIANGLE PARK, N.C., July 31, 2025 (GLOBE NEWSWIRE) -- BioCryst Pharmaceuticals, Inc. (Nasdaq: BCRX) today announced that its president and chief executive officer, Jon Stonehouse, has informed the board of directors of his intention to retire on December 31, 2025. The board has appointed Charlie Gayer, currently the company's chief commercial officer (CCO), as the company's next president, effective August 1, 2025, and next chief executive officer, effective January 1, 2026. "I am grateful for Jon ...

Core Viewpoint - BioCryst Pharmaceuticals (BCRX) is anticipated to report a year-over-year increase in earnings and revenues for the quarter ended June 2025, with the actual results having a significant impact on its near-term stock price [1][2]. Financial Expectations - The upcoming earnings report is expected to show quarterly earnings of $0.03 per share, reflecting a year-over-year increase of 150% [3]. - Revenues are projected to be $148.85 million, which is a 36.2% increase from the same quarter last year [3]. Estimate Revisions - The consensus EPS estimate has remained unchanged over the last 30 days, indicating that analysts have not significantly reassessed their initial estimates [4]. - For BioCryst, the Most Accurate Estimate is lower than the Zacks Consensus Estimate, resulting in an Earnings ESP of -66.67%, suggesting a bearish outlook from analysts [11]. Earnings Surprise History - In the last reported quarter, BioCryst was expected to post a loss of $0.07 per share but instead delivered break-even earnings, resulting in a surprise of +100.00% [12]. - Over the past four quarters, the company has beaten consensus EPS estimates two times [13]. Industry Comparison - In the Zacks Medical - Drugs industry, Indivior PLC (INDV) is expected to report earnings of $0.26 per share for the same quarter, indicating a year-over-year decline of 40.9% [17]. - Indivior's revenue is projected to be $244.27 million, down 18.3% from the previous year, but it has an Earnings ESP of +11.54%, suggesting a likelihood of beating the consensus EPS estimate [18][19].

RESEARCH TRIANGLE PARK, N.C., July 21, 2025 (GLOBE NEWSWIRE) -- BioCryst Pharmaceuticals, Inc. (Nasdaq: BCRX) today announced that the company will report its second quarter 2025 financial results on Monday, August 4, 2025. BCRXW Contact: John Bluth +1 919 859 7910 jbluth@biocryst.com About BioCryst Pharmaceuticals BioCryst Pharmaceuticals is a global biotechnology company with a deep commitment to improving the lives of people living with hereditary angioedema and other rare diseases. BioCryst leverages it ...

Core Insights - BioCryst Pharmaceuticals will present new findings on the burden of current treatments for hereditary angioedema (HAE) on pediatric patients under 12 and their caregivers at the 2025 US HAEA National Summit [1][2] - The company emphasizes its commitment to the HAE patient community and its efforts to develop effective treatments, including the first oral, once-daily prophylactic therapy for HAE [2] Company Overview - BioCryst Pharmaceuticals is a global biotechnology company focused on improving the lives of individuals with hereditary angioedema and other rare diseases [12] - The company has commercialized ORLADEYO (berotralstat), the first oral plasma kallikrein inhibitor for HAE, and is advancing a pipeline of small-molecule and protein therapies [12] Product Information - ORLADEYO is indicated for the prophylaxis of HAE attacks in adults and pediatric patients aged 12 years and older [5] - The product works by decreasing the activity of plasma kallikrein, preventing HAE attacks with a once-daily capsule [4] Research Presentation - BioCryst will present three abstracts at the summit, focusing on patient perspectives, treatment burdens for pediatric patients, and interim analysis results of prophylactic berotralstat in pediatric patients aged 2 to under 12 years [3][10]

Company Overview - BioCryst Pharmaceuticals (BCRX) is part of the Medical group, which consists of 987 companies and is currently ranked 6 in the Zacks Sector Rank [2] - The Zacks Rank system identifies stocks with characteristics likely to outperform the market in the short term, with BioCryst Pharmaceuticals holding a Zacks Rank of 2 (Buy) [3] Performance Metrics - Over the past 90 days, the Zacks Consensus Estimate for BCRX's full-year earnings has increased by 324.2%, indicating improved analyst sentiment and a positive earnings outlook [4] - Year-to-date, BCRX has returned 18.9%, significantly outperforming the average return of -3.1% for Medical companies [4] - BioCryst Pharmaceuticals belongs to the Medical - Drugs industry, which includes 155 companies and is currently ranked 67 in the Zacks Industry Rank, with an average gain of 3.5% year-to-date [6] Comparative Analysis - Another outperforming stock in the Medical sector is Cardinal Health (CAH), which has increased by 39.5% year-to-date and has a Zacks Rank of 2 (Buy) [5] - Cardinal Health is part of the Medical - Dental Supplies industry, which has a current ranking of 27 and has seen a year-to-date increase of 0.7% [7]

