Core Viewpoint - Tevogen Bio Holdings Inc. has successfully developed the alpha version of its AI-driven PredicTcell™ model in collaboration with Microsoft and Databricks, aiming to revolutionize therapeutic development through enhanced target discovery and accelerated clinical research [1][3]. Group 1: Technology and Innovation - The PredicTcell model utilizes a terabyte-scale dataset with nearly a billion genetic and proteomic elements, significantly improving target discovery and reducing protein sequence analysis time from months to hours through advanced machine learning techniques [2][7]. - Tevogen.AI's initiatives are expected to streamline early-stage drug discovery, potentially generating billions in cost savings across the healthcare system and creating substantial top-line revenues for early adopters [7]. Group 2: Future Developments - The company plans to enhance the PredicTcell platform by expanding its datasets to include virology, oncology, and neurology, which may lead to improved accuracy and reduced time for wet lab testing [3][4]. - Additional advancements in clinical trial optimization and patient market analysis through the complementary AdapTcell™ model are anticipated to be announced in future communications [4].

Company Overview - Tevogen Bio Holdings Inc. has officially opened its newly expanded corporate headquarters in Warren, New Jersey, which was fully funded by the CEO, Ryan Saadi, resulting in no costs to the company or its shareholders [2][6]. Facility Expansion - The new facility has been completed ahead of schedule and more than doubles the previous footprint of Tevogen, allowing for the centralization of research, regulatory affairs, and the expanding Tevogen.AI teams under one roof [3][6]. Future Plans - A formal ribbon-cutting ceremony is planned to celebrate the new headquarters, which will include local officials, employees, and community partners [3].

Core Insights - Tevogen Bio Holdings Inc. emphasizes the significance of AI in drug discovery and has made a substantial investment in its new corporate headquarters [1][2] - The new facility will enhance collaboration among cross-functional teams and support the development of Tevogen's AI platforms [2][3] - The CEO's personal investment reflects strong leadership conviction in the company's mission and long-term vision for affordable cell therapies [3] Company Developments - The CEO, Ryan Saadi, M.D., M.P.H., contributed $500,000 for the build-out and first-year operating costs of the new headquarters in Warren, New Jersey [1] - The new facility more than doubles the previous operational footprint and centralizes various teams, including research and regulatory affairs [2] - The dedicated collaboration spaces are designed to facilitate the work of data scientists and engineers on Tevogen's proprietary AI platforms, PredicTcell™ and AdapTcell™ [2] Financial Outlook - The CFO, Kirti Desai, highlighted that the CEO's investment underscores the leadership's commitment to capital discipline while enabling efficient scaling [3]

Core Insights - Tevogen Bio is advancing its development of a cytotoxic T lymphocyte (CTL) therapy targeting Epstein-Barr virus (EBV)-associated lymphomas [1] - The company is utilizing its proprietary ExacTcell™ technology to manufacture EBV-specific CTLs for potential clinical trials [2] - Collaboration with Tevogen.AI aims to enhance peptide selection strategies for identifying immunologically active targets across the EBV genome [3] - The understanding of EBV-induced tumorigenesis has improved, highlighting the potential for CTLs to target EBV proteins for therapeutic breakthroughs [4] Research and Development - Computer-based selection of EBV peptides is in progress as part of preparation for clinical trials [2] - Confirmation studies are being conducted in Tevogen's R&D laboratory to validate CTL responses to selected viral peptides [2] - The collaboration with Tevogen.AI is focused on accelerating the identification of effective immunological targets [3] Scientific Insights - Recent advancements have clarified the mechanisms of EBV-induced tumorigenesis, which involve disruption of cellular pathways and promotion of malignant growth [4] - Targeting EBV proteins with specific CTLs represents a promising area for research and potential therapeutic advancements in EBV-driven cancers [4] Future Directions - Tevogen Bio plans to provide ongoing updates as its EBV research progresses through the preclinical evaluation phase [4]

