The most talked about and market moving research calls around Wall Street are now in one place. Here are today's research calls that investors need to know, as compiled by The Fly.Top 5 Upgrades: TD Cowen upgraded Medpace (MEDP) to Hold from Sell with a price target of $419, down from $462. The shares have re-rated from a peak multiple and now reflect fair value, the firm tells investors in a research note.Citizens upgraded Rush Street Interactive (RSI) to Outperform from Market Perform with a $24 price ta ...

Medpace Holdings Under Investigation After Book-to-Bill Miss Exposes Cancellation Surge and Pipeline Fragility [Accessibility Statement] Skip Navigation(NASDAQ: MEDP)NEW YORK, Feb. 18, 2026 /PRNewswire/ -- Levi & Korsinsky, LLP is investigating Medpace Holdings, Inc. (NASDAQ: MEDP) concerning potential securities law claims on behalf of shareholders. The investigation centers on whether the company and its senior officers made statements about the health of its clinical-trial booking pipeline that were inco ...

New York, New York--(Newsfile Corp. - February 17, 2026) - Levi & Korsinsky notifies investors that it has commenced an investigation into Medpace Holdings, Inc. ("Medpace Holdings, Inc.") (NASDAQ: MEDP) concerning potential violations of the federal securities laws.On February 10, 2026, Medpace shares fell approximately 10% by mid-day and closed down 15.9%, according to data from Quiver Quantitative and GuruFocus. Approximately $10.2 million in trading volume was recorded during the sell-off, reflecting h ...

Core Viewpoint - The article discusses the investment positions of various analysts and the recommendations made by The Motley Fool regarding Medpace, highlighting the firm's involvement in the stock market [1] Group 1 - Jason Hall, Lou Whiteman, and Toby Bordelon do not hold any positions in the stocks mentioned [1] - The Motley Fool has positions in and recommends Medpace, indicating a positive outlook on the company's stock [1]

Core Insights - Zelluna has announced a clinical partnership with Medpace to support the first clinical trial of its lead product candidate, ZI-MA4-1, which is an allogeneic T Cell Receptor-based Natural Killer (TCR-NK) cell therapy for solid cancers [1][3][9] Company Overview - Zelluna ASA is pioneering TCR-NK cell therapies targeting solid cancers, with ZI-MA4-1 being the world's first MAGE-A4 targeting TCR-NK therapy [7] - The company is headquartered in Oslo, Norway, and is listed on the Oslo Stock Exchange under the ticker ZLNA [7] Clinical Development - The partnership with Medpace is a strategic move for Zelluna as it transitions from preclinical to clinical stage, providing access to necessary infrastructure and expertise for executing a complex cell therapy trial [3][6] - The planned Phase 1 study will assess safety, tolerability, and early signs of clinical activity in patients with advanced solid cancers, including lung cancer, ovarian cancer, head and neck cancer, and sarcomas [5][9] - Initial clinical data from the study is expected to emerge from mid-2026, marking the first clinical validation of Zelluna's proprietary TCR-NK platform [5][9] Medpace's Role - Medpace will provide comprehensive clinical development services, including clinical operations, trial management, regulatory support, data management, and pharmacovigilance [3][9] - Medpace has a strong track record in early-phase development and oncology, which aligns with Zelluna's goals for the ZI-MA4-1 study [6][10]

Financial Performance - The company reported a significant increase in revenue, achieving $1.5 billion for the fiscal year, representing a 20% year-over-year growth[8] - The company reported a net income of $300 million, a 15% increase compared to the previous year[8] - Operating margins improved by 5%, reaching 25%, due to cost optimization strategies implemented during the year[9] - The board approved a dividend increase of 10%, reflecting the company's strong financial performance and commitment to returning value to shareholders[9] User Growth - User data showed a 15% increase in active users, reaching 2 million by the end of the quarter[8] Future Projections - The company provided an optimistic outlook, projecting a revenue growth of 25% for the next fiscal year, driven by new product launches and market expansion[9] - The company aims to launch three new products in the next fiscal year, expected to contribute an additional $300 million in revenue[9] Market Expansion - The company plans to expand its market presence in Asia, targeting a 10% market share increase in the region over the next two years[9] Research and Development - Investment in research and development increased by 30%, totaling $200 million, focusing on innovative technologies and product enhancements[9] Strategic Acquisitions - A strategic acquisition was completed, enhancing the company's capabilities in the biopharmaceutical sector, valued at $500 million[9] Market Analysis - Market data in the report is based on management's estimates and industry sources, indicating reliance on third-party publications[12] - The report defines large pharmaceutical companies as the top 20 by worldwide prescription drug sales, highlighting the competitive landscape[15] - Mid-sized biopharmaceutical companies are identified as those with at least $250 million in sales, indicating a significant market segment[16] - Small biopharmaceutical companies are defined as those with less than $250 million in sales, showcasing the diversity in the industry[17] Clinical Trials - Phase I trials typically involve 20 to 100 subjects and focus on establishing safety and dosage[18] - Phase II trials evaluate efficacy and safety in a few hundred patients, lasting one to two years[19] - Phase III trials assess the clinical product candidate in larger populations, lasting from one to four years, crucial for regulatory approval[20] - Phase IV trials monitor long-term risks and benefits of approved drugs, enrolling thousands of patients[21] Risk Factors - The company acknowledges the inherent uncertainty in market position and performance projections due to various risk factors[14] Communication - The company emphasizes the importance of monitoring its website and social media channels for material information distribution[10]

