Summary of Pharming Group FY Conference Call Company Overview - **Company**: Pharming Group (NasdaqGM:PHAR) - **CEO**: Fabrice Chouraqui - **Date of Conference**: September 08, 2025 Key Points Company Transformation - Pharming has evolved from a one-asset company with RUCONEST to a company with two commercial assets: RUCONEST and Joenja, both experiencing double-digit growth [2][3] - The company has a high-value pipeline with two programs projected to have sales potential exceeding $1 billion [2] Financial Performance - Sales grew by 26% in the last quarter, driven by RUCONEST and Joenja [4] - Revenue guidance for the year has been raised to between $335 million and $350 million [4] RUCONEST - RUCONEST is a cornerstone treatment for hereditary angioedema, with 97% of attacks treated with one dose and 93% of attacks stopped for at least three days [5][6] - The drug has been on the market for 10 years and is growing at a rate of 28% year-on-year [6] - RUCONEST's unique manufacturing process from transgenic rabbits makes it difficult to replicate [7] Joenja - Joenja is indicated for activated PI3K delta syndrome (APDS) and has shown significant patient uptake, with more new patients in the first half of the year than in the entire previous year [10][11] - Three growth catalysts for Joenja include: 1. Reclassification of VUS patients, with an estimated 20% of VUS patients potentially reclassified as APDS [12][13] 2. Expansion of the label to pediatric patients, with an NDA submitted to the FDA [14] 3. Geographic expansion, including recent launches in the UK and an NDA filed in Japan [15] Pipeline and Future Prospects - Pharming is studying Joenja's efficacy in adjacent indications, which could significantly broaden its market potential [16][17] - KL1333, acquired from Ableva, is being developed for primary mitochondrial disease, with a Phase 2 registrational trial ongoing [18][19] - The company aims to self-fund the development of its pipeline and launch of new drugs, leveraging cash flows from RUCONEST [20] Growth Outlook - The company has raised its revenue guidance and expects continued strong growth, with significant short-term catalysts for both Joenja and KL1333 [21][22] Additional Insights - The company is focused on creating a world leader in rare diseases, leveraging its capabilities in clinical development, supply chain, and commercial operations [3] - The strong performance of RUCONEST is critical for funding the expansion of the portfolio and pipeline [20]

Core Points - Pharming Group N.V. will participate in the H.C. Wainwright 27th Annual Global Investment Conference in New York from September 8-10, 2025 [1] - CEO Fabrice Chouraqui is scheduled to present on September 8 at 1:30pm EDT/19:30 CEST [1] - A live webcast and replay of the presentation will be available on Pharming's website [1] Company Overview - Pharming Group N.V. is a global biopharmaceutical company focused on developing innovative medicines for patients with rare and life-threatening diseases [3] - The company is headquartered in Leiden, the Netherlands, and operates in over 30 markets across North America, Europe, the Middle East, Africa, and Asia-Pacific [3]

Core Viewpoint - Pharming Group N.V. has appointed Kenneth Lynard as Chief Financial Officer, effective October 1, 2025, to strengthen its financial leadership and support its growth strategy [1][2][3] Company Overview - Pharming Group N.V. is a global biopharmaceutical company focused on developing and commercializing innovative medicines for patients with rare and life-threatening diseases [5] - The company is headquartered in Leiden, the Netherlands, and operates in over 30 markets globally [5] Appointment Details - Kenneth Lynard brings over 20 years of experience in the life sciences industry, with a strong background in financial and operational transformation [2][3] - His previous roles include CFO positions at Schoeller Allibert, Zentiva, and Affidea, as well as senior leadership at Gilead Sciences, where he contributed to significant business growth [3][4] Leadership Perspective - CEO Fabrice Chouraqui expressed enthusiasm about Lynard's appointment, highlighting his extensive finance leadership capabilities and operational experience in both the U.S. and EU [3] - Lynard emphasized his commitment to Pharming's mission of serving patients with rare diseases and his focus on operational efficiency and sustainable value creation [4]

