Group 1: Earnings Performance - Verve Therapeutics reported a quarterly loss of $0.35 per share, significantly better than the Zacks Consensus Estimate of a loss of $0.71, representing an earnings surprise of 50.70% [1] - The company has surpassed consensus EPS estimates in all four of the last quarters [2] - The revenue for the quarter ended March 2025 was $32.98 million, exceeding the Zacks Consensus Estimate by 362.76%, compared to $5.7 million in the same quarter last year [2] Group 2: Stock Performance and Outlook - Verve Therapeutics shares have declined approximately 26.2% since the beginning of the year, while the S&P 500 has gained 0.1% [3] - The company's earnings outlook is mixed, with the current consensus EPS estimate for the upcoming quarter at -$0.70 on revenues of $8.29 million, and for the current fiscal year at -$2.73 on revenues of $29.74 million [7] - The Zacks Rank for Verve Therapeutics is currently 3 (Hold), indicating expected performance in line with the market in the near future [6] Group 3: Industry Context - The Medical - Drugs industry, to which Verve Therapeutics belongs, is currently in the top 29% of over 250 Zacks industries, suggesting a favorable outlook compared to lower-ranked industries [8] - Another company in the same industry, Plus Therapeutics, is expected to report a quarterly loss of $0.17 per share, reflecting a year-over-year change of +77.3% [9]

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2025 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from ____________ to ____________ Commission File Number: 001-40489 VERVE THERAPEUTICS, INC. (Exact Name of Registrant as Specified in its Charter) Delaware 82-48001 ...

Exhibit 99.1 Verve Therapeutics Announces Pipeline Progress and Reports First Quarter 2025 Financial Results Reported positive initial data from the Heart-2 Phase 1b clinical trial of VERVE-102 demonstrating dose-dependent decreases in blood LDL-C and PCSK9 Mean reduction in LDL-C of 53%, with a maximum reduction of 69%, observed after a single infusion of VERVE-102 in the 0.6 mg/kg dose cohort in the Heart-2 clinical trial Pulse-1 Phase 1b clinical trial of VERVE-201 targeting ANGPTL3 continues to progress ...

Company Overview - Verve Therapeutics is a clinical-stage biotech company focused on developing gene editing therapies, particularly VERVE-102, aimed at treating heterozygous familial hypercholesterolemia (HeFH) and premature coronary artery disease [2][4] - The company has a partnership with Eli Lilly, which provides financial backing and reduces the risk of funding issues [5] Clinical Progress - Verve Therapeutics recently announced positive results from a Phase 1b clinical trial for VERVE-102, showing a mean LDL-C reduction of 53% in patients after a single injection [3][4] - The potential target market for VERVE-102 includes approximately three million patients in the U.S. and the European Union, and 31 million globally [3] Market Expectations - Wall Street has set an average price target of $24.43 for Verve Therapeutics, suggesting a potential stock increase of 321% over the next 12 months [1] - Despite the promising clinical results, the stock only saw a 24% increase in one day following the announcement, indicating cautious market sentiment [4] Future Outlook - The company plans to start Phase 2 studies in the second half of the year, but it may take a couple of years before VERVE-102 enters Phase 3 studies [5][6] - There are concerns about potential clinical and regulatory setbacks that could impact the company's progress and stock performance [4][6]

Core Viewpoint - Verve Therapeutics experienced a significant stock price increase of 40% due to positive laboratory news and favorable analyst reports [1]. Company Developments - Verve is a clinical-stage biotech company focused on its drug pipeline, with recent encouraging results from a phase 1b clinical trial of VERVE-102, aimed at treating heterozygous familial hypercholesterolemia (HeFH) [2]. - The trial involved 14 patients and demonstrated efficacy in reducing low-density lipoprotein cholesterol (LDL-C) levels, with no serious adverse events reported, indicating a well-tolerated treatment [3]. Analyst Reactions - Following the trial results, analysts issued bullish notes on Verve, with several raising their price targets; Cantor Fitzgerald upgraded its recommendation to a buy [3]. - Despite the overall positive sentiment, JPMorgan Chase analyst Eric Joseph lowered his price target from $19 to $16 per share [4]. - BMO Capital's Kostas Biliouris reiterated an outperform (buy) recommendation, noting that the drug's performance exceeded expectations and its safety profile suggested a wide therapeutic window [4].