RESEARCH TRIANGLE PARK, N.C., July 07, 2025 (GLOBE NEWSWIRE) -- BioCryst Pharmaceuticals, Inc. (Nasdaq: BCRX) today announced the appointment of Babar Ghias as chief financial officer (CFO) and head of corporate development. Mr. Ghias joins BioCryst from AvenCell Therapeutics, a clinical-stage CAR-T company focused on hematologic malignancies, where he served as CFO since 2022. "Babar brings extensive deal making and operational experience in addition to his previous roles as a CFO at rare disease companies ...

Summary of BioCryst Pharmaceuticals (BCRX) Conference Call Company Overview - **Company**: BioCryst Pharmaceuticals (BCRX) - **Event**: Conference call regarding the sale of the European business - **Date**: June 27, 2025 Key Points Industry and Company Strategy - BioCryst Pharmaceuticals is focused on creating value through three main drivers: 1. Establishing ORLIDEAL as a global market leader with a target of $1 billion in peak revenue [5] 2. Launching new products from its pipeline to ensure sustainable growth [6] 3. Strengthening financial independence and profitability to facilitate business development opportunities [6] Sale of European Business - BioCryst announced the sale of its European business to NeoPharmad Gentile (NG) for $250 million, which includes the PEOPLE and Orlodayo products in Europe [5][6] - The deal is expected to provide up to $14 million in future milestones related to sales in Central and Eastern Europe [7] - The European business accounts for less than 10% of global sales and has lower margins compared to other regions [7] Financial Impact - The upfront cash from the sale will be used to pay off all remaining term debt, saving approximately $70 million in interest payments over the loan's remaining life [8] - By the end of 2027, BioCryst anticipates having nearly $700 million in cash with no term debt, an improvement of about $400 million in net cash from previous projections [8] - The transaction is expected to significantly enhance profitability by focusing on higher-margin business primarily in the U.S. [8] Royalty Structure - The agreement allows BioCryst to benefit from European revenue in global royalty calculations, with NG responsible for royalties from European sales [10] - This structure will help reduce future royalty payments significantly once certain thresholds are reached [10] Future Growth and Pipeline - BioCryst is excited about two main pipeline programs: 17,725 for Netherlands and oral staff for DME, and is in a stronger financial position to fund these programs [23] - The company does not plan to expand its sales force but aims to optimize performance with the existing team of 40 representatives [24] Business Development Strategy - BioCryst is looking to acquire additional products, particularly in the rare disease space, with a focus on later-stage programs [32] - The company aims to be a consolidator in the U.S. market, similar to NG's strategy in Europe [33] Regulatory Updates - The PDUFA date for the pediatric Orlodayo NDA has been extended to December 12 due to a major amendment, but the company remains confident about the product's potential [51] Cost Savings - The sale is expected to result in a minimum of $50 million in annual operating expense savings, effective after the transaction closes [61] Additional Insights - The transaction aligns with BioCryst's strategy to enhance financial strength and operational efficiency [13] - The company emphasizes the importance of cash flow and profitability, particularly from the U.S. market, which is seen as the most valuable contributor to the company's financial health [26] This summary encapsulates the key discussions and strategic insights from the BioCryst Pharmaceuticals conference call, highlighting the company's focus on financial strength, strategic sales, and future growth opportunities.

Core Viewpoint - BioCryst Pharmaceuticals has entered into a definitive agreement to sell its European ORLADEYO business to Neopharmed Gentili for up to $264 million, which includes $250 million upfront and up to $14 million in future milestones [1][8] Financial Impact - BioCryst plans to use the proceeds from the transaction to retire all remaining term debt of $249 million, eliminating approximately $70 million in future interest payments [2][8] - The company expects to end 2027 with approximately $700 million in cash and no term debt, an increase of $400 million from prior net cash guidance [2][8] Strategic Rationale - The transaction aligns with BioCryst's strategy to make ORLADEYO available to patients in Europe while providing capital to retire debt, resulting in a higher margin business [3] - Neopharmed Gentili aims to leverage this acquisition to enhance its position in the rare disease field and strengthen its growth trajectory as a leading European specialty pharmaceutical company [4] Operational Efficiency - The acquisition will enable commercial continuity for ORLADEYO and is expected to result in at least $50 million in annual operating expense savings for BioCryst [8] Advisory and Legal Support - BofA Securities, Inc. and TD Cowen are serving as financial advisors to BioCryst, while Centerview Partners UK LLP is acting as exclusive financial advisor to Neopharmed Gentili [6]