Group 1 - BioCryst Pharmaceuticals (BCRX) closed at $10.59, with a 26.2% gain over the past four weeks, and a mean price target of $16.50 indicating a 55.8% upside potential [1] - The average of 12 short-term price targets ranges from a low of $11 to a high of $30, with a standard deviation of $5.32, suggesting variability in analyst estimates [2] - Analysts show strong agreement on BCRX's ability to report better earnings than previously predicted, which supports the potential for stock upside [4][11] Group 2 - The Zacks Consensus Estimate for the current year has increased by 366.9% over the past month, with six estimates revised higher and no negative revisions [12] - BCRX holds a Zacks Rank 2 (Buy), placing it in the top 20% of over 4,000 ranked stocks based on earnings estimates [13] - While consensus price targets may not be reliable for predicting stock gains, they can indicate potential price movement direction [13]

Core Insights - BioCryst Pharmaceuticals announced significant real-world evidence demonstrating the effectiveness of ORLADEYO (berotralstat) in reducing hereditary angioedema (HAE) attack rates in adolescents and individuals with severe HAE over an 18-month follow-up period [1][3][7] Group 1: Study Findings - The study presented at the ISPOR 2025 conference showed that patients experienced significantly lower HAE attack rates while on ORLADEYO, with a reduction from a baseline of 7.78-8.23 attacks/month to 1.24-1.90 attacks/month [10] - Specifically, patients had 6.25 fewer attacks/month at 12 months and 6.43 fewer attacks/month at 18 months after starting ORLADEYO [10] - Adolescents aged 12-17 years also showed significant reductions, with 1.56 fewer attacks/month at 12 months and 1.85 fewer attacks/month at 18 months [10] Group 2: Patient Population - The findings were based on a retrospective pre-post study involving 56 U.S. patients with C1-inhibitor deficiency and 99 U.S. adolescents with HAE [5][6] - The results indicate that ORLADEYO is effective across different age groups and severity levels of HAE, providing confidence to both physicians and patients [3][7] Group 3: Product Information - ORLADEYO is the first and only oral therapy specifically designed for the prophylaxis of HAE attacks in patients aged 12 years and older, functioning as a plasma kallikrein inhibitor [8][9] - The therapy is administered as a once-daily capsule, which works by decreasing the activity of plasma kallikrein to prevent HAE attacks [8]

Summary of BioCryst Pharmaceuticals (BCRX) Conference Call Company Overview - **Company**: BioCryst Pharmaceuticals (BCRX) - **Event**: 2025 Conference on May 14, 2025 - **Speakers**: John Stonehouse (CEO), Charlie Geier (Chief Commercial Officer) Key Industry Insights - **Impact of Executive Orders**: The recent executive order regarding most favored nation status may affect BioCryst, but details are still unclear. The company is monitoring the situation closely [3][4][5] - **Tariff Position**: BioCryst feels well-positioned regarding tariffs due to low cost of goods for Orlodea and a redundant supply chain in both Europe and the US [8] Financial Performance - **Q1 Results**: BioCryst reported a 51% year-over-year growth in Q1, driven by strong demand and an increase in the paid rate for Orlodea [13][14] - **Paid Rate Increase**: The paid rate for patients has jumped to 84%, with Medicare segment reaching 89%, attributed to the IRA making drugs more affordable [15] - **Sales Guidance**: The company is confident in achieving at least $800 million in US sales, with a global sales target of $1 billion by 2029 [27][29] Product Insights - **Orlodea**: The product has shown strong market demand and patient retention due to its efficacy and convenience. Patients prefer Orlodea for its oral administration and low attack rates [18][19][20][22] - **Market Stickiness**: The stickiness of the market is attributed to patient satisfaction with Orlodea, making it difficult for new competitors to gain traction [20] Pipeline Developments - **BCX1775**: The company is advancing its first biologic for Netherton Syndrome, aiming to control KLK activity and improve skin turnover [36][38] - **Avorostat**: This drug is being explored for diabetic macular edema (DME), with a focus on its potential to address unmet needs in patients who do not respond to VEGF therapies [68][70] Clinical Trials and Future Outlook - **Clinical Trials**: BioCryst is conducting studies for both BCX1775 and Avorostat, with expectations for data by the end of the year. The company is optimistic about the potential for accelerated pathways to market if results are favorable [61][66][78] - **Market Potential**: The company believes that the market for Netherton Syndrome could grow significantly if a targeted therapy is introduced, similar to the growth seen in other rare diseases [56] Conclusion - BioCryst Pharmaceuticals is positioned for strong growth with its current product offerings and pipeline developments. The company is actively monitoring regulatory changes and market dynamics while focusing on delivering effective therapies for rare diseases.

