Financial Data and Key Metrics Changes - Total revenues grew by 26% year-on-year in Q2 2025, reaching $80,400,000, with a significant operating profit of $12,900,000 compared to a loss in the previous year [3][29] - Gross profit increased by 27% to $84,200,000, primarily driven by revenue growth [29] - For the first half of 2025, total revenues increased by 33% and gross profit increased by 37% compared to the same period in 2024 [30] Business Line Data and Key Metrics Changes - Reconnect revenue grew by 28% year-on-year, contributing significantly to the overall revenue growth [4][8] - Joenja achieved a revenue of $12,800,000 in Q2 2025, with a 15% quarter-on-quarter growth and a notable increase in patient uptake [13][14] Market Data and Key Metrics Changes - The U.S. market saw a 27% increase in new patient enrollments for Reconnect, driven by the addition of new prescribers [10] - Joenja's patient base is expanding, with 185 patients identified globally, including a launch in the UK [14][18] Company Strategy and Development Direction - The company aims to build a leading global rare disease platform, leveraging its strong capabilities and pipeline [7] - The focus is on expanding the patient base for Joenja through reclassification of VUS patients and geographic expansion [15][34] - The company is raising its 2025 total revenue guidance to between $335 million and $350 million, reflecting confidence in continued growth [32] Management's Comments on Operating Environment and Future Outlook - Management expressed optimism about the growth potential of both Reconnect and Joenja, highlighting the unique value propositions of their products [33][34] - The company is committed to optimizing capital allocation and reducing G&A expenses by 15% to support growth [32] Other Important Information - The company has a high-value late-stage pipeline with two assets, each with over $1 billion potential [4][6] - The acquisition of Abliva is expected to enhance the company's pipeline and market position [29] Q&A Session Summary Question: How will the VUS patient reclassification translate to new patients on paid therapy? - Management expects about 20% of the 1,400 identified VUS patients to be reclassified as APDS, which will take time as diagnostic labs process the data [39][41] Question: Can you comment on the revenue growth for Joenja? - The revenue growth for Joenja was impacted by increased stock inventory in Q2 last year, not a change in conversion rates [47] Question: Are there segments of the Reconnect patient population at risk from the launch of sevitralstat? - The majority of Reconnect patients are those who have failed other treatments, and the patient populations targeted by both drugs are different [48][52] Question: Does the OpEx forecast include milestones on leniolumab? - Yes, the forecast includes a $5 million milestone related to leniolumab [68]

Pharming Group N.V. Second quarter and first half 2025 financial results and business update July 31, 2025 NASDAQ: PHAR | EURONEXT Amsterdam: PHARM Fabrice Chouraqui Chief Executive Officer Stephen Toor Chief Commercial Officer Anurag Relan, MD Chief Medical Officer SPEAKERS Forward-looking statements This presentation may contain forward-looking statements. Forward-looking statements are statements of future expectations that are based on management's current expectations and assumptions and involve known ...

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Darwinweg 24 2333 CR Leiden The Netherlands (Address of principal executive offices) Indicate by check mark whether the registrant files or will file annual reports under cover of Form 20-F or Form 40-F. REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the Month of July 2025 Commission File Number: 001-39822 Pharming Group N.V. (Exact Name of Registrant as Specifie ...