Financial Data and Key Metrics Changes - Revenue in Q4 2025 was $708.5 million, a year-over-year increase of 32%, while full year 2025 revenue reached $2.53 billion, reflecting a 20% increase from 2024 [7][9] - EBITDA for Q4 2025 was $160.2 million, up 20% from $133.5 million in Q4 2024, with a full year EBITDA of $557.7 million, an increase of 16.1% [9][10] - Net income for Q4 2025 was $135.1 million, a 15.5% increase compared to $117 million in the prior year, with full year net income at $451.1 million, representing an 11.6% increase [10][11] Business Line Data and Key Metrics Changes - Net new business awards entering backlog in Q4 increased by 39.1% year-over-year to $736.6 million, resulting in a net book-to-bill ratio of 1.04 [7][9] - Ending backlog as of December 31, 2025, was approximately $3 billion, a 4.3% increase from the prior year [7][8] Market Data and Key Metrics Changes - The company reported a backlog conversion rate of 23.6% in Q4, with an expectation that approximately $1.9 billion of backlog will convert to revenue in the next 12 months [8][9] Company Strategy and Development Direction - The company views the overall business environment as adequate and improving, with continued opportunities for growth despite elevated cancellation rates [5][6] - There is an expectation for accelerated hiring in 2026, with a focus on mid to high single-digit growth in headcount to support business growth [17][18] Management's Comments on Operating Environment and Future Outlook - Management noted that cancellations were elevated in Q4, the highest level in over a year, but does not expect this trend to continue [5][6] - The company anticipates revenue growth in 2026 to be in the range of $2.755 billion to $2.855 billion, representing growth of 8.9% to 12.8% over 2025 [12][13] Other Important Information - The company repurchased 2.96 million shares for $912.9 million in 2025, with $821.7 million remaining under the share repurchase authorization program [11][12] - Management indicated that the impact of AI on productivity is expected to be gradual, with no immediate advantages anticipated in 2026 [55][56] Q&A Session Summary Question: What is embedded in your guidance for revenue growth excluding pass-throughs? - Management does not provide guidance on direct service revenue but expects reimbursable costs to be around 41%-42% of revenue in 2026 [16] Question: What do you expect headcount growth to be in 2026? - Management anticipates hiring in 2026 to be above 25 levels, in the mid to high single-digit growth area [18] Question: Can you unpack the business environment and RFP activity? - Management noted that RFPs were up slightly, but cancellations led to missing expectations [21] Question: Can you provide details on cancellations? - Cancellations were widespread, with no single large project responsible, and were particularly elevated in the metabolic area [27][28] Question: How do you view the competitive landscape? - Management does not perceive a significant change in the competitive dynamics, stating that the same competitors remain active in the space [63] Question: What are your thoughts on AI and its impact? - Management believes that while AI will bring changes, the benefits will take time to materialize, and there may be a net negative impact on staffing needs [55][56]