–FDA grants Priority Review of application, with PDUFA target action date of September 12, 2025– –ORLADEYO would be the first targeted oral prophylactic therapy for patients with HAE under the age of 12, if approved– RESEARCH TRIANGLE PARK, N.C., May 14, 2025 (GLOBE NEWSWIRE) -- BioCryst Pharmaceuticals, Inc. (Nasdaq: BCRX) today announced that the U.S. Food and Drug Administration (FDA) has accepted its New Drug Application (NDA) for the use of oral, once-daily ORLADEYO (berotralstat) in pediatric patients ...

Group 1: BioCryst Pharmaceuticals, Inc. (BCRX) - BioCryst has a Zacks Rank 1 and the Zacks Consensus Estimate for its current year earnings increased by 285.7% over the last 60 days [1] - The company's shares gained 15% over the last three months, while the S&P 500 declined by 7.2% [1] - BioCryst possesses a Momentum Score of A [1] Group 2: WidePoint Corporation (WYY) - WidePoint has a Zacks Rank 1 and the Zacks Consensus Estimate for its current year earnings increased by 108.3% over the last 60 days [2] - The company's shares gained 35.7% over the last three months, compared to the S&P 500's decline of 7.2% [2] - WidePoint possesses a Momentum Score of B [2] Group 3: Rambus Inc. (RMBS) - Rambus has a Zacks Rank 1 and the Zacks Consensus Estimate for its current year earnings increased by 3.9% over the last 60 days [3] - The company's shares gained 11.6% over the past month, while the S&P 500 advanced by 6.9% [3] - Rambus possesses a Momentum Score of B [3]

Group 1 - Chain Bridge Bancorp, Inc. (CBNA) has seen a 9.5% increase in the Zacks Consensus Estimate for its current year earnings over the last 60 days [1] - Fresenius Medical Care AG (FMS) has experienced a 4.5% increase in the Zacks Consensus Estimate for its current year earnings over the last 60 days [1] - Brenntag SE (BNTGY) has seen a 14.1% increase in the Zacks Consensus Estimate for its next year earnings over the last 60 days [2] - WidePoint Corporation (WYY) has experienced a significant 108.3% increase in the Zacks Consensus Estimate for its current year earnings over the last 60 days [2] - BioCryst Pharmaceuticals, Inc. (BCRX) has seen an impressive 285.7% increase in the Zacks Consensus Estimate for its current year earnings over the last 60 days [3]

Core Viewpoint - BioCryst Pharmaceuticals (BCRX) is positioned as a strong investment opportunity due to its improving earnings outlook and analysts' increasing earnings estimates [1][2]. Earnings Estimates - Analysts are optimistic about BioCryst's earnings prospects, leading to higher estimates that are expected to positively impact the stock price [2]. - The current quarter's earnings estimate is projected at $0.02 per share, reflecting a significant increase of +133.33% from the previous year [5]. - For the full year, the earnings estimate is expected to be $0.13 per share, representing a change of +130.95% from the prior year [6]. Estimate Revisions - Over the last 30 days, the Zacks Consensus Estimate for BioCryst has increased by 158.18%, with three estimates moving higher and no negative revisions [5]. - The consensus estimate for the current year has seen a remarkable increase of 341.56% during the same period [7]. Zacks Rank - BioCryst currently holds a Zacks Rank 2 (Buy), indicating strong agreement among analysts in revising earnings estimates upward [8]. - Stocks with Zacks Rank 1 (Strong Buy) and 2 (Buy) have historically outperformed the S&P 500 [8]. Stock Performance - BioCryst shares have appreciated by 48.9% over the past four weeks, suggesting strong investor confidence in the company's earnings growth prospects [9].

