Core Insights - Tevogen Bio Holdings Inc. has made significant advancements in its PredicTcell™ platform, which aims to enhance precision immunotherapy through advanced machine learning and transformer-based models, supported by Microsoft and Databricks [1][3] Development Progress - The alpha version of PredicTcell was trained on over 124,000 records with transformer-based architecture and 91,000 records using traditional machine learning, achieving recall levels of approximately 92–97% and precision between 38–43% [2] - The beta version has expanded its training dataset to around 1.4 million records, with a total dataset exceeding 6.7 billion records, significantly increasing the number of features for training from 22 to 27 [5][6] Clinical Implications - The advancements in the PredicTcell platform could lead to T-cell therapies that reliably bind to their target, potentially transforming clinical success rates and reducing drug development costs [3][6] - Insights from Tevogen's ExacTcell™ platform and positive Phase 1 trial results inform the beta version's focus on higher precision in identifying virology targets [3] Market Potential - The company aims to raise efficacy standards in T-cell therapies, unlock new markets in immunotherapy, and improve patient access to life-saving therapies across various diseases, including infectious diseases and oncology [3][6]

Core Insights - Tevogen Bio Holdings Inc. emphasizes the potential of its investigational precision T cell therapy, TVGN 489, for treating Long COVID, which affects an estimated 20 million Americans [2][5] - Recent peer-reviewed studies indicate the presence of residual SARS-CoV-2 proteins and RNA long after acute infection, suggesting a viral reservoir that contributes to Long COVID symptoms [3] - TVGN 489 is designed to target multiple SARS-CoV-2 proteins across the entire viral genome, showing efficacy in reducing viral load and persisting in patients for at least 6 months without interfering with their immune responses [4] Scientific Evidence - Peer-reviewed studies published in notable journals report the detection of residual SARS-CoV-2 proteins and RNA for months to years post-infection, indicating chronic immune inflammation linked to Long COVID [3] - These findings support the development of therapeutic approaches aimed at eliminating residual virus and restoring immune homeostasis [3] Product Development - TVGN 489, derived from Tevogen's ExacTcell™ platform, is an off-the-shelf cytotoxic CD8+ T lymphocyte therapy targeting multiple viral proteins, not limited to the Spike protein [4] - In proof-of-concept trials, TVGN 489 demonstrated efficacy in reducing viral load across all patients, with CTLs persisting for at least 6 months [4] Company Outlook - The CEO of Tevogen expresses optimism regarding TVGN 489's potential to restore homeostasis in Long COVID patients, highlighting the company's preparations for clinical manufacturing [5]

Core Insights - Tevogen Bio Holdings Inc. expresses gratitude to the U.S. Department of Health and Human Services for addressing Long COVID through roundtables focused on patient experiences and research [1] - Approximately 20 million adults in the U.S. are affected by Long COVID, leading to significant economic consequences due to workforce absenteeism and productivity losses [2] - Tevogen's investigational drug, TVGN 489, shows promising results in clinical trials and may play a crucial role in addressing the Long COVID public health crisis [3] Company Developments - The CEO of Tevogen emphasizes the importance of addressing the lasting consequences of SARS-CoV-2, highlighting the potential of TVGN 489 to restore health for those affected by Long COVID [4] - Tevogen is committed to developing accessible and affordable personalized therapeutics through its ExacTcell™ platform, which focuses on precision T cell therapies [4]

Core Insights - Tevogen Bio Holdings Inc. will have its Chief Information Officer, Mittul Mehta, participate in the Startup Forum at the Databricks DATA + AI World Tour on October 8, 2025 [2][3] - The Startup Forum will focus on insights from venture capital leaders and early-stage innovators regarding scaling companies with Databricks [3] Company Participation - Mittul Mehta will join industry peers such as Chris Gervais, CTO of Codametrix, and Stavros Papadopoulos, CEO of TileDB, in a discussion moderated by Tony Pezzullo, Principal at SignalFire [3] - Mehta will discuss Tevogen.AI's use of advanced data and AI technologies, particularly the PredicTcell™ platform, which was developed in collaboration with Microsoft and Databricks to enhance precision immunotherapy development [3] Event Details - The Databricks DATA + AI World Tour will be held at the Sheraton Boston Hotel [4]

Core Insights - Tevogen Bio Holdings Inc. estimates the risk-adjusted Net Present Value (rNPV) for its product TVGN 116, aimed at liver cancer prevention in high-risk chronic Hepatitis B patients, to exceed approximately $325 million in the US alone [1][3] - The cumulative 5-year top-line revenue forecast for TVGN 116 is projected to be around $6.5 billion, reflecting the company's innovative and efficient drug development model [2] Financial Projections - The current rNPV for TVGN 116 is based on the understanding of unmet medical needs and the competitive landscape, with adjustments made at each milestone in the product development lifecycle [3] - Tevogen's progress with its first clinical-stage product, TVGN 489, demonstrates the rapid achievement of development milestones [3] Strategic Outlook - The company’s drug development model is positioned as a potential blueprint for sustainable medical innovation in the future [2]