Core Viewpoint - Tevogen Bio Holdings Inc. has executed a lease agreement to expand its corporate headquarters in Warren, New Jersey, significantly increasing its operational footprint and enhancing collaboration among its teams [2][3]. Group 1: Expansion and Operational Efficiency - The new headquarters will centralize various cross-functional teams, including executive leadership, regulatory affairs, corporate strategy, and research and development, which were previously located in Philadelphia [3]. - The expanded facility will also accommodate Tevogen.AI and the Generics & Biosimilars initiative, providing dedicated space for data scientists and engineers as the development of proprietary algorithms accelerates [3][4]. Group 2: Future Growth and Business Diversification - The newly leased space, previously occupied by CAPTRUST, will support potential new business units as Tevogen continues to grow and diversify its portfolio [4]. - Tevogen aims to finalize in-house manufacturing capabilities, which are projected to support cumulative revenues of $10–14 billion for Tevogen Oncology and $18–22 billion for Tevogen Specialty Care [5]. Group 3: Commitment to Healthcare - Tevogen remains dedicated to enhancing healthcare affordability and accessibility through drug development, AI-powered innovation, and domestic manufacturing of generics and biosimilars [5].

Core Insights - Tevogen Bio Holdings Inc. is advancing its artificial intelligence initiative, Tevogen.AI™, to enhance its immunotherapy development pipeline and reduce costs [1][2] Group 1: Tevogen.AI Initiative - Tevogen.AI aims to integrate machine learning and predictive modeling with ExacTcell™ technology to improve target identification and pre-clinical processes [2] - The initiative includes two proprietary technologies with patents pending, and the company plans to expand its AI applications beyond its current scope [3] Group 2: Strategic Partnerships - Tevogen has partnered with Microsoft for AI expertise and cloud infrastructure, and with Databricks for data engineering and analytics to enhance predictive accuracy [5] Group 3: Proprietary Technologies - PredicTcell™ utilizes AI to predict immunologically active peptide complexes, improving precision in immunotherapy treatments [6] - AdapTcell™ focuses on decoding interactions between human leukocyte antigens and T cells, enhancing understanding of immune responses [8][9] Group 4: Future Plans - Tevogen.AI plans to utilize its platforms for clinical trial patient identification, aiming for efficiency and cost reduction in drug development [10]

Core Insights - Tevogen Bio Holdings Inc. plans to expand the target population for its product TVGN 489 to include patients aged 65 and older, enhancing its market potential [1] - The top-line revenue forecast for the specialty care pipeline is projected at nearly $1 billion in its launch year, with a cumulative five-year estimate ranging between $18 billion and $22 billion [1] - The expansion aims to address significant unmet medical needs, particularly in light of the new COVID variant NB.1.8.1 [2] Company Developments - Tevogen's Chief Commercial Officer emphasized the importance of expanding clinical manufacturing capacity to meet the demands posed by the new COVID variant [2] - The expanded pipeline will include treatments for SARS-CoV-2 infection in various patient groups, including those with B cell hematologic cancer and patients aged 65 and older [5] Financial Projections - The updated forecast and risk-adjusted net present value (rNPV) will be provided to reflect the inclusion of the 65+ patient population [1] - The anticipated revenue growth reflects the company's strategic focus on specialty pharmaceuticals and addressing broader market needs [1]

Core Insights - Tevogen Bio Holdings Inc. is preparing to provide updates to stockholders ahead of its Annual Meeting scheduled for June 23, 2025, focusing on its innovative business model and strategic growth initiatives [1] Group 1: Portfolio Assets - The company will update investors on its portfolio assets, which include Tevogen Bio Oncology, Tevogen Bio Specialty Care, and Tevogen.AI, valued at over $10 billion as of October 2024 [2] Group 2: Corporate Highlights - Tevogen will detail two strategic initiatives: Tevogen.AI and Tevogen Generics & Biosimilars, alongside plans to expand its operational footprint with an upgraded headquarters [3] Group 3: Financial Market Dynamics - Management is monitoring stock dynamics, noting the impact of a limited tradable float and the growing institutional ownership, which reflects strong investor confidence and long-term holding patterns [4]

