Financial Performance - Puma Biotechnology reported first-quarter 2025 adjusted earnings of 10 cents per share, exceeding the Zacks Consensus Estimate of 2 cents, compared to a loss of 5 cents per share in the same quarter last year [1] - Total revenues for the quarter were $46.0 million, surpassing the Zacks Consensus Estimate of $44.0 million, with a year-over-year increase of 5% attributed to higher product revenues [1][2] - Product revenues from Nerlynx totaled $43.1 million, reflecting a 7% year-over-year increase and slightly above the guidance of $41-$43 million, although there was a sequential decline of 20.7% [5] - Royalty revenues amounted to $2.9 million, down from $3.5 million in the year-ago quarter but exceeding the model estimate of $1.7 million [6] Cost Management - Total operating costs for the quarter were $42.0 million, a decrease of 9% year over year [6] - Selling, general and administrative expenses declined by 19.2% year over year to $17.6 million, primarily due to lower legal fees [6] - Research and development expenses totaled $13.8 million, reflecting a 1.5% year-over-year increase [7] Future Guidance - Puma Biotechnology maintained its financial guidance for 2025, expecting Nerlynx's product sales to be in the range of $192-$198 million and royalty revenues between $20-$24 million [10] - For the second quarter of 2025, Nerlynx product sales are anticipated to be between $48-$50 million, with royalty revenues expected to be in the range of $2-$3 million [11] Pipeline Developments - The company is developing alisertib, an aurora kinase A inhibitor, for hormone receptor-positive breast cancer and small-cell lung cancer, having in-licensed the rights from Takeda in 2022 [12] - Puma Biotechnology is conducting a phase II study (ALISCA-Lung1) for alisertib as a monotherapy in extensive-stage small-cell lung cancer, with interim data expected in the second half of 2025 [13] - A phase II study (ALISCA-Breast1) is also underway for alisertib in combination with endocrine treatment for chemotherapy-naïve HER2-negative, hormone receptor-positive metastatic breast cancer, with initial data expected in the second half of 2025 [14] Stock Performance - Shares of Puma Biotechnology increased by 4.2% in after-hours trading on May 8 due to better-than-expected results [2] - The stock has risen 0.7% year to date, contrasting with an 8.4% decline in the industry [3]

Puma Biotechnology Earnings Call Commercial Update May 8, 2025 Forward-Looking Safe-Harbor Statement This presentation contains forward-looking statements, including statements regarding commercialization of NERLYNX® and the potential indications and development of our drug candidates. All forward-looking statements involve risks and uncertainties that could cause our actual results to differ materially from the anticipated results and expectations expressed in these forward-looking statements. These statem ...

Core Insights - Puma Biotech reported quarterly earnings of $0.10 per share, exceeding the Zacks Consensus Estimate of $0.02 per share, and showing a significant improvement from a loss of $0.05 per share a year ago, resulting in an earnings surprise of 400% [1] - The company achieved revenues of $46 million for the quarter ended March 2025, surpassing the Zacks Consensus Estimate by 4.65% and increasing from $43.8 million year-over-year [2] Earnings Performance - Over the last four quarters, Puma Biotech has consistently surpassed consensus EPS estimates, achieving this four times [2] - The company had an earnings surprise of 207.14% in the previous quarter, where it reported earnings of $0.43 per share against an expectation of $0.14 per share [1] Future Outlook - The current consensus EPS estimate for the upcoming quarter is $0.12 on revenues of $49.38 million, and for the current fiscal year, it is $0.54 on revenues of $216.4 million [7] - The estimate revisions trend for Puma Biotech is currently favorable, leading to a Zacks Rank 1 (Strong Buy) for the stock, indicating expected outperformance in the near future [6] Industry Context - The Medical - Biomedical and Genetics industry, to which Puma Biotech belongs, is currently ranked in the top 33% of over 250 Zacks industries, suggesting a positive outlook for stocks within this sector [8] - Empirical research indicates a strong correlation between near-term stock movements and trends in earnings estimate revisions, which can be tracked by investors [5]

Puma Biotechnology (PBYI) Q1 2025 Earnings Call May 08, 2025 04:30 PM ET Company Participants Mariann Ohanesian - Senior Director of Investor RelationsAlan Auerbach - Founder, Chairman, President, CEO & SecretaryJeffrey Ludwig - Chief Commercial OfficerHeather Blaber - VP - MarketingRoger Storms - VP - SalesMaximo F. Nougues - CFO & Principal Accounting Officer Conference Call Participants Divya Rao - AnalystNone - Analyst Operator Good afternoon. My name is Sherry, and I will be your conference call operat ...

