Financial Data and Key Metrics Changes - The company achieved a reduction in annual run rate costs of $205 million between Q1 2024 and Q1 2025, surpassing the initial target of $200 million [7] - Cash and cash equivalents on the balance sheet stand at $517 million with no bank debt, positioning the company strongly among peers in the biotechnology sector [8][26] - Total company adjusted EBITDA improved to negative $47 million in Q1 2025 from negative $117 million in Q1 2024, indicating significant progress in profitability [17] - Cash burn decreased to $58 million in Q1 2025 from $104 million in Q1 2024, reflecting the impact of restructuring efforts [18] Business Line Data and Key Metrics Changes - Cell engineering revenue reached $38 million in Q1 2025, a 37% increase year-over-year, with a 10% increase to $31 million when excluding noncash revenue [11] - The biosecurity business generated $10 million in revenue in Q1 2025, with a segment gross margin of 28% [13] - The number of revenue-generating programs in cell engineering increased by 32% year-over-year, totaling 123 programs [12] Market Data and Key Metrics Changes - The company has 28 government projects across cell engineering and biosecurity, with a contracted backlog exceeding $180 million [32] - The company is positioned to benefit from increased government investment in biotechnology, as highlighted by recent speeches from government officials [28][32] Company Strategy and Development Direction - The company aims to reach adjusted EBITDA breakeven by the end of 2026 while maintaining a cash margin of safety [4] - The strategic focus includes expanding the tools business and enhancing the way the platform is sold, moving beyond traditional R&D solutions [6][21] - The company is actively pursuing opportunities in the automation and data points sectors, leveraging its expertise in high-throughput screening and AI [46][84] Management's Comments on Operating Environment and Future Outlook - The management expressed optimism about the biotechnology sector's resilience despite current market challenges, emphasizing that companies that navigate this period successfully will be in a strong position [9][26] - The management highlighted the importance of government funding for biotechnology and expressed confidence in the continuation of such funding [32][96] Other Important Information - The company has made significant strides in cost reduction while continuing to serve existing customers effectively [7][20] - The introduction of new metrics for revenue-generating programs aims to provide more useful data for analysts and investors [12] Q&A Session Summary Question: Is there an opportunity for data points to evolve into a SaaS cloud computing product? - The management acknowledged the potential for Ginkgo to assist large pharma companies with data architecture and automation technology, but clarified that the approach to market is still being evaluated [87][89] Question: Can you provide more details on the ARPA H contract and its revenue recognition? - The ARPA H contract is valued at $29 million over two years, with revenue expected to be recognized accordingly, which significantly derisks the revenue guidance for the year [94][95] - The management remains hopeful about the continuation of funding for biotechnology projects despite potential cuts in government spending [96]

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q ______________________________________________ (Mark One) x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2025 OR o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from _________________ to _________________ Commission File Number: 001-40097 ______________________ ...