Core Viewpoint - Pharming Group N.V. (PHAR) has shown a significant price increase of 24.2% over the past four weeks, with analysts projecting a mean price target of $30.67, indicating a potential upside of 142.3% from the current price of $12.66 [1] Price Targets and Analyst Consensus - The average price target for PHAR ranges from a low of $14.00 to a high of $41.00, with a standard deviation of $14.57, suggesting variability in analyst estimates [2] - The lowest estimate indicates a potential increase of 10.6%, while the most optimistic estimate suggests a 223.9% upside [2] - A low standard deviation among price targets indicates a high degree of agreement among analysts regarding the stock's price movement [9] Earnings Estimates and Market Sentiment - Analysts have shown increasing optimism regarding PHAR's earnings prospects, with a strong consensus on higher EPS estimates, which correlates with potential stock price increases [11] - Over the last 30 days, two earnings estimates have been revised upward, resulting in a 75% increase in the Zacks Consensus Estimate for the current year [12] - PHAR holds a Zacks Rank 1 (Strong Buy), placing it in the top 5% of over 4,000 ranked stocks based on earnings estimate factors, indicating strong potential for near-term upside [13] Caution on Price Targets - While price targets are a common tool for investors, they can often mislead, as empirical research shows that they rarely indicate actual stock price movements [7][10] - Analysts may set overly optimistic price targets due to business incentives, which can inflate expectations [8]

Core Viewpoint - Pharming Group N.V. (PHAR) shares have increased by 17.9% in the past four weeks, closing at $12.48, with a mean price target of $30.67 indicating a potential upside of 145.8% [1] Price Targets and Analyst Consensus - The average price target consists of three estimates ranging from a low of $14.00 to a high of $41.00, with a standard deviation of $14.57, suggesting a potential increase of 12.2% to 228.5% from the current price [2] - A low standard deviation indicates a strong agreement among analysts regarding the stock's price movement, which can be a useful starting point for further research [9] Earnings Estimates and Market Sentiment - Analysts have shown increasing optimism about PHAR's earnings prospects, with a strong consensus in revising EPS estimates higher, which correlates with potential stock price increases [11] - Over the last 30 days, two estimates have been revised upward, leading to a 75% increase in the Zacks Consensus Estimate for the current year [12] Zacks Rank and Investment Potential - PHAR holds a Zacks Rank 1 (Strong Buy), placing it in the top 5% of over 4,000 ranked stocks based on earnings estimate factors, indicating strong potential for upside in the near term [13] - While consensus price targets may not be entirely reliable, the implied direction of price movement appears to be a good guide for potential investment [14]

Group 1 - Pharming Group N.V. will participate in the Canaccord Genuity 45 Annual Growth Conference in Boston, USA, on August 12-13, 2025 [1] - CEO Fabrice Chouraqui will present on August 12 at 12:00pm EDT/18:00 CEST [1] - Investors can schedule one-to-one meetings with Pharming's management team through the Investor Relations team [1] Group 2 - Pharming Group N.V. is a global biopharmaceutical company focused on patients with rare, debilitating, and life-threatening diseases [2] - The company is involved in the commercialization and development of innovative medicines, including small molecules and biologics [2] - Pharming is headquartered in Leiden, the Netherlands, and operates in over 30 markets worldwide [2]