Financial Data and Key Metrics Changes - Revenue in Q4 2025 was $708.5 million, a year-over-year increase of 32%, while full year 2025 revenue reached $2.53 billion, reflecting a 20% increase from 2024 [7][9] - EBITDA for Q4 2025 was $160.2 million, up 20% from $133.5 million in Q4 2024, with a full year EBITDA of $557.7 million, an increase of 16.1% [9][10] - Net income for Q4 2025 was $135.1 million, a 15.5% increase compared to $117 million in the prior year, with full year net income at $451.1 million, representing an 11.6% increase [10][11] - The EBITDA margin for Q4 was 22.6%, down from 24.9% in the prior year, while the full year EBITDA margin was 22%, compared to 22.8% in the previous year [9][10] Business Line Data and Key Metrics Changes - Net new business awards entering backlog in Q4 increased by 39.1% year-over-year to $736.6 million, resulting in a net book-to-bill ratio of 1.04 [7][9] - Ending backlog as of December 31, 2025, was approximately $3 billion, a 4.3% increase from the prior year [7][8] Market Data and Key Metrics Changes - The company reported a backlog conversion rate of 23.6% in Q4, with an expectation that approximately $1.9 billion of backlog will convert to revenue in the next 12 months [8][9] Company Strategy and Development Direction - The company views the overall business environment as adequate and improving, with continued opportunities for growth despite elevated cancellation rates [5][6] - The company anticipates a revenue growth range of 8.9%-12.8% for 2026, with total revenue expected between $2.755 billion and $2.855 billion [12][13] Management's Comments on Operating Environment and Future Outlook - Management noted that cancellations were elevated in Q4, the highest in over a year, but expressed optimism that this trend would not continue [5][6] - The management team highlighted that the competitive landscape remains stable, with no significant changes in dynamics despite increased aggressiveness from top competitors [62][63] Other Important Information - The company repurchased 2.96 million shares for $912.9 million in 2025, with $821.7 million remaining under the share repurchase authorization program [11][12] - The effective tax rate for 2026 is projected to be between 18.5% and 19.5%, with interest income expected to be between $24.3 million and $29.2 million [12][13] Q&A Session Summary Question: What is embedded in your guidance for revenue growth excluding pass-throughs? - Management does not provide guidance on direct service revenue but expects reimbursable costs to be around 41%-42% of revenue in 2026 [16] Question: What do you expect headcount growth to be in 2026? - The company anticipates accelerated hiring in 2026, with growth in the mid to high single-digit range [17] Question: Can you unpack the business environment and RFP activity? - Management reported that RFPs were up slightly, but cancellations impacted net bookings [21] Question: Can you provide details on the cancellations? - Cancellations were widespread and not concentrated in any single project or client [27] Question: How do you view the competitive landscape? - Management sees no significant change in the competitive dynamics despite increased aggressiveness from top CROs [62][63] Question: What are your thoughts on AI's impact on the industry? - Management believes it is too early to assess AI's impact, expecting gradual changes rather than immediate productivity advantages [55][56]

Financial Data and Key Metrics Changes - Revenue in Q4 2025 was $708.5 million, representing a year-over-year increase of 32% [5][6] - Full year 2025 revenue was $2.53 billion, a 20% increase from 2024 [5][6] - EBITDA for Q4 2025 was $160.2 million, up 20% from $133.5 million in Q4 2024 [6][7] - Full year EBITDA was $557.7 million, a 16.1% increase from the prior year [7] - Net income for Q4 2025 was $135.1 million, a 15.5% increase compared to $117 million in the prior year [7][8] - Full year net income was $451.1 million, an 11.6% increase from $404.4 million in 2024 [8] Business Line Data and Key Metrics Changes - Net new business awards entering backlog in Q4 increased 39.1% year-over-year to $736.6 million [5] - Ending backlog as of December 31, 2025, was approximately $3 billion, a 4.3% increase from the prior year [5] - Backlog conversion rate in Q4 was 23.6% of beginning backlog [5] Market Data and Key Metrics Changes - Cancellations were elevated in Q4, resulting in the highest backlog cancellations in over a year [4] - The net book-to-bill ratio was 1.04, lower than anticipated due to increased cancellations [4] Company Strategy and Development Direction - The company rates the overall business environment as adequate and improving [4] - There is an expectation for accelerated hiring in 2026, with a focus on mid to high single-digit growth [15] - The company anticipates a shift in the therapeutic area concentration, with metabolic trials expected to normalize as a percentage of revenue [31] Management's Comments on Operating Environment and Future Outlook - Management noted that the business environment remains reasonably good, with RFPs up slightly [18] - There is no significant change in decision-making or project progression despite elevated cancellations [55] - The company does not foresee a long-term risk from the concentration in the metabolic area [31] Other Important Information - Full year 2026 total revenue is expected to be in the range of $2.755 billion to $2.855 billion, representing growth of 8.9% to 12.8% over 2025 [9] - The company plans to maintain a focus on improving efficiency through technology and AI applications [65] Q&A Session Summary Question: What is embedded in your guidance for revenue growth excluding pass-throughs? - The company does not provide guidance on direct service revenue but expects reimbursable costs to be consistent with previous expectations [12][13] Question: What do you expect headcount growth to be in 2026? - The company anticipates hiring in 2026 to be above 25 levels, in the mid to high single-digit growth area [14] Question: Can you unpack the business environment and RFP activity? - The business environment is reasonably good, with RFPs up slightly, but cancellations led to missing expectations [18] Question: Can you provide details on cancellations? - Cancellations were widespread and not concentrated in any single project or client [24][22] Question: How do you view the competitive landscape? - The competitive landscape remains stable, with no significant changes in dynamics observed [59] Question: What are your thoughts on AI and its impact? - The company believes it is too early to determine the long-term impact of AI, with expectations for gradual changes [51]

Q4 2025 FINANCIAL RESULTS FEBRUARY 9, 2026 FORWARD LOOKING STATEMENTS & NON-GAAP FINANCIAL MEASURES Forward-Looking Statements This presentation contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. All statements contained in this presentation that do not relate to matters of historical fact should be considered forward- looking statements, including without limitation, statements regarding our forecasted financial results and the effective tax rate ...