Core Insights - Altimmune, Inc. announced positive topline results from the IMPACT Phase 2b trial of pemvidutide, a dual receptor agonist, in patients with metabolic dysfunction-associated steatohepatitis (MASH) at 48 weeks [2][3] Group 1: Trial Results - Statistically significant improvements in key non-invasive markers of fibrosis, including Enhanced Liver Fibrosis (ELF) and Liver Stiffness Measurement (LSM), were observed across treatment arms compared to placebo [3][5] - The 1.2 mg and 1.8 mg doses of pemvidutide achieved mean reductions in ELF of -0.49 and -0.58 respectively, versus +0.16 in placebo (p<0.0001) [5] - The 1.2 mg and 1.8 mg doses achieved mean reductions in LSM of -3.04 (p<0.05) and -3.97 (p<0.001) respectively, compared to -0.03 in placebo [5] - Participants receiving pemvidutide also showed significant reductions in liver fat content, alanine aminotransferase (ALT), and corrected T1 (cT1) [5] - Weight loss was observed with the 1.2 mg and 1.8 mg doses at 4.5% and 7.5% respectively, compared to 0.2% in placebo (p<0.0001) [13] Group 2: Tolerability and Safety - The tolerability profile of pemvidutide was favorable at 48 weeks, with low treatment-related discontinuation rates of 0% and 1.2% for the 1.2 mg and 1.8 mg doses respectively, compared to 3.5% for placebo [13] - No serious or severe adverse events related to treatment were reported [13] Group 3: Regulatory Progress - The company held a productive End-of-Phase 2 meeting with the FDA, aligning on parameters for a registrational Phase 3 trial for pemvidutide in MASH patients with moderate to advanced liver fibrosis [6][7] - The FDA's qualification of AIM-MASH AI Assist was noted, which aims to standardize histologic assessment in the Phase 3 trial [6] Group 4: Future Plans - The company plans to initiate the Phase 3 program for pemvidutide in 2026, leveraging the strong evidence of antifibrotic improvements and favorable tolerability [7]

SAN FRANCISCO--(BUSINESS WIRE)--Nextdoor announced expanded integrations for Nextdoor Alerts, implementing real-time earthquake data from the U.S. Geological Survey (USGS). ...

Core Viewpoint - TNL Mediagene announced a 1-for-20 share consolidation to increase the trading price of its ordinary shares and regain compliance with Nasdaq's minimum bid price requirement of $1.00 per share [1][2]. Group 1: Share Consolidation Details - The share consolidation is set to take effect on December 23, 2025, with shares trading under the existing ticker symbol "TNMG" and a new CUSIP number [1]. - The consolidation aims to enhance the company's appeal to institutional investors who require a minimum share price for investment [2]. - Shareholders approved a consolidation ratio of up to 1-to-100, with the final ratio of 1-for-20 approved by the Board of Directors on December 9, 2025 [3]. Group 2: Impact on Shareholders - No fractional shares will be issued; all fractional shares will be rounded up to the next whole share, ensuring uniform impact on all shareholders [4]. - Registered shareholders will not need to take any action to receive split-adjusted shares, as adjustments will be made automatically for those holding shares through brokers or other organizations [5]. Group 3: Company Background - TNL Mediagene was formed in May 2023 through the merger of The News Lens Co. and Mediagene Inc., focusing on digital media and data services across Asia [6]. - The company operates in multiple languages and offers a range of services including AI-driven advertising and marketing technology [6].

Core Viewpoint - Gunnison Copper Corp. has entered into a Collaboration Framework Agreement with Lunasonde Inc. to utilize advanced remote sensing technology for mineral exploration in the Cochise Mining District, Arizona [1][2][3] Collaboration Agreement - Lunasonde will conduct a high-resolution subsurface survey over a portion of Gunnison's mineral property using its Airborne Georadiotomography (aGRT) technology [2] - The survey will include test flights and data analysis to create three-dimensional imaging of subsurface anomalies that may contain critical minerals [2][5] - The collaboration aims to enhance exploration and targeting efficiency across Gunnison's land position, which includes multiple known copper deposits [3] Company Strategy - The partnership reflects Gunnison's commitment to innovation and data-driven decision-making to improve geological understanding and long-term value creation [4] - The technology from Lunasonde is expected to complement traditional exploration methods, providing a non-invasive data acquisition approach [5] Financial Update - Gunnison has received a third conversion notice from Nebari Natural Resources Credit Fund for US$500,000, resulting in the issuance of 2,384,358 common shares [6][7] - The conversion will reduce the principal amount of the Second Amended and Restated Credit Agreement, potentially allowing for full repayment using proceeds from the sale of 48C tax credits [6] Company Overview - Gunnison Copper Corp. is a multi-asset copper developer and producer, controlling the Cochise Mining District with 12 known deposits within an 8 km radius [8] - The flagship Gunnison Copper Project has a Measured and Indicated Mineral Resource of over 831.6 million tons with a total copper grade of 0.31% and a preliminary economic assessment indicating an NPV of $1.3 billion and an IRR of 20.9% [9]