Core Viewpoint - Verve Therapeutics' shares increased by 26.4% following the announcement of positive initial data from the early-stage study of VERVE-102, a candidate aimed at reducing cholesterol levels [1] Group 1: Study Details - The phase Ib Heart-2 study includes patients with heterozygous familial hypercholesterolemia and/or premature coronary artery disease, both of which require significant reductions in low-density lipoprotein cholesterol (LDL-C) levels [2] - The data readout involved 14 patients from the first three cohorts who received doses of VERVE-102 at 0.3 mg/kg, 0.45 mg/kg, or 0.6 mg/kg, with each participant having at least 28 days of follow-up as of March 13, 2025 [3] Group 2: Efficacy Results - A single infusion of VERVE-102 led to dose-dependent reductions in blood PCSK9 protein levels and LDL-C, with an average LDL-C decrease of 53% and a maximum reduction of 69% in the 0.6 mg/kg cohort [4] - In cohort 1, patients receiving 0.3 mg/kg showed a 21% reduction in LDL-C and a 46% reduction in PCSK9; those receiving 0.45 mg/kg had a 41% reduction in LDL-C and a 53% reduction in PCSK9; and in cohort 3, the reductions were 53% in LDL-C and 60% in PCSK9 [5][7] Group 3: Safety and Next Steps - VERVE-102 was well-tolerated across all doses, with no serious adverse events reported and no significant changes in liver enzymes or other clinical parameters among participants [7] - The Heart-2 study is currently enrolling participants for a fourth dose cohort of 0.7 mg/kg, with early safety findings consistent with previous cohorts; final data from the dose escalation phase is expected in the second half of 2025 [8] - A phase II clinical study for VERVE-102 is planned to begin in the second half of 2025, following FDA clearance of its investigational new drug application [9] Group 4: Collaboration and Future Plans - Verve Therapeutics has a collaboration agreement with Eli Lilly for the PCSK9 program, where Lilly can opt in to share development costs and profits; Verve retains control over development and commercialization in the U.S. [11] - The company plans to submit the opt-in package to Eli Lilly and expects a decision in the second half of 2025 [11]

Verve Therapeutics (VERV 23.79%) stock is seeing explosive gains Tuesday. The biotech company's share price was up 24.5% as of 12:30 p.m. ET and had been up as much as 41% earlier in the session.Yesterday, Verve published promising data from its Heart-2 Phase 1b clinical trial of its VERVE-102 treatment for heterozygous familial hypercholesterolemia (HeFH) and premature coronary artery disease. Several analysts have now raised their price targets on the stock, and investors are buying up shares in response. ...

Verve Therapeutics Inc VERV on Monday released initial data from the Heart-2 Phase 1b trial of VERVE-102 in patients with heterozygous familial hypercholesterolemia (HeFH) and/or premature coronary artery disease (CAD), which requires reducing low-density lipoprotein cholesterol (LDL-C) levels in the blood.VERVE-102 was well-tolerated among 14 participants across three dose levels. No treatment-related serious adverse events (SAEs) and no clinically significant laboratory abnormalities were observed.A singl ...

Core Insights - Verve Therapeutics announced positive initial data from the Heart-2 Phase 1b clinical trial of VERVE-102, showing significant reductions in LDL-C and PCSK9 levels with a single infusion [1][2][10] Efficacy - A single infusion of VERVE-102 resulted in a mean LDL-C reduction of 53% and a maximum reduction of 69% in the 0.6 mg/kg dose cohort [1][11] - The trial demonstrated a dose-dependent response, with mean LDL-C reductions of 21% at 0.3 mg/kg, 41% at 0.45 mg/kg, and 53% at 0.6 mg/kg [11] - Among participants receiving a total RNA dose greater than 50 mg, a mean LDL-C reduction of 59% was observed [9][10] Safety and Tolerability - VERVE-102 was well-tolerated with no treatment-related serious adverse events and no clinically significant changes in liver enzymes or platelets [1][6] - One infusion-related reaction was reported, which was transient and resolved with acetaminophen [6] Clinical Trial Design - The Heart-2 trial is an open-label Phase 1b study evaluating the safety and tolerability of VERVE-102 in patients with heterozygous familial hypercholesterolemia (HeFH) and/or premature coronary artery disease (CAD) [4][5] - The trial includes four dose cohorts, with initial data reported from 14 participants across the first three cohorts [5] Future Plans - Verve plans to report final Heart-2 dose escalation data and initiate a Phase 2 clinical trial for VERVE-102 in the second half of 2025 [1][13] - The company expects to receive a decision from Eli Lilly regarding the PCSK9 opt-in in the second half of 2025 [14] Company Overview - Verve Therapeutics is focused on developing genetic medicines for cardiovascular disease, with VERVE-102 targeting the PCSK9 gene to reduce LDL-C levels [16] - The company aims to transform treatment from chronic therapies to single-course gene editing medicines [16]

Core Insights - Verve Therapeutics has received Fast Track designation from the FDA for its investigational drug VERVE-102, aimed at treating hyperlipidemia and reducing LDL-C levels in patients at high cardiovascular risk [1][2] - VERVE-102 is designed as a single-course treatment that permanently disables the PCSK9 gene in the liver, potentially transforming the management of atherosclerotic cardiovascular disease [1][5] - The company is currently conducting the Phase 1b Heart-2 clinical trial to assess the safety and tolerability of VERVE-102 in patients with heterozygous familial hypercholesterolemia and/or premature coronary artery disease [1][3] Company Overview - Verve Therapeutics is a clinical-stage company focused on developing genetic medicines for cardiovascular diseases, with a goal to shift treatment from chronic therapies to single-course gene editing solutions [5] - The company's lead programs include VERVE-102, VERVE-201, and VERVE-301, targeting key cholesterol drivers associated with atherosclerosis [5] - VERVE-201 aims to turn off the ANGPTL3 gene for patients with refractory hypercholesterolemia, while VERVE-301 targets the LPA gene to reduce Lp(a) levels, an independent risk factor for cardiovascular diseases [5] Clinical Trial Updates - Initial demographic and safety data from the Heart-2 clinical trial are expected to be announced in Q2 2025, including results from three dose cohorts [3] - The final data for the dose escalation portion of the Heart-2 trial is anticipated in the second half of 2025, along with the initiation of the Phase 2 clinical trial for the PCSK9 program [4]