Core Viewpoint - Momentum investing focuses on following a stock's recent price trends, aiming to buy high and sell higher, with the expectation that established trends will continue [1] Company Summary: BioCryst Pharmaceuticals (BCRX) - BCRX currently holds a Momentum Style Score of A, indicating strong momentum characteristics [2] - The company has a Zacks Rank of 2 (Buy), suggesting it is positioned for potential outperformance in the market [3] - Over the past week, BCRX shares increased by 6.44%, significantly outperforming the Zacks Medical - Drugs industry, which rose by 0.39% [5] - In a longer timeframe, BCRX's monthly price change is 48.89%, compared to the industry's 6.21% [5] - Over the last quarter, BCRX shares rose by 14.81%, and they have increased by 97.65% over the past year, while the S&P 500 saw movements of -6.34% and 9.94%, respectively [6] - The average 20-day trading volume for BCRX is 5,448,160 shares, indicating strong trading activity [7] Earnings Outlook - In the past two months, 6 earnings estimates for BCRX have been revised upwards, with no downward revisions, leading to an increase in the consensus estimate from -$0.07 to $0.13 [9] - For the next fiscal year, 6 estimates have also moved upwards without any downward revisions [9] Conclusion - Considering the strong momentum indicators and positive earnings outlook, BCRX is identified as a 2 (Buy) stock with a Momentum Score of A, making it a potential candidate for near-term investment [11]

Core Viewpoint - BioCryst Pharmaceuticals (BCRX) has shown a significant price increase of 48.9% over the past four weeks, with a mean price target of $16.25 indicating a potential upside of 61.2% from the current price of $10.08 [1] Price Targets and Analyst Estimates - The mean estimate consists of 12 short-term price targets with a standard deviation of $5.66, indicating variability among analysts; the lowest estimate is $8 (20.6% decline), while the highest is $30 (197.6% increase) [2] - Analysts' price targets can often mislead investors, as empirical research shows that they rarely indicate the actual price direction of a stock [7] - A low standard deviation in price targets suggests a high degree of agreement among analysts regarding the stock's price movement, which can serve as a starting point for further research [9] Earnings Estimates and Analyst Consensus - There is growing optimism among analysts regarding BCRX's earnings prospects, as indicated by a strong consensus in revising EPS estimates higher, which correlates with potential stock price increases [11] - The Zacks Consensus Estimate for the current year has increased by 341.6% over the past month, with five estimates rising and no negative revisions [12] - BCRX holds a Zacks Rank 2 (Buy), placing it in the top 20% of over 4,000 ranked stocks based on earnings estimates, suggesting a strong potential upside [13]

BioCryst Pharmaceuticals (BCRX) Conference Call Summary Company Overview - BioCryst Pharmaceuticals is a commercial stage and profitable biotech company focused on developing medicines for rare diseases, particularly hereditary angioedema (HAE) [3][4] - The company's commercial product, Orlodeo, is a once-daily oral pill for HAE patients, which has been on the market for about five years and is projected to generate peak sales of $1 billion [4][6] Financial Performance - BioCryst raised its sales guidance for Orlodeo to $580 to $600 million for the current year [5][27] - The company is in a strong cash position and expects to be profitable on a full-year basis moving forward [6] Product Success and Market Dynamics - Orlodeo's success is attributed to its efficacy and convenience, with approximately 60% of patients experiencing significant efficacy [9][10] - The product has seen strong demand, with about half of its business coming from patients switching from injectable therapies [10][11] - Market research indicates that patients require compelling reasons to switch therapies, which has contributed to Orlodeo's steady growth [22][23] Pipeline Developments - BioCryst has two additional programs in clinical trials: one for Netherton syndrome (Phase 1) and another for diabetic macular edema (DME) [5][6] - The company anticipates data from both programs by the end of the year [50][66] Netherton Syndrome - Netherton syndrome is a severe rare disease with no current treatment options, affecting skin turnover and leading to significant health risks [50][51] - BioCryst's product, BCX 17725, aims to replace the missing protein that regulates skin turnover [51][52] - The estimated patient population for Netherton syndrome in the U.S. is between 3,000 to 5,000 [55] Diabetic Macular Edema (DME) - Avorostat, initially developed for HAE, is being repurposed for DME using a suprachoroidal delivery method [60][61] - The company is set to begin patient enrollment for the DME trial in Australia [62] Market Research and Competitive Landscape - BioCryst employs comprehensive market research, including Monte Carlo simulations, to accurately forecast sales and understand market dynamics [18][19] - The company maintains a competitive edge in the oral prophylactic space against injectable therapies, with Orlodeo and Tekxaro being market leaders [20][21] Future Outlook - The company aims to achieve $800 million in U.S. sales by adding approximately 200 new patients annually and achieving an 85% reimbursement rate [30][32] - The pediatric formulation of Orlodeo is expected to significantly impact the market, with an estimated 500 affected children in the U.S. [38][39] - BioCryst plans to continue building its cash balance and has already paid off $75 million of its debt early this quarter [68] Conclusion - BioCryst Pharmaceuticals is positioned for continued growth with a strong commercial product, a promising pipeline, and a solid financial outlook, making it a notable player in the biotech sector focused on rare diseases [69]