Core Insights - Pharming Group N.V. reported a strong second quarter with a total revenue growth of 26% and positive operating profit, driven by significant growth in RUCONEST® and Joenja® [2][7][29] - The company raised its full-year revenue guidance to between US$335 million and US$350 million, up from the previous range of US$325 million to US$340 million [7][44] Financial Performance - Total revenues for Q2 2025 increased by 26% to US$93.2 million compared to Q2 2024, with RUCONEST® revenue growing by 28% to US$80.4 million and Joenja® revenue increasing by 15% to US$12.8 million [7][29][30] - Operating profit for Q2 2025 was US$10.8 million, a significant improvement from a loss of US$3.1 million in Q2 2024 [7][31] - For the first half of 2025, total revenues rose by 33% to US$172.3 million, with RUCONEST® revenues up 37% to US$149.0 million [35][36] Product Development and Market Expansion - Joenja® is showing accelerated uptake, with patient growth in the first half of 2025 surpassing the total for all of 2024 [2][11] - A recent study published in the journal Cell suggests that the prevalence of APDS may be up to 100 times higher than previously estimated, potentially expanding Joenja®'s addressable patient population [3][16] - The company launched Joenja® in the U.K. and submitted a regulatory filing for leniolisib in Japan, indicating ongoing efforts to expand market access [4][20] Strategic Initiatives - Pharming is working on mitigating the impact of U.S. tariffs, although it does not expect a material impact on its business [5] - The company is on track to reduce general and administrative expenses by 15% or US$10 million to optimize capital allocation for sustainable growth [26] - The acquisition of Abliva AB was completed, increasing Pharming's ownership to 100% [25] Cash Flow and Financial Position - Cash and marketable securities increased to US$130.8 million at the end of Q2 2025, up from US$108.9 million at the end of Q1 2025, primarily due to cash generated from operations [7][34] - The company reported a net profit of US$4.6 million for Q2 2025, compared to a net loss of US$1.2 million in Q2 2024 [33]

Group 1: ProKidney Corp. (PROK) - ProKidney is a clinical-stage biotechnology company with a Zacks Rank 1 [1] - The Zacks Consensus Estimate for its current year earnings increased by 5.8% over the last 60 days [1] - ProKidney's shares gained 371.7% over the last three months, significantly outperforming the S&P 500's advance of 18.2% [1] - The company has a Momentum Score of A [1] Group 2: Roku, Inc. (ROKU) - Roku operates a TV streaming platform and holds a Zacks Rank 1 [2] - The Zacks Consensus Estimate for its current year earnings increased by 5.3% over the last 60 days [2] - Roku's shares gained 55.4% over the last three months, also outperforming the S&P 500's advance of 18.2% [2] - The company has a Momentum Score of B [2] Group 3: Pharming Group N.V. (PHAR) - Pharming is a biopharmaceutical company with a Zacks Rank 1 [3] - The Zacks Consensus Estimate for its current year earnings increased nearly 7% over the last 60 days [3] - Pharming's shares gained 26.6% over the last three months, again outperforming the S&P 500's advance of 18.2% [3] - The company has a Momentum Score of B [3]

Company Overview - Pharming Group N.V. is a global biopharmaceutical company focused on transforming the lives of patients with rare, debilitating, and life-threatening diseases [5] - The company is involved in the commercialization and development of a portfolio of innovative medicines, including small molecules and biologics [5] - Pharming is headquartered in Leiden, the Netherlands, and operates in over 30 markets across North America, Europe, the Middle East, Africa, and Asia-Pacific [5] Upcoming Financial Results - Pharming will report its preliminary (unaudited) financial results for the second quarter and first half of 2025 on July 31, 2025 [1] - A business update will also be provided during the same announcement [1] - Management will host a conference call and webcast for analysts and investors at 13:30 CEST/07:30 am EDT on the same day [1]

Pharming Group N.V. UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the Month of May 2025 Commission File Number: 001-39822 (Exact Name of Registrant as Specified in Its Charter) Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(1): ☐ Indicate by check mark if the registrant is submitting the Fo ...

Core Insights - Pharming Group N.V. is presenting Phase III clinical data for leniolisib, targeting pediatric patients aged 4-11 years with activated phosphoinositide 3-kinase delta (PI3Kδ) syndrome (APDS) at the 2025 Annual Meeting of the Clinical Immunology Society [1][2] Presentations - The presentation titled "Primary and Safety Outcomes of a Phase 3 Open-Label, Single-Arm, 12-Week Study of Treatment With PI3Kδ Inhibitor Leniolisib in Pediatric Patients Aged 4-11 Years With Activated PI3Kδ Syndrome (APDS)" will be led by Dr. Shanmuganathan Chandrakasan on May 2, 2025 [2] - Additional presentations include a systematic literature review on immune dysregulation in common variable immunodeficiency and insights into APDS from patient perspectives [2] About Leniolisib - Leniolisib is an oral small molecule PI3Kδ inhibitor approved in several countries as the first targeted treatment for APDS in patients aged 12 and older [3] - The drug has shown statistically significant improvement in co-primary endpoints in a Phase III clinical trial, indicating a favorable impact on immune dysregulation [3] - Leniolisib is under regulatory review in the European Economic Area, Canada, and other regions, with plans for approval in Japan [3] About Pharming Group N.V. - Pharming Group N.V. is a global biopharmaceutical company focused on developing innovative medicines for rare and life-threatening diseases [4] - The company is headquartered in Leiden, the Netherlands, and operates in over 30 markets worldwide [4]