Financial Performance - Tevogen Bio reported a net loss of $10.4 million for the three months ended March 31, 2025, compared to a net loss of $11.3 million for the same period in 2024, primarily due to non-cash stock-based compensation expenses [136]. - The net loss for the three months ended March 31, 2025, was $10.4 million, compared to a net loss of $11.3 million for the same period in 2024 [156]. - Research and development expenses for the three months ended March 31, 2025, were $3.2 million, a decrease of 84.7% from $20.8 million for the same period in 2024 [157]. - General and administrative expenses for the three months ended March 31, 2025, were $7.2 million, down 17.7% from $8.7 million in the same period in 2024 [158]. - Cash used in operating activities for the three months ended March 31, 2025, was $3.3 million, compared to $2.2 million for the same period in 2024 [165][166]. Cash and Funding - As of March 31, 2025, Tevogen Bio had an accumulated deficit of $123.8 million and cash reserves of $2.0 million [136]. - As of March 31, 2025, the company had $2.0 million in cash, an increase from $1.3 million as of December 31, 2024 [163]. - The company raised aggregate gross proceeds of $24.0 million from the sale of convertible promissory notes since January 2021 [163]. - The company has drawn $3.0 million from a Loan Agreement with a remaining $27.0 million available for future financing [163]. - The company expects to utilize $8.0 million in grant funding from KRHP for ongoing operational expenses through March 31, 2026 [176]. - The company is exploring various funding strategies, including private placements and partnerships, to support operations [177]. Clinical Development - The first clinical product, TVGN 489, has completed a Phase 1 proof-of-concept trial with no dose-limiting toxicities observed, and secondary endpoints showed a rapid reduction in viral load [126]. - The company aims to commercialize TVGN 489 and other product candidates, expecting to incur expenses related to expanding research and development capabilities and building manufacturing infrastructure [141]. - The company plans to conduct clinical trials for TVGN 489 and other product candidates, which will require considerable financial resources [172]. - The company anticipates increased expenses related to commercialization if marketing approval for TVGN 489 is obtained [174]. Patent and Technology - Tevogen Bio's patent portfolio includes three issued U.S. patents related to TVGN 489, all expiring on December 9, 2040, and nine pending U.S. patent applications [130][131]. - Tevogen Bio's ExacTcell technology is designed to develop off-the-shelf T cell therapies with applications in infectious diseases and cancers [124]. Future Expectations - The company has not generated any revenue to date and does not expect to do so until marketing approval is obtained for its product candidates [141]. - The company expects general and administrative expenses to increase in the future to support ongoing research and development and potential commercialization efforts [149]. - The company expects to incur costs associated with operating as a public company, necessitating additional funding [174]. Obligations and Agreements - Total contractual obligations as of March 31, 2025, amount to $4,846,712, with $1,846,712 due within one year [179]. - The company has committed to a securities purchase agreement with the Patel Family for $6.0 million in Series C Preferred Stock [170]. - The company has not yet received $3.0 million of the $6.0 million purchase price for Series A-1 Preferred Stock [170]. - The company has entered into a Loan Agreement allowing for monthly draws of up to $1.0 million over 27 months, with a maximum loan amount of $36.0 million [171]. - The company has drawn an aggregate of $3.0 million under the Loan Agreement as of March 31, 2025, with an additional $0.5 million drawn in April 2025 [171].

Group 1 - Tevogen Bio Holdings Inc. has received inquiries from shareholders about transferring shares to the Direct Registration System (DRS) following a recent press release [1] - The company will provide step-by-step guidance next week for shareholders to register their shares directly with the transfer agent, Continental Stock Transfer & Trust [2] - Several of Tevogen's largest shareholders have chosen to hold their shares via DRS, indicating their confidence in this method of ownership [2]