Revenue Performance - Total revenue for Q1 2025 was $48 million, a 27% increase from $38 million in the same period last year, primarily due to a $7 million non-cash revenue release[6]. - Cell Engineering revenue for Q1 2025 was $31 million, up 10% from $28 million in the prior year, driven by growth with biopharma and government customers[6]. - Cell Engineering revenue increased to $38,230,000 in Q1 2025 from $27,889,000 in Q1 2024, representing a growth of 37.5%[19]. - Total revenue for Q1 2025 was $48,318,000, up from $37,944,000 in Q1 2024, marking a 27.5% increase[19]. - Full year 2025 revenue guidance updated to $167-$187 million, with Cell Engineering revenue projected at $117-$137 million[12]. Financial Losses and Improvements - GAAP net loss for Q1 2025 was $(91) million, an improvement from $(166) million in the same period last year[6]. - Net loss narrowed to $90,957,000 in Q1 2025 compared to a net loss of $165,911,000 in Q1 2024, improving by 45.0%[19]. - Basic net loss per share improved to $(1.68) in Q1 2025 from $(3.31) in Q1 2024[19]. - Adjusted EBITDA for Q1 2025 was $(47) million, an improvement from $(117) million in the prior year, attributed to increased revenue and decreased operating expenses[6]. - Adjusted EBITDA for Q1 2025 was $(47,451,000), an improvement from $(117,001,000) in Q1 2024[29]. - The total segment operating loss for Q1 2025 was $(36,773,000), compared to $(103,471,000) in Q1 2024, reflecting a significant reduction in losses[25]. Cost Management - The company aims to achieve $250 million in annualized cost reductions by the end of Q3 2025, with a current run-rate cost reduction of $205 million[6]. - Research and development expenses decreased to $70,923,000 in Q1 2025 from $136,457,000 in Q1 2024, a reduction of 48.0%[19]. - Total operating expenses decreased to $137,286,000 in Q1 2025 from $215,946,000 in Q1 2024, a decline of 36.4%[19]. - The company incurred restructuring charges of $5,273,000 in Q1 2025, primarily related to employee termination costs[26]. Cash and Backlog - Cash, cash equivalents, and marketable securities as of March 31, 2025, totaled $517 million[6]. - Cash and cash equivalents at the end of Q1 2025 were $312,420,000, down from $840,440,000 at the end of Q1 2024[23]. - Ginkgo has a contracted backlog of approximately $180 million across 28 US Government projects in Cell Engineering and Biosecurity[6]. Market Position and Growth - Ginkgo's Datapoints and Automation offerings are gaining traction, including a new deal with Aura Genetics, marking its first diagnostics company customer[6]. - The company is well-positioned in the biotechnology sector, which is emphasized as a critical area of national importance by US government reports[6].

Core Insights - Ginkgo Bioworks has made significant progress in its restructuring efforts, targeting $250 million in cost savings by Q3 2025 [1][3][7] - The company reported a total revenue of $48 million for Q1 2025, a 27% increase from $38 million in the same period last year, primarily due to a $7 million non-cash revenue release [6][22] - Ginkgo's Solutions business is becoming a trusted R&D service provider for the US Government and biopharma industry, while its Tools business is gaining traction in AI-related opportunities [3][7] Financial Performance - Q1 2025 total revenue was $48 million, with $31 million from Cell Engineering (up 10% year-over-year) and $10 million from Biosecurity (flat year-over-year) [6][22] - The company reported a GAAP net loss of $91 million for Q1 2025, an improvement from a net loss of $166 million in the prior year [6][22] - Adjusted EBITDA for Q1 2025 was $(47) million, an improvement from $(117) million in the prior year, driven by increased revenue and reduced operating expenses [6][22] Strategic Positioning - Ginkgo is well-positioned in the biotechnology sector, with 28 US Government projects and a contracted backlog of approximately $180 million [7] - The company is focusing on biosecurity and R&D services, which are deemed critical by national policy reports [7] - Ginkgo's Datapoints and Automation offerings are generating new deals, including a recent agreement with Aura Genetics [7] Guidance and Outlook - Ginkgo has updated its 2025 guidance to reflect total revenue expectations of $160-$180 million, with Cell Engineering revenue projected at $110-$130 million and Biosecurity revenue at least $50 million [5][13] - The company aims to achieve Adjusted EBITDA breakeven by the end of 2026 [7]