Core Insights - Tevogen Bio Holdings Inc. estimates the risk-adjusted net present value (rNPV) of its product TVGN-489 to be between $9 billion and $11 billion, targeting treatment for SARS-CoV-2 and Long-COVID in high-risk patients [1][3] Clinical Trial Findings - In a Phase I proof-of-concept trial, two cancer patients received TVGN-489 and were able to proceed to stem cell transplants shortly after treatment, with no complications from COVID-19 observed [2] - High-risk ambulatory patients showed significant viral elimination, with ≥88% of patients achieving viral clearance by Day 4 and >99% by Day 14 [7] - No disease progression or recurrent COVID-19 cases were reported in the treatment arm during a six-month follow-up [7] Revenue Projections - Tevogen's cumulative revenue projections for TVGN-489 over five years indicate a strong market potential, with the rNPV reflecting only U.S. revenue potential and not the broader ExacTcell™ technology platform [3][4] Future Plans - The company plans to provide ongoing updates regarding the valuation of its internally developed assets, including product pipeline developments [4]

Core Insights - Tevogen Bio Holdings Inc. has announced the potential value and forecast for its pipeline product, TVGN 930, aimed at treating non-solid tumor malignancies associated with Epstein-Barr Virus (EBV) [1][2] Financial Projections - The cumulative 5-year top-line revenue forecast for TVGN 930 is approximately $3.5 billion, reflecting the company's innovative drug development model [2] - The risk-adjusted Net Present Value (rNPV) for TVGN 930 is projected to exceed $250 million in the US alone [7] Market Opportunity - There are currently no approved vaccines for EBV, creating a significant therapeutic gap that TVGN 930 aims to fill [4] - The accessible market in the US for TVGN 930 could potentially cover up to 40,000 patients across five rare disease indications [7] Additional Applications - The treatment of multiple sclerosis through tighter EBV control presents an additional opportunity for the product [3]

Core Viewpoint - Tevogen Bio Holdings Inc. emphasizes the ongoing need for effective SARS-CoV-2 treatments, particularly for individuals with weakened immune systems, highlighting the potential of its investigational therapy TVGN 489 to enhance immunity and eliminate the virus [1][3] Group 1: Product Development and Clinical Trials - TVGN 489 is an allogeneic SARS-CoV-2-specific Cytotoxic CD8+ T lymphocyte immunotherapy developed using the ExacTcell platform, targeting the entire viral genome rather than just a single protein [1] - Positive clinical trial data indicates that in the treatment arm, viral elimination reached over 99% in all patients by day 14, with no disease progression or Long COVID observed [6] - The treatment was well-tolerated across all dose levels, and CTLs persisted in treated patients for up to six months, suggesting a durable immune response [6] Group 2: Market Context and Challenges - The emergence of the XFG variant of SARS-CoV-2 underscores the ongoing threat of COVID-19, particularly for vulnerable populations, necessitating continuous surveillance and treatment efforts [3] - The company acknowledges the challenges posed by mutation-prone viruses, indicating that targeting only the spike protein is insufficient for effective treatment [3] Group 3: Future Outlook - Tevogen's leadership expresses confidence in the potential of TVGN 489 to provide necessary immune support for high-risk patients, emphasizing the importance of innovative therapies in the face of evolving viral threats [3]

Core Insights - Tevogen Bio Holdings Inc. has significant internally developed assets that are not reflected on its balance sheet but represent substantial long-term value [1][3] - The company plans to provide detailed information and valuation of these assets in the near future [1] Asset Overview - Key assets include PredicTcell™, which utilizes AI algorithms to predict peptide–T cell receptor interactions, thereby accelerating development and expanding the pipeline [1] - AdapTcell™ employs AI models to decode HLA–T cell interactions, enhancing immune system insights and revealing new therapeutic paths [2] Intellectual Property and Technology - Tevogen holds three granted U.S. patents and has twelve pending U.S. patents, including two related to artificial intelligence [6] - The company has strategic collaborations with Microsoft and Databricks to support its AI technology [6] Drug Development and Clinical Pipeline - The ExacTcell™ platform focuses on highly purified, target-specific CD8+ cytotoxic T lymphocytes (CTL) [6] - The clinical pipeline includes therapeutics designed to treat cancers while allowing patients to continue oncology care, with potential expansion into non-oncology indications [6] Financial Position - Tevogen has access to a line of credit and is well-capitalized for current operations [6] - The company is establishing internal GMP manufacturing capabilities [6] Facilities - Tevogen operates a drug discovery lab in Philadelphia and has its headquarters in New Jersey [6]

Core Insights - Tevogen Bio Holdings Inc. has been recognized by Yale University for its commitment to health equity and the leadership of its Founder and CEO, Dr. Ryan Saadi [2] - The company operates with a lean, capital-efficient business model, fully owning its core intellectual property to minimize costs and complexity in developing CD8+ T cell therapies [3] - Dr. Saadi emphasized that affordability and accessibility are foundational to Tevogen's operations, achieving significant milestones with lower capital expenditure compared to industry norms [4] Business Model and Strategy - Tevogen's business model is designed to withstand market pressures through a capital-efficient structure, focusing on off-the-shelf, genetically unmodified therapies [3] - The company has avoided the typical billion-dollar burn rate seen in the industry, maintaining a lean cash run rate while preserving equity [4] - Tevogen aims to deliver innovative therapies that not only improve patient outcomes but also achieve commercial success at a lower cost [4] Recognition and Impact - The recognition from Yale highlights the impact of Tevogen's mission on making healthcare more affordable and accessible [2] - Dr. Saadi's vision is acknowledged as a significant contribution to the healthcare landscape, reinforcing the company's commitment to health equity [2][4]