The crypto market's rich vein of volatility extended into Friday morning, with bitcoin (BTC) rising from a 1:00 a.m. UTC low of $85,200 to $88,000 over five hours after the Bank of Japan increased interest rates to the highest level in 30 years. The move marked the fourth time bitcoin has jumped by more than 2% this week, although each rally has been temporary and quickly faded as price action resembles the choppy behavior of previous crypto bear markets. Nasdaq 100 futures rose by 0.62% during the same ...

AKRON, Ohio--(BUSINESS WIRE)---- $BW--Project is a significant milestone for B&W, as it grows its business of providing advanced environmental solutions for the refinery industry. ...

Core Insights - Subsea 7 S.A. has received a significant extension of an existing frame agreement from Equinor for subsea inspection, maintenance, and repair services for the vessel Seven Viking, which will last until the end of 2027 [1][2] - The extension allows Seven Viking to perform IMR services for Equinor's oil and gas wells located on the Norwegian Continental Shelf, with project management and engineering work continuing from Subsea 7's Stavanger office [2][3] - Erik Femsteinevik, VP of Subsea 7 Norway, expressed appreciation for Equinor's decision to extend the IMR contract, emphasizing the commitment to support safe and efficient operations [3] Company Overview - Subsea 7 is recognized as a global leader in delivering offshore projects and services, focusing on creating sustainable value and being a preferred partner in the energy industry [3]

Core Insights - Amesite Inc. has launched the NurseMagic™ EMR, expanding its platform into the post-acute care infrastructure following significant revenue growth and enterprise adoption [1][2] Company Summary - The NurseMagic™ EMR is an AI-native, modular electronic medical record system that supports integration with legacy systems and full system replacement, with customer onboarding expected to begin in January 2026 [1][5] - Revenue growth has been driven by the rollout of higher-value product tiers, with a 2.4x increase in quarterly revenue following the launch of Teams+ in May 2025, and an 82% revenue increase in Q4 2025 after introducing the Enterprise tier [2] - The NurseMagic™ platform has evolved from an AI assistant for individual clinicians to an enterprise platform with census-based pricing and now includes an AI-native EMR [3][6] - The company serves over 100 professions across all 50 states and more than 20 countries, focusing on streamlining clinical documentation and supporting point-of-care decision-making [6] Industry Summary - The U.S. post-acute care market is valued at over $470 billion in 2024 and is projected to exceed $850 billion, driven by an aging population and a shift towards lower-cost, home-based care models [4] - Technology-enabled post-acute care has shown significant cost savings and improved clinical outcomes, with NurseMagic™ currently serving various sectors including home health, hospice, skilled nursing, senior living, and home care [4]

Brown Advisory, an investment management company, released its “Brown Advisory Mid-Cap Growth Strategy” third-quarter 2025 investor letter. A copy of the letter can be downloaded here. The strategy underperformed its benchmark, the Russell Midcap® Growth Index, in the third quarter of 2025, which increased approximately 3%.  In addition, please check the fund’s top five holdings to know its best picks in 2025. In its third-quarter 2025 investor letter, Brown Advisory Mid-Cap Growth Strategy highlighted st ...

Core Viewpoint - A more critical perspective on AI winners is deemed sensible by Nomura analysts, suggesting that the current enthusiasm may overlook potential risks and challenges in the sector [1] Group 1: Market Analysis - Analysts highlight that the AI sector has seen significant investment and hype, but caution that not all companies will sustain their growth or profitability [1] - The report indicates that while some firms have reported impressive earnings, the sustainability of these results is questionable in the long term [1] Group 2: Company Performance - Nomura points out that certain AI companies have experienced substantial stock price increases, but this may not accurately reflect their underlying business fundamentals [1] - The analysis suggests that investors should be wary of overvaluation in the AI space, as many companies may not deliver on their growth promises [1]