Verve Therapeutics (VERV) came out with a quarterly loss of $0.35 per share versus the Zacks Consensus Estimate of a loss of $0.71. This compares to loss of $0.59 per share a year ago. These figures are adjusted for non-recurring items.This quarterly report represents an earnings surprise of 50.70%. A quarter ago, it was expected that this biotechnology firm would post a loss of $0.72 per share when it actually produced a loss of $0.58, delivering a surprise of 19.44%.Over the last four quarters, the compan ...

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2025 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from ____________ to ____________ Commission File Number: 001-40489 VERVE THERAPEUTICS, INC. (Exact Name of Registrant as Specified in its Charter) Delaware 82-48001 ...

Exhibit 99.1 Verve Therapeutics Announces Pipeline Progress and Reports First Quarter 2025 Financial Results Reported positive initial data from the Heart-2 Phase 1b clinical trial of VERVE-102 demonstrating dose-dependent decreases in blood LDL-C and PCSK9 Mean reduction in LDL-C of 53%, with a maximum reduction of 69%, observed after a single infusion of VERVE-102 in the 0.6 mg/kg dose cohort in the Heart-2 clinical trial Pulse-1 Phase 1b clinical trial of VERVE-201 targeting ANGPTL3 continues to progress ...

Company Overview - Verve Therapeutics is a clinical-stage biotech company focused on developing gene editing therapies, particularly VERVE-102, aimed at treating heterozygous familial hypercholesterolemia (HeFH) and premature coronary artery disease [2][4] - The company has a partnership with Eli Lilly, which provides financial backing and reduces the risk of funding issues [5] Clinical Progress - Verve Therapeutics recently announced positive results from a Phase 1b clinical trial for VERVE-102, showing a mean LDL-C reduction of 53% in patients after a single injection [3][4] - The potential target market for VERVE-102 includes approximately three million patients in the U.S. and the European Union, and 31 million globally [3] Market Expectations - Wall Street has set an average price target of $24.43 for Verve Therapeutics, suggesting a potential stock increase of 321% over the next 12 months [1] - Despite the promising clinical results, the stock only saw a 24% increase in one day following the announcement, indicating cautious market sentiment [4] Future Outlook - The company plans to start Phase 2 studies in the second half of the year, but it may take a couple of years before VERVE-102 enters Phase 3 studies [5][6] - There are concerns about potential clinical and regulatory setbacks that could impact the company's progress and stock performance [4][6]

Core Viewpoint - Verve Therapeutics experienced a significant stock price increase of 40% due to positive laboratory news and favorable analyst reports [1]. Company Developments - Verve is a clinical-stage biotech company focused on its drug pipeline, with recent encouraging results from a phase 1b clinical trial of VERVE-102, aimed at treating heterozygous familial hypercholesterolemia (HeFH) [2]. - The trial involved 14 patients and demonstrated efficacy in reducing low-density lipoprotein cholesterol (LDL-C) levels, with no serious adverse events reported, indicating a well-tolerated treatment [3]. Analyst Reactions - Following the trial results, analysts issued bullish notes on Verve, with several raising their price targets; Cantor Fitzgerald upgraded its recommendation to a buy [3]. - Despite the overall positive sentiment, JPMorgan Chase analyst Eric Joseph lowered his price target from $19 to $16 per share [4]. - BMO Capital's Kostas Biliouris reiterated an outperform (buy) recommendation, noting that the drug's performance exceeded expectations and its safety profile suggested a wide therapeutic window [4].

Shares of Verve Therapeutics (VERV) surged 26.4% on Monday and continue to soar today after the company announced positive initial data from an early-stage study of its investigational candidate, VERVE-102, which is being developed for reducing cholesterol levels. VERVE-102 is a novel, in vivo, investigational base editing medicine.The patient population enrolled in the phase Ib Heart-2 study comprises individuals with heterozygous familial hypercholesterolemia and/or premature coronary artery disease — two ...

Verve Therapeutics (VERV 23.79%) stock is seeing explosive gains Tuesday. The biotech company's share price was up 24.5% as of 12:30 p.m. ET and had been up as much as 41% earlier in the session.Yesterday, Verve published promising data from its Heart-2 Phase 1b clinical trial of its VERVE-102 treatment for heterozygous familial hypercholesterolemia (HeFH) and premature coronary artery disease. Several analysts have now raised their price targets on the stock, and investors are buying up shares in response. ...

Verve Therapeutics Inc VERV on Monday released initial data from the Heart-2 Phase 1b trial of VERVE-102 in patients with heterozygous familial hypercholesterolemia (HeFH) and/or premature coronary artery disease (CAD), which requires reducing low-density lipoprotein cholesterol (LDL-C) levels in the blood.VERVE-102 was well-tolerated among 14 participants across three dose levels. No treatment-related serious adverse events (SAEs) and no clinically significant laboratory abnormalities were observed.A singl ...

Single infusion of VERVE-102 led to dose-dependent decreases in blood PCSK9 and LDL-C, with mean reduction in LDL-C of 53% and a maximum reduction of 69% observed in the 0.6 mg/kg dose cohort VERVE-102 was well-tolerated with no treatment-related serious adverse events and no clinically significant changes in ALT or platelets observed at any dose level among 14 participants VERVE-102 utilizes a proprietary GalNAc-LNP which has demonstrated a potentially best-in-class safety profile In the second half of 202 ...

Core Insights - Verve Therapeutics has received Fast Track designation from the FDA for its investigational drug VERVE-102, aimed at treating hyperlipidemia and reducing LDL-C levels in patients at high cardiovascular risk [1][2] - VERVE-102 is designed as a single-course treatment that permanently disables the PCSK9 gene in the liver, potentially transforming the management of atherosclerotic cardiovascular disease [1][5] - The company is currently conducting the Phase 1b Heart-2 clinical trial to assess the safety and tolerability of VERVE-102 in patients with heterozygous familial hypercholesterolemia and/or premature coronary artery disease [1][3] Company Overview - Verve Therapeutics is a clinical-stage company focused on developing genetic medicines for cardiovascular diseases, with a goal to shift treatment from chronic therapies to single-course gene editing solutions [5] - The company's lead programs include VERVE-102, VERVE-201, and VERVE-301, targeting key cholesterol drivers associated with atherosclerosis [5] - VERVE-201 aims to turn off the ANGPTL3 gene for patients with refractory hypercholesterolemia, while VERVE-301 targets the LPA gene to reduce Lp(a) levels, an independent risk factor for cardiovascular diseases [5] Clinical Trial Updates - Initial demographic and safety data from the Heart-2 clinical trial are expected to be announced in Q2 2025, including results from three dose cohorts [3] - The final data for the dose escalation portion of the Heart-2 trial is anticipated in the second half of 2025, along with the initiation of the Phase 2 clinical trial for the PCSK9 program [4]