Core Insights - Phytolon and Ginkgo Bioworks have successfully completed the second development milestone in their collaboration to produce natural food colors, leading to an equity milestone distribution to Ginkgo [1][6] - The collaboration aims to develop yeast strains for vibrant, functional replacements to synthetic dyes, responding to regulatory pressures and consumer demand for natural alternatives [2][9] Industry Context - There is increasing regulatory pressure in the U.S. to eliminate artificial food dyes due to health concerns, with initiatives from the FDA and state-level bans on synthetic dyes [3] - The shift towards natural color alternatives is being accelerated by consumer demand and government actions, creating a significant market opportunity for companies like Phytolon and Ginkgo [3][9] Company Developments - Ginkgo Bioworks utilized its AI modeling and high-throughput screening to enhance production efficiency by nearly three times, allowing Phytolon to meet coloring standards across various food categories [4] - Phytolon's fermentation-based process is more energy-efficient and cost-effective compared to traditional farming methods for natural colors, reducing production costs and carbon footprint [5] Future Prospects - The achievement of the second milestone positions Ginkgo to gain additional equity in Phytolon, paving the way for further collaborations in the natural food color sector [6][9] - Phytolon is set to introduce "Beetroot Red" and "Prickly Pear Yellow" in U.S. markets pending FDA approval, expanding its product offerings in the food and beverage market [5][11]

Core Insights - Ginkgo Bioworks Holdings, Inc. plans to host a presentation and Q&A session to review its business performance for Q1 2025 on May 6, 2025, at 5:30 p.m. ET [1] - The presentation details and a replay will be available on Ginkgo's investor relations website [2] - Ginkgo Bioworks is recognized as a leading platform for cell programming, offering services across various markets including food, agriculture, pharmaceuticals, and chemicals [3] Company Overview - Ginkgo Bioworks provides flexible, end-to-end services to address challenges in diverse sectors [3] - The company is also focused on biosecurity, developing infrastructure and technologies to manage biological threats [3] - For further information, Ginkgo maintains an active presence on social media and its websites [3]

Company Performance - Ginkgo Bioworks Holdings, Inc. closed at $7.60, reflecting a +0.8% change from the previous day, underperforming the S&P 500 which gained 1.67% [1] - Over the past month, the company's shares increased by 5.9%, while the Medical sector and S&P 500 saw declines of 9.34% and 6.57% respectively [1] Upcoming Earnings - The upcoming earnings release is expected to show an EPS of -$1.23, a 61.56% increase compared to the same quarter last year [2] - Revenue is anticipated to be $41.26 million, indicating an 8.74% increase from the same quarter last year [2] Fiscal Year Projections - For the entire fiscal year, earnings are projected at -$3.72 per share, representing a +64.09% change from the prior year, while revenue is expected to be $171.48 million, reflecting a -24.47% change [3] Analyst Estimates - Recent changes to analyst estimates indicate confidence in the company's business performance and profit potential [4] - The Zacks Rank system, which assesses estimate changes, currently ranks Ginkgo Bioworks Holdings, Inc. at 2 (Buy) [6] Industry Context - The Medical - Biomedical and Genetics industry, part of the Medical sector, holds a Zacks Industry Rank of 77, placing it in the top 32% of over 250 industries [7] - Research indicates that top-rated industries outperform lower-rated ones by a factor of 2 to 1 [7]

GINKGO BIOWORKS INVESTOR CONTACT: [email protected] GINKGO BIOWORKS MEDIA CONTACT: [email protected] AURA GENETICS MEDIA CONTACT: [email protected] Forward-Looking Statements of Ginkgo Bioworks This press release contains certain forward-looking statements within the meaning of the federal securities laws, including statements regarding the capabilities and potential success of the partnership and Ginkgo's cell programming platform. These forward-looking statements generally are identified by the words "bel ...

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Group 1 - Ginkgo Bioworks Holdings, Inc. (DNA) has experienced a significant decline of 28.8% over the past four weeks, but it is now in oversold territory, indicating a potential trend reversal [1] - The Relative Strength Index (RSI) for DNA is currently at 20.73, suggesting that the heavy selling pressure may be exhausting itself, which could lead to a reversal towards the previous equilibrium of supply and demand [5] - There is strong consensus among Wall Street analysts that DNA will report better earnings than previously predicted, with the consensus EPS estimate increasing by 37.9% over the last 30 days [7] Group 2 - DNA holds a Zacks Rank 2 (Buy), placing it in the top 20% of over 4,000 ranked stocks based on earnings estimate revisions and EPS surprises, indicating a strong potential for a turnaround [8]