Financial Data and Key Metrics Changes - Total revenues grew by 26% year-on-year in Q2 2025, reaching $80,400,000, with a significant operating profit of $12,900,000 compared to a loss in the previous year [3][29] - Gross profit increased by 27% to $84,200,000, primarily driven by revenue growth [29] - For the first half of 2025, total revenues increased by 33% and gross profit increased by 37% compared to the same period in 2024 [30] Business Line Data and Key Metrics Changes - Reconnect revenue grew by 28% year-on-year, contributing significantly to the overall revenue growth [4][8] - Joenja achieved a revenue of $12,800,000 in Q2 2025, with a 15% quarter-on-quarter growth and a notable increase in patient uptake [13][14] Market Data and Key Metrics Changes - The U.S. market saw a 27% increase in new patient enrollments for Reconnect, driven by the addition of new prescribers [10] - Joenja's patient base is expanding, with 185 patients identified globally, including a launch in the UK [14][18] Company Strategy and Development Direction - The company aims to build a leading global rare disease platform, leveraging its strong capabilities and pipeline [7] - The focus is on expanding the patient base for Joenja through reclassification of VUS patients and geographic expansion [15][34] - The company is raising its 2025 total revenue guidance to between $335 million and $350 million, reflecting confidence in continued growth [32] Management's Comments on Operating Environment and Future Outlook - Management expressed optimism about the growth potential of both Reconnect and Joenja, highlighting the unique value propositions of their products [33][34] - The company is committed to optimizing capital allocation and reducing G&A expenses by 15% to support growth [32] Other Important Information - The company has a high-value late-stage pipeline with two assets, each with over $1 billion potential [4][6] - The acquisition of Abliva is expected to enhance the company's pipeline and market position [29] Q&A Session Summary Question: How will the VUS patient reclassification translate to new patients on paid therapy? - Management expects about 20% of the 1,400 identified VUS patients to be reclassified as APDS, which will take time as diagnostic labs process the data [39][41] Question: Can you comment on the revenue growth for Joenja? - The revenue growth for Joenja was impacted by increased stock inventory in Q2 last year, not a change in conversion rates [47] Question: Are there segments of the Reconnect patient population at risk from the launch of sevitralstat? - The majority of Reconnect patients are those who have failed other treatments, and the patient populations targeted by both drugs are different [48][52] Question: Does the OpEx forecast include milestones on leniolumab? - Yes, the forecast includes a $5 million milestone related to leniolumab [68]

Financial Performance - Total revenues for Q2 2025 increased by 26% compared to Q2 2024 [16] - RUCONEST® revenues in Q2 2025 reached $80.4 million, up from $63.0 million in Q2 2024 [14, 23] - Joenja® revenues in Q2 2025 were $12.8 million, compared to $11.1 million in Q2 2024 [14, 28] - Adjusted operating profit for Q2 2025 was $12.9 million, compared to a loss of $3.1 million in Q2 2024 [14] - The company is raising its 2025 revenue guidance to $335-350 million [16] - Revenues for 1H 2025 increased by 33% to $172.315 million, compared to $129.679 million in 1H 2024 [55, 63] Commercial Updates - RUCONEST® U S volume growth increased by 27% in Q2 2025 and 31% in 1H 2025 [23] - The number of U S patients on Joenja® increased by 25% compared to Q2 2024, reaching 114 patients in Q2 2025 [28] Research and Development - A study uncovered >100 new variants leading to PI3Kδ hyperactivity (GOF variants) [38] - Data suggests that VUS patients with these GOF variants should be reclassified as APDS [39] - APDS may be up to 100x more prevalent than previously estimated [40]