Core Viewpoint - Pharming Group N.V. has received positive final guidance from the National Institute for Health and Care Excellence (NICE) for the reimbursement and use of Joenja® (leniolisib) in treating activated phosphoinositide 3-kinase delta (PI3Kδ) syndrome (APDS) in patients aged 12 and older within the NHS in England and Wales [1][2][4] Group 1: NICE Recommendation and Clinical Data - The NICE recommendation is based on comprehensive data from a Phase III clinical trial that showed significant improvements in immune deficiency and dysregulation with leniolisib compared to placebo [2][4] - The Phase III trial results indicated sustained clinical improvements during long-term treatment in an open-label extension trial [2] Group 2: Impact on Patients and Healthcare - The NICE recommendation is viewed as a significant milestone for patients with APDS, enhancing treatment options and potentially improving their quality of life [3][4] - Joenja® is now available for use and funded in England through the Innovative Medicines Fund, with expected funding in Wales within three months [4] Group 3: About Joenja® and APDS - Joenja® is the first and only targeted treatment for APDS, an oral small molecule PI3Kδ inhibitor that addresses the underlying immune system issues associated with the condition [8] - APDS is a rare primary immunodeficiency affecting approximately 1 to 2 people per million worldwide, characterized by severe recurrent infections and immune dysregulation [6][7]

[Form 6-K Report of Foreign Private Issuer (April 2025)](index=1&type=section&id=Form%206-K%20Report%20of%20Foreign%20Private%20Issuer%20(April%202025)) This Form 6-K report provides key announcements from a foreign private issuer in April 2025 [Announcement of 2024 Annual Report and Form 20-F Filing](index=3&type=section&id=Pharming%20Group%20announces%20the%20filing%20of%20its%202024%20Annual%20Report%20and%20Form%2020-F) Pharming Group N.V. announced the filing of its Annual Report for the year ended December 31, 2024, along with its Annual Report on Form 20-F with the U.S. Securities and Exchange Commission (SEC) - Pharming Group N.V. has filed its Annual Report for the year ended December 31, 2024[8](index=8&type=chunk) - The company also filed its Annual Report on Form 20-F with the U.S. SEC for the same period[9](index=9&type=chunk) - The reports are available on the Pharming.com website under the 'Investors' section and through the SEC website[8](index=8&type=chunk)[9](index=9&type=chunk) [About Pharming Group N.V.](index=3&type=section&id=About%20Pharming%20Group%20N.V.) Pharming Group N.V. is a global biopharmaceutical company headquartered in Leiden, the Netherlands, focusing on innovative medicines for rare and life-threatening diseases across over 30 markets - Pharming is a global biopharmaceutical company dedicated to treating patients with rare, debilitating, and life-threatening diseases[10](index=10&type=chunk) - The company's portfolio includes commercialized and developing innovative medicines, such as small molecules and biologics[10](index=10&type=chunk) - Headquartered in Leiden, the Netherlands, Pharming serves patients in over 30 markets worldwide[10](index=10&type=chunk) [Other Information](index=3&type=section&id=Other%20Information) This section discloses that the press release content may qualify as inside information under EU Market Abuse Regulation and provides contact details for investor and public relations - The press release may contain information that qualifies as 'inside information' within the meaning of Article 7(1) of the EU Market Abuse Regulation[12](index=12&type=chunk) - Contact details for investor relations, corporate communications, and public relations are provided for further inquiries[13](index=13&type=chunk)