Puma Biotechnology (PBYI) Q1 2025 Earnings Call May 08, 2025 04:30 PM ET Speaker0 Good afternoon. My name is Sherry, and I will be your conference call operator today. At this time, all participants are in a listen only mode. After the speakers' formal remarks, there will be a question and answer session. As a reminder, this call is being recorded. I would now like to turn the conference over to Mary Anne O'Hanison, Senior Director of Investor Relations for Puma Biotechnology. Thank you. You may begin your ...

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2025 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-35703 PUMA BIOTECHNOLOGY, INC. (Exact name of registrant as specified in its charter) Delaware 77-0683487 (State or othe ...

Financial Performance - Product revenue for Q1 2025 was $43.1 million, a 6.9% increase from $40.3 million in Q1 2024[3] - Net income for Q1 2025 was $3.0 million, compared to a net loss of $4.8 million in Q1 2024, marking a significant turnaround[4] - Non-GAAP adjusted net income for Q1 2025 was $5.0 million, compared to a non-GAAP adjusted net loss of $2.4 million in Q1 2024[5] - Total revenue for Q1 2025 was $46.0 million, compared to $43.8 million in Q1 2024, reflecting a 5.0% increase[8] - Basic and diluted net income per share for Q1 2025 was $0.06, compared to a loss of $0.10 per share in Q1 2024[29] - Non-GAAP adjusted basic net income per share for Q1 2025 was $0.10, compared to a loss of $0.05 per share in Q1 2024[34] Operating Costs - Total operating costs and expenses decreased to $42.0 million in Q1 2025 from $46.1 million in Q1 2024, a reduction of 8.9%[9] - Selling, general and administrative expenses decreased by $4.2 million to $17.6 million in Q1 2025, primarily due to lower professional fees[11] - Research and development expenses slightly increased to $13.8 million in Q1 2025 from $13.6 million in Q1 2024[13] - Stock-based compensation represented approximately 6.4% of operating expenses in Q1 2025, slightly down from 6.7% in Q1 2024[32] Cash and Liquidity - Cash, cash equivalents, and marketable securities totaled $93.2 million as of March 31, 2025, down from $101.0 million at the end of 2024[6] - Cash and cash equivalents as of March 31, 2025, were $63.0 million, down from $69.2 million as of December 31, 2024[31] - The company reported a net decrease in cash, cash equivalents, and restricted cash of $6.2 million for the three months ended March 31, 2025[31] Future Outlook - The company anticipates net product revenue for Q2 2025 to be between $48 million and $50 million, and for the full year 2025 to be between $192 million and $198 million[15] - Key upcoming milestones include interim data presentations from ongoing clinical trials in H2 2025[7]

Puma Biotech (PBYI) could be a solid choice for investors given its recent upgrade to a Zacks Rank #1 (Strong Buy). An upward trend in earnings estimates -- one of the most powerful forces impacting stock prices -- has triggered this rating change.The sole determinant of the Zacks rating is a company's changing earnings picture. The Zacks Consensus Estimate -- the consensus of EPS estimates from the sell-side analysts covering the stock -- for the current and following years is tracked by the system.Individ ...

Core Insights - Er-Kim has signed an agreement with Puma Biotechnology to commercialize NERLYNX in select Eastern European and Central Asian countries [1][2] - NERLYNX is a treatment for HER2-positive breast cancer, approved for both early-stage and metastatic cases [3][7] - Breast cancer is the most common cancer among women globally, with 2.3 million new cases and 670,000 deaths reported in 2022 [4] Company Overview - Er-Kim, established in 1981, partners with over 40 global leaders and has revenues exceeding EUR 260 million, reaching over 600 million patients [6] - Puma Biotechnology focuses on developing innovative cancer care products and has successfully commercialized NERLYNX since its FDA approval in 2017 [7] Market Context - The agreement aims to improve access to NERLYNX in Russia and the Commonwealth of Independent States, addressing the disparity in treatment availability for breast cancer [5] - The burden of breast cancer varies significantly across different regions, highlighting the need for targeted treatment solutions [4][5]

Investors in Puma Biotechnology, Inc. (PBYI) need to pay close attention to the stock based on moves in the options market lately. That is because the Jun 20, 2025 $5 Put had some of the highest implied volatility of all equity options today. What is Implied Volatility?Implied volatility shows how much movement the market is expecting in the future. Options with high levels of implied volatility suggest that investors in the underlying stocks are expecting a big move in one direction or the other. It could ...