Revenue Growth - Total revenues for Q2 2025 increased by 26% to US$93.2 million compared to Q2 2024, driven by strong growth in RUCONEST® and Joenja®[10] - Total revenues for the first half of 2025 increased by 33% to US$172.3 million compared to the first half of 2024[42] - Total revenues for 1H 2025 reached $172.3 million, a 32.7% increase compared to $129.7 million in 1H 2024[85] - Joenja® revenue increased by 15% to US$12.8 million in Q2 2025, with patient uptake accelerating significantly[13] - RUCONEST® revenue for Q2 2025 rose by 28% to US$80.4 million, reflecting strong growth in patients and prescribers[13] - Total RUCONEST® revenues for the first half of 2025 were 37% higher at US$149.0 million compared to US$109.0 million for the first half of 2024[42] Profitability - Operating profit for Q2 2025 amounted to US$10.8 million, a turnaround from a loss of US$3.1 million in Q2 2024[13] - The net profit for Q2 2025 was US$4.6 million, compared to a net loss of US$1.2 million in Q2 2024[40] - Operating profit for the first half of 2025 was $3.8 million, a turnaround from an operating loss of $19.4 million in the first half of 2024[61] - The total comprehensive income for the period was $15.8 million, compared to a loss of $17.8 million in the first half of 2024[62] - The company reported a loss for the period of $10.3 million, an improvement from a loss of $13.7 million in the first half of 2024[61] - The net loss attributable to equity owners of the parent was US$10.0 million in the first half of 2025, compared to a net loss of US$13.7 million in the first half of 2024, reflecting an improvement of about 26.5%[120] Cash and Assets - Cash and marketable securities increased to US$130.8 million at the end of Q2 2025, up from US$108.9 million at the end of Q1 2025[13] - Cash and cash equivalents rose to $92.1 million as of June 30, 2025, compared to $54.9 million at the end of 2024[63] - Non-current assets increased to $200.5 million as of June 30, 2025, up from $121.5 million at the end of 2024[63] - The total assets of the company reached $446.3 million as of June 30, 2025, compared to $400.0 million at the end of 2024[63] - Cash and cash equivalents increased to US$92.1 million as of June 30, 2025, compared to US$54.9 million as of December 31, 2024, an increase of about 67.5%[110] Guidance and Future Plans - Total revenue guidance for 2025 has been raised to US$335 million - US$350 million, up from the previous guidance of US$325 million - US$340 million[13] - The company anticipates total revenues between US$335.0 million and US$350.0 million for 2025, representing 13% to 18% growth[49] - The company plans to advance ongoing clinical trials and focus on potential acquisitions in rare diseases[50] Acquisitions and Investments - Pharming acquired the remaining 11.1% interest in Abliva AB, increasing its ownership to 100%[33] - The acquisition of Abliva AB was completed for a total cash consideration of $67.1 million, enhancing the clinical pipeline with a therapy expected to launch in the U.S. in 2028[74][80] - The lead product KL1333 from Abliva is in a pivotal clinical study, with over 30,000 patients in the U.S. and EU potentially addressable[76] Other Financial Metrics - Gross profit for Q2 2025 increased by US$18.1 million, or 27%, to US$84.2 million compared to Q2 2024[37] - Other income increased to $2.2 million in 1H 2025, up from $1.3 million in 1H 2024, reflecting a growth of 69.2%[86] - Interest income declined to US$1.3 million in the first half of 2025 from US$2.7 million in the first half of 2024, a decrease of approximately 53.2%[92] - The impairment of inventories increased to US$13.3 million as of June 30, 2025, compared to US$8.7 million as of December 31, 2024, an increase of approximately 53.4%[106] - The carrying value of convertible bonds increased to US$96.4 million as of June 30, 2025, from US$82.4 million as of December 31, 2024, an increase of about 16.9%[117]

Core Insights - Pharming Group N.V. reported a strong second quarter with a total revenue growth of 26% and positive operating profit, driven by significant growth in RUCONEST® and Joenja® [2][7][29] - The company raised its full-year revenue guidance to between US$335 million and US$350 million, up from the previous range of US$325 million to US$340 million [7][44] Financial Performance - Total revenues for Q2 2025 increased by 26% to US$93.2 million compared to Q2 2024, with RUCONEST® revenue growing by 28% to US$80.4 million and Joenja® revenue increasing by 15% to US$12.8 million [7][29][30] - Operating profit for Q2 2025 was US$10.8 million, a significant improvement from a loss of US$3.1 million in Q2 2024 [7][31] - For the first half of 2025, total revenues rose by 33% to US$172.3 million, with RUCONEST® revenues up 37% to US$149.0 million [35][36] Product Development and Market Expansion - Joenja® is showing accelerated uptake, with patient growth in the first half of 2025 surpassing the total for all of 2024 [2][11] - A recent study published in the journal Cell suggests that the prevalence of APDS may be up to 100 times higher than previously estimated, potentially expanding Joenja®'s addressable patient population [3][16] - The company launched Joenja® in the U.K. and submitted a regulatory filing for leniolisib in Japan, indicating ongoing efforts to expand market access [4][20] Strategic Initiatives - Pharming is working on mitigating the impact of U.S. tariffs, although it does not expect a material impact on its business [5] - The company is on track to reduce general and administrative expenses by 15% or US$10 million to optimize capital allocation for sustainable growth [26] - The acquisition of Abliva AB was completed, increasing Pharming's ownership to 100% [25] Cash Flow and Financial Position - Cash and marketable securities increased to US$130.8 million at the end of Q2 2025, up from US$108.9 million at the end of Q1 2025, primarily due to cash generated from operations [7][34] - The company reported a net profit of US$4.6 million for Q2 2025, compared to a net loss of US$1.2 million in Q2 2024 [33]